Sulfaquinoxaline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    59-40-5

    Molecular formula
    C14H12N4O2S

    SMILES
    C1=CC=C2C(=C1)N=CC(=N2)NS(=O)(=O)C3=CC=C(C=C3)N

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 61.93%
    Cooked 32.69%
    Meaty 27.69%
    Roasted 26.66%
    Savory 24.91%
    Fruity 24.67%
    Burnt 23.41%
    Grape 22.54%
    Bitter 19.69%
    Sulfurous 19.5%

     

    Flavor
    Bitter 84.71%
    Odorless 31.67%
    Nitrile 21.18%
    Very strong 19.82%
    Bread crust 19.81%
    Taco 19.73%
    Indole 19.4%
    Roasted peanuts 19.3%
    Scallion 18.8%
    Moth ball 18.79%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    6.47 (neutral)

    Molecular weight
    300.34 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    862°C

    Melting point expt.

    • 247.5 °C
    • 247 - 248 °C

    Flash point

    • 287.25 ˚C est.

    Solubility expt.

    • Mol wt: 322.32. Very sol in water; pH of 1% aqueous solution is about 10. The amorphous salt is deliquescent and absorbs carbon dioxide which liberates the practically insoluble sulfaquinoxaline /Sodium salt/
    • Solubility = 730 mg/L in 95% alcohol and 4,300 mg/L in acetone. Soluble in aqueous sodium bicarbonate and sodium hydroxide solutions.
    • In water, 7.5 mg/L at pH 7 / room temp/
    • >45.1 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • sulfaquinoxaline
    • 59-40-5
    • Sulfabenzpyrazine
    • Avicocid
    • Sulfaline
    • Sulquin
    • Italquina
    • Kokozigal
    • Ursokoxaline
    • Sulfacox
    • Sulfachinoxalin
    • Sulfaquinoxalina
    • 2-Sulfanilamidoquinoxaline
    • Sulfaquinoxalinum
    • Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-
    • SQ 40
    • Sul-q-nox
    • 4-AMINO-N-(QUINOXALIN-2-YL)BENZENE-1-SULFONAMIDE
    • 4-Amino-N-2-quinoxalinylbenzenesulfonamide
    • NSC-41805
    • WNW8115TM9
    • DTXSID8042424
    • DTXCID6022424
    • RefChem:58611
    • 25 % S.Q. Soluble
    • 20% Sulfaquinoxaline Sodium Solution
    • S.Q. 40%
    • 200-423-2
    • Sulphaquinoxaline
    • 4-Amino-N-(quinoxalin-2-yl)benzenesulfonamide
    • Sulfa-Q 20
    • Compound 3-120
    • 2-Sulfanilamidobenzopyrazine
    • Anti-K
    • 2-(p-Sulfanilamido)quinoxaline
    • Sulfaquinoxalin
    • N-(2-Quinoxalinyl)sulfanilamide
    • 4-amino-N-quinoxalin-2-ylbenzenesulfonamide
    • N1-(2-Quinoxalinyl)sulfanilamide
    • N'-2-Quinoxalylsulfanilamide
    • 2-p-Aminobenzenesulfonamidoquinoxaline
    • MFCD00055406
    • N-(2-Quinoxalinyl)sulfanilide
    • 2-p-Aminobenzenesulphonamidoquinoxaline
    • AI3-17254
    • NSC41805
    • SQX
    • 4-amino-N-(2-quinoxalinyl)benzenesulfonamide
    • N(sup 1)-2-Quinoxalinylsulfanilamide
    • N(sup 1)-(2-Quinoxalinyl)sulfanilamide
    • 4-amino-N-quinoxalin-2-yl-benzenesulfonamide
    • Sulfanilamide, N1-2-quinoxalinyl-
    • Sulfaquinoxaline (USP/INN)
    • MLS000737045
    • N'-(2-Quinoxalyl)sulfanilamide
    • N1-2-Quinoxalinyl, sulfanilamide
    • Embazin
    • N(sup1)-Quinoxalin-2-ylsulfanilamide
    • N(sup1)-(2-Quinoxalinyl)sulfanilamide
    • 2-(p-Aminobenzene)sulfonamidoquinoxaline
    • Caswell No. 721
    • CAS-59-40-5
    • NSC 41805
    • SMR000394001
    • Sulfaquinoxalinum [INN-Latin]
    • Sulfaquinoxalina [INN-Spanish]
    • HSDB 7440
    • Sulfaquinoxaline [USAN:INN:BAN]
    • EINECS 200-423-2
    • EPA Pesticide Chemical Code 077901
    • BRN 0290026
    • UNII-WNW8115TM9
    • Aviochina
    • Nococcin
    • Quinoxipra C
    • Kokozigal S
    • Sulfa-Q
    • Sulfaquinoxaline [USP:INN:BAN]
    • Spectrum_001410
    • Sulfanilamide, N(sup 1)-2-quinoxalinyl-
    • 4-Amino-n-2-quinoxalinyl-benzenesulfonamide
    • Prestwick0_000731
    • Prestwick1_000731
    • Prestwick2_000731
    • Prestwick3_000731
    • Spectrum2_000986
    • Spectrum3_001455
    • Spectrum4_000423
    • Spectrum5_000983
    • S. Q. 40 Per cent
    • NCIStruc1_000587
    • NCIStruc2_000454
    • Oprea1_705564
    • SCHEMBL93789
    • Sulfaquinoxaline, BAN, INN
    • BSPBio_000682
    • BSPBio_002949
    • KBioGR_000746
    • KBioSS_001890
    • SULFAQUINOXALINE [MI]
    • 5-25-11-00125 (Beilstein Handbook Reference)
    • MLS001176103
    • S. Q. "40 per cent"
    • S. Q. '40 per cent'
    • BIDD:GT0642
    • DivK1c_000035
    • SULFAQUINOXALINE [INN]
    • SPBio_001051
    • SPBio_002621
    • SULFAQUINOXALINE [HSDB]
    • BPBio1_000752
    • orb1709326
    • CHEMBL1437847
    • N1-2-quinoxalinyl-Sulfanilamide
    • SCHEMBL21295162
    • SCHEMBL29391090
    • SULFAQUINOXALINE [MART.]
    • CHEBI:94719
    • GTPL13878
    • KBio1_000035
    • KBio2_001890
    • KBio2_004458
    • KBio2_007026
    • KBio3_002449
    • MSK4028
    • NINDS_000035
    • HMS2744N03
    • 59-40-5

  • Applications

    Sulfaquinoxaline (CAS 59-40-5) is a sulfonamide antibiotic used in veterinary medicine. Its applications include treatment of bacterial infections in animals, particularly in livestock and companion animals; use as a coccidiostat in poultry feeds to prevent coccidiosis; inclusion in veterinary drug formulations as the active ingredient; involvement in veterinary pharmaceutical research and development; and residue monitoring and regulatory compliance considerations for animal products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.82
    methanol 1.51
    isopropanol 0.53
    water 0.02
    ethyl acetate 1.19
    n-propanol 0.91
    acetone 1.3
    n-butanol 0.56
    acetonitrile 2.66
    DMF 29.91
    toluene 0.06
    isobutanol 0.35
    1,4-dioxane 3.27
    methyl acetate 2.48
    THF 13.82
    2-butanone 4.2
    n-pentanol 0.4
    sec-butanol 0.66
    n-hexane 0.0
    ethylene glycol 1.73
    NMP 32.92
    cyclohexane 0.0
    DMSO 29.57
    n-butyl acetate 1.37
    n-octanol 0.11
    chloroform 0.06
    n-propyl acetate 1.33
    acetic acid 5.18
    dichloromethane 0.18
    cyclohexanone 4.53
    propylene glycol 2.36
    isopropyl acetate 0.75
    DMAc 54.19
    2-ethoxyethanol 8.73
    isopentanol 0.45
    n-heptane 0.01
    ethyl formate 2.19
    1,2-dichloroethane 0.28
    n-hexanol 0.32
    2-methoxyethanol 24.84
    isobutyl acetate 0.43
    tetrachloromethane 0.01
    n-pentyl acetate 0.6
    transcutol 16.12
    n-heptanol 0.26
    ethylbenzene 0.04
    MIBK 0.67
    2-propoxyethanol 7.03
    tert-butanol 0.42
    MTBE 0.18
    2-butoxyethanol 3.12
    propionic acid 2.71
    o-xylene 0.06
    formic acid 7.12
    diethyl ether 0.21
    m-xylene 0.04
    p-xylene 0.1
    chlorobenzene 0.14
    dimethyl carbonate 1.89
    n-octane 0.0
    formamide 21.61
    cyclopentanone 13.96
    2-pentanone 1.17
    anisole 0.53
    cyclopentyl methyl ether 0.67
    gamma-butyrolactone 19.51
    1-methoxy-2-propanol 10.23
    pyridine 5.11
    3-pentanone 1.01
    furfural 19.93
    n-dodecane 0.01
    diethylene glycol 10.18
    diisopropyl ether 0.05
    tert-amyl alcohol 0.49
    acetylacetone 3.79
    n-hexadecane 0.01
    acetophenone 1.59
    methyl propionate 1.85
    isopentyl acetate 1.21
    trichloroethylene 0.64
    n-nonanol 0.15
    cyclohexanol 0.37
    benzyl alcohol 0.99
    2-ethylhexanol 0.25
    isooctanol 0.23
    dipropyl ether 0.5
    1,2-dichlorobenzene 0.2
    ethyl lactate 2.39
    propylene carbonate 5.01
    n-methylformamide 12.15
    2-pentanol 0.24
    n-pentane 0.0
    1-propoxy-2-propanol 4.09
    1-methoxy-2-propyl acetate 3.81
    2-(2-methoxypropoxy) propanol 4.4
    mesitylene 0.03
    ε-caprolactone 5.35
    p-cymene 0.12
    epichlorohydrin 11.85
    1,1,1-trichloroethane 0.07
    2-aminoethanol 2.89
    morpholine-4-carbaldehyde 29.24
    sulfolane 26.6
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 2.37
    n-hexyl acetate 0.44
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 5.41
    sec-butyl acetate 0.62
    tert-butyl acetate 0.78
    decalin 0.01
    glycerin 9.18
    diglyme 13.89
    acrylic acid 4.3
    isopropyl myristate 0.28
    n-butyric acid 2.32
    acetyl acetate 1.16
    di(2-ethylhexyl) phthalate 0.83
    ethyl propionate 1.04
    nitromethane 20.45
    1,2-diethoxyethane 1.93
    benzonitrile 1.41
    trioctyl phosphate 0.4
    1-bromopropane 0.06
    gamma-valerolactone 34.42
    n-decanol 0.12
    triethyl phosphate 1.14
    4-methyl-2-pentanol 0.15
    propionitrile 1.4
    vinylene carbonate 3.97
    1,1,2-trichlorotrifluoroethane 10.08
    DMS 1.36
    cumene 0.04
    2-octanol 0.12
    2-hexanone 1.46
    octyl acetate 0.39
    limonene 0.15
    1,2-dimethoxyethane 11.05
    ethyl orthosilicate 0.92
    tributyl phosphate 0.58
    diacetone alcohol 2.99
    N,N-dimethylaniline 0.41
    acrylonitrile 3.9
    aniline 0.53
    1,3-propanediol 4.74
    bromobenzene 0.08
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.49
    2-methyl-cyclohexyl acetate 1.22
    tetrabutyl urea 1.2
    diisobutyl methanol 0.2
    2-phenylethanol 1.18
    styrene 0.06
    dioctyl adipate 0.96
    dimethyl sulfate 5.65
    ethyl butyrate 1.63
    methyl lactate 5.53
    butyl lactate 1.63
    diethyl carbonate 1.31
    propanediol butyl ether 2.26
    triethyl orthoformate 1.6
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 2.03
    morpholine 7.37
    tert-butylamine 0.1
    n-dodecanol 0.1
    dimethoxymethane 6.26
    ethylene carbonate 2.66
    cyrene 7.63
    2-ethoxyethyl acetate 2.25
    2-ethylhexyl acetate 0.87
    1,2,4-trichlorobenzene 0.44
    4-methylpyridine 1.79
    dibutyl ether 0.23
    2,6-dimethyl-4-heptanol 0.2
    DEF 3.78
    dimethyl isosorbide 10.19
    tetrachloroethylene 0.26
    eugenol 2.96
    triacetin 2.11
    span 80 2.2
    1,4-butanediol 1.37
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.39
    methyl formate 6.97
    2-methyl-1-butanol 0.43
    n-decane 0.01
    butyronitrile 0.99
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 1.1
    tetrahydropyran 0.93
    tert-amyl methyl ether 0.22
    2,5,8-trioxanonane 10.08
    1-hexene 0.02
    2-isopropoxyethanol 3.1
    2,2,2-trifluoroethanol 2.43
    methyl butyrate 2.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction