Syringetin

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  • Identifiers

    CAS number
    4423-37-4

    Molecular formula
    C17H14O8

    SMILES
    COC1=CC(=CC(=C1O)OC)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 57.3%
    Odorless 48.36%
    Burnt 38.68%
    Smoky 32.69%
    Vanilla 30.77%
    Spicy 30.63%
    Balsamic 27.0%
    Woody 23.8%
    Medicinal 23.39%
    Fruity 21.79%

     

    Flavor
    Bitter 83.49%
    Bland 26.2%
    Odorless 25.8%
    Eugenol 22.3%
    Sweet-like 21.91%
    Parsley 21.57%
    Ham 20.35%
    Cedarleaf 20.34%
    Allspice 20.07%
    Lovage 19.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    9.87 (weak base)

    Molecular weight
    346.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1350°C

    Flash point

    • 245.21 ˚C est.

  • Synonyms

    • Syringetin
    • 4423-37-4
    • 3',5'-Dimethoxy-3,5,7,4'-tetrahydroxyflavone
    • 3',5'-O-Dimethylmyricetin
    • J68JG79B9W
    • CHEBI:18215
    • 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one
    • 3,5,7-Trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-
    • DTXSID60196074
    • 3,5,7,4'-Tetrahydroxy-3',5'-dimethoxyflavone
    • 3,5,7,4'-tetrahydroxy-3',5'dimethoxyflavone
    • RefChem:187007
    • DTXCID70118565
    • 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one
    • MFCD00017449
    • 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)chromen-4-one
    • DIBOA trihexose
    • UNII-J68JG79B9W
    • SCHEMBL810981
    • CHEMBL489142
    • orb1681622
    • SCHEMBL29929167
    • Myricetin-3',5'-dimethyl ether
    • UZMAPBJVXOGOFT-UHFFFAOYSA-N
    • HY-N8920
    • BDBM50025603
    • LMPK12112498
    • MSK159719
    • MYRICETIN-3,5-DIMETHYL ETHER
    • AKOS030530648
    • FS66069
    • MS-25319
    • DB-051197
    • CS-0149371
    • NS00116307
    • ST50331606
    • E88713
    • 3',5'-Dimethoxy-3,4',5,7-tetrahydroxyflavone
    • 3,5-DIMETHOXY-3,5,7,4-TETRAHYDROXYFLAVONE
    • Q3509026
    • FLAVONE, 3,4,5,7-TETRAHYDROXY-3,5-DIMETHOXY-
    • 3',5'-Dimethoxy-3,5,7,4'-tetrahydroxyflavone; 3',5'-O-Dimethylmyricetin; Myricetin-3',5'-dimethyl ether
    • 4423-37-4

  • Applications

    Syringetin (CAS 4423-37-4) is a natural flavonol with potential applications across several industries, including cosmetics and personal care as an antioxidant ingredient and natural colorant in formulations; pharmaceutical synthesis and R&D as an intermediate or precursor for flavonoid-related compounds; coatings, inks, and plastics as a natural colorant and functional additive to impart color and stability; and analytical chemistry and research as a reference material or standard for flavonoid analysis, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.18
    methanol 0.3
    isopropanol 0.21
    water 0.0
    ethyl acetate 0.26
    n-propanol 0.48
    acetone 0.04
    n-butanol 0.43
    acetonitrile 0.04
    DMF 4.83
    toluene 0.01
    isobutanol 0.25
    1,4-dioxane 0.4
    methyl acetate 0.27
    THF 2.74
    2-butanone 0.55
    n-pentanol 0.25
    sec-butanol 0.62
    n-hexane 0.0
    ethylene glycol 0.5
    NMP 11.11
    cyclohexane 0.0
    DMSO 23.04
    n-butyl acetate 0.43
    n-octanol 0.35
    chloroform 0.01
    n-propyl acetate 0.23
    acetic acid 0.46
    dichloromethane 0.02
    cyclohexanone 0.83
    propylene glycol 0.67
    isopropyl acetate 0.18
    DMAc 10.74
    2-ethoxyethanol 2.56
    isopentanol 0.38
    n-heptane 0.01
    ethyl formate 0.18
    1,2-dichloroethane 0.04
    n-hexanol 0.29
    2-methoxyethanol 7.6
    isobutyl acetate 0.08
    tetrachloromethane 0.01
    n-pentyl acetate 0.4
    transcutol 5.84
    n-heptanol 0.4
    ethylbenzene 0.01
    MIBK 0.21
    2-propoxyethanol 4.18
    tert-butanol 0.34
    MTBE 0.14
    2-butoxyethanol 2.25
    propionic acid 0.63
    o-xylene 0.02
    formic acid 0.78
    diethyl ether 0.12
    m-xylene 0.01
    p-xylene 0.02
    chlorobenzene 0.01
    dimethyl carbonate 0.47
    n-octane 0.01
    formamide 1.42
    cyclopentanone 1.68
    2-pentanone 0.26
    anisole 0.1
    cyclopentyl methyl ether 0.47
    gamma-butyrolactone 2.77
    1-methoxy-2-propanol 5.61
    pyridine 0.28
    3-pentanone 0.27
    furfural 1.92
    n-dodecane 0.0
    diethylene glycol 4.2
    diisopropyl ether 0.03
    tert-amyl alcohol 0.78
    acetylacetone 0.31
    n-hexadecane 0.01
    acetophenone 0.22
    methyl propionate 0.75
    isopentyl acetate 0.41
    trichloroethylene 0.08
    n-nonanol 0.41
    cyclohexanol 0.35
    benzyl alcohol 0.17
    2-ethylhexanol 0.28
    isooctanol 0.33
    dipropyl ether 0.29
    1,2-dichlorobenzene 0.02
    ethyl lactate 0.77
    propylene carbonate 0.57
    n-methylformamide 1.44
    2-pentanol 0.29
    n-pentane 0.0
    1-propoxy-2-propanol 2.77
    1-methoxy-2-propyl acetate 1.39
    2-(2-methoxypropoxy) propanol 2.66
    mesitylene 0.01
    ε-caprolactone 1.32
    p-cymene 0.05
    epichlorohydrin 1.75
    1,1,1-trichloroethane 0.01
    2-aminoethanol 0.96
    morpholine-4-carbaldehyde 6.44
    sulfolane 13.04
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.88
    n-hexyl acetate 0.57
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 3.12
    sec-butyl acetate 0.17
    tert-butyl acetate 0.36
    decalin 0.0
    glycerin 4.1
    diglyme 6.08
    acrylic acid 0.69
    isopropyl myristate 0.21
    n-butyric acid 0.63
    acetyl acetate 0.09
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.38
    nitromethane 1.1
    1,2-diethoxyethane 0.66
    benzonitrile 0.08
    trioctyl phosphate 0.34
    1-bromopropane 0.03
    gamma-valerolactone 4.66
    n-decanol 0.27
    triethyl phosphate 0.55
    4-methyl-2-pentanol 0.15
    propionitrile 0.17
    vinylene carbonate 0.36
    1,1,2-trichlorotrifluoroethane 4.37
    DMS 0.52
    cumene 0.01
    2-octanol 0.26
    2-hexanone 0.28
    octyl acetate 0.35
    limonene 0.08
    1,2-dimethoxyethane 3.45
    ethyl orthosilicate 0.44
    tributyl phosphate 0.36
    diacetone alcohol 2.02
    N,N-dimethylaniline 0.16
    acrylonitrile 0.31
    aniline 0.1
    1,3-propanediol 1.75
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.12
    2-methyl-cyclohexyl acetate 0.4
    tetrabutyl urea 0.72
    diisobutyl methanol 0.16
    2-phenylethanol 0.31
    styrene 0.01
    dioctyl adipate 0.47
    dimethyl sulfate 2.25
    ethyl butyrate 0.47
    methyl lactate 2.09
    butyl lactate 0.95
    diethyl carbonate 0.31
    propanediol butyl ether 1.89
    triethyl orthoformate 0.63
    p-tert-butyltoluene 0.05
    methyl 4-tert-butylbenzoate 0.99
    morpholine 1.72
    tert-butylamine 0.08
    n-dodecanol 0.16
    dimethoxymethane 1.89
    ethylene carbonate 0.27
    cyrene 2.89
    2-ethoxyethyl acetate 0.83
    2-ethylhexyl acetate 0.31
    1,2,4-trichlorobenzene 0.04
    4-methylpyridine 0.15
    dibutyl ether 0.23
    2,6-dimethyl-4-heptanol 0.16
    DEF 1.57
    dimethyl isosorbide 4.12
    tetrachloroethylene 0.07
    eugenol 1.2
    triacetin 0.85
    span 80 1.59
    1,4-butanediol 0.31
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.3
    methyl formate 0.56
    2-methyl-1-butanol 0.51
    n-decane 0.01
    butyronitrile 0.11
    3,7-dimethyl-1-octanol 0.26
    1-chlorooctane 0.06
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.57
    tetrahydropyran 0.26
    tert-amyl methyl ether 0.38
    2,5,8-trioxanonane 4.16
    1-hexene 0.02
    2-isopropoxyethanol 1.18
    2,2,2-trifluoroethanol 0.34
    methyl butyrate 0.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction