Sulfobromophthalein Sodium

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  • Identifiers

    CAS number
    71-67-0

    Molecular formula
    C20H8Br4Na2O10S2

    SMILES
    C1=CC(=C(C=C1C2(C3=C(C(=C(C(=C3Br)Br)Br)Br)C(=O)O2)C4=CC(=C(C=C4)O)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+]

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 86.66%
    Savory 17.52%
    Bitter 17.42%
    Cooked 15.28%
    Burnt 14.81%
    Milky 13.45%
    Clean 12.38%
    Cooling 12.05%
    Phenolic 11.14%
    Roasted 10.55%

     

    Flavor
    Bitter 93.61%
    Odorless 34.54%
    Bland 23.3%
    Nitrile 19.47%
    Sweet-like 18.5%
    Cedarleaf 18.14%
    Very strong 17.98%
    Indole 17.77%
    Taco 17.58%
    Bread crust 17.54%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.64 (weak acid)

    Molecular weight
    838.0 g/mol

    Flash point

    • 332.4 ˚C est.

    Solubility expt.

    • SOL IN WATER; INSOL IN ALCOHOL, ACETONE

  • Synonyms

    • Bromosulfalein
    • bromsulphthalein
    • 71-67-0
    • Bromosulfophthalein
    • Hepatestabrome
    • Hepatosulfalein
    • Hepartest
    • BSP sodium
    • Sodium bromsulphalein
    • Bromotaleina
    • Bromsulphalein
    • Bromthalein
    • Bromsulfan
    • Sodium bromsulphthalein
    • Bromosulphthalein
    • Bromsulfophthalein
    • BSF simes
    • Bromsulfalein
    • Sodium bromosulfalein
    • Bromsulphalein R sodium
    • SODIUM SULFOBROMOPHTHALEIN
    • Sulfobromophthalein disodium salt
    • Sodium bromosulfophthalein
    • Sodium sulphobromophthalein
    • Sulphobromophthalein sodium
    • Disodium bromosulfophthalein
    • Tetrabromophenolsulfophthalein
    • Sodium phenol tetrabromophthalein
    • Sulfobromopthalein sodium
    • Disodium phenoltetrabromophthalein sulfonate
    • 62E5JU30OV
    • SULFOBROMPHTHALEIN SODIUM
    • DTXSID9023621
    • CHEBI:63827
    • 4,5,6,7-Tetrabromo-3',3''-disulfophenolphthalein disodium salt
    • Sulfobromophthalein sodium (JP17)
    • Benzenesulfonic acid, 3,3'-(4,5,6,7-tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis(6-hydroxy-, disodium salt
    • Benzenesulfonic acid, 3,3'-(4,5,6,7-tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis[6-hydroxy-, disodium salt
    • Disodium 6,6'-dihydroxy-3,3'-(4,5,6,7-tetrabromo-1,3-dihydro-3-oxoisobenzofuran-1-ylidene)dibenzenesulphonate
    • Bromsulfthalein
    • Hepartestabrome
    • Brom-tetragnost
    • Phenolphthalein, 4,5,6,7-tetrabromo-3',3''-disulfo-, disodium salt
    • DTXCID503621
    • CAS-71-67-0
    • BSF
    • disodium 3,3'-(4,5,6,7-tetrabromo-3-oxo-1,3-dihydro-2-benzofuran-1,1-diyl)bis(6-hydroxybenzenesulfonate)
    • CBSP
    • NCGC00159391-02
    • NCGC00159391-03
    • UNII-62E5JU30OV
    • Bromtetragnost
    • HSDB 2183
    • disodium 2-hydroxy-5-[4,5,6,7-tetrabromo-1-(4-hydroxy-3-sulfonatophenyl)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]benzene-1-sulfonate
    • EINECS 200-761-0
    • BROMOSULPHALEIN
    • Sulfobromophthalein sodium [USP:JAN]
    • bromsulphthalein sodium
    • bromosulfophthalein sodium
    • [3H]BSP
    • TETRABROMOSULFOPHTHALEIN
    • SCHEMBL487073
    • [3H]-BSP
    • CHEMBL453904
    • GTPL4505
    • GTPL4506
    • bromosulfophthalein disodium salt
    • phenoltetrabromophthaleinsulfonate
    • Tox21_111628
    • AKOS024373601
    • Tox21_111628_1
    • 5,5'-(4,5,6,7-Tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis(2-hydroxybenzenesulfonic acid) disodium salt
    • DA-58185
    • NS00079056
    • D02210
    • G12059
    • Q926998
    • 4,5,6,7-Tetrabromo-3',3'-disulfophenolphthalein disodium salt
    • 4,5,6,7Tetrabromo3',3''disulfophenolphthalein disodium salt
    • Phenolphthalein, 4,5,6,7tetrabromo3',3''disulfo, disodium salt
    • 3,3'(4,5,6,7Tetrabromo3oxo1(3H)isobenzofuranylidene)bis disodium salt
    • 5,5'-(4,5,6,7-TETRABROMO-3-OXO-1(3H)-ISOBENZOFURANYLID ENE)BIS
    • 5,5'(4,5,6,7Tetrabromo3oxo1(3H)isobenzofuranylidene)bis(2hydroxybenzenesulfonic acid) disodium salt
    • 626-376-1
    • Benzenesulfonic acid, 3,3'(4,5,6,7tetrabromo3oxo1(3H)isobenzofuranylidene)bis(6hydroxy, disodium salt
    • Benzenesulfonic Acid, 3,3'-(4,5,6,7-Tetrabromo-3-Oxo-1(3H)-Isobenzofuranylidene)Bis(6-Hydroxy)-, Disodium Salt
    • Disodium 5,5'-(4,5,6,7-tetrabromo-3-oxo-1,3-dihydroisobenzofuran-1,1-diyl)bis(2-hydroxybenzenesulfonate)
    • Disodium 6,6'dihydroxy3,3'(4,5,6,7tetrabromo1,3dihydro3oxoisobenzofuran1ylidene)dibenzenesulphonate

  • Applications

    Sulfobromophthalein Sodium (CAS 71-67-0) is a water-soluble dye historically used in clinical diagnostics as the bromsulphalein (BSP) test to evaluate hepatic excretory function. In laboratory settings, BSP-based reagents serve as colorimetric indicators and analytical reagents in biochemical assays and chromatography, enabling color-based measurements. The compound is also encountered as a staining/marker dye in research workflows and histology. In pharmaceutical analysis, it can be used as a reference dye or analytical standard, with current use largely historical or niche and subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.61
    methanol 3.05
    isopropanol 1.2
    water 0.02
    ethyl acetate 3.52
    n-propanol 2.35
    acetone 3.44
    n-butanol 1.35
    acetonitrile 1.7
    DMF 52.55
    toluene 1.44
    isobutanol 1.12
    1,4-dioxane 7.24
    methyl acetate 4.14
    THF 22.34
    2-butanone 5.8
    n-pentanol 1.06
    sec-butanol 1.69
    n-hexane 0.08
    ethylene glycol 2.77
    NMP 61.25
    cyclohexane 0.13
    DMSO 10.84
    n-butyl acetate 4.33
    n-octanol 1.61
    chloroform 3.76
    n-propyl acetate 3.58
    acetic acid 4.39
    dichloromethane 3.31
    cyclohexanone 7.96
    propylene glycol 3.61
    isopropyl acetate 2.65
    DMAc 43.63
    2-ethoxyethanol 7.73
    isopentanol 0.82
    n-heptane 0.17
    ethyl formate 3.35
    1,2-dichloroethane 1.97
    n-hexanol 1.34
    2-methoxyethanol 17.54
    isobutyl acetate 1.6
    tetrachloromethane 0.34
    n-pentyl acetate 4.19
    transcutol 13.93
    n-heptanol 1.63
    ethylbenzene 0.6
    MIBK 2.14
    2-propoxyethanol 13.53
    tert-butanol 0.88
    MTBE 1.3
    2-butoxyethanol 8.35
    propionic acid 3.87
    o-xylene 0.91
    formic acid 5.61
    diethyl ether 1.87
    m-xylene 0.88
    p-xylene 0.62
    chlorobenzene 0.96
    dimethyl carbonate 7.31
    n-octane 0.1
    formamide 9.58
    cyclopentanone 16.95
    2-pentanone 4.25
    anisole 2.78
    cyclopentyl methyl ether 6.41
    gamma-butyrolactone 20.25
    1-methoxy-2-propanol 15.03
    pyridine 8.94
    3-pentanone 3.76
    furfural 17.37
    n-dodecane 0.09
    diethylene glycol 10.12
    diisopropyl ether 0.48
    tert-amyl alcohol 1.4
    acetylacetone 6.88
    n-hexadecane 0.11
    acetophenone 4.47
    methyl propionate 6.96
    isopentyl acetate 2.63
    trichloroethylene 6.62
    n-nonanol 1.78
    cyclohexanol 1.64
    benzyl alcohol 2.85
    2-ethylhexanol 1.03
    isooctanol 1.13
    dipropyl ether 2.72
    1,2-dichlorobenzene 1.02
    ethyl lactate 5.08
    propylene carbonate 8.21
    n-methylformamide 15.2
    2-pentanol 1.01
    n-pentane 0.1
    1-propoxy-2-propanol 10.92
    1-methoxy-2-propyl acetate 10.38
    2-(2-methoxypropoxy) propanol 8.86
    mesitylene 0.47
    ε-caprolactone 9.62
    p-cymene 0.71
    epichlorohydrin 14.13
    1,1,1-trichloroethane 1.05
    2-aminoethanol 4.22
    morpholine-4-carbaldehyde 44.38
    sulfolane 28.61
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 6.99
    n-hexyl acetate 4.16
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 9.75
    sec-butyl acetate 2.12
    tert-butyl acetate 2.93
    decalin 0.07
    glycerin 9.68
    diglyme 16.69
    acrylic acid 5.36
    isopropyl myristate 1.77
    n-butyric acid 3.73
    acetyl acetate 2.33
    di(2-ethylhexyl) phthalate 2.27
    ethyl propionate 3.71
    nitromethane 10.95
    1,2-diethoxyethane 4.23
    benzonitrile 2.35
    trioctyl phosphate 1.71
    1-bromopropane 1.13
    gamma-valerolactone 35.13
    n-decanol 1.27
    triethyl phosphate 2.09
    4-methyl-2-pentanol 0.52
    propionitrile 2.25
    vinylene carbonate 7.18
    1,1,2-trichlorotrifluoroethane 21.48
    DMS 5.82
    cumene 0.35
    2-octanol 1.27
    2-hexanone 3.18
    octyl acetate 2.7
    limonene 1.08
    1,2-dimethoxyethane 12.48
    ethyl orthosilicate 1.88
    tributyl phosphate 1.71
    diacetone alcohol 5.8
    N,N-dimethylaniline 2.72
    acrylonitrile 4.61
    aniline 2.89
    1,3-propanediol 3.88
    bromobenzene 0.84
    dibromomethane 1.66
    1,1,2,2-tetrachloroethane 5.38
    2-methyl-cyclohexyl acetate 3.33
    tetrabutyl urea 4.26
    diisobutyl methanol 0.6
    2-phenylethanol 3.56
    styrene 0.76
    dioctyl adipate 3.07
    dimethyl sulfate 13.53
    ethyl butyrate 3.86
    methyl lactate 11.35
    butyl lactate 6.37
    diethyl carbonate 2.34
    propanediol butyl ether 7.73
    triethyl orthoformate 3.68
    p-tert-butyltoluene 0.76
    methyl 4-tert-butylbenzoate 6.49
    morpholine 13.64
    tert-butylamine 0.46
    n-dodecanol 0.89
    dimethoxymethane 20.62
    ethylene carbonate 4.78
    cyrene 12.7
    2-ethoxyethyl acetate 6.85
    2-ethylhexyl acetate 2.5
    1,2,4-trichlorobenzene 1.93
    4-methylpyridine 6.08
    dibutyl ether 1.62
    2,6-dimethyl-4-heptanol 0.6
    DEF 11.57
    dimethyl isosorbide 17.38
    tetrachloroethylene 2.95
    eugenol 8.02
    triacetin 6.69
    span 80 7.73
    1,4-butanediol 1.5
    1,1-dichloroethane 1.39
    2-methyl-1-pentanol 0.76
    methyl formate 10.05
    2-methyl-1-butanol 1.18
    n-decane 0.17
    butyronitrile 1.79
    3,7-dimethyl-1-octanol 1.08
    1-chlorooctane 0.65
    1-chlorotetradecane 0.28
    n-nonane 0.14
    undecane 0.12
    tert-butylcyclohexane 0.05
    cyclooctane 0.08
    cyclopentanol 3.47
    tetrahydropyran 4.43
    tert-amyl methyl ether 2.01
    2,5,8-trioxanonane 12.73
    1-hexene 0.36
    2-isopropoxyethanol 4.38
    2,2,2-trifluoroethanol 2.79
    methyl butyrate 4.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction