Succinic anhydride

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  • Identifiers

    CAS number
    108-30-5

    Molecular formula
    C4H4O3

    SMILES
    C1CC(=O)OC1=O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Caramellic 41.83%
    Nutty 39.7%
    Buttery 38.39%
    Burnt 37.64%
    Sweet 35.25%
    Odorless 34.84%
    Creamy 32.13%
    Sour 31.73%
    Coconut 29.1%
    Fatty 27.25%

     

    Flavor
    Sweet 53.43%
    Caramel 39.7%
    Buttery 37.61%
    Creamy 36.32%
    Fatty 35.69%
    Oily 27.08%
    Tonka 26.25%
    Coconut 25.64%
    Tobacco 23.05%
    Bread 23.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    7.95 (neutral)

    Molecular weight
    100.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 247.3 °F (NTP, 1992)
    • 119.6 °C
    • 119 °C

    Boiling point

    • 502 °F at 760 mmHg (NTP, 1992)
    • 261 °C at 760 mm Hg
    • 261 °C

    Flash point

    • 95.6 ˚C est.
    • 157 °C

    Solubility expt.

    • less than 1 mg/mL at 70 °F (NTP, 1992)
    • Insoluble in water
    • IN ETHANOL AT 25 °C: 2.56 G/100 ML; IN ETHER AT 25 °C: 0.64 G/100 ML; IN CHLOROFORM AT 25 °C: 0.87 G/100 ML
    • Soluble in chloroform, carbon tetrachloride, alcohol; very slightly soluble in ether and water.
    • Solubility in water: none

  • Synonyms

    • SUCCINIC ANHYDRIDE
    • 108-30-5
    • dihydrofuran-2,5-dione
    • oxolane-2,5-dione
    • Succinic acid anhydride
    • Succinyl oxide
    • Dihydro-2,5-furandione
    • 2,5-Diketotetrahydrofuran
    • Succinyl anhydride
    • Butanedioic anhydride
    • Rikacid SA
    • 2,5-Furandione, dihydro-
    • Tetrahydro-2,5-dioxofuran
    • 2,5-Dioxotetrahydrofuran
    • Tetrahydro-2,5-furandione
    • Bernsteinsaure-anhydrid
    • NCI-C55696
    • Dihydro-furan-2,5-dione
    • NSC 8518
    • MFCD00005525
    • CCRIS 2386
    • HSDB 792
    • Dihydro-2,5-diketotetrahydrofuran
    • EINECS 203-570-0
    • UNII-6RF4O17Z8J
    • BRN 0108441
    • 6RF4O17Z8J
    • Bernsteinsaeureanhydrid
    • DTXSID7021287
    • CHEBI:36595
    • AI3-52664
    • SuccinicAnhydride-13C4
    • NSC-8518
    • 2,5(3H,4H)-Furandione
    • Succinic anhydride treated BSA
    • DTXCID701287
    • EC 203-570-0
    • 5-17-11-00006 (Beilstein Handbook Reference)
    • Succinyloxide
    • SUCCINIC ANHYDRIDE (IARC)
    • SUCCINIC ANHYDRIDE [IARC]
    • Bernsteinsaure-anhydrid [German]
    • tetrahydrofuran-2,5-dione
    • 2, dihydro-
    • EINECS 270-161-1
    • Oxolan-2,5-dione
    • WLN: T5VOVTJ
    • butanedioic acid anhydride
    • Dihydro-2, 5-furandione
    • Succinic anhydride, 97%
    • BERNSTEINSAUREANHYDRID
    • tetrahydro-furan-2,5-dione
    • Tetrahydro-2, 5-dioxofuran
    • SCHEMBL16123
    • MLS002454448
    • SUCCINIC ANHYDRIDE [MI]
    • CHEMBL1370164
    • NSC8518
    • SUCCINIC ANHYDRIDE [HSDB]
    • HMS3039B10
    • STR01303
    • Succinic anhydride, >=99% (GC)
    • Tox21_201179
    • STL194303
    • AKOS000121191
    • FS37926
    • Succinic anhydride, >=97.0% (NT)
    • NCGC00091291-01
    • NCGC00091291-02
    • NCGC00258731-01
    • BP-13070
    • CAS-108-30-5
    • HY-79369
    • SMR001372026
    • DB-042683
    • DB-050501
    • Butanedioic acid,anhydride succinic anhydride
    • CS-0011581
    • NS00003241
    • S0107
    • EN300-18021
    • C19524
    • D78120
    • Succinic anhydride, puriss., >=99.0% (NT)
    • Succinic anhydride, SAJ first grade, >=99.0%
    • A801840
    • Q417847
    • BUTANEDIOIC ACID,ANHYDRIDE SUCCINIC ANHYDRIDE
    • Z57127506
    • F1908-0090
    • InChI=1/C4H4O3/c5-3-1-2-4(6)7-3/h1-2H
    • 203-570-0
    • Tetrahydro-2,5-furandione(National Library of Medicine, SIS; ChemIDplus Record for Succinic anhydride (108-30-5) Available from, as of July 21, 2005: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp)

  • Applications

    Succinic anhydride is a versatile chemical intermediate used in various industrial syntheses. It is employed to introduce succinyl groups into polymers and polyester resins by reacting with diols or diamines, enabling the production of aliphatic polyesters for plastics and functional coatings and adhesives. It serves as a building block for succinylated intermediates in pharmaceutical and agrochemical manufacturing. In coatings, inks, and related formulations, it provides reactive functionality for crosslinking and performance optimization, and it can function as a precursor for specialty chemicals in agrochemical and other industrial product lines, subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 168.56
    methanol 334.5
    isopropanol 135.0
    water 56.89
    ethyl acetate 107.2
    n-propanol 97.11
    acetone 255.19
    n-butanol 72.72
    acetonitrile 393.39
    DMF 507.09
    toluene 34.0
    isobutanol 75.79
    1,4-dioxane 194.02
    methyl acetate 241.02
    THF 136.0
    2-butanone 176.88
    n-pentanol 69.46
    sec-butanol 105.61
    n-hexane 6.11
    ethylene glycol 90.91
    NMP 680.57
    cyclohexane 3.63
    DMSO 604.6
    n-butyl acetate 48.82
    n-octanol 38.97
    chloroform 165.19
    n-propyl acetate 87.29
    acetic acid 461.44
    dichloromethane 238.23
    cyclohexanone 157.55
    propylene glycol 85.48
    isopropyl acetate 60.84
    DMAc 667.38
    2-ethoxyethanol 193.16
    isopentanol 72.76
    n-heptane 2.66
    ethyl formate 163.43
    1,2-dichloroethane 137.39
    n-hexanol 30.84
    2-methoxyethanol 289.73
    isobutyl acetate 38.25
    tetrachloromethane 14.54
    n-pentyl acetate 48.85
    transcutol 334.71
    n-heptanol 22.55
    ethylbenzene 32.53
    MIBK 55.82
    2-propoxyethanol 99.48
    tert-butanol 139.06
    MTBE 91.51
    2-butoxyethanol 69.58
    propionic acid 219.99
    o-xylene 38.01
    formic acid 375.84
    diethyl ether 63.24
    m-xylene 24.08
    p-xylene 53.34
    chlorobenzene 71.03
    dimethyl carbonate 112.3
    n-octane 2.1
    formamide 625.78
    cyclopentanone 226.48
    2-pentanone 86.36
    anisole 122.23
    cyclopentyl methyl ether 61.83
    gamma-butyrolactone 473.46
    1-methoxy-2-propanol 178.8
    pyridine 208.67
    3-pentanone 76.03
    furfural 496.72
    n-dodecane 2.96
    diethylene glycol 114.91
    diisopropyl ether 19.05
    tert-amyl alcohol 130.3
    acetylacetone 150.78
    n-hexadecane 3.26
    acetophenone 163.45
    methyl propionate 125.5
    isopentyl acetate 44.73
    trichloroethylene 275.19
    n-nonanol 34.67
    cyclohexanol 59.61
    benzyl alcohol 110.08
    2-ethylhexanol 22.09
    isooctanol 21.34
    dipropyl ether 23.19
    1,2-dichlorobenzene 86.07
    ethyl lactate 68.95
    propylene carbonate 233.62
    n-methylformamide 402.65
    2-pentanol 54.48
    n-pentane 4.22
    1-propoxy-2-propanol 59.54
    1-methoxy-2-propyl acetate 66.9
    2-(2-methoxypropoxy) propanol 118.03
    mesitylene 15.79
    ε-caprolactone 188.0
    p-cymene 16.09
    epichlorohydrin 289.88
    1,1,1-trichloroethane 78.21
    2-aminoethanol 128.75
    morpholine-4-carbaldehyde 529.32
    sulfolane 481.87
    2,2,4-trimethylpentane 4.59
    2-methyltetrahydrofuran 127.79
    n-hexyl acetate 82.45
    isooctane 2.3
    2-(2-butoxyethoxy)ethanol 130.18
    sec-butyl acetate 52.09
    tert-butyl acetate 63.09
    decalin 6.1
    glycerin 132.61
    diglyme 234.6
    acrylic acid 296.8
    isopropyl myristate 30.68
    n-butyric acid 141.29
    acetyl acetate 100.22
    di(2-ethylhexyl) phthalate 46.91
    ethyl propionate 82.86
    nitromethane 919.91
    1,2-diethoxyethane 72.68
    benzonitrile 143.68
    trioctyl phosphate 27.54
    1-bromopropane 54.68
    gamma-valerolactone 435.36
    n-decanol 26.16
    triethyl phosphate 36.59
    4-methyl-2-pentanol 33.71
    propionitrile 143.26
    vinylene carbonate 259.87
    1,1,2-trichlorotrifluoroethane 253.11
    DMS 107.54
    cumene 26.12
    2-octanol 21.97
    2-hexanone 82.35
    octyl acetate 43.6
    limonene 18.4
    1,2-dimethoxyethane 272.75
    ethyl orthosilicate 30.36
    tributyl phosphate 39.36
    diacetone alcohol 100.07
    N,N-dimethylaniline 101.64
    acrylonitrile 271.98
    aniline 88.58
    1,3-propanediol 139.94
    bromobenzene 59.07
    dibromomethane 117.54
    1,1,2,2-tetrachloroethane 179.78
    2-methyl-cyclohexyl acetate 43.85
    tetrabutyl urea 59.88
    diisobutyl methanol 16.23
    2-phenylethanol 57.01
    styrene 44.49
    dioctyl adipate 56.37
    dimethyl sulfate 256.52
    ethyl butyrate 49.84
    methyl lactate 121.0
    butyl lactate 56.03
    diethyl carbonate 47.66
    propanediol butyl ether 97.61
    triethyl orthoformate 36.69
    p-tert-butyltoluene 14.54
    methyl 4-tert-butylbenzoate 105.23
    morpholine 207.83
    tert-butylamine 73.22
    n-dodecanol 20.38
    dimethoxymethane 171.02
    ethylene carbonate 170.06
    cyrene 149.03
    2-ethoxyethyl acetate 86.65
    2-ethylhexyl acetate 34.95
    1,2,4-trichlorobenzene 112.24
    4-methylpyridine 235.61
    dibutyl ether 36.44
    2,6-dimethyl-4-heptanol 16.23
    DEF 171.84
    dimethyl isosorbide 155.85
    tetrachloroethylene 101.65
    eugenol 108.79
    triacetin 125.21
    span 80 82.98
    1,4-butanediol 76.33
    1,1-dichloroethane 109.21
    2-methyl-1-pentanol 73.43
    methyl formate 313.09
    2-methyl-1-butanol 74.03
    n-decane 4.28
    butyronitrile 100.15
    3,7-dimethyl-1-octanol 37.4
    1-chlorooctane 18.68
    1-chlorotetradecane 9.35
    n-nonane 3.84
    undecane 3.49
    tert-butylcyclohexane 5.74
    cyclooctane 1.64
    cyclopentanol 79.49
    tetrahydropyran 79.73
    tert-amyl methyl ether 79.5
    2,5,8-trioxanonane 174.73
    1-hexene 22.61
    2-isopropoxyethanol 112.91
    2,2,2-trifluoroethanol 220.58
    methyl butyrate 116.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction