Terramycin

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  • Identifiers

    CAS number
    79-57-2

    Molecular formula
    C22H24N2O9

    SMILES
    C[C@@]1([C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 73.33%
    Sweet 31.97%
    Cooling 21.28%
    Bitter 21.27%
    Savory 21.14%
    Milky 18.39%
    Burnt 17.63%
    Spicy 17.43%
    Phenolic 15.72%
    Balsamic 14.61%

     

    Flavor
    Bitter 86.23%
    Odorless 36.79%
    Bland 25.56%
    Sweet-like 21.78%
    Very mild 21.05%
    Cedarleaf 20.11%
    Nitrile 19.12%
    Lovage 18.75%
    Leaves 18.55%
    Basil 18.47%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.6

    pKa est.
    5.65 (weak acid)

    Molecular weight
    460.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2715°C

    Flash point

    • 299.72 ˚C est.

    Solubility expt.

    • 47 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Terramycin
    • RefChem:932744
    • Lidocaine hydrochloride; oxytetracycline
    • (4S,4aR,5S,5aR,6S,12aR)-2-carbamoyl-4-(dimethylazaniumyl)-5,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracen-1-olate
    • 103-115-5
    • oxytetracycline
    • 79-57-2
    • Oxymycin
    • Oxitetraciclina
    • Oxytetracyclin
    • Oxyterracine
    • Ryomycin
    • Biostat
    • Oxitetracyclin
    • Terramitsin
    • Adamycin
    • Riomitsin
    • Oxytetracycline (anhydrous)
    • Tetran
    • Oxitetracyclinum
    • Oxytetracyclinum
    • Oxyterracin
    • Oxytetracycline anhydrous
    • Terrafungine
    • 5-Hydroxytetracycline
    • Oxyterracyne
    • Solkaciclina
    • Dabicycline
    • Fanterrin
    • Geomycin
    • Geotilin
    • Imperacin
    • Lenocycline
    • Oksisyklin
    • Proteroxyna
    • Ursocyclin
    • Ursocycline
    • Oxypam
    • Tarocyn
    • Tarosin
    • Teravit
    • Antibiotic TM 25
    • Oxytetracycline amphoteric
    • Liquamycin LA 200
    • Biostat PA
    • Oxytetracycline [INN]
    • Berkmycen
    • Oxysteclin
    • Oxymykoin
    • Vendarcin
    • Ossitetraciclina
    • Pennox 200
    • Oxy-Kesso-tetra
    • Oxytetracycline (Terramycin)
    • Stevacin
    • Mycoshield TMQTHC 20
    • Bisolvomycin
    • Dalimycin
    • Oxacycline
    • Unimycin
    • NSC-9169
    • Macocyn
    • Medamycin
    • Oxytetracycline calcium
    • Biosolvomycin
    • Mepatar
    • OTC (antibiotic)
    • (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
    • Stecsolin
    • Oxydon
    • MLS000069429
    • NSC 9169
    • SLF0D9077S
    • C22H24N2O9
    • DTXSID1034260
    • Tetracycline, 5-hydroxy-
    • Terramycine
    • Nitox
    • Oxytetracycline (internal use)
    • MFCD00003700
    • TM 5
    • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6S,12aS)-
    • Oxytetracid
    • E703
    • NCI-C56473
    • SMR000059000
    • Terramycin im
    • Terramycin Q50
    • Oxytetracycline base
    • Galsenomycin
    • Oxytetracycline (dihydrate)
    • Ossitetraciclina [DCIT]
    • (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
    • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-
    • OTC
    • Oxytetracyclinum [INN-Latin]
    • Oxitetraciclina [INN-Spanish]
    • Terramicina Oftalmica
    • Geomycin (Streptomyces vimosus)
    • HSDB 3145
    • NSC-757262
    • EINECS 201-212-8
    • LA 200
    • BRN 2714587
    • UNII-SLF0D9077S
    • Embryostat
    • SR-01000003006
    • Hydroxytetracyclinum
    • Oxytetracycline CRS
    • 5-Hydroxy-Tetracycline
    • Spectrum_001055
    • Opera_ID_661
    • Oxytetracycline dehydrate
    • Oxytetracyclinum dihydras
    • Prestwick0_000307
    • Prestwick1_000307
    • Prestwick2_000307
    • Prestwick3_000307
    • Spectrum2_000988
    • Spectrum3_000536
    • Spectrum4_000466
    • Spectrum5_001148
    • Doxycycline EP Impurity E
    • Oxytetracycline (Standard)
    • SCHEMBL2899
    • CHEMBL1517
    • OXYTETRACYCLINE [MI]
    • 79-57-2

  • Applications

    Terramycin (CAS 79-57-2) is oxytetracycline, a broad-spectrum antibiotic used primarily in agriculture and medicine: as a veterinary medicine to treat bacterial infections in livestock, poultry, and companion animals; administered as a feed or drinking-water additive in animal production; for disease control in aquaculture; and in ophthalmic and topical pharmaceutical formulations for animals and humans where permitted by local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.95
    methanol 4.67
    isopropanol 0.17
    water 0.06
    ethyl acetate 0.18
    n-propanol 0.45
    acetone 0.28
    n-butanol 0.27
    acetonitrile 0.34
    DMF 4.4
    toluene 0.05
    isobutanol 0.14
    1,4-dioxane 0.96
    methyl acetate 0.35
    THF 3.26
    2-butanone 0.38
    n-pentanol 0.22
    sec-butanol 0.13
    n-hexane 0.02
    ethylene glycol 1.83
    NMP 8.18
    cyclohexane 0.02
    DMSO 10.74
    n-butyl acetate 0.25
    n-octanol 0.07
    chloroform 0.34
    n-propyl acetate 0.21
    acetic acid 2.0
    dichloromethane 0.41
    cyclohexanone 0.82
    propylene glycol 0.71
    isopropyl acetate 0.07
    DMAc 4.18
    2-ethoxyethanol 2.26
    isopentanol 0.12
    n-heptane 0.01
    ethyl formate 0.75
    1,2-dichloroethane 0.32
    n-hexanol 0.22
    2-methoxyethanol 5.73
    isobutyl acetate 0.07
    tetrachloromethane 0.09
    n-pentyl acetate 0.14
    transcutol 0.59
    n-heptanol 0.17
    ethylbenzene 0.05
    MIBK 0.09
    2-propoxyethanol 2.42
    tert-butanol 0.09
    MTBE 0.03
    2-butoxyethanol 1.15
    propionic acid 0.6
    o-xylene 0.04
    formic acid 10.11
    diethyl ether 0.12
    m-xylene 0.03
    p-xylene 0.05
    chlorobenzene 0.06
    dimethyl carbonate 0.7
    n-octane 0.01
    formamide 8.95
    cyclopentanone 2.12
    2-pentanone 0.21
    anisole 0.11
    cyclopentyl methyl ether 0.34
    gamma-butyrolactone 3.52
    1-methoxy-2-propanol 1.53
    pyridine 0.93
    3-pentanone 0.21
    furfural 3.17
    n-dodecane 0.0
    diethylene glycol 3.81
    diisopropyl ether 0.01
    tert-amyl alcohol 0.09
    acetylacetone 0.26
    n-hexadecane 0.0
    acetophenone 0.26
    methyl propionate 0.45
    isopentyl acetate 0.14
    trichloroethylene 0.56
    n-nonanol 0.08
    cyclohexanol 0.16
    benzyl alcohol 0.27
    2-ethylhexanol 0.09
    isooctanol 0.08
    dipropyl ether 0.13
    1,2-dichlorobenzene 0.08
    ethyl lactate 0.48
    propylene carbonate 0.85
    n-methylformamide 4.46
    2-pentanol 0.07
    n-pentane 0.01
    1-propoxy-2-propanol 0.69
    1-methoxy-2-propyl acetate 0.4
    2-(2-methoxypropoxy) propanol 0.5
    mesitylene 0.02
    ε-caprolactone 0.87
    p-cymene 0.03
    epichlorohydrin 2.58
    1,1,1-trichloroethane 0.08
    2-aminoethanol 1.75
    morpholine-4-carbaldehyde 5.42
    sulfolane 7.3
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.57
    n-hexyl acetate 0.11
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.65
    sec-butyl acetate 0.07
    tert-butyl acetate 0.07
    decalin 0.01
    glycerin 3.17
    diglyme 1.41
    acrylic acid 1.25
    isopropyl myristate 0.03
    n-butyric acid 0.46
    acetyl acetate 0.12
    di(2-ethylhexyl) phthalate 0.12
    ethyl propionate 0.23
    nitromethane 3.03
    1,2-diethoxyethane 0.14
    benzonitrile 0.24
    trioctyl phosphate 0.11
    1-bromopropane 0.12
    gamma-valerolactone 4.75
    n-decanol 0.05
    triethyl phosphate 0.2
    4-methyl-2-pentanol 0.04
    propionitrile 0.37
    vinylene carbonate 1.0
    1,1,2-trichlorotrifluoroethane 4.83
    DMS 0.23
    cumene 0.03
    2-octanol 0.05
    2-hexanone 0.24
    octyl acetate 0.07
    limonene 0.04
    1,2-dimethoxyethane 2.34
    ethyl orthosilicate 0.14
    tributyl phosphate 0.09
    diacetone alcohol 0.36
    N,N-dimethylaniline 0.12
    acrylonitrile 0.86
    aniline 0.15
    1,3-propanediol 1.74
    bromobenzene 0.04
    dibromomethane 0.2
    1,1,2,2-tetrachloroethane 0.44
    2-methyl-cyclohexyl acetate 0.17
    tetrabutyl urea 0.21
    diisobutyl methanol 0.03
    2-phenylethanol 0.32
    styrene 0.04
    dioctyl adipate 0.08
    dimethyl sulfate 1.76
    ethyl butyrate 0.2
    methyl lactate 1.24
    butyl lactate 0.29
    diethyl carbonate 0.18
    propanediol butyl ether 0.51
    triethyl orthoformate 0.18
    p-tert-butyltoluene 0.02
    methyl 4-tert-butylbenzoate 0.27
    morpholine 1.74
    tert-butylamine 0.03
    n-dodecanol 0.03
    dimethoxymethane 2.08
    ethylene carbonate 0.68
    cyrene 1.85
    2-ethoxyethyl acetate 0.27
    2-ethylhexyl acetate 0.13
    1,2,4-trichlorobenzene 0.12
    4-methylpyridine 0.34
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.03
    DEF 0.74
    dimethyl isosorbide 1.33
    tetrachloroethylene 0.53
    eugenol 0.46
    triacetin 0.18
    span 80 0.37
    1,4-butanediol 0.68
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.12
    methyl formate 3.02
    2-methyl-1-butanol 0.14
    n-decane 0.01
    butyronitrile 0.27
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 0.4
    tetrahydropyran 0.38
    tert-amyl methyl ether 0.05
    2,5,8-trioxanonane 0.94
    1-hexene 0.05
    2-isopropoxyethanol 0.59
    2,2,2-trifluoroethanol 1.66
    methyl butyrate 0.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction