Tetraacetylphytosphingosine

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  • Identifiers

    CAS number
    13018-48-9

    Molecular formula
    C26H47NO7

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COC(=O)C)NC(=O)C)OC(=O)C)OC(=O)C

    Safety labels

    Corrosive
    Corrosive

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 45.78%
    Fresh 31.79%
    Floral 25.73%
    Lactonic 24.36%
    Waxy 23.24%
    Milky 23.16%
    Woody 23.01%
    Oily 22.9%
    Fatty 21.19%
    Savory 19.98%

     

    Flavor
    Fruity 37.85%
    Mild 33.99%
    Odorless 33.31%
    Bland 30.24%
    Oily 24.73%
    Waxy 24.39%
    Woody 23.23%
    Fatty 21.34%
    Bay oil 20.63%
    Bitter 20.49%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.6

    pKa est.
    6.45 (neutral)

    Molecular weight
    485.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    515°C

    Flash point

    • 231.5 ˚C est.

  • Synonyms

    • Tetraacetylphytosphingosine
    • Cytomide taps
    • 13018-48-9
    • Biomide taps
    • DS-Taps
    • Tetraacetylphytospingosine
    • Tetraacetyl-4-hydroxysphinganine
    • UNII-S6T795QLF2
    • S6T795QLF2
    • Tetraacetylphytosphingosine [INCI]
    • D-Ribo-1,3,4-triacetoxy-2-acetamidooctadecane
    • DTXSID30156382
    • Acetamide, N-((1S,2S,3R)-2,3-bis(acetyloxy)-1-((acetyloxy)methyl)heptadecyl)-
    • Acetamide, N-(2,3-bis(acetyloxy)-1-((acetyloxy)methyl)heptadecyl)-, (1S-(1R*,2R*,3S*))-
    • Acetamide, N-(2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)-, triacetate (ester), d-ribo-
    • RefChem:188362
    • DTXCID0078873
    • 815-527-9
    • orb2646255
    • SCHEMBL30884648
    • FT180755
    • HY-138875
    • CS-0169736
    • Tetraacetylphytosphingosine, >=98% (HPLC)
    • Q27288744
    • (2S,3S,4R)-2-Acetamidooctadecane-1,3,4-triyl triacetate
    • [(2S,3S,4R)-2-acetamido-3,4-diacetyloxyoctadecyl] acetate
    • N-[(1S,2S,3R)-2,3-Bis(acetyloxy)-1-[(acetyloxy)methyl]heptadecyl]acetamide
    • 13018-48-9

  • Applications

    Tetraacetylphytosphingosine (CAS 13018-48-9) is used primarily in cosmetics and personal care as a skin-conditioning agent and a ceramide precursor to support the skin barrier; in pharmaceuticals it may function as a lipid-based excipient or building block for dermal delivery formulations, aiding lipid organization in the vehicle; and it serves as an intermediate in sphingolipid chemistry to enable the synthesis of ceramide-related derivatives and other lipid building blocks used in research and development. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 87.5
    methanol 109.64
    isopropanol 63.71
    water 1.8
    ethyl acetate 175.31
    n-propanol 91.41
    acetone 282.03
    n-butanol 65.14
    acetonitrile 98.06
    DMF 725.56
    toluene 44.03
    isobutanol 64.63
    1,4-dioxane 156.39
    methyl acetate 222.87
    THF 370.87
    2-butanone 232.78
    n-pentanol 59.25
    sec-butanol 80.41
    n-hexane 5.33
    ethylene glycol 22.17
    NMP 1316.43
    cyclohexane 6.9
    DMSO 719.7
    n-butyl acetate 92.87
    n-octanol 24.62
    chloroform 351.35
    n-propyl acetate 123.99
    acetic acid 499.42
    dichloromethane 388.34
    cyclohexanone 384.87
    propylene glycol 45.46
    isopropyl acetate 110.03
    DMAc 1366.08
    2-ethoxyethanol 172.29
    isopentanol 52.92
    n-heptane 2.07
    ethyl formate 144.03
    1,2-dichloroethane 256.12
    n-hexanol 27.48
    2-methoxyethanol 221.87
    isobutyl acetate 64.5
    tetrachloromethane 69.71
    n-pentyl acetate 96.38
    transcutol 341.46
    n-heptanol 23.8
    ethylbenzene 27.91
    MIBK 81.42
    2-propoxyethanol 115.04
    tert-butanol 71.38
    MTBE 78.84
    2-butoxyethanol 103.25
    propionic acid 230.16
    o-xylene 45.07
    formic acid 196.0
    diethyl ether 62.18
    m-xylene 25.63
    p-xylene 43.85
    chlorobenzene 92.2
    dimethyl carbonate 151.29
    n-octane 1.39
    formamide 267.34
    cyclopentanone 478.75
    2-pentanone 156.48
    anisole 77.31
    cyclopentyl methyl ether 133.01
    gamma-butyrolactone 650.62
    1-methoxy-2-propanol 156.37
    pyridine 198.61
    3-pentanone 159.47
    furfural 486.7
    n-dodecane 1.09
    diethylene glycol 73.87
    diisopropyl ether 16.42
    tert-amyl alcohol 95.01
    acetylacetone 260.09
    n-hexadecane 1.24
    acetophenone 143.84
    methyl propionate 210.86
    isopentyl acetate 84.79
    trichloroethylene 498.93
    n-nonanol 24.98
    cyclohexanol 84.68
    benzyl alcohol 81.19
    2-ethylhexanol 20.32
    isooctanol 20.81
    dipropyl ether 35.1
    1,2-dichlorobenzene 107.93
    ethyl lactate 84.46
    propylene carbonate 338.52
    n-methylformamide 306.52
    2-pentanol 40.19
    n-pentane 3.7
    1-propoxy-2-propanol 82.81
    1-methoxy-2-propyl acetate 128.23
    2-(2-methoxypropoxy) propanol 127.03
    mesitylene 14.68
    ε-caprolactone 433.04
    p-cymene 15.74
    epichlorohydrin 463.41
    1,1,1-trichloroethane 263.16
    2-aminoethanol 62.47
    morpholine-4-carbaldehyde 595.66
    sulfolane 1107.21
    2,2,4-trimethylpentane 4.09
    2-methyltetrahydrofuran 245.4
    n-hexyl acetate 103.4
    isooctane 1.24
    2-(2-butoxyethoxy)ethanol 133.45
    sec-butyl acetate 81.93
    tert-butyl acetate 113.04
    decalin 6.14
    glycerin 86.41
    diglyme 303.49
    acrylic acid 225.31
    isopropyl myristate 28.35
    n-butyric acid 251.76
    acetyl acetate 161.37
    di(2-ethylhexyl) phthalate 48.75
    ethyl propionate 128.99
    nitromethane 761.33
    1,2-diethoxyethane 92.48
    benzonitrile 81.07
    trioctyl phosphate 29.68
    1-bromopropane 97.59
    gamma-valerolactone 684.27
    n-decanol 15.84
    triethyl phosphate 77.52
    4-methyl-2-pentanol 20.16
    propionitrile 70.83
    vinylene carbonate 290.61
    1,1,2-trichlorotrifluoroethane 498.13
    DMS 134.12
    cumene 20.68
    2-octanol 16.59
    2-hexanone 115.15
    octyl acetate 46.03
    limonene 25.19
    1,2-dimethoxyethane 245.7
    ethyl orthosilicate 64.5
    tributyl phosphate 46.3
    diacetone alcohol 143.77
    N,N-dimethylaniline 67.47
    acrylonitrile 102.29
    aniline 81.54
    1,3-propanediol 89.27
    bromobenzene 82.84
    dibromomethane 203.98
    1,1,2,2-tetrachloroethane 445.37
    2-methyl-cyclohexyl acetate 81.65
    tetrabutyl urea 71.42
    diisobutyl methanol 11.12
    2-phenylethanol 48.6
    styrene 35.88
    dioctyl adipate 74.82
    dimethyl sulfate 453.94
    ethyl butyrate 89.34
    methyl lactate 143.8
    butyl lactate 92.3
    diethyl carbonate 71.06
    propanediol butyl ether 84.56
    triethyl orthoformate 74.17
    p-tert-butyltoluene 13.66
    methyl 4-tert-butylbenzoate 137.32
    morpholine 250.18
    tert-butylamine 33.01
    n-dodecanol 10.56
    dimethoxymethane 221.42
    ethylene carbonate 230.95
    cyrene 168.78
    2-ethoxyethyl acetate 163.8
    2-ethylhexyl acetate 68.46
    1,2,4-trichlorobenzene 161.16
    4-methylpyridine 220.3
    dibutyl ether 34.71
    2,6-dimethyl-4-heptanol 11.12
    DEF 293.76
    dimethyl isosorbide 218.27
    tetrachloroethylene 281.07
    eugenol 103.36
    triacetin 188.65
    span 80 83.76
    1,4-butanediol 43.14
    1,1-dichloroethane 206.82
    2-methyl-1-pentanol 58.6
    methyl formate 230.16
    2-methyl-1-butanol 70.33
    n-decane 2.28
    butyronitrile 65.3
    3,7-dimethyl-1-octanol 23.52
    1-chlorooctane 17.13
    1-chlorotetradecane 5.55
    n-nonane 2.01
    undecane 1.47
    tert-butylcyclohexane 4.38
    cyclooctane 1.91
    cyclopentanol 117.67
    tetrahydropyran 146.68
    tert-amyl methyl ether 87.19
    2,5,8-trioxanonane 194.88
    1-hexene 23.17
    2-isopropoxyethanol 111.23
    2,2,2-trifluoroethanol 263.02
    methyl butyrate 184.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction