Sulfosalicylic Acid

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  • Identifiers

    CAS number
    97-05-2

    Molecular formula
    C7H6O6S

    SMILES
    C1=CC(=C(C=C1S(=O)(=O)O)C(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 86.87%
    Burnt 23.38%
    Sour 19.48%
    Bitter 19.18%
    Cooked 18.63%
    Roasted 18.53%
    Phenolic 17.7%
    Savory 17.28%
    Sharp 16.11%
    Sulfurous 14.68%

     

    Flavor
    Bitter 58.06%
    Odorless 45.97%
    Nutty 30.55%
    Mild 29.81%
    Phenolic 24.38%
    Very mild 23.42%
    Bland 22.99%
    Faint 21.95%
    Urine 21.81%
    Nitrile 21.47%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    6.26 (neutral)

    Molecular weight
    218.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    429°C

    Flash point

    • 242.21 ˚C est.

  • Synonyms

    • 2-Hydroxy-5-sulfobenzoic acid
    • 5-Sulfosalicylic acid
    • SULFOSALICYLIC ACID
    • 97-05-2
    • Salicylsulfonic acid
    • Benzoic acid, 2-hydroxy-5-sulfo-
    • 2-Hydroxybenzoic-5-sulfonic acid
    • 3-Carboxy-4-hydroxybenzenesulfonic acid
    • Sulphosalicylic acid
    • Kalcolor anodizing acid
    • L8XED79U3U
    • NSC-190565
    • DTXSID7059145
    • CHEBI:68555
    • RefChem:889703
    • DTXCID1049015
    • 3-carboxy-4-hydroxybenzenesulfonate
    • 202-555-6
    • 5-Sulphosalicylic acid
    • Salicylic acid, sulfo-
    • Benzoic acid, 2-hydroxysulfo-
    • Salicylic acid, 5-sulfo-
    • NSC 190565
    • SULFOSALICYLIC
    • 2-hydroxy-5-sulfo-benzoic acid
    • 5-Sulfosalicylate
    • 5-sulfo-Salicylic acid
    • CHEMBL229241
    • WLN: WSQR DQ CVQ
    • Sulfosalicylic acid (VAN)
    • Salicylsulfonic acid (VAN)
    • Sulphosalicylic acid (VAN)
    • C7H6O6S
    • EINECS 202-555-6
    • UNII-L8XED79U3U
    • BRN 0650741
    • CP 18121
    • AI3-18246
    • AI3-32582
    • sulfo salicylic acid
    • 5-sulfosalicyclic acid
    • 2-hydroxysulfo-Benzoate
    • 2-hydroxysulfo-Benzoic acid
    • SCHEMBL34766
    • 2-Hydroxy-5-sulfobenzoicacid
    • 4-11-00-00702 (Beilstein Handbook Reference)
    • orb2567172
    • SCHEMBL6242319
    • SCHEMBL29364125
    • SULFOSALICYLIC ACID [MI]
    • NSC4741
    • HY-B1785
    • NSC-4741
    • BBL008587
    • BDBM50219498
    • NSC190565
    • SBB008927
    • STK301570
    • SULFOSALICYLIC ACID [WHO-DD]
    • AKOS000120294
    • EBC-612588
    • AC-11271
    • CS-0013816
    • NS00014762
    • S0830
    • ST45061279
    • EN300-20563
    • G76479
    • Q238569
    • Z104478882
    • InChI=1/C7H6O6S/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h1-3,8H,(H,9,10)(H,11,12,13
    • 97-05-2

  • Applications

    Sulfosalicylic Acid (CAS 97-05-2) is primarily used in clinical urinalysis as the precipitating reagent for protein detection (the sulfosalicylic acid test). It is also employed in analytical chemistry as a reagent for sample preparation, particularly to precipitate proteins and clarify biological samples before measurement. In organic synthesis and chemical manufacturing, it may serve as an intermediate or reagent when preparing sulfonated aromatic compounds. In laboratory settings, SSA is used as a general analytical reagent for method development and sample testing, depending on the formulation and protocol.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 18.47
    methanol 23.53
    isopropanol 8.05
    water 2.1
    ethyl acetate 1.38
    n-propanol 9.39
    acetone 7.04
    n-butanol 5.88
    acetonitrile 3.7
    DMF 51.25
    toluene 1.12
    isobutanol 3.62
    1,4-dioxane 12.38
    methyl acetate 1.77
    THF 21.31
    2-butanone 4.22
    n-pentanol 3.74
    sec-butanol 4.46
    n-hexane 0.25
    ethylene glycol 23.25
    NMP 64.08
    cyclohexane 0.38
    DMSO 60.46
    n-butyl acetate 2.2
    n-octanol 6.25
    chloroform 0.06
    n-propyl acetate 1.04
    acetic acid 5.78
    dichloromethane 0.3
    cyclohexanone 4.26
    propylene glycol 18.04
    isopropyl acetate 1.09
    DMAc 39.45
    2-ethoxyethanol 22.9
    isopentanol 2.9
    n-heptane 0.95
    ethyl formate 2.12
    1,2-dichloroethane 0.65
    n-hexanol 4.29
    2-methoxyethanol 48.56
    isobutyl acetate 0.3
    tetrachloromethane 0.03
    n-pentyl acetate 3.61
    transcutol 39.14
    n-heptanol 7.68
    ethylbenzene 0.62
    MIBK 1.63
    2-propoxyethanol 26.34
    tert-butanol 5.07
    MTBE 1.56
    2-butoxyethanol 25.5
    propionic acid 3.79
    o-xylene 1.31
    formic acid 19.49
    diethyl ether 3.6
    m-xylene 1.02
    p-xylene 0.55
    chlorobenzene 0.28
    dimethyl carbonate 2.93
    n-octane 0.46
    formamide 34.21
    cyclopentanone 9.31
    2-pentanone 3.29
    anisole 2.18
    cyclopentyl methyl ether 4.74
    gamma-butyrolactone 10.99
    1-methoxy-2-propanol 33.76
    pyridine 7.44
    3-pentanone 2.61
    furfural 12.06
    n-dodecane 0.38
    diethylene glycol 32.09
    diisopropyl ether 0.82
    tert-amyl alcohol 3.07
    acetylacetone 3.54
    n-hexadecane 0.43
    acetophenone 2.62
    methyl propionate 3.02
    isopentyl acetate 1.41
    trichloroethylene 0.44
    n-nonanol 6.6
    cyclohexanol 2.93
    benzyl alcohol 3.41
    2-ethylhexanol 2.06
    isooctanol 4.31
    dipropyl ether 4.78
    1,2-dichlorobenzene 0.29
    ethyl lactate 3.11
    propylene carbonate 2.76
    n-methylformamide 22.06
    2-pentanol 3.02
    n-pentane 0.43
    1-propoxy-2-propanol 16.4
    1-methoxy-2-propyl acetate 5.94
    2-(2-methoxypropoxy) propanol 19.76
    mesitylene 0.78
    ε-caprolactone 4.49
    p-cymene 1.2
    epichlorohydrin 7.19
    1,1,1-trichloroethane 0.07
    2-aminoethanol 28.32
    morpholine-4-carbaldehyde 38.56
    sulfolane 21.37
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 6.01
    n-hexyl acetate 4.23
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 30.52
    sec-butyl acetate 0.54
    tert-butyl acetate 1.42
    decalin 0.14
    glycerin 38.08
    diglyme 30.75
    acrylic acid 5.79
    isopropyl myristate 2.4
    n-butyric acid 2.77
    acetyl acetate 0.62
    di(2-ethylhexyl) phthalate 3.29
    ethyl propionate 1.36
    nitromethane 8.54
    1,2-diethoxyethane 6.5
    benzonitrile 1.6
    trioctyl phosphate 3.07
    1-bromopropane 0.39
    gamma-valerolactone 20.0
    n-decanol 5.13
    triethyl phosphate 1.25
    4-methyl-2-pentanol 1.43
    propionitrile 2.31
    vinylene carbonate 2.25
    1,1,2-trichlorotrifluoroethane 7.77
    DMS 1.85
    cumene 0.47
    2-octanol 3.88
    2-hexanone 1.75
    octyl acetate 3.73
    limonene 1.52
    1,2-dimethoxyethane 15.49
    ethyl orthosilicate 1.28
    tributyl phosphate 1.63
    diacetone alcohol 6.0
    N,N-dimethylaniline 3.16
    acrylonitrile 4.27
    aniline 2.82
    1,3-propanediol 19.34
    bromobenzene 0.16
    dibromomethane 0.16
    1,1,2,2-tetrachloroethane 0.49
    2-methyl-cyclohexyl acetate 1.61
    tetrabutyl urea 6.41
    diisobutyl methanol 1.82
    2-phenylethanol 4.05
    styrene 0.56
    dioctyl adipate 3.64
    dimethyl sulfate 6.39
    ethyl butyrate 1.89
    methyl lactate 9.33
    butyl lactate 6.14
    diethyl carbonate 0.96
    propanediol butyl ether 23.27
    triethyl orthoformate 2.12
    p-tert-butyltoluene 1.24
    methyl 4-tert-butylbenzoate 11.57
    morpholine 18.47
    tert-butylamine 2.42
    n-dodecanol 3.6
    dimethoxymethane 26.83
    ethylene carbonate 1.64
    cyrene 18.66
    2-ethoxyethyl acetate 5.72
    2-ethylhexyl acetate 1.05
    1,2,4-trichlorobenzene 0.4
    4-methylpyridine 3.81
    dibutyl ether 2.73
    2,6-dimethyl-4-heptanol 1.82
    DEF 8.13
    dimethyl isosorbide 22.07
    tetrachloroethylene 0.39
    eugenol 14.46
    triacetin 5.11
    span 80 15.38
    1,4-butanediol 7.98
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 1.75
    methyl formate 9.52
    2-methyl-1-butanol 2.86
    n-decane 0.61
    butyronitrile 2.04
    3,7-dimethyl-1-octanol 2.89
    1-chlorooctane 1.24
    1-chlorotetradecane 0.67
    n-nonane 0.53
    undecane 0.48
    tert-butylcyclohexane 0.09
    cyclooctane 0.3
    cyclopentanol 5.15
    tetrahydropyran 4.51
    tert-amyl methyl ether 1.8
    2,5,8-trioxanonane 30.47
    1-hexene 0.61
    2-isopropoxyethanol 9.39
    2,2,2-trifluoroethanol 2.71
    methyl butyrate 1.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction