Syringic alcohol

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  • Identifiers

    CAS number
    530-56-3

    Molecular formula
    C9H12O4

    SMILES
    COC1=CC(=CC(=C1O)OC)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Vanilla 77.38%
    Balsamic 59.64%
    Sweet 54.94%
    Phenolic 54.47%
    Floral 53.8%
    Spicy 49.21%
    Powdery 45.43%
    Smoky 42.48%
    Creamy 40.81%
    Woody 36.67%

     

    Flavor
    Sweet 64.33%
    Vanilla 55.61%
    Woody 54.2%
    Phenolic 52.55%
    Smoky 51.85%
    Spice 42.78%
    Bacon 41.25%
    Powdery 41.02%
    Caramel 36.9%
    Smoke 36.79%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    9.7 (weak base)

    Molecular weight
    184.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    363°C

    Flash point

    • 146.8 ˚C est.

  • Synonyms

    • 530-56-3
    • 4-HYDROXY-3,5-DIMETHOXYBENZYL ALCOHOL
    • Syringyl alcohol
    • syringic alcohol
    • 4-(Hydroxymethyl)-2,6-dimethoxyphenol
    • 3,5-Dimethoxy-4-hydroxybenzyl alcohol
    • Benzenemethanol, 4-hydroxy-3,5-dimethoxy-
    • 2,6-dimethoxy-4-(hydroxymethyl)phenol
    • K7G66I59XC
    • EINECS 208-485-2
    • CHEBI:86948
    • DTXSID00201050
    • 3,5-dimethoxy-4-hydroxy-benzylalcohol
    • 4-HYDROXY-3,5-DIMETHOXYBENZENEMETHANOL
    • UNII-K7G66I59XC
    • 4-Hydroxy-3,5-dimethoxybenzylalcohol
    • MFCD00016871
    • SBB058585
    • bmse010007
    • SCHEMBL1067240
    • DTXCID00123541
    • HY-N6654
    • s4942
    • AKOS009159361
    • CCG-266464
    • FD71202
    • 4-(hydroxymethyl)-2,6-dimethoxy-phenol
    • AS-81451
    • 4-(Hydroxymethyl)-2,6-dimethoxyphenol #
    • DB-052244
    • CS-0083210
    • NS00022304
    • G12063
    • EN300-1837509
    • Q2376479
    • 208-485-2
    • InChI=1/C9H12O4/c1-12-7-3-6(5-10)4-8(13-2)9(7)11/h3-4,10-11H,5H2,1-2H

  • Applications

    Syringic alcohol (CAS 530-56-3), a 3,5-dimethoxy-4-hydroxybenzyl alcohol, is used mainly as an aromatic building block and intermediate in the chemical industry. It is commonly evaluated for fragrance and flavor applications as a potential odor-active and taste-modifying component, and it can serve as a precursor to more complex phenolic compounds. In cosmetics and personal care, it may be employed as a fragrance ingredient or fragrance-related additive. In polymers and coatings, it can function as a specialty building block or functional additive for resin formulations and surface coatings. It is also encountered as a raw material in industrial manufacturing for phenolic resin systems and other lignin-derived chemical routes. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 76.54
    methanol 129.6
    isopropanol 30.59
    water 7.67
    ethyl acetate 19.2
    n-propanol 38.07
    acetone 58.73
    n-butanol 22.04
    acetonitrile 35.29
    DMF 222.72
    toluene 3.67
    isobutanol 19.54
    1,4-dioxane 101.29
    methyl acetate 43.02
    THF 102.73
    2-butanone 30.37
    n-pentanol 21.15
    sec-butanol 19.79
    n-hexane 0.49
    ethylene glycol 237.96
    NMP 130.07
    cyclohexane 1.96
    DMSO 559.39
    n-butyl acetate 14.32
    n-octanol 18.14
    chloroform 42.66
    n-propyl acetate 19.36
    acetic acid 120.65
    dichloromethane 83.34
    cyclohexanone 47.98
    propylene glycol 73.89
    isopropyl acetate 10.06
    DMAc 130.76
    2-ethoxyethanol 122.5
    isopentanol 15.58
    n-heptane 2.01
    ethyl formate 52.79
    1,2-dichloroethane 50.93
    n-hexanol 19.72
    2-methoxyethanol 224.15
    isobutyl acetate 11.2
    tetrachloromethane 9.36
    n-pentyl acetate 14.69
    transcutol 80.69
    n-heptanol 20.39
    ethylbenzene 5.95
    MIBK 10.88
    2-propoxyethanol 68.23
    tert-butanol 44.12
    MTBE 13.9
    2-butoxyethanol 51.24
    propionic acid 48.29
    o-xylene 6.76
    formic acid 180.69
    diethyl ether 10.79
    m-xylene 5.09
    p-xylene 7.89
    chlorobenzene 13.36
    dimethyl carbonate 29.32
    n-octane 1.41
    formamide 281.63
    cyclopentanone 77.55
    2-pentanone 15.02
    anisole 24.72
    cyclopentyl methyl ether 20.69
    gamma-butyrolactone 123.76
    1-methoxy-2-propanol 83.03
    pyridine 45.09
    3-pentanone 12.37
    furfural 144.16
    n-dodecane 1.57
    diethylene glycol 136.29
    diisopropyl ether 3.31
    tert-amyl alcohol 28.05
    acetylacetone 33.21
    n-hexadecane 1.75
    acetophenone 32.04
    methyl propionate 27.22
    isopentyl acetate 13.34
    trichloroethylene 84.86
    n-nonanol 17.21
    cyclohexanol 22.16
    benzyl alcohol 38.09
    2-ethylhexanol 13.33
    isooctanol 15.55
    dipropyl ether 10.82
    1,2-dichlorobenzene 20.61
    ethyl lactate 30.53
    propylene carbonate 56.19
    n-methylformamide 164.3
    2-pentanol 9.83
    n-pentane 0.6
    1-propoxy-2-propanol 36.25
    1-methoxy-2-propyl acetate 25.03
    2-(2-methoxypropoxy) propanol 38.56
    mesitylene 4.39
    ε-caprolactone 48.45
    p-cymene 7.89
    epichlorohydrin 121.03
    1,1,1-trichloroethane 21.75
    2-aminoethanol 137.1
    morpholine-4-carbaldehyde 149.32
    sulfolane 216.74
    2,2,4-trimethylpentane 0.87
    2-methyltetrahydrofuran 38.1
    n-hexyl acetate 20.39
    isooctane 0.64
    2-(2-butoxyethoxy)ethanol 53.23
    sec-butyl acetate 9.31
    tert-butyl acetate 14.42
    decalin 1.74
    glycerin 162.41
    diglyme 114.54
    acrylic acid 69.52
    isopropyl myristate 9.18
    n-butyric acid 38.17
    acetyl acetate 18.23
    di(2-ethylhexyl) phthalate 16.99
    ethyl propionate 14.48
    nitromethane 215.37
    1,2-diethoxyethane 20.38
    benzonitrile 30.65
    trioctyl phosphate 13.44
    1-bromopropane 9.59
    gamma-valerolactone 123.2
    n-decanol 13.71
    triethyl phosphate 16.52
    4-methyl-2-pentanol 7.11
    propionitrile 21.8
    vinylene carbonate 63.45
    1,1,2-trichlorotrifluoroethane 162.98
    DMS 22.19
    cumene 6.19
    2-octanol 11.84
    2-hexanone 17.43
    octyl acetate 14.02
    limonene 10.26
    1,2-dimethoxyethane 124.86
    ethyl orthosilicate 13.5
    tributyl phosphate 12.01
    diacetone alcohol 37.5
    N,N-dimethylaniline 23.05
    acrylonitrile 46.41
    aniline 17.28
    1,3-propanediol 112.75
    bromobenzene 11.43
    dibromomethane 36.51
    1,1,2,2-tetrachloroethane 63.2
    2-methyl-cyclohexyl acetate 19.08
    tetrabutyl urea 19.15
    diisobutyl methanol 9.02
    2-phenylethanol 31.59
    styrene 6.47
    dioctyl adipate 19.88
    dimethyl sulfate 67.3
    ethyl butyrate 15.11
    methyl lactate 47.0
    butyl lactate 20.66
    diethyl carbonate 15.13
    propanediol butyl ether 44.38
    triethyl orthoformate 14.78
    p-tert-butyltoluene 7.58
    methyl 4-tert-butylbenzoate 37.83
    morpholine 101.93
    tert-butylamine 16.89
    n-dodecanol 10.97
    dimethoxymethane 92.31
    ethylene carbonate 45.43
    cyrene 67.36
    2-ethoxyethyl acetate 24.28
    2-ethylhexyl acetate 10.23
    1,2,4-trichlorobenzene 25.93
    4-methylpyridine 28.32
    dibutyl ether 9.8
    2,6-dimethyl-4-heptanol 9.02
    DEF 37.59
    dimethyl isosorbide 67.18
    tetrachloroethylene 49.57
    eugenol 42.96
    triacetin 31.53
    span 80 33.35
    1,4-butanediol 63.39
    1,1-dichloroethane 20.55
    2-methyl-1-pentanol 15.85
    methyl formate 151.7
    2-methyl-1-butanol 15.4
    n-decane 2.24
    butyronitrile 18.56
    3,7-dimethyl-1-octanol 13.36
    1-chlorooctane 8.28
    1-chlorotetradecane 4.16
    n-nonane 1.93
    undecane 1.85
    tert-butylcyclohexane 1.46
    cyclooctane 0.99
    cyclopentanol 37.25
    tetrahydropyran 30.66
    tert-amyl methyl ether 11.26
    2,5,8-trioxanonane 82.28
    1-hexene 2.1
    2-isopropoxyethanol 56.33
    2,2,2-trifluoroethanol 79.61
    methyl butyrate 25.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction