Synaptamide

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  • Identifiers

    CAS number
    162758-94-3

    Molecular formula
    C24H37NO2

    SMILES
    CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCO

    Safety labels

  • Odor profile

    Fragrance
    Fatty 56.07%
    Oily 43.65%
    Fruity 29.74%
    Herbal 28.52%
    Waxy 28.35%
    Meaty 26.94%
    Fishy 26.93%
    Sweet 25.78%
    Citrus 23.74%
    Spicy 22.88%

     

    Flavor
    Faint 19.39%
    Oriental 19.2%
    Nitrile 18.17%
    Diterpene 17.84%
    Pumpkin 17.82%
    Delicate 17.76%
    Low 17.51%
    Honeydew 17.45%
    Terpentine 17.43%
    Skunky 17.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.3

    pKa est.
    9.16 (weak base)

    Molecular weight
    371.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    144°C

    Flash point

    • 285.18 ˚C est.

  • Synonyms

    • Synaptamide
    • 162758-94-3
    • RefChem:932454
    • N-docosahexaenoylethanolamine
    • Docosahexaenoyl Ethanolamide
    • (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide
    • Anandamide (22:6, n-3)
    • CHEMBL1482206
    • CHEBI:85252
    • N-cis-4,7,10,13,16,19-docosahexanoylethanolamine
    • N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-ethanolamine
    • N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine
    • LMFA08040009
    • SCHEMBL1228084
    • EX-A7999E
    • GTPL14141
    • DTXSID50678596
    • HMS3650G19
    • NAE 22:6
    • BDBM50463963
    • NAE(22:6)
    • CS-5605
    • NCGC00161198-02
    • DB-214929
    • HY-100197
    • G90859
    • SR-01000946787
    • SR-01000946787-1
    • Q27158436
    • N-(2-Hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide
    • N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine
    • N-(2-Hydroxyethyl)-4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenamide
    • (4Z,7z,10z,13z,16z,19z)-N-(2-hydroxyethyl)-4,7,10,13,16,19-docosahexaenamide
    • N-(2-hydroxyethyl)-4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-docosahexaenamide
    • 162758-94-3

  • Applications

    Synaptamide (CAS 162758-94-3) is primarily used as a research tool in neuroscience and lipid signaling to investigate neuronal development and synapse formation; it is employed in in vitro assays and animal models to study receptor interactions and signaling pathways related to DHA-derived lipid signaling; it supports lipidomics work and analytical method development based on this bioactive lipid; it is evaluated in pharmacology research to understand neuromodulatory mechanisms and endogenous signaling effects in the brain; it also serves as a reference tool to map lipid signaling networks and endocannabinoid-like signaling mechanisms; these applications are mainly confined to research environments and the biotech/pharmaceutical industry, and are subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.66
    methanol 2.76
    isopropanol 1.23
    water 0.02
    ethyl acetate 5.33
    n-propanol 2.12
    acetone 6.18
    n-butanol 2.57
    acetonitrile 1.73
    DMF 16.58
    toluene 4.64
    isobutanol 1.74
    1,4-dioxane 11.21
    methyl acetate 5.03
    THF 47.4
    2-butanone 8.68
    n-pentanol 3.67
    sec-butanol 2.65
    n-hexane 1.46
    ethylene glycol 0.26
    NMP 44.55
    cyclohexane 2.95
    DMSO 37.48
    n-butyl acetate 8.37
    n-octanol 4.25
    chloroform 36.49
    n-propyl acetate 9.6
    acetic acid 4.86
    dichloromethane 37.17
    cyclohexanone 28.05
    propylene glycol 0.85
    isopropyl acetate 5.96
    DMAc 67.38
    2-ethoxyethanol 9.51
    isopentanol 3.34
    n-heptane 1.58
    ethyl formate 4.17
    1,2-dichloroethane 21.12
    n-hexanol 3.09
    2-methoxyethanol 7.32
    isobutyl acetate 7.45
    tetrachloromethane 7.06
    n-pentyl acetate 11.98
    transcutol 63.21
    n-heptanol 4.02
    ethylbenzene 4.83
    MIBK 8.04
    2-propoxyethanol 9.84
    tert-butanol 3.05
    MTBE 6.42
    2-butoxyethanol 12.74
    propionic acid 3.68
    o-xylene 5.1
    formic acid 1.76
    diethyl ether 3.63
    m-xylene 3.76
    p-xylene 6.4
    chlorobenzene 7.34
    dimethyl carbonate 3.75
    n-octane 0.91
    formamide 3.02
    cyclopentanone 29.79
    2-pentanone 7.89
    anisole 10.15
    cyclopentyl methyl ether 14.96
    gamma-butyrolactone 26.65
    1-methoxy-2-propanol 7.72
    pyridine 13.76
    3-pentanone 8.91
    furfural 23.96
    n-dodecane 0.65
    diethylene glycol 4.35
    diisopropyl ether 2.47
    tert-amyl alcohol 5.2
    acetylacetone 12.65
    n-hexadecane 0.73
    acetophenone 15.65
    methyl propionate 6.31
    isopentyl acetate 10.2
    trichloroethylene 37.57
    n-nonanol 5.13
    cyclohexanol 5.65
    benzyl alcohol 6.23
    2-ethylhexanol 4.53
    isooctanol 4.47
    dipropyl ether 8.07
    1,2-dichlorobenzene 10.59
    ethyl lactate 7.02
    propylene carbonate 15.16
    n-methylformamide 3.99
    2-pentanol 2.2
    n-pentane 0.75
    1-propoxy-2-propanol 10.45
    1-methoxy-2-propyl acetate 13.02
    2-(2-methoxypropoxy) propanol 19.35
    mesitylene 3.09
    ε-caprolactone 24.23
    p-cymene 4.28
    epichlorohydrin 30.92
    1,1,1-trichloroethane 18.74
    2-aminoethanol 1.04
    morpholine-4-carbaldehyde 26.52
    sulfolane 61.28
    2,2,4-trimethylpentane 1.42
    2-methyltetrahydrofuran 19.38
    n-hexyl acetate 12.64
    isooctane 0.59
    2-(2-butoxyethoxy)ethanol 21.82
    sec-butyl acetate 8.73
    tert-butyl acetate 11.01
    decalin 2.39
    glycerin 2.03
    diglyme 49.28
    acrylic acid 3.16
    isopropyl myristate 6.15
    n-butyric acid 6.83
    acetyl acetate 5.26
    di(2-ethylhexyl) phthalate 6.9
    ethyl propionate 8.8
    nitromethane 9.6
    1,2-diethoxyethane 18.44
    benzonitrile 6.18
    trioctyl phosphate 4.48
    1-bromopropane 10.49
    gamma-valerolactone 37.29
    n-decanol 3.51
    triethyl phosphate 11.45
    4-methyl-2-pentanol 2.58
    propionitrile 2.66
    vinylene carbonate 11.3
    1,1,2-trichlorotrifluoroethane 26.1
    DMS 8.5
    cumene 4.35
    2-octanol 3.31
    2-hexanone 12.11
    octyl acetate 7.01
    limonene 6.54
    1,2-dimethoxyethane 26.84
    ethyl orthosilicate 12.34
    tributyl phosphate 6.26
    diacetone alcohol 12.98
    N,N-dimethylaniline 11.46
    acrylonitrile 2.93
    aniline 4.65
    1,3-propanediol 2.0
    bromobenzene 8.36
    dibromomethane 21.51
    1,1,2,2-tetrachloroethane 42.06
    2-methyl-cyclohexyl acetate 14.14
    tetrabutyl urea 11.28
    diisobutyl methanol 4.11
    2-phenylethanol 5.97
    styrene 4.97
    dioctyl adipate 12.36
    dimethyl sulfate 11.83
    ethyl butyrate 11.81
    methyl lactate 5.19
    butyl lactate 11.3
    diethyl carbonate 7.85
    propanediol butyl ether 9.74
    triethyl orthoformate 14.99
    p-tert-butyltoluene 4.04
    methyl 4-tert-butylbenzoate 19.12
    morpholine 14.56
    tert-butylamine 2.49
    n-dodecanol 2.59
    dimethoxymethane 10.13
    ethylene carbonate 9.36
    cyrene 22.73
    2-ethoxyethyl acetate 15.86
    2-ethylhexyl acetate 9.29
    1,2,4-trichlorobenzene 13.95
    4-methylpyridine 11.46
    dibutyl ether 10.11
    2,6-dimethyl-4-heptanol 4.11
    DEF 16.0
    dimethyl isosorbide 40.86
    tetrachloroethylene 24.91
    eugenol 17.4
    triacetin 19.57
    span 80 15.05
    1,4-butanediol 1.36
    1,1-dichloroethane 12.38
    2-methyl-1-pentanol 5.46
    methyl formate 3.15
    2-methyl-1-butanol 3.54
    n-decane 1.36
    butyronitrile 3.27
    3,7-dimethyl-1-octanol 4.9
    1-chlorooctane 4.83
    1-chlorotetradecane 1.85
    n-nonane 1.2
    undecane 0.89
    tert-butylcyclohexane 1.82
    cyclooctane 1.02
    cyclopentanol 5.21
    tetrahydropyran 14.41
    tert-amyl methyl ether 8.85
    2,5,8-trioxanonane 33.88
    1-hexene 3.71
    2-isopropoxyethanol 7.84
    2,2,2-trifluoroethanol 2.93
    methyl butyrate 13.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction