Sulfamethazine Sodium

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  • Identifiers

    CAS number
    1981-58-4

    Molecular formula
    C12H13N4NaO2S

    SMILES
    CC1=CC(=NC(=N1)[N-]S(=O)(=O)C2=CC=C(C=C2)N)C.[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 68.86%
    Roasted 29.89%
    Meaty 28.14%
    Cooked 27.92%
    Savory 23.41%
    Grape 20.05%
    Bitter 19.43%
    Burnt 18.42%
    Sulfurous 16.91%
    Animal 14.9%

     

    Flavor
    Bitter 78.12%
    Odorless 30.7%
    Mild 21.9%
    Nitrile 21.15%
    Bread crust 20.81%
    Taco 20.47%
    Roasted peanuts 20.21%
    Very strong 19.99%
    Indole 19.68%
    Scallion 19.55%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    5.84 (weak acid)

    Molecular weight
    300.31 g/mol

    Flash point

    • 247.49 ˚C est.

  • Synonyms

    • Sulfamethazine sodium salt
    • 1981-58-4
    • SULFAMETHAZINE SODIUM
    • Sulfadimidine sodium
    • Sodium sulfamethazine
    • Sodium sulfametazine
    • Bovibol
    • Vesadin
    • Sodium sulfamethamide
    • Sodium sulfamezathine
    • Sodium sulfamethiazine
    • Sodium sulphamezathine
    • Sodium sulfadimidine
    • Sulfadimidin natrium
    • Sulfamethazine (sodium)
    • EINECS 217-840-0
    • Intradine (TN)
    • UNII-7Z13P9Q95C
    • 7Z13P9Q95C
    • DTXSID70890551
    • Sodium, (N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-
    • Sodium ((4-aminophenyl)sulfonyl)(4,6-dimethylpyrimidin-2-yl)amide
    • sodium;(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
    • Sale sodico della 2-p-aminobenzensulfonamido-4,6-dimetil-pirimidina [Italian]
    • SULFADIMIDINE SODIUM [MART.]
    • SULFADIMIDINE SODIUM [WHO-DD]
    • SULFADIMIDINE SODIUM [WHO-IP]
    • SULFAMETHAZINE SODIUM SALT [MI]
    • SULFAMETHAZINE SODIUM [GREEN BOOK]
    • Sale sodico della 2-p-aminobenzensulfonamido-4,6-dimetil-pirimidina
    • Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt
    • SULFADIMIDINUM NATRICUM [WHO-IP LATIN]
    • Sulfadimidine (sodium);Sulfadimerazine (sodium)
    • 4,6-DIMETHYL-2-SULFANILAMIDOPYRIMIDINE SODIUM SALT
    • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, sodium salt (1:1)
    • 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide sodium salt
    • N(SUP 1)-(4,6-DIMETHYL-2-PYRIMIDYL)SULFANILAMIDE SODIUM SALT
    • SULFADIMIDINE SODIUM (MART.)
    • N(SUP 1)-(4,6-DIMETHYL-2-PYRIMIDINYL)SULFANILAMIDE SODIUM SALT
    • N 1-(4,6-DIMETHYL-2-PYRIMIDINYL)SULFANILAMIDE MONOSODIUM SALT [WHO-IP]
    • Sulfamethazine and its sodium salt
    • Sulfadimidin (TN)
    • MFCD00068333
    • Prestwick_1014
    • Sulphadimidine Sodium
    • Sulmet Soluble Powder
    • SULFAMETHAZINESODIUM
    • MLS002153994
    • SULFADIMIDINUM NATRICUM
    • Sulfadimethyldiazine Sodium Salt
    • CHEMBL1563050
    • HY-B0035A
    • NGIVTUVVBWOTNT-UHFFFAOYSA-N
    • DTXCID201030763
    • HMS1570K12
    • HMS2097K12
    • HMS2236G08
    • HMS3374N06
    • HMS3714K12
    • BAA98158
    • BCP12146
    • s5210
    • sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
    • AKOS005068202
    • AKOS015913840
    • AKOS025311025
    • CCG-220775
    • CCG-267468
    • SB57952
    • NCGC00017038-01
    • AS-13841
    • SMR001233328
    • CAS-1981-58-4
    • DB-044991
    • CS-0013813
    • S0583
    • D08539
    • SR-01000841213
    • SR-01000841213-2
    • Q27269044
    • 4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide Sodium Salt
    • N 1-(4,6-DIMETHYL-2-PYRIMIDINYL)SULFANILAMIDE MONOSODIUM SALT

  • Applications

    Sulfamethazine Sodium (CAS 1981-58-4) applications primarily include veterinary medicines and antibiotic treatments for livestock, poultry, and swine through medicated feeds and dosage forms to prevent and treat bacterial infections. The sodium salt is used to improve water solubility, facilitating aqueous formulations such as solutions and suspensions in veterinary products. In medicinal chemistry, it serves as a sulfonamide building block and intermediate for the synthesis of related antibiotics. It is also used as an analytical reagent and reference material in quality-control laboratories to quantify sulfamethazine and related sulfonamides. Additionally, the solubility properties of the sodium salt can support formulation development and optimization of dosing, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.49
    methanol 0.48
    isopropanol 0.43
    water 0.11
    ethyl acetate 3.08
    n-propanol 0.63
    acetone 0.75
    n-butanol 0.61
    acetonitrile 9.87
    DMF 56.73
    toluene 0.31
    isobutanol 0.51
    1,4-dioxane 6.22
    methyl acetate 6.25
    THF 21.56
    2-butanone 3.39
    n-pentanol 0.62
    sec-butanol 0.64
    n-hexane 0.01
    ethylene glycol 4.51
    NMP 203.88
    cyclohexane 0.02
    DMSO 48.48
    n-butyl acetate 4.87
    n-octanol 0.42
    chloroform 1.71
    n-propyl acetate 3.78
    acetic acid 15.3
    dichloromethane 2.32
    cyclohexanone 11.36
    propylene glycol 12.01
    isopropyl acetate 2.17
    DMAc 102.22
    2-ethoxyethanol 9.13
    isopentanol 0.83
    n-heptane 0.02
    ethyl formate 5.22
    1,2-dichloroethane 1.69
    n-hexanol 0.88
    2-methoxyethanol 28.74
    isobutyl acetate 2.47
    tetrachloromethane 0.15
    n-pentyl acetate 2.39
    transcutol 34.2
    n-heptanol 0.77
    ethylbenzene 0.19
    MIBK 1.85
    2-propoxyethanol 16.16
    tert-butanol 0.95
    MTBE 0.39
    2-butoxyethanol 7.64
    propionic acid 9.07
    o-xylene 0.32
    formic acid 16.04
    diethyl ether 0.2
    m-xylene 0.29
    p-xylene 0.47
    chlorobenzene 1.54
    dimethyl carbonate 9.92
    n-octane 0.01
    formamide 32.97
    cyclopentanone 32.65
    2-pentanone 1.7
    anisole 2.13
    cyclopentyl methyl ether 2.25
    gamma-butyrolactone 76.65
    1-methoxy-2-propanol 20.07
    pyridine 10.09
    3-pentanone 1.61
    furfural 78.17
    n-dodecane 0.02
    diethylene glycol 24.93
    diisopropyl ether 0.11
    tert-amyl alcohol 1.01
    acetylacetone 9.53
    n-hexadecane 0.02
    acetophenone 6.72
    methyl propionate 5.65
    isopentyl acetate 4.81
    trichloroethylene 7.19
    n-nonanol 0.48
    cyclohexanol 1.04
    benzyl alcohol 4.07
    2-ethylhexanol 0.78
    isooctanol 0.75
    dipropyl ether 0.72
    1,2-dichlorobenzene 2.48
    ethyl lactate 9.89
    propylene carbonate 37.73
    n-methylformamide 19.59
    2-pentanol 0.37
    n-pentane 0.01
    1-propoxy-2-propanol 10.63
    1-methoxy-2-propyl acetate 14.92
    2-(2-methoxypropoxy) propanol 14.49
    mesitylene 0.21
    ε-caprolactone 20.41
    p-cymene 0.58
    epichlorohydrin 36.54
    1,1,1-trichloroethane 1.22
    2-aminoethanol 5.71
    morpholine-4-carbaldehyde 112.45
    sulfolane 131.56
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 5.89
    n-hexyl acetate 2.06
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 13.85
    sec-butyl acetate 2.23
    tert-butyl acetate 3.46
    decalin 0.03
    glycerin 37.43
    diglyme 27.36
    acrylic acid 18.8
    isopropyl myristate 1.11
    n-butyric acid 7.0
    acetyl acetate 5.29
    di(2-ethylhexyl) phthalate 4.41
    ethyl propionate 3.56
    nitromethane 58.12
    1,2-diethoxyethane 2.95
    benzonitrile 7.62
    trioctyl phosphate 2.12
    1-bromopropane 0.24
    gamma-valerolactone 94.1
    n-decanol 0.4
    triethyl phosphate 5.06
    4-methyl-2-pentanol 0.43
    propionitrile 3.62
    vinylene carbonate 30.25
    1,1,2-trichlorotrifluoroethane 53.69
    DMS 8.51
    cumene 0.21
    2-octanol 0.4
    2-hexanone 2.59
    octyl acetate 1.63
    limonene 0.66
    1,2-dimethoxyethane 13.22
    ethyl orthosilicate 3.56
    tributyl phosphate 2.81
    diacetone alcohol 11.16
    N,N-dimethylaniline 1.81
    acrylonitrile 10.83
    aniline 2.09
    1,3-propanediol 6.86
    bromobenzene 1.09
    dibromomethane 0.8
    1,1,2,2-tetrachloroethane 5.46
    2-methyl-cyclohexyl acetate 6.1
    tetrabutyl urea 4.78
    diisobutyl methanol 0.61
    2-phenylethanol 5.21
    styrene 0.27
    dioctyl adipate 4.14
    dimethyl sulfate 35.23
    ethyl butyrate 4.74
    methyl lactate 23.35
    butyl lactate 6.76
    diethyl carbonate 5.04
    propanediol butyl ether 8.5
    triethyl orthoformate 4.57
    p-tert-butyltoluene 0.54
    methyl 4-tert-butylbenzoate 9.29
    morpholine 11.3
    tert-butylamine 0.26
    n-dodecanol 0.31
    dimethoxymethane 9.77
    ethylene carbonate 18.93
    cyrene 35.08
    2-ethoxyethyl acetate 7.34
    2-ethylhexyl acetate 3.58
    1,2,4-trichlorobenzene 5.93
    4-methylpyridine 6.64
    dibutyl ether 0.43
    2,6-dimethyl-4-heptanol 0.61
    DEF 7.65
    dimethyl isosorbide 40.45
    tetrachloroethylene 2.05
    eugenol 11.57
    triacetin 10.28
    span 80 9.58
    1,4-butanediol 2.79
    1,1-dichloroethane 0.71
    2-methyl-1-pentanol 0.87
    methyl formate 14.83
    2-methyl-1-butanol 0.75
    n-decane 0.02
    butyronitrile 2.27
    3,7-dimethyl-1-octanol 0.6
    1-chlorooctane 0.14
    1-chlorotetradecane 0.09
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.01
    cyclopentanol 2.94
    tetrahydropyran 1.44
    tert-amyl methyl ether 0.55
    2,5,8-trioxanonane 25.25
    1-hexene 0.05
    2-isopropoxyethanol 4.97
    2,2,2-trifluoroethanol 11.83
    methyl butyrate 5.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction