Sulfuryl chloride

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  • Identifiers

    CAS number
    7791-25-5

    Molecular formula
    Cl2O2S

    SMILES
    O=S(=O)(Cl)Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 85.44%
    Sulfurous 21.41%
    Pungent 20.26%
    Cooked 17.58%
    Savory 16.99%
    Roasted 14.16%
    Garlic 13.87%
    Burnt 13.6%
    Onion 13.52%
    Alliaceous 12.34%

     

    Flavor
    Bitter 51.98%
    Odorless 38.23%
    Sulfur 22.39%
    Bland 21.49%
    Formyl 20.25%
    Nitrile 20.02%
    Mustard 19.94%
    Rotten 19.7%
    Mousy 19.41%
    Bread crust 18.67%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    -0.5 (strong acid)

    Molecular weight
    134.97 g/mol

    Melting point expt.

    • -54.1 °C

    Boiling point

    • 156.4 °F at 760 mmHg (USCG, 1999)
    • 69.3 °C
    • 69.1 °C

    Flash point

    • 76.06 ˚C est.

    Solubility expt.

    • Miscible with benzene, toluene, ether, glacial acetic acid, and other org solvents
    • Solubility in water: reaction

  • Synonyms

    • SULFURYL CHLORIDE
    • Sulfuryl dichloride
    • 7791-25-5
    • Sulfonyl chloride
    • Sulphuryl chloride
    • Sulfonyl dichloride
    • Sulfuric dichloride
    • Sulfuric oxychloride
    • Sulphuryl dichloride
    • Sulfurylchlorid
    • Caswell No. 816
    • Sulfuryl chloride (SO2Cl2)
    • Sulfur oxychloride (SO2Cl2)
    • HSDB 827
    • SO2Cl2
    • EINECS 232-245-6
    • UN1834
    • EPA Pesticide Chemical Code 078002
    • JD26K0R3J1
    • dichloridodioxidosulfur
    • DTXSID6029707
    • CHEBI:29291
    • sulfur dichloride dioxide
    • SCl2O2
    • [SCl2O2]
    • SULFURYL CHLORIDE [MI]
    • DTXCID109707
    • SULFURYL CHLORIDE [HSDB]
    • EC 232-245-6
    • MFCD00011451
    • Sulfuryl chloride, 97%
    • (SCl2O2)
    • sulfurylchloride
    • Sulfuric chloride
    • sulfuroyl dichloride
    • chlorosulfone
    • chlorosulphone
    • dichlorosulfone
    • sulfurylchoride
    • UNII-JD26K0R3J1
    • sulfonylchloride
    • sulphonylchloride
    • sulphuryichloride
    • sulphurylchloride
    • sulfonly chloride
    • sulphonyl chloride
    • ClSO2Cl
    • chlorosulfonyl chloride
    • Sulfuryl chloride solutio
    • CHEMBL3186735
    • Tox21_200484
    • AKOS015856722
    • SULFUR CHLORIDE OXIDE (SCL2O2)
    • SULFUR CHLORIDE OXIDE (SO2CL2)
    • NCGC00248654-01
    • NCGC00258038-01
    • CAS-7791-25-5
    • Sulfuryl chloride [UN1834] [Corrosive]
    • NS00046212
    • Sulfuryl chloride, SAJ first grade, >=90.0%
    • Q409926
    • Sulfuryl chloride solution 1.0M in methylene chloride
    • 232-245-6

  • Applications

    Sulfuryl chloride (CAS 7791-25-5) is a versatile chlorinating and sulfonylating reagent used in organic synthesis to convert alcohols and related substrates to chlorinated intermediates and to install sulfonyl chloride functionality. In industrial manufacturing, it is commonly employed to generate chlorosulfonyl intermediates that are subsequently transformed into sulfonyl derivatives for applications in polymers/plastics, coatings/inks, and adhesives. In agrochemical and pharmaceutical synthesis, sulfuryl chloride–derived intermediates enable the introduction of sulfonyl groups and related motifs, supporting the preparation of sulfonamide- and sulfone-containing compounds. It may also be used for surface functionalization in electronics or specialty coatings, where reactive sulfonyl chloride groups enable subsequent coupling to form interfaces. Use is subject to appropriate handling, safety practices, and regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 99.1
    methanol 157.82
    isopropanol 75.18
    water 37.98
    ethyl acetate 82.54
    n-propanol 67.42
    acetone 233.94
    n-butanol 54.69
    acetonitrile 126.3
    DMF 721.89
    toluene 47.36
    isobutanol 48.77
    1,4-dioxane 171.43
    methyl acetate 110.63
    THF 250.22
    2-butanone 129.14
    n-pentanol 40.68
    sec-butanol 64.88
    n-hexane 15.55
    ethylene glycol 69.48
    NMP 528.75
    cyclohexane 36.09
    DMSO 652.6
    n-butyl acetate 51.2
    n-octanol 42.85
    chloroform 107.08
    n-propyl acetate 57.27
    acetic acid 119.99
    dichloromethane 133.36
    cyclohexanone 148.16
    propylene glycol 41.0
    isopropyl acetate 61.07
    DMAc 547.52
    2-ethoxyethanol 109.88
    isopentanol 45.43
    n-heptane 22.69
    ethyl formate 75.8
    1,2-dichloroethane 113.54
    n-hexanol 39.3
    2-methoxyethanol 211.34
    isobutyl acetate 31.1
    tetrachloromethane 32.76
    n-pentyl acetate 46.76
    transcutol 158.49
    n-heptanol 34.67
    ethylbenzene 26.53
    MIBK 66.44
    2-propoxyethanol 91.4
    tert-butanol 89.13
    MTBE 88.27
    2-butoxyethanol 63.68
    propionic acid 59.75
    o-xylene 51.47
    formic acid 107.59
    diethyl ether 118.07
    m-xylene 38.69
    p-xylene 34.07
    chlorobenzene 44.37
    dimethyl carbonate 85.24
    n-octane 11.36
    formamide 219.97
    cyclopentanone 205.94
    2-pentanone 104.48
    anisole 68.88
    cyclopentyl methyl ether 120.52
    gamma-butyrolactone 187.07
    1-methoxy-2-propanol 146.65
    pyridine 144.73
    3-pentanone 106.89
    furfural 201.79
    n-dodecane 8.49
    diethylene glycol 102.76
    diisopropyl ether 43.38
    tert-amyl alcohol 73.12
    acetylacetone 132.7
    n-hexadecane 9.33
    acetophenone 85.05
    methyl propionate 100.41
    isopentyl acetate 40.11
    trichloroethylene 145.55
    n-nonanol 39.25
    cyclohexanol 68.08
    benzyl alcohol 58.13
    2-ethylhexanol 32.14
    isooctanol 28.18
    dipropyl ether 64.55
    1,2-dichlorobenzene 48.43
    ethyl lactate 43.52
    propylene carbonate 82.31
    n-methylformamide 225.26
    2-pentanol 49.02
    n-pentane 26.79
    1-propoxy-2-propanol 72.98
    1-methoxy-2-propyl acetate 66.63
    2-(2-methoxypropoxy) propanol 68.97
    mesitylene 32.84
    ε-caprolactone 105.83
    p-cymene 29.56
    epichlorohydrin 152.7
    1,1,1-trichloroethane 70.24
    2-aminoethanol 74.85
    morpholine-4-carbaldehyde 340.68
    sulfolane 282.8
    2,2,4-trimethylpentane 10.84
    2-methyltetrahydrofuran 144.76
    n-hexyl acetate 53.98
    isooctane 8.01
    2-(2-butoxyethoxy)ethanol 79.35
    sec-butyl acetate 39.29
    tert-butyl acetate 64.67
    decalin 10.77
    glycerin 80.33
    diglyme 167.72
    acrylic acid 72.86
    isopropyl myristate 33.42
    n-butyric acid 60.41
    acetyl acetate 59.16
    di(2-ethylhexyl) phthalate 30.5
    ethyl propionate 56.68
    nitromethane 256.9
    1,2-diethoxyethane 73.92
    benzonitrile 63.36
    trioctyl phosphate 26.68
    1-bromopropane 67.37
    gamma-valerolactone 213.14
    n-decanol 32.23
    triethyl phosphate 38.33
    4-methyl-2-pentanol 30.16
    propionitrile 73.12
    vinylene carbonate 74.54
    1,1,2-trichlorotrifluoroethane 147.25
    DMS 55.83
    cumene 21.4
    2-octanol 29.74
    2-hexanone 65.06
    octyl acetate 40.47
    limonene 46.33
    1,2-dimethoxyethane 208.84
    ethyl orthosilicate 37.08
    tributyl phosphate 28.33
    diacetone alcohol 85.38
    N,N-dimethylaniline 84.99
    acrylonitrile 102.23
    aniline 69.48
    1,3-propanediol 74.38
    bromobenzene 38.39
    dibromomethane 96.38
    1,1,2,2-tetrachloroethane 129.51
    2-methyl-cyclohexyl acetate 42.96
    tetrabutyl urea 56.67
    diisobutyl methanol 29.44
    2-phenylethanol 48.7
    styrene 35.34
    dioctyl adipate 44.42
    dimethyl sulfate 167.44
    ethyl butyrate 54.29
    methyl lactate 78.25
    butyl lactate 41.17
    diethyl carbonate 38.27
    propanediol butyl ether 56.29
    triethyl orthoformate 46.37
    p-tert-butyltoluene 30.92
    methyl 4-tert-butylbenzoate 77.68
    morpholine 188.92
    tert-butylamine 64.32
    n-dodecanol 27.6
    dimethoxymethane 288.92
    ethylene carbonate 60.81
    cyrene 82.21
    2-ethoxyethyl acetate 57.86
    2-ethylhexyl acetate 36.11
    1,2,4-trichlorobenzene 59.04
    4-methylpyridine 126.19
    dibutyl ether 44.79
    2,6-dimethyl-4-heptanol 29.44
    DEF 216.16
    dimethyl isosorbide 108.0
    tetrachloroethylene 102.97
    eugenol 74.6
    triacetin 63.74
    span 80 60.62
    1,4-butanediol 39.47
    1,1-dichloroethane 84.41
    2-methyl-1-pentanol 32.37
    methyl formate 169.41
    2-methyl-1-butanol 45.21
    n-decane 12.95
    butyronitrile 63.71
    3,7-dimethyl-1-octanol 36.51
    1-chlorooctane 31.47
    1-chlorotetradecane 16.21
    n-nonane 13.26
    undecane 10.12
    tert-butylcyclohexane 9.2
    cyclooctane 16.75
    cyclopentanol 85.75
    tetrahydropyran 121.66
    tert-amyl methyl ether 85.49
    2,5,8-trioxanonane 126.64
    1-hexene 29.33
    2-isopropoxyethanol 72.83
    2,2,2-trifluoroethanol 83.64
    methyl butyrate 73.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction