Sulfanilic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    121-57-3

    Molecular formula
    C6H7NO3S

    SMILES
    C1=CC(=CC=C1N)S(=O)(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 82.35%
    Cooked 23.44%
    Sulfurous 21.71%
    Roasted 20.67%
    Burnt 20.05%
    Savory 20.02%
    Bitter 19.58%
    Meaty 19.35%
    Grape 13.69%
    Pungent 13.61%

     

    Flavor
    Bitter 70.31%
    Odorless 32.49%
    Mild 23.87%
    Nitrile 22.26%
    Urine 20.74%
    Bland 20.18%
    Bread crust 20.13%
    Taco 19.84%
    Formyl 19.82%
    Very strong 19.64%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    7.81 (neutral)

    Molecular weight
    173.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    382°C

    Melting point expt.

    • Decomposes without melting at 550 °F (NTP, 1992)
    • 288 °C decomposes without melting

    Flash point

    • 207.91 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Insoluble in ethanol and ether
    • Soluble in fuming hydrochloric acid
    • Slowly sol in water: about 1% at 20 °C, about 1.45% at 30 °C, about 1.94% at 40 °C
    • In water, 10.68 g/L at 20 °C; 14.68 g/L at 30 °C
    • Solubility in water: poor

  • Synonyms

    • SULFANILIC ACID
    • 4-Aminobenzenesulfonic acid
    • 121-57-3
    • Sulphanilic acid
    • p-Aminobenzenesulfonic acid
    • Aniline-4-sulfonic acid
    • Aniline-p-sulfonic acid
    • Sulfanilsaeure
    • Aniline-p-sulphonic acid
    • p-Aminophenylsulfonic acid
    • p-Anilinesulfonic acid
    • Kyselina sulfanilova
    • p-sulfoaniline
    • 4-Sulfoaniline
    • 4-Sulfanilic acid
    • NSC 7170
    • CCRIS 4576
    • CHEBI:27500
    • HSDB 5590
    • EINECS 204-482-5
    • 1-aminobenzene-4-sulfonic acid
    • AI3-15414
    • UNII-434Z8C2635
    • NSC-7170
    • 4-aminophenylsulfonic acid
    • p-aminobenzene sulfonic acid
    • 434Z8C2635
    • DTXSID6024464
    • EC 204-482-5
    • SULFANILIC ACID (USP-RS)
    • SULFANILIC ACID [USP-RS]
    • MESALAZINE IMPURITY O (EP IMPURITY)
    • MESALAZINE IMPURITY O [EP IMPURITY]
    • SULFADIAZINE IMPURITY B (EP IMPURITY)
    • SULFADIAZINE IMPURITY B [EP IMPURITY]
    • SULFADIMIDINE IMPURITY F (EP IMPURITY)
    • SULFADIMIDINE IMPURITY F [EP IMPURITY]
    • SULFADIMETHOXINE IMPURITY D (EP IMPURITY)
    • SULFADIMETHOXINE IMPURITY D [EP IMPURITY]
    • SULFAMETHOXAZOLE IMPURITY D (EP IMPURITY)
    • SULFAMETHOXAZOLE IMPURITY D [EP IMPURITY]
    • 4-aminobenzene sulfonic acid
    • SULFADIMETHOXINE SODIUM FOR VETERINARY USE IMPURITY D (EP IMPURITY)
    • SULFADIMETHOXINE SODIUM FOR VETERINARY USE IMPURITY D [EP IMPURITY]
    • RefChem:6272
    • DTXCID604464
    • PARA-ANILINE SULFONIC ACID
    • 204-482-5
    • Benzenesulfonic acid, 4-amino-
    • 4-aminobenzene-1-sulfonic acid
    • MFCD00007886
    • SUFANILIC ACID
    • P-SULFANILIC ACID
    • CHEMBL1566888
    • 4-AMINOBENZENESULPHONIC ACID
    • 97675-28-0
    • Sulfanilsaeure [German]
    • Kyselina sulfanilova [Czech]
    • SULFANILLIC ACID
    • 4-Aminobenzenesulphonic Acid (Sulphanilic Acid)
    • p-sulphanilic acid
    • Sulfanilic acid, 99%
    • Mesalazine EP Impurity O
    • bmse000726
    • Epitope ID:122241
    • p-aminobenzenesulphonic acid
    • 4-aminobenzene-sulfonic acid
    • SCHEMBL24407
    • SULFANILIC ACID [MI]
    • 4-Amino benzenesulphonic acid
    • SCHEMBL157614
    • Sulfanilic acid, >=99.0%
    • Sulfadimethoxine EP Impurity D
    • SULFANILIC ACID [HSDB]
    • SCHEMBL3290419
    • SCHEMBL3914014
    • SCHEMBL6630970
    • SCHEMBL7068968
    • Sulfanilic acid, 98%, tech.
    • NSC7170
    • BB_SC-07049
    • Nitrate Reagent B, for microbiology
    • BBL011603
    • BDBM50443531
    • EBC-03233
    • MSK159314
    • SBB028140
    • STK661383
    • Sulfanilic acid, ACS reagent, 99%
    • AKOS000118732
    • NCGC00090886-01
    • NCGC00090886-02
    • AC-12565
    • FA139881
    • VS-02984
    • Sulfanilic Acid [for Biochemical Research]
    • ST4084010
    • Sulfanilic acid, p.a., 98.0-102.0%
    • NS00000298
    • S0120
    • U0107
    • EN300-19269
    • C06335
    • E80415
    • Sulfanilic acid, Vetec(TM) reagent grade, 99%
    • USP Solution Sulfanilic Acid TS Conforms to USP
    • Q253746
    • Sulfanilic acid, puriss. p.a., >=99.0% (T)
    • 4-Aminobenzenesulfonic acid 100 microg/mL in Methanol
    • Sulfanilic acid, JIS special grade, 99.0-100.5%
    • F0001-0346
    • Z104473374
    • Sulfanilic acid, United States Pharmacopeia (USP) Reference Standard
    • Sulfanilic acid, 99.0-100.5%, suitable for determination of nitroxide
    • Benzenesulfonic acid,4-amino-,diazotized,coupled with dyer's mulberry extract
    • InChI=1/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10
    • Sulfanilic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
    • 129674-17-5
    • Benzenesulfonic acid,4-amino-,diazotized,coupled with 5,5'-oxybis[1,3-benzenediol],sodium salt
    • Mesalazine EP Impurity O; Sulfamethoxazole EP Impurity D; Sulfadiazine EP Impurity B; Sulfadimethoxine EP Impurity D; Sulfadimidine EP Impurity F
    • 121-57-3

  • Applications

    Sulfanilic acid (CAS 121-57-3) is primarily used as an intermediate in the production of azo dyes and pigments for textiles, inks, and coatings. It also serves as a diazotization reagent in analytical chemistry for nitrite determination (Griess-type assays). In addition, Sulfanilic acid provides a building block to prepare sulfonated aromatic compounds used in surfactants, ion-exchange resins, and polymer additives, and it is a precursor for dye intermediates used in plastics and coatings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.14
    methanol 1.7
    isopropanol 0.83
    water 0.64
    ethyl acetate 0.03
    n-propanol 0.6
    acetone 1.02
    n-butanol 0.53
    acetonitrile 0.68
    DMF 8.48
    toluene 0.01
    isobutanol 0.31
    1,4-dioxane 7.23
    methyl acetate 0.17
    THF 6.52
    2-butanone 0.44
    n-pentanol 0.4
    sec-butanol 0.41
    n-hexane 0.01
    ethylene glycol 2.56
    NMP 32.36
    cyclohexane 0.03
    DMSO 12.56
    n-butyl acetate 0.53
    n-octanol 0.62
    chloroform 0.0
    n-propyl acetate 0.16
    acetic acid 7.3
    dichloromethane 0.01
    cyclohexanone 1.41
    propylene glycol 2.65
    isopropyl acetate 0.07
    DMAc 11.45
    2-ethoxyethanol 4.56
    isopentanol 0.46
    n-heptane 0.07
    ethyl formate 0.3
    1,2-dichloroethane 0.02
    n-hexanol 0.74
    2-methoxyethanol 8.4
    isobutyl acetate 0.1
    tetrachloromethane 0.0
    n-pentyl acetate 0.62
    transcutol 10.92
    n-heptanol 1.1
    ethylbenzene 0.02
    MIBK 0.24
    2-propoxyethanol 5.94
    tert-butanol 0.93
    MTBE 0.19
    2-butoxyethanol 5.78
    propionic acid 0.8
    o-xylene 0.03
    formic acid 7.1
    diethyl ether 0.11
    m-xylene 0.02
    p-xylene 0.05
    chlorobenzene 0.02
    dimethyl carbonate 0.21
    n-octane 0.03
    formamide 11.77
    cyclopentanone 3.61
    2-pentanone 0.19
    anisole 0.22
    cyclopentyl methyl ether 0.33
    gamma-butyrolactone 4.46
    1-methoxy-2-propanol 4.08
    pyridine 0.87
    3-pentanone 0.12
    furfural 5.68
    n-dodecane 0.03
    diethylene glycol 8.38
    diisopropyl ether 0.05
    tert-amyl alcohol 0.55
    acetylacetone 0.71
    n-hexadecane 0.03
    acetophenone 0.53
    methyl propionate 0.07
    isopentyl acetate 0.62
    trichloroethylene 0.02
    n-nonanol 0.7
    cyclohexanol 0.39
    benzyl alcohol 0.46
    2-ethylhexanol 0.45
    isooctanol 0.79
    dipropyl ether 0.45
    1,2-dichlorobenzene 0.03
    ethyl lactate 0.77
    propylene carbonate 1.44
    n-methylformamide 2.71
    2-pentanol 0.2
    n-pentane 0.01
    1-propoxy-2-propanol 3.5
    1-methoxy-2-propyl acetate 1.57
    2-(2-methoxypropoxy) propanol 6.76
    mesitylene 0.03
    ε-caprolactone 1.38
    p-cymene 0.17
    epichlorohydrin 1.21
    1,1,1-trichloroethane 0.01
    2-aminoethanol 3.36
    morpholine-4-carbaldehyde 21.28
    sulfolane 12.51
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.28
    n-hexyl acetate 0.79
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 8.9
    sec-butyl acetate 0.1
    tert-butyl acetate 0.31
    decalin 0.01
    glycerin 8.17
    diglyme 13.16
    acrylic acid 1.81
    isopropyl myristate 0.51
    n-butyric acid 0.55
    acetyl acetate 0.12
    di(2-ethylhexyl) phthalate 1.63
    ethyl propionate 0.09
    nitromethane 5.3
    1,2-diethoxyethane 1.22
    benzonitrile 0.33
    trioctyl phosphate 1.0
    1-bromopropane 0.01
    gamma-valerolactone 11.64
    n-decanol 0.57
    triethyl phosphate 0.56
    4-methyl-2-pentanol 0.18
    propionitrile 0.18
    vinylene carbonate 0.83
    1,1,2-trichlorotrifluoroethane 2.54
    DMS 0.51
    cumene 0.04
    2-octanol 0.45
    2-hexanone 0.34
    octyl acetate 0.8
    limonene 0.25
    1,2-dimethoxyethane 4.34
    ethyl orthosilicate 0.51
    tributyl phosphate 0.71
    diacetone alcohol 2.18
    N,N-dimethylaniline 0.4
    acrylonitrile 0.41
    aniline 0.13
    1,3-propanediol 3.77
    bromobenzene 0.01
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.02
    2-methyl-cyclohexyl acetate 1.01
    tetrabutyl urea 2.24
    diisobutyl methanol 0.4
    2-phenylethanol 1.09
    styrene 0.02
    dioctyl adipate 1.37
    dimethyl sulfate 1.05
    ethyl butyrate 0.4
    methyl lactate 1.31
    butyl lactate 1.78
    diethyl carbonate 0.34
    propanediol butyl ether 5.57
    triethyl orthoformate 0.7
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 3.55
    morpholine 6.51
    tert-butylamine 0.3
    n-dodecanol 0.44
    dimethoxymethane 1.58
    ethylene carbonate 0.54
    cyrene 10.78
    2-ethoxyethyl acetate 1.33
    2-ethylhexyl acetate 0.43
    1,2,4-trichlorobenzene 0.06
    4-methylpyridine 0.24
    dibutyl ether 0.35
    2,6-dimethyl-4-heptanol 0.4
    DEF 0.68
    dimethyl isosorbide 10.37
    tetrachloroethylene 0.02
    eugenol 4.51
    triacetin 2.08
    span 80 5.55
    1,4-butanediol 1.74
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.33
    methyl formate 1.58
    2-methyl-1-butanol 0.31
    n-decane 0.04
    butyronitrile 0.21
    3,7-dimethyl-1-octanol 0.5
    1-chlorooctane 0.09
    1-chlorotetradecane 0.07
    n-nonane 0.03
    undecane 0.03
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 1.05
    tetrahydropyran 0.82
    tert-amyl methyl ether 0.17
    2,5,8-trioxanonane 13.74
    1-hexene 0.03
    2-isopropoxyethanol 2.1
    2,2,2-trifluoroethanol 1.83
    methyl butyrate 0.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction