Tert-Butylamine

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  • Identifiers

    CAS number
    75-64-9

    Molecular formula
    C4H11N

    SMILES
    CC(C)(C)N

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Camphoreous 37.4%
    Mint 36.27%
    Sulfurous 34.6%
    Fishy 34.22%
    Fermented 27.97%
    Musty 27.51%
    Solvent 24.91%
    Pungent 24.76%
    Cheesy 24.08%
    Sweaty 24.07%

     

    Flavor
    Pungent 32.63%
    Fishy 28.95%
    Green 20.97%
    Oily 20.91%
    Rotten 20.06%
    Earthy 20.0%
    Catty 19.77%
    Black currant 19.67%
    Blackberry 19.66%
    Yeasty 19.55%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    9.33 (weak base)

    Molecular weight
    73.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -89.5 °F (NTP, 1992)
    • -72.65 °C

    Boiling point

    • 111.9 °F at 760 mmHg (NTP, 1992)
    • 44 - 46 °C

    Flash point

    • -15.99 ˚C est.
    • 50 °F (NTP, 1992)
    • -8 °C
    • 16 °F (-8 °C) (closed cup)

    Solubility expt.

    • Very soluble (NTP, 1992)
    • Miscible with alcohol and ether; soluble in chloroform
    • Sol in common organic solvents
    • In water, 1X10+6 mg/L at 25 °C /miscible/

  • Synonyms

    • tert-Butylamine
    • 75-64-9
    • 2-methylpropan-2-amine
    • Erbumine
    • t-Butylamine
    • 2-Amino-2-methylpropane
    • 2-Propanamine, 2-methyl-
    • 1,1-Dimethylethylamine
    • 2-Aminoisobutane
    • 1,1-Dimethylethanamine
    • 2-METHYL-2-PROPANAMINE
    • TERTIARY-BUTYLAMINE
    • Butylamine, tert
    • 2-Methyl-2-aminopropane
    • Erbumine [INN]
    • Butylamine, tertiary
    • tert-butyl-amine
    • 2-Methyl-2-propylamine
    • Butylamine, tert-
    • tert-C4H9NH2
    • CCRIS 4758
    • HSDB 5209
    • t-Butyl amine
    • N-tert-butylamine
    • NSC 9571
    • EINECS 200-888-1
    • 1-amino-1,1-dimethylethane
    • UNII-91Z53KF68U
    • 1,1dimethylethanamine
    • DTXSID5024681
    • CHEBI:44639
    • AI3-24036
    • NSC-9571
    • MFCD00008050
    • TERT-BUTYLAMINE [MI]
    • DTXCID404681
    • EC 200-888-1
    • PROPANE,2-AMINO,2-METHYL
    • 91Z53KF68U
    • 2-METHYL-2-PROPANAMINE [HSDB]
    • propane, 2-amino-2-methyl-
    • tertbutylamine
    • tert-butyl amine
    • tert.-butylamine
    • tbutylamine
    • CP 11093
    • t-butylarnine
    • ter-butylamine
    • tert butylamine
    • tert-buylamine
    • tert.butylamine
    • 2Aminoisobutane
    • tert-buyl amine
    • C4H11N
    • t-butyl-amine
    • t-butylamine-
    • tert. butylamine
    • tert.butyl-amine
    • tertiarybutylamine
    • N-tert.butylamine
    • tert. -butylamine
    • tert. butyl amine
    • tertiary butylamine
    • tert-BuNH2
    • 2Methyl2propanamine
    • N-tert-butyl amine
    • N-tert-butyl-amine
    • N-tert.-butylamine
    • 2Amino2methylpropane
    • 2Methyl2aminopropane
    • tBuNH2
    • Tertiary butyl amine
    • trimethyl aminomethane
    • 1,1dimethylethylamine
    • t-BuNH2
    • 2Propanamine, 2methyl
    • tert-Butylamine, 98%
    • 2-methyl-2-propaneamine
    • 2-methylpropane-2-amine
    • (1,1-dimethylethyl)amine
    • TRIMETHYLCARBINYLAMINE
    • CHEMBL13782
    • 1,1-DIMETHYLAMINOMETHANE
    • NSC9571
    • WLN: ZX1&1&1
    • BCP30723
    • STR00192
    • Tox21_301289
    • STL185610
    • AKOS000269018
    • CAS-75-64-9
    • NCGC00257538-01
    • B0709
    • NS00005359
    • EN300-16766
    • D87618
    • Q288188
    • tert-Butylamine, purified by redistillation, >=99.5%
    • F2190-0362
    • 2-Methylpropan-2-amine pound>>t-Butylamine pound>>2-Amino-2-methylpropane

  • Applications

    Tert-Butylamine (CAS 75-64-9) is primarily used as an amine building block in organic synthesis, serving as a precursor for pharmaceutical and agrochemical intermediates; it participates in Boc-protection processes to form Boc-protected amines for peptide and small-molecule synthesis; it also serves as a feedstock for amine-functional polymers and coating components, contributing to epoxy and polyurethane formulations; and it can be used as a reactive starting material to prepare specialty chemicals and high-performance materials for various industrial manufacturing applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 105.69
    methanol 173.97
    isopropanol 91.64
    water 35.28
    ethyl acetate 52.21
    n-propanol 102.75
    acetone 64.3
    n-butanol 94.07
    acetonitrile 49.61
    DMF 110.36
    toluene 20.21
    isobutanol 74.68
    1,4-dioxane 77.72
    methyl acetate 59.93
    THF 122.85
    2-butanone 69.81
    n-pentanol 54.23
    sec-butanol 91.79
    n-hexane 36.35
    ethylene glycol 85.95
    NMP 155.77
    cyclohexane 29.74
    DMSO 66.81
    n-butyl acetate 68.1
    n-octanol 78.17
    chloroform 100.57
    n-propyl acetate 35.77
    acetic acid 149.31
    dichloromethane 47.51
    cyclohexanone 82.43
    propylene glycol 128.18
    isopropyl acetate 39.95
    DMAc 143.0
    2-ethoxyethanol 66.48
    isopentanol 62.85
    n-heptane 59.05
    ethyl formate 39.36
    1,2-dichloroethane 29.04
    n-hexanol 129.13
    2-methoxyethanol 126.83
    isobutyl acetate 31.71
    tetrachloromethane 44.67
    n-pentyl acetate 43.84
    transcutol 145.3
    n-heptanol 82.44
    ethylbenzene 14.28
    MIBK 31.86
    2-propoxyethanol 156.84
    tert-butanol 107.54
    MTBE 72.39
    2-butoxyethanol 106.56
    propionic acid 125.42
    o-xylene 23.85
    formic acid 90.08
    diethyl ether 54.65
    m-xylene 21.04
    p-xylene 20.73
    chlorobenzene 24.94
    dimethyl carbonate 36.8
    n-octane 18.73
    formamide 57.67
    cyclopentanone 105.42
    2-pentanone 49.23
    anisole 34.62
    cyclopentyl methyl ether 72.17
    gamma-butyrolactone 107.46
    1-methoxy-2-propanol 113.83
    pyridine 47.97
    3-pentanone 57.59
    furfural 89.35
    n-dodecane 13.86
    diethylene glycol 123.43
    diisopropyl ether 28.99
    tert-amyl alcohol 110.09
    acetylacetone 45.08
    n-hexadecane 13.67
    acetophenone 37.01
    methyl propionate 61.35
    isopentyl acetate 60.28
    trichloroethylene 55.69
    n-nonanol 69.78
    cyclohexanol 84.78
    benzyl alcohol 33.74
    2-ethylhexanol 86.97
    isooctanol 56.63
    dipropyl ether 82.9
    1,2-dichlorobenzene 28.36
    ethyl lactate 49.87
    propylene carbonate 73.57
    n-methylformamide 74.29
    2-pentanol 71.26
    n-pentane 33.25
    1-propoxy-2-propanol 150.04
    1-methoxy-2-propyl acetate 78.85
    2-(2-methoxypropoxy) propanol 102.64
    mesitylene 17.51
    ε-caprolactone 78.85
    p-cymene 32.22
    epichlorohydrin 58.68
    1,1,1-trichloroethane 53.25
    2-aminoethanol 125.88
    morpholine-4-carbaldehyde 119.37
    sulfolane 124.41
    2,2,4-trimethylpentane 22.08
    2-methyltetrahydrofuran 86.38
    n-hexyl acetate 68.07
    isooctane 13.79
    2-(2-butoxyethoxy)ethanol 112.37
    sec-butyl acetate 31.08
    tert-butyl acetate 51.03
    decalin 14.74
    glycerin 166.48
    diglyme 137.2
    acrylic acid 113.58
    isopropyl myristate 39.84
    n-butyric acid 108.48
    acetyl acetate 43.64
    di(2-ethylhexyl) phthalate 44.73
    ethyl propionate 43.0
    nitromethane 93.11
    1,2-diethoxyethane 51.06
    benzonitrile 32.1
    trioctyl phosphate 37.19
    1-bromopropane 32.02
    gamma-valerolactone 108.43
    n-decanol 55.99
    triethyl phosphate 42.02
    4-methyl-2-pentanol 41.66
    propionitrile 58.86
    vinylene carbonate 60.07
    1,1,2-trichlorotrifluoroethane 117.3
    DMS 47.36
    cumene 15.74
    2-octanol 51.33
    2-hexanone 39.73
    octyl acetate 55.93
    limonene 49.45
    1,2-dimethoxyethane 76.17
    ethyl orthosilicate 44.03
    tributyl phosphate 41.99
    diacetone alcohol 69.47
    N,N-dimethylaniline 34.39
    acrylonitrile 56.15
    aniline 45.93
    1,3-propanediol 99.38
    bromobenzene 19.2
    dibromomethane 40.65
    1,1,2,2-tetrachloroethane 66.36
    2-methyl-cyclohexyl acetate 60.7
    tetrabutyl urea 53.63
    diisobutyl methanol 48.12
    2-phenylethanol 57.4
    styrene 15.76
    dioctyl adipate 50.5
    dimethyl sulfate 50.74
    ethyl butyrate 59.36
    methyl lactate 82.11
    butyl lactate 62.43
    diethyl carbonate 44.12
    propanediol butyl ether 108.33
    triethyl orthoformate 57.94
    p-tert-butyltoluene 36.93
    methyl 4-tert-butylbenzoate 69.04
    morpholine 97.51
    tert-butylamine 87.68
    n-dodecanol 47.02
    dimethoxymethane 63.79
    ethylene carbonate 53.05
    cyrene 78.3
    2-ethoxyethyl acetate 45.01
    2-ethylhexyl acetate 54.11
    1,2,4-trichlorobenzene 40.7
    4-methylpyridine 43.86
    dibutyl ether 52.1
    2,6-dimethyl-4-heptanol 48.12
    DEF 68.88
    dimethyl isosorbide 111.18
    tetrachloroethylene 56.85
    eugenol 69.63
    triacetin 72.35
    span 80 126.5
    1,4-butanediol 50.26
    1,1-dichloroethane 43.55
    2-methyl-1-pentanol 42.21
    methyl formate 49.88
    2-methyl-1-butanol 72.82
    n-decane 21.51
    butyronitrile 48.52
    3,7-dimethyl-1-octanol 63.55
    1-chlorooctane 37.23
    1-chlorotetradecane 20.47
    n-nonane 21.76
    undecane 16.58
    tert-butylcyclohexane 18.68
    cyclooctane 16.44
    cyclopentanol 97.59
    tetrahydropyran 78.21
    tert-amyl methyl ether 72.07
    2,5,8-trioxanonane 116.16
    1-hexene 43.22
    2-isopropoxyethanol 52.0
    2,2,2-trifluoroethanol 79.02
    methyl butyrate 45.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction