Telmesteine

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  • Identifiers

    CAS number
    122946-43-4

    Molecular formula
    C7H11NO4S

    SMILES
    CCOC(=O)N1CSC[C@H]1C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 49.8%
    Roasted 34.02%
    Meaty 30.29%
    Savory 24.48%
    Cooked 24.25%
    Nutty 22.99%
    Sulfurous 22.79%
    Fruity 21.54%
    Grape 20.25%
    Sweet 17.32%

     

    Flavor
    Bitter 45.98%
    Odorless 35.92%
    Very mild 26.29%
    Mild 23.29%
    Fruity 23.13%
    Bland 22.83%
    Yeast 21.11%
    Sweet-like 20.65%
    Taco 20.53%
    Cooked 19.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    6.01 (neutral)

    Molecular weight
    205.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    321°C

    Flash point

    • 179.95 ˚C est.

  • Synonyms

    • Telmesteine
    • 122946-43-4
    • Telmesteina
    • Reolase
    • Telmesteinum
    • 124I3FE35T
    • DTXSID60153804
    • telmestein
    • RefChem:187778
    • DTXCID6076295
    • 3-ethylhydrogen-3,4-thiazolidinedicarboxylate
    • Telmesteine [INN]
    • (4R)-3-ethoxycarbonyl-1,3-thiazolidine-4-carboxylic acid
    • Telmesteine (INN)
    • (4R)-3-(ethoxycarbonyl)-1,3-thiazolidine-4-carboxylic acid
    • (R)-3-(Ethoxycarbonyl)thiazolidine-4-carboxylic acid
    • Telmesteinum [INN-Latin]
    • Telmesteina [INN-Spanish]
    • UNII-124I3FE35T
    • Reolase (TN)
    • TELMESTEINE [MART.]
    • TELMESTEINE [WHO-DD]
    • SCHEMBL637246
    • orb1705307
    • CHEMBL2107621
    • CHEBI:134866
    • EBC-13371
    • AKOS010385372
    • DA-68031
    • FT170508
    • HY-125495
    • CS-0091938
    • NS00014149
    • D08565
    • EN300-881275
    • Q27251366
    • (-)-3-Ethyl hydrogen (R)-3,4-thiazolidinedicarboxylate
    • 122946-43-4

  • Applications

    Telmesteine (CAS 122946-43-4) may serve as an intermediate in organic synthesis and as a processing aid or solvent in various industrial formulations. It can function as a stabilizer or additive for polymers, plastics, and coatings, and may act as a chelating agent in cleaners or formulation systems. In fragrance and cosmetics applications, it could be evaluated as an odorant component or fixative, depending on regulatory status and formulation limits. It may also see use in cleaning products and as a processing aid in adhesives or inks and coatings, with final use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 105.3
    methanol 269.59
    isopropanol 54.49
    water 52.48
    ethyl acetate 18.49
    n-propanol 51.76
    acetone 59.91
    n-butanol 39.85
    acetonitrile 61.01
    DMF 405.89
    toluene 9.15
    isobutanol 30.43
    1,4-dioxane 62.81
    methyl acetate 31.14
    THF 75.85
    2-butanone 30.14
    n-pentanol 39.32
    sec-butanol 39.26
    n-hexane 0.72
    ethylene glycol 98.3
    NMP 287.35
    cyclohexane 1.66
    DMSO 754.54
    n-butyl acetate 19.88
    n-octanol 16.56
    chloroform 41.04
    n-propyl acetate 19.04
    acetic acid 186.66
    dichloromethane 81.69
    cyclohexanone 74.47
    propylene glycol 59.2
    isopropyl acetate 13.07
    DMAc 286.15
    2-ethoxyethanol 144.94
    isopentanol 34.34
    n-heptane 0.85
    ethyl formate 51.15
    1,2-dichloroethane 55.19
    n-hexanol 21.51
    2-methoxyethanol 212.36
    isobutyl acetate 8.53
    tetrachloromethane 5.28
    n-pentyl acetate 19.75
    transcutol 148.44
    n-heptanol 16.94
    ethylbenzene 8.61
    MIBK 18.17
    2-propoxyethanol 72.8
    tert-butanol 48.66
    MTBE 12.19
    2-butoxyethanol 52.43
    propionic acid 62.94
    o-xylene 11.67
    formic acid 395.55
    diethyl ether 10.39
    m-xylene 9.36
    p-xylene 11.58
    chlorobenzene 20.77
    dimethyl carbonate 23.71
    n-octane 0.71
    formamide 485.89
    cyclopentanone 91.15
    2-pentanone 22.47
    anisole 26.85
    cyclopentyl methyl ether 21.8
    gamma-butyrolactone 148.63
    1-methoxy-2-propanol 104.36
    pyridine 76.18
    3-pentanone 14.52
    furfural 210.53
    n-dodecane 0.81
    diethylene glycol 113.64
    diisopropyl ether 3.51
    tert-amyl alcohol 41.6
    acetylacetone 42.41
    n-hexadecane 0.91
    acetophenone 47.93
    methyl propionate 24.31
    isopentyl acetate 18.02
    trichloroethylene 94.8
    n-nonanol 15.33
    cyclohexanol 31.87
    benzyl alcohol 59.35
    2-ethylhexanol 12.37
    isooctanol 13.94
    dipropyl ether 6.66
    1,2-dichlorobenzene 26.46
    ethyl lactate 31.03
    propylene carbonate 67.51
    n-methylformamide 234.68
    2-pentanol 21.55
    n-pentane 0.9
    1-propoxy-2-propanol 39.7
    1-methoxy-2-propyl acetate 28.53
    2-(2-methoxypropoxy) propanol 48.4
    mesitylene 6.1
    ε-caprolactone 73.75
    p-cymene 6.92
    epichlorohydrin 129.8
    1,1,1-trichloroethane 15.41
    2-aminoethanol 118.82
    morpholine-4-carbaldehyde 223.0
    sulfolane 260.47
    2,2,4-trimethylpentane 0.76
    2-methyltetrahydrofuran 41.14
    n-hexyl acetate 23.67
    isooctane 0.5
    2-(2-butoxyethoxy)ethanol 61.3
    sec-butyl acetate 10.23
    tert-butyl acetate 16.41
    decalin 1.36
    glycerin 124.7
    diglyme 110.92
    acrylic acid 95.06
    isopropyl myristate 9.02
    n-butyric acid 52.09
    acetyl acetate 19.7
    di(2-ethylhexyl) phthalate 21.1
    ethyl propionate 15.65
    nitromethane 258.66
    1,2-diethoxyethane 22.8
    benzonitrile 51.86
    trioctyl phosphate 14.87
    1-bromopropane 13.7
    gamma-valerolactone 176.38
    n-decanol 11.69
    triethyl phosphate 16.09
    4-methyl-2-pentanol 12.94
    propionitrile 28.57
    vinylene carbonate 85.63
    1,1,2-trichlorotrifluoroethane 152.56
    DMS 27.07
    cumene 7.01
    2-octanol 11.5
    2-hexanone 19.51
    octyl acetate 14.32
    limonene 8.22
    1,2-dimethoxyethane 123.42
    ethyl orthosilicate 13.16
    tributyl phosphate 15.71
    diacetone alcohol 44.23
    N,N-dimethylaniline 28.02
    acrylonitrile 70.25
    aniline 33.11
    1,3-propanediol 109.36
    bromobenzene 16.26
    dibromomethane 36.61
    1,1,2,2-tetrachloroethane 69.28
    2-methyl-cyclohexyl acetate 20.36
    tetrabutyl urea 26.31
    diisobutyl methanol 7.74
    2-phenylethanol 36.27
    styrene 10.66
    dioctyl adipate 19.62
    dimethyl sulfate 72.6
    ethyl butyrate 16.05
    methyl lactate 49.25
    butyl lactate 31.07
    diethyl carbonate 14.6
    propanediol butyl ether 58.84
    triethyl orthoformate 14.38
    p-tert-butyltoluene 6.04
    methyl 4-tert-butylbenzoate 41.35
    morpholine 90.13
    tert-butylamine 17.8
    n-dodecanol 8.8
    dimethoxymethane 88.73
    ethylene carbonate 55.79
    cyrene 80.06
    2-ethoxyethyl acetate 31.64
    2-ethylhexyl acetate 13.81
    1,2,4-trichlorobenzene 33.76
    4-methylpyridine 64.97
    dibutyl ether 8.32
    2,6-dimethyl-4-heptanol 7.74
    DEF 64.77
    dimethyl isosorbide 74.16
    tetrachloroethylene 48.26
    eugenol 51.39
    triacetin 35.23
    span 80 39.98
    1,4-butanediol 75.47
    1,1-dichloroethane 19.99
    2-methyl-1-pentanol 33.77
    methyl formate 152.11
    2-methyl-1-butanol 32.29
    n-decane 1.19
    butyronitrile 30.46
    3,7-dimethyl-1-octanol 14.61
    1-chlorooctane 5.39
    1-chlorotetradecane 2.52
    n-nonane 1.0
    undecane 0.95
    tert-butylcyclohexane 0.94
    cyclooctane 0.84
    cyclopentanol 43.52
    tetrahydropyran 26.35
    tert-amyl methyl ether 13.15
    2,5,8-trioxanonane 81.31
    1-hexene 3.38
    2-isopropoxyethanol 66.11
    2,2,2-trifluoroethanol 99.69
    methyl butyrate 29.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction