Sulfamethoxypyridazine

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  • Identifiers

    CAS number
    80-35-3

    Molecular formula
    C11H12N4O3S

    SMILES
    COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 66.3%
    Cooked 30.73%
    Roasted 30.56%
    Meaty 27.99%
    Savory 25.61%
    Grape 22.56%
    Burnt 18.79%
    Bitter 18.66%
    Sulfurous 17.65%
    Fruity 17.52%

     

    Flavor
    Bitter 82.65%
    Odorless 32.62%
    Bland 21.51%
    Mild 20.81%
    Nitrile 20.76%
    Bread crust 20.07%
    Taco 20.06%
    Roasted peanuts 19.75%
    Very strong 19.31%
    Scallion 18.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    6.96 (neutral)

    Molecular weight
    280.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    861°C

    Flash point

    • 260.94 ˚C est.

  • Synonyms

    • sulfamethoxypyridazine
    • 80-35-3
    • Sulphamethoxypyridazine
    • Midicel
    • Sulfapyridazine
    • Depovernil
    • Sulfalex
    • Longin
    • Sulfametoxipiridazine
    • Spofadazine
    • Sulfdurazin
    • Lederkyn
    • Kynex
    • Vinces
    • Sulfametoxipiridazina
    • 3-Sulfa-6-methoxypyridazine
    • Sulfamethoxypyridazinum
    • 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
    • Retasulphine
    • Lisulfen
    • Petrisul
    • Piridolo
    • Quinoseptyl
    • Retasulfin
    • Sulfozona
    • Sultirene
    • Altezol
    • Davosin
    • Lentac
    • Medicel
    • Midikel
    • Myasul
    • Opinsul
    • Paramid
    • Retamid
    • Slosul
    • Durox
    • Kinex
    • Smop
    • Solfametossipiridazina
    • Paramid Supra
    • 3-Methoxy-6-sulfanylamidopyridazine
    • 3-Sulfanilamide-6-methoxypyridazine
    • 3-Sulfanilamido-6-methoxypyridazine
    • 6-Methoxy-3-sulfanilamidopyridazine
    • 6-Sulfanilamido-3-methoxypyridazine
    • Sulfamethoxipyridazinum
    • Benzenesulfonamide, 4-amino-N-(6-methoxy-3-pyridazinyl)-
    • sulfamethoxipyridazine
    • 3-(p-Aminobenzenesulfamido)-6-methoxypyridazine
    • 3-p-Aminobenzenesulphonamido-6-methoxypyridazine
    • Sulfamethoxypyridazine [INN]
    • 6-Methoxy-3-pyridazinylsulfanilamide
    • Kineks
    • 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide
    • CHEBI:102516
    • Sulfamethoxypyridazinum [INN-Latin]
    • Sulfametoxipiridazina [INN-Spanish]
    • EINECS 201-272-5
    • UNII-T034E4NS2Z
    • NSC-757875
    • RP 7522
    • BRN 0277076
    • T034E4NS2Z
    • 3-(4-Aminobenzenesulfonamido)-6-methoxypyridazine
    • CL 13494
    • DTXSID5023611
    • N1-(6-Methoxy-3-pyridazinyl)sulfanilamide
    • 4-amino-N-(6-methoxy-3-pyridazinyl)benzenesulfonamide
    • N(1)-(6-Methoxy-3-pyridazinyl)sulfanilamide
    • Pyridazine, sulfamethoxy-
    • N(sup 1)-(6-Methoxy-3-pyridazinyl)sulfanilamide
    • Sulfamethoxypyridazine [USP:INN:BAN]
    • 4-Amino-N-(6-methoxy-3-pyridazinyl)benzolsulfonamid
    • Sulfamethoxypyridazine (INN)
    • CL-13494
    • MLS000069641
    • DTXCID203611
    • Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)-
    • SULFAMETHOXYPYRIDAZINE [MI]
    • 3-Methoxy-6-sulfanilamidopyridazine
    • 5-25-12-00424 (Beilstein Handbook Reference)
    • Sulfanilamide, N(sup 1)-(6-methoxy-3-pyridazinyl)-
    • SULFAMETHOXYPYRIDAZINE [MART.]
    • NSC 757875
    • SULFAMETHOXYPYRIDAZINE [WHO-DD]
    • SULFAMETHOXYPYRIDAZINE [WHO-IP]
    • NCGC00016324-01
    • N-(6-Methoxy-3-pyridazinyl)sulfanilamide
    • SMR000018386
    • Sulfamethoxypyridazine 100 microg/mL in Acetonitrile
    • Sulfamethoxypyridazinum (INN-Latin)
    • Sulfametoxipiridazina (INN-Spanish)
    • SULFAMETHOXYPYRIDAZINE (MART.)
    • Sulfamethoxypyridazine (USP:INN:BAN)
    • CAS-80-35-3
    • Solfametossipiridazina [DCIT]
    • SR-01000000179
    • Succinylsulfathi
    • Lederkyn (TN)
    • Prestwick_118
    • MFCD00057372
    • Spectrum_001151
    • Opera_ID_698
    • Prestwick0_000724
    • Prestwick1_000724
    • Prestwick2_000724
    • Prestwick3_000724
    • Spectrum2_001429
    • Spectrum3_001462
    • Spectrum4_000430
    • Spectrum5_001187
    • Epitope ID:122239
    • Oprea1_275757
    • SCHEMBL93617
    • BSPBio_000648
    • BSPBio_002983
    • KBioGR_000760
    • KBioSS_001631
    • MLS000100719
    • MLS001148433
    • DivK1c_000239
    • SPECTRUM1501156
    • SPBio_001538
    • SPBio_002587
    • BPBio1_000714
    • CHEMBL268869
    • 4-Amino-N-(6-methoxy-pyridazin-3-yl)-benzenesulfonamide

  • Applications

    Sulfamethoxypyridazine (CAS 80-35-3) is a veterinary sulfonamide antibiotic used as an active pharmaceutical ingredient in livestock formulations; it also serves as an intermediate in the synthesis of related sulfonamide medicines; in pharmaceutical manufacturing and quality control, it is used as an analytical reference material and for method development to detect sulfonamides; in research and development, it provides a building block for sulfonamide derivatives; it may be evaluated for inclusion in agricultural or animal-health product programs, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.59
    methanol 4.38
    isopropanol 1.09
    water 0.1
    ethyl acetate 4.41
    n-propanol 1.52
    acetone 11.74
    n-butanol 0.87
    acetonitrile 14.28
    DMF 59.33
    toluene 0.11
    isobutanol 0.55
    1,4-dioxane 11.39
    methyl acetate 10.28
    THF 24.4
    2-butanone 16.84
    n-pentanol 0.56
    sec-butanol 1.18
    n-hexane 0.0
    ethylene glycol 4.19
    NMP 60.05
    cyclohexane 0.02
    DMSO 64.48
    n-butyl acetate 2.13
    n-octanol 0.15
    chloroform 0.23
    n-propyl acetate 2.72
    acetic acid 13.53
    dichloromethane 0.46
    cyclohexanone 14.54
    propylene glycol 5.29
    isopropyl acetate 1.61
    DMAc 121.06
    2-ethoxyethanol 16.87
    isopentanol 0.69
    n-heptane 0.02
    ethyl formate 8.97
    1,2-dichloroethane 0.58
    n-hexanol 0.43
    2-methoxyethanol 51.79
    isobutyl acetate 0.72
    tetrachloromethane 0.04
    n-pentyl acetate 0.75
    transcutol 16.09
    n-heptanol 0.31
    ethylbenzene 0.07
    MIBK 1.26
    2-propoxyethanol 9.78
    tert-butanol 1.15
    MTBE 0.42
    2-butoxyethanol 3.7
    propionic acid 5.6
    o-xylene 0.13
    formic acid 21.44
    diethyl ether 0.54
    m-xylene 0.07
    p-xylene 0.19
    chlorobenzene 0.25
    dimethyl carbonate 5.3
    n-octane 0.01
    formamide 73.08
    cyclopentanone 34.38
    2-pentanone 3.93
    anisole 1.21
    cyclopentyl methyl ether 0.96
    gamma-butyrolactone 41.58
    1-methoxy-2-propanol 17.0
    pyridine 8.02
    3-pentanone 3.37
    furfural 38.56
    n-dodecane 0.01
    diethylene glycol 18.27
    diisopropyl ether 0.09
    tert-amyl alcohol 1.05
    acetylacetone 10.92
    n-hexadecane 0.01
    acetophenone 3.32
    methyl propionate 5.66
    isopentyl acetate 1.65
    trichloroethylene 1.32
    n-nonanol 0.19
    cyclohexanol 0.75
    benzyl alcohol 1.83
    2-ethylhexanol 0.3
    isooctanol 0.26
    dipropyl ether 0.6
    1,2-dichlorobenzene 0.37
    ethyl lactate 4.86
    propylene carbonate 11.84
    n-methylformamide 32.71
    2-pentanol 0.36
    n-pentane 0.0
    1-propoxy-2-propanol 5.13
    1-methoxy-2-propyl acetate 5.66
    2-(2-methoxypropoxy) propanol 6.37
    mesitylene 0.07
    ε-caprolactone 11.85
    p-cymene 0.17
    epichlorohydrin 16.79
    1,1,1-trichloroethane 0.22
    2-aminoethanol 5.53
    morpholine-4-carbaldehyde 54.74
    sulfolane 45.72
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 4.19
    n-hexyl acetate 0.57
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 6.3
    sec-butyl acetate 1.04
    tert-butyl acetate 1.54
    decalin 0.01
    glycerin 19.49
    diglyme 16.75
    acrylic acid 8.25
    isopropyl myristate 0.38
    n-butyric acid 4.75
    acetyl acetate 3.53
    di(2-ethylhexyl) phthalate 1.29
    ethyl propionate 2.26
    nitromethane 83.99
    1,2-diethoxyethane 2.29
    benzonitrile 2.92
    trioctyl phosphate 0.6
    1-bromopropane 0.13
    gamma-valerolactone 79.9
    n-decanol 0.17
    triethyl phosphate 2.02
    4-methyl-2-pentanol 0.2
    propionitrile 4.29
    vinylene carbonate 9.92
    1,1,2-trichlorotrifluoroethane 19.72
    DMS 2.35
    cumene 0.06
    2-octanol 0.15
    2-hexanone 3.04
    octyl acetate 0.54
    limonene 0.24
    1,2-dimethoxyethane 26.94
    ethyl orthosilicate 1.43
    tributyl phosphate 0.88
    diacetone alcohol 6.33
    N,N-dimethylaniline 0.77
    acrylonitrile 10.11
    aniline 0.85
    1,3-propanediol 8.55
    bromobenzene 0.14
    dibromomethane 0.18
    1,1,2,2-tetrachloroethane 1.08
    2-methyl-cyclohexyl acetate 2.0
    tetrabutyl urea 1.92
    diisobutyl methanol 0.23
    2-phenylethanol 1.9
    styrene 0.11
    dioctyl adipate 1.37
    dimethyl sulfate 13.05
    ethyl butyrate 2.66
    methyl lactate 12.19
    butyl lactate 2.11
    diethyl carbonate 2.53
    propanediol butyl ether 2.96
    triethyl orthoformate 2.35
    p-tert-butyltoluene 0.15
    methyl 4-tert-butylbenzoate 3.17
    morpholine 18.42
    tert-butylamine 0.2
    n-dodecanol 0.15
    dimethoxymethane 15.87
    ethylene carbonate 7.32
    cyrene 14.17
    2-ethoxyethyl acetate 2.67
    2-ethylhexyl acetate 1.12
    1,2,4-trichlorobenzene 0.79
    4-methylpyridine 3.32
    dibutyl ether 0.28
    2,6-dimethyl-4-heptanol 0.23
    DEF 8.91
    dimethyl isosorbide 14.47
    tetrachloroethylene 0.54
    eugenol 4.2
    triacetin 3.31
    span 80 2.93
    1,4-butanediol 2.66
    1,1-dichloroethane 0.2
    2-methyl-1-pentanol 0.54
    methyl formate 25.34
    2-methyl-1-butanol 0.64
    n-decane 0.01
    butyronitrile 2.61
    3,7-dimethyl-1-octanol 0.22
    1-chlorooctane 0.05
    1-chlorotetradecane 0.03
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 1.88
    tetrahydropyran 2.7
    tert-amyl methyl ether 0.46
    2,5,8-trioxanonane 13.34
    1-hexene 0.03
    2-isopropoxyethanol 5.15
    2,2,2-trifluoroethanol 8.44
    methyl butyrate 4.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction