Streptozocin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    18883-66-4

    Molecular formula
    C8H15N3O7

    SMILES
    CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 83.86%
    Savory 26.78%
    Cooling 19.07%
    Sweet 17.42%
    Meaty 16.55%
    Fishy 15.56%
    Milky 14.52%
    Bitter 14.42%
    Cooked 13.62%
    Popcorn 12.31%

     

    Flavor
    Bitter 67.16%
    Odorless 50.8%
    Bland 28.05%
    Sweet-like 26.62%
    Very mild 25.03%
    Yeast 19.85%
    Mild 19.7%
    Nitrile 19.55%
    Cedarleaf 19.35%
    Very slight 19.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.4

    pKa est.
    4.92 (weak acid)

    Molecular weight
    265.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    134°C

    Melting point expt.

    • 239 °F (Decomposes) (NTP, 1992)
    • 115 °C

    Flash point

    • 240.9 ˚C est.

    Solubility expt.

    • Soluble (NTP, 1992)
    • 5070 mg/L
    • SOL IN WATER, LOWER ALCOHOLS & KETONES.
    • SLIGHTLY SOL IN POLAR ORG SOLVENTS; INSOL IN NON-POLAR ORGANIC SOLVENTS.
    • 3.35e+01 g/L

  • Synonyms

    • streptozocin
    • STREPTOZOTOCIN
    • 18883-66-4
    • Estreptozocina
    • Streptozocine
    • Streptozocinium
    • Streptozocinum
    • STRZ
    • N-D-Glucosyl-(2)-N'-nitrosomethylurea
    • Streptozoticin
    • Streptozocinium [Latin]
    • N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff
    • CHEBI:9288
    • 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose
    • DTXSID2021282
    • 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
    • 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
    • 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
    • Streptozocinium (Latin)
    • Streptozotocine
    • 1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl)urea
    • 3-methyl-3-nitroso-1-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl)urea
    • RefChem:57836
    • GlyTouCan:G44151BN
    • 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose
    • L01AD04
    • DTXCID701768187
    • G44151BN
    • 2-deoxy-2-(((methylnitrosamino)-carbonyl)amino)-D-glucopyranose
    • 242-646-8
    • 2-Deoxy-2-(3-methyl-3-nitrosoureido)-alpha(and beta)-D-glucopyranose
    • 5W494URQ81
    • D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
    • D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
    • D-Glucose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-
    • Glucopyranose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-, D-
    • NCI-C03167
    • NRRL 2697
    • NSC 85998
    • NSC-37917
    • NSC-85998
    • NSC85998
    • U 9889
    • U-9889
    • Zanosar
    • streptozosin
    • 66395-18-4
    • 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
    • MFCD00006607
    • alpha-Streptozocin
    • streptozotocin (stz)
    • C8H15N3O7
    • 1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)urea
    • 8H27GUR065
    • M02540
    • DTXCID701282
    • binds to DNA
    • 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]urea
    • Zanosar (TN)
    • Streptozotocin;U 9889
    • SR-05000001720
    • 2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-alpha-D-glucopyranose
    • NCGC00016738-01
    • CAS-18883-66-4
    • Spectrum_000960
    • Prestwick3_000732
    • Spectrum2_000062
    • Spectrum3_001087
    • Spectrum4_001244
    • Spectrum5_001047
    • Epitope ID:134282
    • SCHEMBL4748
    • Streptozocin; Streptozotocin
    • .ALPHA.-STREPTOZOCIN
    • BSPBio_000684
    • BSPBio_002734
    • KBioGR_001768
    • KBioSS_001440
    • MLS004774123
    • DivK1c_000531
    • SPECTRUM1500543
    • UNII-8H27GUR065
    • SPBio_000243
    • BPBio1_000754
    • Streptozocin (JAN/USAN/INN)
    • BCBcMAP01_000142
    • HMS501K13
    • KBio1_000531
    • KBio2_001440
    • KBio2_004008
    • KBio2_006576
    • KBio3_001954
    • NINDS_000531
    • ZSJLQEPLLKMAKR-GKHCUFPYSA-N
    • HMS1921A07
    • HMS2092I09
    • HMS2097C06
    • HMS3714C06
    • Pharmakon1600-01500543
    • 2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose
    • Streptozocin, >=98.0% (HPLC)
    • Tox21_110585
    • Tox21_201859
    • Tox21_302974
    • 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
    • CCG-39870
    • EBC-11136
    • HB4097
    • NSC757321
    • s1312
    • AKOS025310730
    • Tox21_110585_1
    • DB00428
    • MS07936
    • NSC-757321
    • IDI1_000531
    • SMP1_000282
    • NCGC00178500-01
    • NCGC00178500-02
    • NCGC00178500-03
    • NCGC00178500-04
    • NCGC00178500-07
    • NCGC00256594-01
    • NCGC00259408-01
    • SMR001233317
    • SY066622
    • SBI-0051517.P003
    • 18883-66-4

  • Applications

    Streptozocin is used clinically as an antineoplastic agent in certain cancer indications, notably pancreatic neuroendocrine tumors, where it is given as part of chemotherapy regimens; In biomedical research, it is routinely employed as a diabetogenic cytotoxic agent to induce pancreatic beta-cell destruction in rodent models, enabling study of diabetes pathophysiology and testing of diabetes drugs; It also serves as a laboratory tool to investigate nitrosourea-induced DNA damage and cytotoxic responses in cancer and other cell types; In preclinical contexts, Streptozocin provides a reference compound for pharmacology and toxicology studies related to nitrosourea-based therapeutics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.09
    methanol 5.49
    isopropanol 0.52
    water 157.62
    ethyl acetate 0.17
    n-propanol 0.54
    acetone 0.7
    n-butanol 0.39
    acetonitrile 0.52
    DMF 84.98
    toluene 0.23
    isobutanol 0.27
    1,4-dioxane 2.25
    methyl acetate 0.28
    THF 1.77
    2-butanone 0.37
    n-pentanol 0.23
    sec-butanol 0.39
    n-hexane 0.06
    ethylene glycol 15.8
    NMP 65.6
    cyclohexane 0.28
    DMSO 311.58
    n-butyl acetate 0.16
    n-octanol 0.21
    chloroform 0.13
    n-propyl acetate 0.13
    acetic acid 7.51
    dichloromethane 0.29
    cyclohexanone 1.86
    propylene glycol 6.11
    isopropyl acetate 0.13
    DMAc 40.94
    2-ethoxyethanol 4.8
    isopentanol 0.3
    n-heptane 0.15
    ethyl formate 0.54
    1,2-dichloroethane 0.34
    n-hexanol 0.3
    2-methoxyethanol 15.75
    isobutyl acetate 0.06
    tetrachloromethane 0.1
    n-pentyl acetate 0.14
    transcutol 5.04
    n-heptanol 0.31
    ethylbenzene 0.14
    MIBK 0.22
    2-propoxyethanol 2.68
    tert-butanol 0.73
    MTBE 0.16
    2-butoxyethanol 1.54
    propionic acid 1.03
    o-xylene 0.39
    formic acid 147.47
    diethyl ether 0.25
    m-xylene 0.22
    p-xylene 0.19
    chlorobenzene 0.08
    dimethyl carbonate 1.26
    n-octane 0.07
    formamide 116.46
    cyclopentanone 2.14
    2-pentanone 0.31
    anisole 0.28
    cyclopentyl methyl ether 0.88
    gamma-butyrolactone 3.04
    1-methoxy-2-propanol 5.79
    pyridine 1.37
    3-pentanone 0.43
    furfural 7.34
    n-dodecane 0.03
    diethylene glycol 10.03
    diisopropyl ether 0.08
    tert-amyl alcohol 0.55
    acetylacetone 0.86
    n-hexadecane 0.04
    acetophenone 0.62
    methyl propionate 0.55
    isopentyl acetate 0.15
    trichloroethylene 0.37
    n-nonanol 0.22
    cyclohexanol 1.01
    benzyl alcohol 0.66
    2-ethylhexanol 0.2
    isooctanol 0.21
    dipropyl ether 0.42
    1,2-dichlorobenzene 0.13
    ethyl lactate 0.75
    propylene carbonate 1.01
    n-methylformamide 18.97
    2-pentanol 0.24
    n-pentane 0.08
    1-propoxy-2-propanol 1.37
    1-methoxy-2-propyl acetate 0.62
    2-(2-methoxypropoxy) propanol 2.12
    mesitylene 0.18
    ε-caprolactone 1.48
    p-cymene 0.16
    epichlorohydrin 1.42
    1,1,1-trichloroethane 0.08
    2-aminoethanol 9.17
    morpholine-4-carbaldehyde 31.6
    sulfolane 30.06
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 0.67
    n-hexyl acetate 0.17
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.64
    sec-butyl acetate 0.07
    tert-butyl acetate 0.21
    decalin 0.05
    glycerin 32.4
    diglyme 5.73
    acrylic acid 2.79
    isopropyl myristate 0.09
    n-butyric acid 0.62
    acetyl acetate 0.21
    di(2-ethylhexyl) phthalate 0.26
    ethyl propionate 0.17
    nitromethane 8.66
    1,2-diethoxyethane 0.46
    benzonitrile 0.34
    trioctyl phosphate 0.21
    1-bromopropane 0.12
    gamma-valerolactone 8.96
    n-decanol 0.18
    triethyl phosphate 0.4
    4-methyl-2-pentanol 0.14
    propionitrile 0.27
    vinylene carbonate 1.28
    1,1,2-trichlorotrifluoroethane 9.21
    DMS 0.38
    cumene 0.1
    2-octanol 0.16
    2-hexanone 0.19
    octyl acetate 0.15
    limonene 0.25
    1,2-dimethoxyethane 4.16
    ethyl orthosilicate 0.34
    tributyl phosphate 0.21
    diacetone alcohol 1.53
    N,N-dimethylaniline 0.55
    acrylonitrile 0.73
    aniline 0.67
    1,3-propanediol 5.59
    bromobenzene 0.07
    dibromomethane 0.16
    1,1,2,2-tetrachloroethane 0.43
    2-methyl-cyclohexyl acetate 0.28
    tetrabutyl urea 0.61
    diisobutyl methanol 0.16
    2-phenylethanol 0.49
    styrene 0.11
    dioctyl adipate 0.23
    dimethyl sulfate 6.81
    ethyl butyrate 0.23
    methyl lactate 3.43
    butyl lactate 0.47
    diethyl carbonate 0.2
    propanediol butyl ether 1.88
    triethyl orthoformate 0.35
    p-tert-butyltoluene 0.16
    methyl 4-tert-butylbenzoate 0.95
    morpholine 3.89
    tert-butylamine 0.29
    n-dodecanol 0.14
    dimethoxymethane 6.45
    ethylene carbonate 0.77
    cyrene 6.09
    2-ethoxyethyl acetate 0.29
    2-ethylhexyl acetate 0.12
    1,2,4-trichlorobenzene 0.19
    4-methylpyridine 0.87
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.16
    DEF 2.92
    dimethyl isosorbide 3.4
    tetrachloroethylene 0.47
    eugenol 1.26
    triacetin 0.48
    span 80 1.4
    1,4-butanediol 2.23
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.17
    methyl formate 8.79
    2-methyl-1-butanol 0.3
    n-decane 0.06
    butyronitrile 0.21
    3,7-dimethyl-1-octanol 0.14
    1-chlorooctane 0.08
    1-chlorotetradecane 0.04
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.02
    cyclooctane 0.13
    cyclopentanol 1.11
    tetrahydropyran 0.79
    tert-amyl methyl ether 0.28
    2,5,8-trioxanonane 5.22
    1-hexene 0.09
    2-isopropoxyethanol 1.44
    2,2,2-trifluoroethanol 8.08
    methyl butyrate 0.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction