Syringic acid

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  • Identifiers

    CAS number
    530-57-4

    Molecular formula
    C9H10O5

    SMILES
    COC1=CC(=CC(=C1O)OC)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Vanilla 65.36%
    Balsamic 56.38%
    Phenolic 53.02%
    Sweet 50.71%
    Powdery 41.76%
    Creamy 39.91%
    Floral 38.8%
    Odorless 38.22%
    Spicy 37.22%
    Milky 34.57%

     

    Flavor
    Sweet 66.04%
    Vanilla 42.2%
    Woody 39.9%
    Caramel 38.31%
    Creamy 38.17%
    Phenolic 37.67%
    Powdery 36.85%
    Smoky 33.33%
    Odorless 30.03%
    Faint 29.68%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.34 (neutral)

    Molecular weight
    198.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 206 - 209 °C

    Boiling point

    • 440.00 °C. @ 760.00 mm Hg

    Flash point

    • 167.8 ˚C est.

  • Synonyms

    • SYRINGIC ACID
    • 530-57-4
    • 4-Hydroxy-3,5-dimethoxybenzoic acid
    • 3,5-Dimethoxy-4-hydroxybenzoic acid
    • Cedar acid
    • Gallic acid 3,5-dimethyl ether
    • Benzoic acid, 4-hydroxy-3,5-dimethoxy-
    • 3,5-Dimethoxy-4-hydroxybenzyl acid
    • NSC 2129
    • EINECS 208-486-8
    • MFCD00002552
    • BRN 2115262
    • UNII-E390O181H5
    • CHEBI:68329
    • AI3-24376
    • NSC-2129
    • E390O181H5
    • CHEMBL1414
    • DTXSID0060191
    • 4-Hydroxy-3,5-dimethoxy-benzoic acid
    • 4-10-00-01995 (Beilstein Handbook Reference)
    • 4-Hydroxy-3,5-dimethoxybenzoicacid
    • 2,6-DIMETHOXY-4-CARBOXYPHENOL
    • 3,5-dimethoxy-4-oxidanyl-benzoic acid
    • Syringicacid
    • Syringlicacid
    • SpecPlus_000485
    • Spectrum3_001866
    • Spectrum5_000963
    • Syringic acid (Standard)
    • Syringic acid, >=95%
    • bmse000607
    • bmse010206
    • SCHEMBL42751
    • BSPBio_003312
    • DivK1c_006581
    • 3,5-Dimethyl-4-hydroxybenzoate
    • 4-hydroxy-3,5-dimethylbenzoate
    • DTXCID2041337
    • HY-N0339R
    • KBio1_001525
    • KBio3_002814
    • 3,5-Dimethoxy-4-hydroxybenzoate
    • NSC2129
    • HMS3885G17
    • Syringic acid, analytical standard
    • HY-N0339
    • BBL012974
    • BDBM50187132
    • s3629
    • STL163855
    • AKOS000269664
    • AC-7975
    • CCG-214218
    • FS39302
    • PS-8244
    • NCGC00178148-01
    • 1ST40130
    • SY005479
    • DB-022071
    • CS-0008899
    • G0014
    • NS00001894
    • A10287
    • EN300-117146
    • 3 pound not5-DIMETHOXY-4-HYDROXYBENZOICACID
    • Q408428
    • BRD-K51980294-001-01-9
    • F3157-0001
    • Z1255360342
    • 3,5-Dimethoxy-4-hydroxybenzoic acid, 4-Hydroxy-3,5-dimethoxy-benzoic acid
    • IJP
    • InChI=1/C9H10O5/c1-13-6-3-5(9(11)12)4-7(14-2)8(6)10/h3-4,10H,1-2H3,(H,11,12

  • Applications

    Syringic acid (CAS 530-57-4) is primarily used as an intermediate in organic synthesis and as a building block for more complex phenolic compounds. In industrial materials, it serves as an antioxidant and stabilizer in polymers and coatings to improve oxidative durability. In fragrance and flavor chemistry, it is considered a building block for certain fragrance and flavor components. In cosmetics and personal care, it is used as an antioxidant ingredient and formulation additive. It is also explored as a pharmaceutical intermediate for the synthesis of drug-like compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 50.63
    methanol 84.13
    isopropanol 16.43
    water 3.17
    ethyl acetate 3.33
    n-propanol 20.46
    acetone 31.54
    n-butanol 11.02
    acetonitrile 13.51
    DMF 136.04
    toluene 2.15
    isobutanol 8.63
    1,4-dioxane 44.01
    methyl acetate 12.74
    THF 79.25
    2-butanone 12.27
    n-pentanol 10.36
    sec-butanol 8.05
    n-hexane 0.49
    ethylene glycol 47.43
    NMP 126.33
    cyclohexane 1.21
    DMSO 340.7
    n-butyl acetate 4.71
    n-octanol 8.9
    chloroform 4.48
    n-propyl acetate 5.41
    acetic acid 27.69
    dichloromethane 17.09
    cyclohexanone 20.03
    propylene glycol 18.32
    isopropyl acetate 2.43
    DMAc 115.42
    2-ethoxyethanol 49.26
    isopentanol 7.58
    n-heptane 1.48
    ethyl formate 11.83
    1,2-dichloroethane 15.12
    n-hexanol 8.28
    2-methoxyethanol 91.13
    isobutyl acetate 2.66
    tetrachloromethane 1.25
    n-pentyl acetate 5.68
    transcutol 34.48
    n-heptanol 9.4
    ethylbenzene 3.23
    MIBK 4.03
    2-propoxyethanol 28.63
    tert-butanol 22.68
    MTBE 6.88
    2-butoxyethanol 22.71
    propionic acid 12.62
    o-xylene 4.28
    formic acid 72.44
    diethyl ether 5.93
    m-xylene 2.67
    p-xylene 4.54
    chlorobenzene 3.39
    dimethyl carbonate 9.11
    n-octane 0.9
    formamide 150.29
    cyclopentanone 37.61
    2-pentanone 5.81
    anisole 10.6
    cyclopentyl methyl ether 11.37
    gamma-butyrolactone 50.55
    1-methoxy-2-propanol 29.86
    pyridine 23.11
    3-pentanone 5.04
    furfural 48.12
    n-dodecane 0.8
    diethylene glycol 45.42
    diisopropyl ether 1.48
    tert-amyl alcohol 13.07
    acetylacetone 10.57
    n-hexadecane 0.89
    acetophenone 13.52
    methyl propionate 7.25
    isopentyl acetate 4.6
    trichloroethylene 15.77
    n-nonanol 8.81
    cyclohexanol 9.39
    benzyl alcohol 14.93
    2-ethylhexanol 5.61
    isooctanol 7.35
    dipropyl ether 5.66
    1,2-dichlorobenzene 5.41
    ethyl lactate 7.87
    propylene carbonate 14.78
    n-methylformamide 70.73
    2-pentanol 4.32
    n-pentane 0.57
    1-propoxy-2-propanol 14.39
    1-methoxy-2-propyl acetate 8.29
    2-(2-methoxypropoxy) propanol 21.58
    mesitylene 2.17
    ε-caprolactone 18.04
    p-cymene 3.78
    epichlorohydrin 48.8
    1,1,1-trichloroethane 3.46
    2-aminoethanol 45.55
    morpholine-4-carbaldehyde 85.15
    sulfolane 88.3
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 24.24
    n-hexyl acetate 8.29
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 26.24
    sec-butyl acetate 2.68
    tert-butyl acetate 4.81
    decalin 0.82
    glycerin 43.6
    diglyme 50.81
    acrylic acid 16.49
    isopropyl myristate 4.37
    n-butyric acid 7.49
    acetyl acetate 3.48
    di(2-ethylhexyl) phthalate 7.52
    ethyl propionate 4.33
    nitromethane 60.81
    1,2-diethoxyethane 9.79
    benzonitrile 9.58
    trioctyl phosphate 6.02
    1-bromopropane 4.24
    gamma-valerolactone 61.31
    n-decanol 7.06
    triethyl phosphate 6.82
    4-methyl-2-pentanol 2.94
    propionitrile 7.79
    vinylene carbonate 14.75
    1,1,2-trichlorotrifluoroethane 39.67
    DMS 7.94
    cumene 2.99
    2-octanol 5.2
    2-hexanone 6.72
    octyl acetate 6.56
    limonene 4.42
    1,2-dimethoxyethane 59.61
    ethyl orthosilicate 6.23
    tributyl phosphate 4.86
    diacetone alcohol 13.31
    N,N-dimethylaniline 12.8
    acrylonitrile 15.59
    aniline 7.86
    1,3-propanediol 39.89
    bromobenzene 3.05
    dibromomethane 7.73
    1,1,2,2-tetrachloroethane 11.87
    2-methyl-cyclohexyl acetate 7.94
    tetrabutyl urea 10.41
    diisobutyl methanol 3.66
    2-phenylethanol 12.77
    styrene 3.04
    dioctyl adipate 8.65
    dimethyl sulfate 24.87
    ethyl butyrate 5.23
    methyl lactate 11.99
    butyl lactate 6.83
    diethyl carbonate 5.15
    propanediol butyl ether 16.23
    triethyl orthoformate 6.17
    p-tert-butyltoluene 3.63
    methyl 4-tert-butylbenzoate 18.05
    morpholine 54.36
    tert-butylamine 9.37
    n-dodecanol 5.65
    dimethoxymethane 46.94
    ethylene carbonate 10.67
    cyrene 33.4
    2-ethoxyethyl acetate 9.56
    2-ethylhexyl acetate 3.73
    1,2,4-trichlorobenzene 7.15
    4-methylpyridine 14.38
    dibutyl ether 5.12
    2,6-dimethyl-4-heptanol 3.66
    DEF 17.75
    dimethyl isosorbide 37.38
    tetrachloroethylene 9.72
    eugenol 18.4
    triacetin 11.97
    span 80 15.62
    1,4-butanediol 20.5
    1,1-dichloroethane 4.11
    2-methyl-1-pentanol 7.38
    methyl formate 51.23
    2-methyl-1-butanol 6.74
    n-decane 1.18
    butyronitrile 6.23
    3,7-dimethyl-1-octanol 5.86
    1-chlorooctane 3.38
    1-chlorotetradecane 1.86
    n-nonane 1.05
    undecane 0.96
    tert-butylcyclohexane 0.59
    cyclooctane 0.68
    cyclopentanol 15.82
    tetrahydropyran 15.86
    tert-amyl methyl ether 6.19
    2,5,8-trioxanonane 41.58
    1-hexene 1.65
    2-isopropoxyethanol 22.5
    2,2,2-trifluoroethanol 16.61
    methyl butyrate 7.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction