Taxifolin

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  • Identifiers

    CAS number
    480-18-2

    Molecular formula
    C15H12O7

    SMILES
    C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 72.45%
    Phenolic 50.0%
    Burnt 31.75%
    Vanilla 24.29%
    Smoky 24.03%
    Spicy 23.32%
    Savory 20.55%
    Medicinal 20.11%
    Bitter 19.28%
    Balsamic 18.97%

     

    Flavor
    Bitter 91.23%
    Odorless 28.04%
    Bland 25.67%
    Sweet-like 23.25%
    Cedarleaf 20.45%
    Lovage 19.81%
    Eugenol 19.77%
    Parsley 19.61%
    Nitrile 19.6%
    Very strong 19.1%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    9.8 (weak base)

    Molecular weight
    304.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    846°C

    Flash point

    • 266.69 ˚C est.

  • Synonyms

    • TAXIFOLIN
    • 480-18-2
    • (+)-Taxifolin
    • Distylin
    • Taxifoliol
    • (+)-Dihydroquercetin
    • (2R,3R)-Dihydroquercetin
    • Lavitol
    • Diquertin
    • 2,3-Dihydroquercetin
    • Flamena D
    • (2R,3R)-(+)-Taxifolin
    • (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
    • trans-Dihydroquercetin
    • (+)-(2R,3R)-dihydroquercetin
    • (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE
    • DTXSID8022450
    • Flavanone, 3,3',4',5,7-pentahydroxy-
    • 9SOB9E3987
    • CHEBI:17948
    • CHEBI:38747
    • RefChem:6285
    • GlyTouCan:G55446YY
    • DTXCID502450
    • G55446YY
    • 207-543-4
    • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
    • Catechin hydrate
    • dihydroquercetin
    • 24198-97-8
    • (+/-)-Taxifolin
    • TAXIFOLIN-(+)
    • Lariksin
    • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
    • (+)-trans-Taxifolin
    • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
    • (+/-)-dihydroquercetin
    • taxifolin (dihydroquercetin)
    • (+)-trans Taxifolin
    • 17654-26-1
    • Taxifolin, (+/-)-
    • (+/-)-trans Taxifolin
    • EAS93SC1VS
    • Dihydroquercetin, (+/-)-
    • (2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone
    • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one
    • rel-(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
    • (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
    • (?)-Taxifolin
    • MFCD00006845
    • (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)-
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, trans-(+/-)-
    • DQH
    • SMR000466389
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-
    • taxifoline
    • toxifolin
    • UNII-9SOB9E3987
    • CCRIS 9292
    • Taxifolin CRS
    • (+)-Dihydroquercetin; (+)-Taxifolin
    • Taxifolin (Tax)
    • ()-Taxifolin
    • EINECS 207-543-4
    • FLAMENA
    • 3,3',4',5,7-Pentahydroxyflavanone hydrate
    • Taxifolin (Standard)
    • (2R,3R)-TRANS-DIHYDROQUERCETIN
    • BRN 0093548
    • (2R,3R)-Taxifolin
    • UNII-EAS93SC1VS
    • (+/-)-Taxifolin hydrate
    • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
    • SCHEMBL39786
    • 5-18-05-00451 (Beilstein Handbook Reference)
    • MLS000759539
    • MLS001066341
    • MLS001074712
    • MLS001424044
    • MLS002153142
    • BIDD:ER0483
    • Taxifolin, analytical standard
    • Flavone, 2,3-dihydro-3,3',4',5,7-pentahydroxy-
    • MEGxp0_000741
    • orb1307570
    • orb1690847
    • SCHEMBL29361519
    • SCHEMBL29367955
    • SCHEMBL30631315
    • ACon1_000239
    • HY-N0136R
    • DIHYDROQUERCETIN [WHO-DD]
    • WLZ4646
    • BDBM212435
    • DTXSID301017215
    • HMS2051M22
    • HMS2234L14
    • HY-N0136
    • AC-935
    • MFCD11044454
    • MSK174293
    • s2366
    • AKOS015965399
    • (+/-)-Taxifolin - Bio-X trade mark
    • CCG-100909
    • CS-3365
    • DB02224
    • EBC-223039
    • FT28009
    • FT28010
    • KS-1312
    • NC00159
    • NCGC00016024-08
    • NCGC00180750-01
    • 20254-28-8
    • AS-17723
    • BT300132
    • DIHYDROQUERCETIN, (+)-(2R,3R)-
    • NS00015857
    • SW197539-2
    • T3666
    • C01617
    • G12170
    • (2R,3R)-3,5,7,3',4'-Pentahydroxyflavanone
    • Q412191
    • Taxifolin

  • Applications

    Taxifolin (CAS 480-18-2) is a natural dihydroflavonol with strong antioxidant activity, commonly considered an active ingredient across several industrial applications. In cosmetics and personal care, it is used as an antioxidant and stabilizer in formulations. In food processing and packaging, taxifolin is evaluated as a natural antioxidant to help preserve quality and extend product shelf life. In pharmaceuticals and nutraceuticals, it has potential as a nutraceutical ingredient and as an intermediate for the synthesis of other bioactive flavonoids. In polymers and plastics, it is studied as a natural antioxidant and stabilizer for polymer materials to improve oxidative stability. In coatings and inks, it is also explored as a natural additive to enhance oxidative stability and coating properties. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 111.21
    methanol 201.94
    isopropanol 93.96
    water 0.63
    ethyl acetate 39.9
    n-propanol 97.75
    acetone 58.39
    n-butanol 61.43
    acetonitrile 18.89
    DMF 377.98
    toluene 0.84
    isobutanol 27.42
    1,4-dioxane 44.04
    methyl acetate 29.15
    THF 328.4
    2-butanone 71.33
    n-pentanol 18.7
    sec-butanol 51.92
    n-hexane 0.08
    ethylene glycol 112.38
    NMP 135.53
    cyclohexane 0.13
    DMSO 1348.21
    n-butyl acetate 8.93
    n-octanol 10.1
    chloroform 0.09
    n-propyl acetate 13.45
    acetic acid 51.97
    dichloromethane 0.1
    cyclohexanone 42.96
    propylene glycol 91.66
    isopropyl acetate 21.38
    DMAc 335.99
    2-ethoxyethanol 235.07
    isopentanol 30.32
    n-heptane 0.33
    ethyl formate 25.66
    1,2-dichloroethane 0.6
    n-hexanol 13.42
    2-methoxyethanol 632.32
    isobutyl acetate 2.43
    tetrachloromethane 0.11
    n-pentyl acetate 7.19
    transcutol 76.11
    n-heptanol 10.05
    ethylbenzene 0.51
    MIBK 22.42
    2-propoxyethanol 125.63
    tert-butanol 76.58
    MTBE 12.52
    2-butoxyethanol 36.7
    propionic acid 33.41
    o-xylene 0.97
    formic acid 111.82
    diethyl ether 20.41
    m-xylene 0.89
    p-xylene 0.48
    chlorobenzene 0.21
    dimethyl carbonate 28.5
    n-octane 0.19
    formamide 256.11
    cyclopentanone 106.27
    2-pentanone 70.39
    anisole 5.18
    cyclopentyl methyl ether 31.92
    gamma-butyrolactone 105.33
    1-methoxy-2-propanol 427.48
    pyridine 11.61
    3-pentanone 25.45
    furfural 37.78
    n-dodecane 0.22
    diethylene glycol 161.25
    diisopropyl ether 2.98
    tert-amyl alcohol 43.93
    acetylacetone 70.74
    n-hexadecane 0.26
    acetophenone 7.41
    methyl propionate 56.78
    isopentyl acetate 6.38
    trichloroethylene 0.79
    n-nonanol 9.73
    cyclohexanol 18.57
    benzyl alcohol 7.91
    2-ethylhexanol 5.57
    isooctanol 6.61
    dipropyl ether 11.28
    1,2-dichlorobenzene 0.27
    ethyl lactate 26.58
    propylene carbonate 17.05
    n-methylformamide 227.21
    2-pentanol 30.33
    n-pentane 0.15
    1-propoxy-2-propanol 64.76
    1-methoxy-2-propyl acetate 29.48
    2-(2-methoxypropoxy) propanol 33.53
    mesitylene 0.64
    ε-caprolactone 34.76
    p-cymene 0.92
    epichlorohydrin 59.95
    1,1,1-trichloroethane 0.29
    2-aminoethanol 155.0
    morpholine-4-carbaldehyde 133.68
    sulfolane 179.04
    2,2,4-trimethylpentane 0.13
    2-methyltetrahydrofuran 50.35
    n-hexyl acetate 10.32
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 44.94
    sec-butyl acetate 6.64
    tert-butyl acetate 23.17
    decalin 0.09
    glycerin 212.6
    diglyme 75.17
    acrylic acid 28.24
    isopropyl myristate 4.38
    n-butyric acid 44.24
    acetyl acetate 10.11
    di(2-ethylhexyl) phthalate 4.04
    ethyl propionate 16.96
    nitromethane 150.4
    1,2-diethoxyethane 16.39
    benzonitrile 2.78
    trioctyl phosphate 4.58
    1-bromopropane 0.56
    gamma-valerolactone 152.12
    n-decanol 6.93
    triethyl phosphate 5.85
    4-methyl-2-pentanol 10.98
    propionitrile 17.74
    vinylene carbonate 10.09
    1,1,2-trichlorotrifluoroethane 55.98
    DMS 8.41
    cumene 0.37
    2-octanol 6.74
    2-hexanone 14.84
    octyl acetate 6.68
    limonene 1.68
    1,2-dimethoxyethane 162.12
    ethyl orthosilicate 5.1
    tributyl phosphate 4.37
    diacetone alcohol 95.87
    N,N-dimethylaniline 4.15
    acrylonitrile 24.54
    aniline 4.84
    1,3-propanediol 225.34
    bromobenzene 0.11
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 1.37
    2-methyl-cyclohexyl acetate 5.0
    tetrabutyl urea 8.86
    diisobutyl methanol 4.62
    2-phenylethanol 7.87
    styrene 0.44
    dioctyl adipate 6.88
    dimethyl sulfate 56.85
    ethyl butyrate 10.74
    methyl lactate 91.68
    butyl lactate 12.03
    diethyl carbonate 5.42
    propanediol butyl ether 32.22
    triethyl orthoformate 8.9
    p-tert-butyltoluene 1.05
    methyl 4-tert-butylbenzoate 12.24
    morpholine 131.08
    tert-butylamine 11.09
    n-dodecanol 4.58
    dimethoxymethane 284.6
    ethylene carbonate 11.29
    cyrene 38.39
    2-ethoxyethyl acetate 12.13
    2-ethylhexyl acetate 3.55
    1,2,4-trichlorobenzene 0.52
    4-methylpyridine 8.11
    dibutyl ether 5.56
    2,6-dimethyl-4-heptanol 4.62
    DEF 82.12
    dimethyl isosorbide 42.37
    tetrachloroethylene 1.05
    eugenol 13.56
    triacetin 11.52
    span 80 18.79
    1,4-butanediol 56.13
    1,1-dichloroethane 0.25
    2-methyl-1-pentanol 10.34
    methyl formate 100.75
    2-methyl-1-butanol 26.49
    n-decane 0.44
    butyronitrile 15.19
    3,7-dimethyl-1-octanol 6.42
    1-chlorooctane 1.54
    1-chlorotetradecane 0.62
    n-nonane 0.34
    undecane 0.31
    tert-butylcyclohexane 0.08
    cyclooctane 0.12
    cyclopentanol 37.98
    tetrahydropyran 28.2
    tert-amyl methyl ether 14.66
    2,5,8-trioxanonane 56.59
    1-hexene 0.49
    2-isopropoxyethanol 72.0
    2,2,2-trifluoroethanol 20.25
    methyl butyrate 25.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction