Sucralose

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  • Identifiers

    CAS number
    56038-13-2

    Molecular formula
    C12H19Cl3O8

    SMILES
    C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 74.04%
    Sweet 41.28%
    Alcoholic 20.48%
    Cooling 19.65%
    Savory 18.43%
    Fishy 17.57%
    Milky 16.02%
    Woody 15.92%
    Bitter 15.67%
    Caramellic 14.2%

     

    Flavor
    Sweet 57.39%
    Odorless 53.44%
    Bitter 44.1%
    Sweet-like 31.42%
    Cauliflower 21.77%
    Bland 21.36%
    Very slight 21.29%
    Alkaline 20.75%
    Soup 20.25%
    Bouillon 20.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.5

    pKa est.
    4.6 (weak acid)

    Molecular weight
    397.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1607°C

    Melting point expt.

    • 130 °C
    • MP: 36.5 °C /Sucralose pentahydrate/

    Flash point

    • 227.58 ˚C est.

    Solubility expt.

    • Freely soluble in water, methanol and ethanol; Slightly soluble in ethyl acetate
    • Freely soluble in methanol, alcohol; slightly soluble in ethyl acetate

  • Synonyms

    • Sucralose
    • 56038-13-2
    • Splenda
    • Trichlorosucrose
    • Aspasvit
    • Trichlorogalacto-sucrose
    • Sucrazit
    • Trichlorogalactosucrose
    • Sansweet su 100
    • 96K6UQ3ZD4
    • San sweet sa 8020
    • 4,1',6'-trichlorogalactosucrose
    • NSC-759272
    • INS NO.955
    • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside
    • DTXSID1040245
    • CHEBI:32159
    • INS-955
    • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside
    • 1',4',6'-TRICHLORO-GALACTOSUCROSE
    • DTXCID9020245
    • E-955
    • alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-
    • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-5-chloro-6-(hydroxymethyl)tetrahydropyran-3,4-diol
    • (2R,3R,4R,5R,6R)-2-((2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)oxy-5-chloro-6-(hydroxymethyl)tetrahydropyran-3,4-diol
    • RefChem:6267
    • GlyTouCan:G30984WQ
    • 1',4',6'-trichloro-1',4,6'-trideoxygalactosucrose
    • G30984WQ
    • 259-952-2
    • 1',4,6'-Trichlorogalactosucrose
    • EINECS 259-952-2
    • C12H19Cl3O8
    • CHEMBL3185084
    • a-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl4-chloro-4-deoxy-
    • (2R,3R,4R,5R,6R)-2-(((2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol
    • Acucar Light
    • MFCD03648615
    • 1-(1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl)-4-chloro-4-deoxy-alpha-D-galactopyranoside
    • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
    • .alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy-
    • 4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose
    • E955;Trichlorosucrose
    • UNII-96K6UQ3ZD4
    • CAS-56038-13-2
    • BRN 3654410
    • Sucralose [BAN:NF]
    • CCRIS 8449
    • Sucralose CRS
    • HSDB 7964
    • Sucralose; 1,6-Dichloro-1,6-dideoxy-beta-d-fructofuranosyl 4-chloro-4-deoxy-alpha-d-galactopyranoside
    • SUCRALOSE [FCC]
    • SUCRALOSE [II]
    • SUCRALOSE [MI]
    • SUCRALOSE [MART.]
    • SCHEMBL3686
    • SUCRALOSE [USP-RS]
    • SUCRALOSE [WHO-DD]
    • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose
    • Sucralose, analytical standard
    • orb1308737
    • SUCRALOSE [EP MONOGRAPH]
    • MSK3215
    • BAQAVOSOZGMPRM-QBMZZYIRSA-N
    • HMS2093H16
    • Pharmakon1600-01505953
    • 1,6-Dichloro-1,6-dideoxy-|A-D-fructofuranosyl-4-chloro-4-deoxy-|A-D-galactopyranoside; E955; Trichlorosucrose
    • HY-N0614
    • Sucralose, >=98.0% (HPLC)
    • Tox21_113658
    • Tox21_201752
    • Tox21_303425
    • BDBM50367128
    • NSC759272
    • s4214
    • AKOS015962432
    • CCG-213995
    • CS-8130
    • NSC 759272
    • OS04165
    • NCGC00249110-01
    • NCGC00249110-03
    • NCGC00249110-04
    • NCGC00257400-01
    • NCGC00259301-01
    • SBI-0206860.P001
    • Sucralose 1000 microg/mL in Acetonitrile
    • NS00000320
    • AB01563242_01
    • AB01563242_02
    • 038S132
    • Q410209
    • SR-05000001935
    • SR-05000001935-1
    • BRD-K58968598-001-02-8
    • BRD-K58968598-001-03-6
    • Sucralose, European Pharmacopoeia (EP) Reference Standard
    • Sucralose, United States Pharmacopeia (USP) Reference Standard
    • Sucralose, Pharmaceutical Secondary Standard; Certified Reference Material
    • 1,6-Dichloro-1,6-dideoxy-|A-D-fructofuranosyl 4-chloro-4-deoxy-|A-D-galactopyranoside
    • 1,6-Dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside
    • 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-chloro-4-deoxy-alpha-d-gala
    • 1,6-dichloro-1,6-dideoxy-.beta.-d-fructofuranosyl-4-chloro-4-deoxy-.alpha.-d-galactopyranoside
    • 56038-13-2

  • Applications

    Sucralose (CAS 56038-13-2) is a high-intensity, non-nutritive sweetener used to replace sugar in a wide range of products while contributing minimal calories. In food processing, it is routinely employed in confectionery, baked goods, dairy products and frozen desserts, as well as general beverage formulations, to provide a stable sweetness under processing conditions. In pharmaceutical and nutraceutical applications, it is used to sweeten syrups, oral solutions and chewable tablets without adding bulk. It is also used in flavor systems and sugar-free formulations across consumer products where a stable, heat- and pH-tolerant sweetener is advantageous.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 92.44
    methanol 314.9
    isopropanol 28.12
    water 215.17
    ethyl acetate 5.0
    n-propanol 29.05
    acetone 20.54
    n-butanol 17.45
    acetonitrile 6.49
    DMF 576.45
    toluene 1.51
    isobutanol 10.97
    1,4-dioxane 28.35
    methyl acetate 5.62
    THF 56.51
    2-butanone 8.03
    n-pentanol 10.04
    sec-butanol 11.45
    n-hexane 0.29
    ethylene glycol 252.21
    NMP 284.49
    cyclohexane 1.7
    DMSO 764.86
    n-butyl acetate 3.9
    n-octanol 7.76
    chloroform 2.84
    n-propyl acetate 4.27
    acetic acid 142.57
    dichloromethane 3.91
    cyclohexanone 22.35
    propylene glycol 104.48
    isopropyl acetate 4.14
    DMAc 280.86
    2-ethoxyethanol 110.87
    isopentanol 9.15
    n-heptane 1.41
    ethyl formate 13.32
    1,2-dichloroethane 4.13
    n-hexanol 8.44
    2-methoxyethanol 288.05
    isobutyl acetate 2.19
    tetrachloromethane 0.95
    n-pentyl acetate 6.39
    transcutol 105.26
    n-heptanol 10.35
    ethylbenzene 0.95
    MIBK 5.79
    2-propoxyethanol 59.26
    tert-butanol 15.13
    MTBE 3.5
    2-butoxyethanol 45.73
    propionic acid 23.14
    o-xylene 2.21
    formic acid 746.89
    diethyl ether 5.31
    m-xylene 1.69
    p-xylene 1.13
    chlorobenzene 0.98
    dimethyl carbonate 23.01
    n-octane 0.81
    formamide 665.21
    cyclopentanone 39.16
    2-pentanone 8.68
    anisole 4.19
    cyclopentyl methyl ether 15.84
    gamma-butyrolactone 55.33
    1-methoxy-2-propanol 138.16
    pyridine 13.22
    3-pentanone 6.47
    furfural 60.88
    n-dodecane 0.46
    diethylene glycol 136.83
    diisopropyl ether 1.71
    tert-amyl alcohol 9.91
    acetylacetone 19.74
    n-hexadecane 0.51
    acetophenone 8.35
    methyl propionate 12.61
    isopentyl acetate 3.45
    trichloroethylene 6.43
    n-nonanol 7.63
    cyclohexanol 15.13
    benzyl alcohol 12.27
    2-ethylhexanol 4.28
    isooctanol 7.18
    dipropyl ether 6.52
    1,2-dichlorobenzene 1.37
    ethyl lactate 19.71
    propylene carbonate 18.74
    n-methylformamide 239.79
    2-pentanol 7.96
    n-pentane 0.69
    1-propoxy-2-propanol 33.5
    1-methoxy-2-propyl acetate 16.25
    2-(2-methoxypropoxy) propanol 35.2
    mesitylene 1.47
    ε-caprolactone 23.25
    p-cymene 1.92
    epichlorohydrin 30.0
    1,1,1-trichloroethane 1.12
    2-aminoethanol 193.68
    morpholine-4-carbaldehyde 212.86
    sulfolane 156.45
    2,2,4-trimethylpentane 0.32
    2-methyltetrahydrofuran 14.52
    n-hexyl acetate 6.8
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 50.39
    sec-butyl acetate 2.43
    tert-butyl acetate 5.61
    decalin 0.44
    glycerin 281.03
    diglyme 93.84
    acrylic acid 44.28
    isopropyl myristate 3.02
    n-butyric acid 21.06
    acetyl acetate 5.2
    di(2-ethylhexyl) phthalate 6.14
    ethyl propionate 4.25
    nitromethane 119.31
    1,2-diethoxyethane 11.37
    benzonitrile 4.23
    trioctyl phosphate 5.61
    1-bromopropane 1.44
    gamma-valerolactone 99.65
    n-decanol 5.61
    triethyl phosphate 5.35
    4-methyl-2-pentanol 4.16
    propionitrile 3.81
    vinylene carbonate 19.79
    1,1,2-trichlorotrifluoroethane 95.34
    DMS 7.7
    cumene 0.87
    2-octanol 6.01
    2-hexanone 4.57
    octyl acetate 4.79
    limonene 3.43
    1,2-dimethoxyethane 72.39
    ethyl orthosilicate 4.89
    tributyl phosphate 4.52
    diacetone alcohol 25.88
    N,N-dimethylaniline 7.11
    acrylonitrile 9.95
    aniline 6.45
    1,3-propanediol 141.88
    bromobenzene 0.65
    dibromomethane 1.96
    1,1,2,2-tetrachloroethane 7.09
    2-methyl-cyclohexyl acetate 5.48
    tetrabutyl urea 10.77
    diisobutyl methanol 3.28
    2-phenylethanol 9.48
    styrene 1.04
    dioctyl adipate 6.98
    dimethyl sulfate 64.08
    ethyl butyrate 5.14
    methyl lactate 58.0
    butyl lactate 16.86
    diethyl carbonate 3.77
    propanediol butyl ether 51.28
    triethyl orthoformate 6.82
    p-tert-butyltoluene 2.03
    methyl 4-tert-butylbenzoate 19.17
    morpholine 63.74
    tert-butylamine 5.24
    n-dodecanol 4.13
    dimethoxymethane 130.09
    ethylene carbonate 14.97
    cyrene 67.54
    2-ethoxyethyl acetate 11.89
    2-ethylhexyl acetate 2.68
    1,2,4-trichlorobenzene 2.13
    4-methylpyridine 8.34
    dibutyl ether 3.76
    2,6-dimethyl-4-heptanol 3.28
    DEF 45.48
    dimethyl isosorbide 51.14
    tetrachloroethylene 6.42
    eugenol 26.07
    triacetin 16.98
    span 80 31.14
    1,4-butanediol 58.3
    1,1-dichloroethane 1.33
    2-methyl-1-pentanol 5.41
    methyl formate 120.14
    2-methyl-1-butanol 8.39
    n-decane 0.86
    butyronitrile 4.07
    3,7-dimethyl-1-octanol 4.85
    1-chlorooctane 1.94
    1-chlorotetradecane 0.91
    n-nonane 0.81
    undecane 0.61
    tert-butylcyclohexane 0.28
    cyclooctane 0.92
    cyclopentanol 22.73
    tetrahydropyran 12.58
    tert-amyl methyl ether 4.84
    2,5,8-trioxanonane 70.05
    1-hexene 0.73
    2-isopropoxyethanol 39.5
    2,2,2-trifluoroethanol 89.07
    methyl butyrate 7.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction