Sulpiride

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  • Identifiers

    CAS number
    15676-16-1

    Molecular formula
    C15H23N3O4S

    SMILES
    CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 77.83%
    Savory 32.27%
    Meaty 24.76%
    Roasted 24.65%
    Cooked 22.62%
    Cooling 21.83%
    Popcorn 20.24%
    Fishy 17.9%
    Bitter 14.33%
    Pungent 14.05%

     

    Flavor
    Bitter 86.49%
    Odorless 35.04%
    Bland 26.57%
    Nitrile 19.95%
    Sweet-like 19.75%
    Cedarleaf 19.47%
    Taco 18.53%
    Heather 18.45%
    Lovage 18.36%
    Broom 18.24%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    9.65 (weak base)

    Molecular weight
    341.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    436°C

    Melting point expt.

    • 178 dec °C
    • 178 °C

    Flash point

    • 254.22 ˚C est.

    Solubility expt.

    • >51.2 [ug/mL] (The mean of the results at pH 7.4)
    • 5.37e-01 g/L

  • Synonyms

    • sulpiride
    • 15676-16-1
    • Sulpyrid
    • (+/-)-Sulpiride
    • Sulpirid
    • Dolmatil
    • Aiglonyl
    • Dogmatil
    • Dogmatyl
    • Guastil
    • Miradol
    • Mirbanil
    • Misulvan
    • Omperan
    • Splotin
    • Sursumid
    • Abilit
    • Dobren
    • Meresa
    • Coolspan
    • Sernevin
    • Neogama
    • (RS)-(+/-)-sulpiride
    • Pyrkappl
    • Eglonyl
    • Calmoflorine
    • Championyl
    • Lisopiride
    • Stamonevrol
    • Alimoral
    • Darleton
    • Desmenat
    • Dresent
    • Eglonil
    • Equilid
    • Eusulpid
    • Fardalan
    • Fidelan
    • Isnamide
    • Kylistro
    • Mariastel
    • Norestran
    • Nufarol
    • Ozoderpin
    • Restful
    • Sulpirida
    • Sulpitil
    • Suprium
    • Valirem
    • Zemorcon
    • Enimon
    • Normum
    • Omiryl
    • N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
    • Pyrikappl
    • Sulpiridum
    • Synedil
    • Sulpiridum [INN-Latin]
    • Sulpirida [INN-Spanish]
    • Sulpor
    • dl-sulpiride
    • RD 1403
    • N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
    • CCRIS 4248
    • 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
    • R.D. 1403
    • N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
    • EINECS 239-753-7
    • (+-)-sulpiride
    • UNII-7MNE9M8287
    • BRN 0494008
    • DTXSID1042574
    • CHEBI:32168
    • N05AL01
    • 7MNE9M8287
    • Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-
    • Magnetic resonance imaging sulpiride
    • CHEMBL26
    • MFCD00055061
    • Psicocen
    • o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-
    • NSC-757850
    • RD-1403
    • rac Sulpiride
    • DTXCID9022574
    • n-((1-ethylpyrrolidin-2-yl)methyl)-2-methoxy-5-sulfamoylbenzamide
    • N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
    • 5-22-08-00105 (Beilstein Handbook Reference)
    • Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-
    • NSC 757850
    • Sulperide
    • Sulpiridum (INN-Latin)
    • Sulpirida (INN-Spanish)
    • SULPIRIDE (MART.)
    • SULPIRIDE [MART.]
    • Sulpiride-R
    • SULPIRIDE (EP IMPURITY)
    • SULPIRIDE [EP IMPURITY]
    • SULPIRIDE (EP MONOGRAPH)
    • SULPIRIDE [EP MONOGRAPH]
    • (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
    • SMR000038923
    • SULPIRIDE,(+)
    • Sulpiride [USAN:INN:BAN:JAN]
    • SR-01000075402
    • CCRIS-4248
    • (y)-Sulpiride
    • Sulpiride, SLP
    • (plusmn)-sulpiride
    • Dogmatyl (TN)
    • (?)-Sulpiride
    • Prestwick_431
    • CAS-15676-16-1
    • Sulpiride (Standard)
    • PS30 - Sulpiride
    • SULPIRIDE [INN]
    • SULPIRIDE [JAN]
    • SULPIRIDE [MI]
    • SULPIRIDE [USAN]
    • (.+/-.)-Sulpiride
    • Prestwick0_000056
    • Prestwick1_000056
    • Prestwick2_000056
    • Prestwick3_000056
    • SULPIRIDE,(-)
    • Biomol-NT_000037
    • Biomol-NT_000162
    • SCHEMBL8421

  • Applications

    Sulpiride (CAS 15676-16-1) is a pharmaceutical agent that acts as a selective dopamine D2/D3 receptor antagonist, used as an active pharmaceutical ingredient in antipsychotic medications for schizophrenia; it may also be employed in gastroenterology as a prokinetic agent in certain indications due to its dopaminergic effects; in research settings it serves as a tool compound to study dopaminergic signaling; and in drug development and manufacturing it is prepared and formulated for oral dosage forms, with use governed by local regulatory frameworks.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.58
    methanol 18.71
    isopropanol 1.61
    water 0.96
    ethyl acetate 7.37
    n-propanol 2.64
    acetone 10.02
    n-butanol 1.69
    acetonitrile 7.85
    DMF 294.5
    toluene 0.45
    isobutanol 1.31
    1,4-dioxane 6.19
    methyl acetate 9.38
    THF 9.18
    2-butanone 8.78
    n-pentanol 0.94
    sec-butanol 1.4
    n-hexane 0.02
    ethylene glycol 12.21
    NMP 405.84
    cyclohexane 0.08
    DMSO 154.97
    n-butyl acetate 3.59
    n-octanol 0.39
    chloroform 14.96
    n-propyl acetate 4.05
    acetic acid 97.46
    dichloromethane 19.56
    cyclohexanone 17.95
    propylene glycol 15.65
    isopropyl acetate 4.31
    DMAc 317.05
    2-ethoxyethanol 20.44
    isopentanol 1.41
    n-heptane 0.03
    ethyl formate 12.35
    1,2-dichloroethane 8.2
    n-hexanol 0.82
    2-methoxyethanol 57.1
    isobutyl acetate 1.82
    tetrachloromethane 1.16
    n-pentyl acetate 2.13
    transcutol 47.02
    n-heptanol 0.71
    ethylbenzene 0.23
    MIBK 2.92
    2-propoxyethanol 15.35
    tert-butanol 1.5
    MTBE 0.74
    2-butoxyethanol 7.95
    propionic acid 19.62
    o-xylene 0.56
    formic acid 154.15
    diethyl ether 0.93
    m-xylene 0.44
    p-xylene 0.47
    chlorobenzene 2.1
    dimethyl carbonate 17.59
    n-octane 0.02
    formamide 226.12
    cyclopentanone 36.65
    2-pentanone 5.11
    anisole 2.18
    cyclopentyl methyl ether 2.6
    gamma-butyrolactone 80.18
    1-methoxy-2-propanol 27.72
    pyridine 11.07
    3-pentanone 5.03
    furfural 99.93
    n-dodecane 0.01
    diethylene glycol 29.0
    diisopropyl ether 0.28
    tert-amyl alcohol 1.61
    acetylacetone 20.25
    n-hexadecane 0.01
    acetophenone 6.96
    methyl propionate 11.43
    isopentyl acetate 3.13
    trichloroethylene 35.37
    n-nonanol 0.43
    cyclohexanol 1.62
    benzyl alcohol 4.42
    2-ethylhexanol 0.52
    isooctanol 0.58
    dipropyl ether 0.7
    1,2-dichlorobenzene 3.72
    ethyl lactate 9.95
    propylene carbonate 36.27
    n-methylformamide 103.11
    2-pentanol 0.75
    n-pentane 0.03
    1-propoxy-2-propanol 7.58
    1-methoxy-2-propyl acetate 13.01
    2-(2-methoxypropoxy) propanol 12.2
    mesitylene 0.31
    ε-caprolactone 24.63
    p-cymene 0.38
    epichlorohydrin 41.31
    1,1,1-trichloroethane 4.77
    2-aminoethanol 16.88
    morpholine-4-carbaldehyde 167.84
    sulfolane 166.74
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 4.41
    n-hexyl acetate 1.9
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 12.83
    sec-butyl acetate 2.18
    tert-butyl acetate 4.17
    decalin 0.04
    glycerin 63.42
    diglyme 32.35
    acrylic acid 42.28
    isopropyl myristate 0.62
    n-butyric acid 17.12
    acetyl acetate 12.15
    di(2-ethylhexyl) phthalate 2.7
    ethyl propionate 4.12
    nitromethane 200.23
    1,2-diethoxyethane 2.94
    benzonitrile 5.34
    trioctyl phosphate 1.26
    1-bromopropane 1.06
    gamma-valerolactone 114.3
    n-decanol 0.29
    triethyl phosphate 3.97
    4-methyl-2-pentanol 0.57
    propionitrile 3.48
    vinylene carbonate 42.69
    1,1,2-trichlorotrifluoroethane 129.81
    DMS 8.69
    cumene 0.22
    2-octanol 0.3
    2-hexanone 2.63
    octyl acetate 1.01
    limonene 0.5
    1,2-dimethoxyethane 20.23
    ethyl orthosilicate 2.82
    tributyl phosphate 1.94
    diacetone alcohol 11.13
    N,N-dimethylaniline 1.9
    acrylonitrile 12.36
    aniline 3.05
    1,3-propanediol 15.14
    bromobenzene 1.55
    dibromomethane 5.45
    1,1,2,2-tetrachloroethane 22.01
    2-methyl-cyclohexyl acetate 3.63
    tetrabutyl urea 3.12
    diisobutyl methanol 0.38
    2-phenylethanol 4.01
    styrene 0.36
    dioctyl adipate 2.56
    dimethyl sulfate 70.36
    ethyl butyrate 3.88
    methyl lactate 34.15
    butyl lactate 5.51
    diethyl carbonate 3.99
    propanediol butyl ether 8.6
    triethyl orthoformate 3.4
    p-tert-butyltoluene 0.34
    methyl 4-tert-butylbenzoate 8.14
    morpholine 12.54
    tert-butylamine 0.42
    n-dodecanol 0.2
    dimethoxymethane 26.5
    ethylene carbonate 23.24
    cyrene 33.46
    2-ethoxyethyl acetate 7.65
    2-ethylhexyl acetate 2.26
    1,2,4-trichlorobenzene 6.94
    4-methylpyridine 7.49
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 0.38
    DEF 23.71
    dimethyl isosorbide 25.15
    tetrachloroethylene 12.21
    eugenol 10.4
    triacetin 10.6
    span 80 6.92
    1,4-butanediol 5.0
    1,1-dichloroethane 3.94
    2-methyl-1-pentanol 1.0
    methyl formate 58.54
    2-methyl-1-butanol 1.32
    n-decane 0.02
    butyronitrile 2.27
    3,7-dimethyl-1-octanol 0.46
    1-chlorooctane 0.14
    1-chlorotetradecane 0.06
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.03
    cyclooctane 0.03
    cyclopentanol 3.15
    tetrahydropyran 2.05
    tert-amyl methyl ether 0.95
    2,5,8-trioxanonane 22.27
    1-hexene 0.1
    2-isopropoxyethanol 7.6
    2,2,2-trifluoroethanol 60.69
    methyl butyrate 6.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction