Stevioside

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  • Identifiers

    CAS number
    57817-89-7

    Molecular formula
    C38H60O18

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 64.74%
    Sweet 29.29%
    Woody 29.16%
    Cooling 24.08%
    Spicy 23.99%
    Balsamic 18.76%
    Mint 18.52%
    Warm 18.47%
    Clean 18.42%
    Amber 18.41%

     

    Flavor
    Bitter 61.26%
    Fatty 35.08%
    Sweet 34.86%
    Odorless 34.4%
    Sweet-like 29.38%
    Bland 25.55%
    Cedarleaf 21.61%
    Cauliflower 21.21%
    Alkaline 21.12%
    Metallic 20.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    3.97 (weak acid)

    Molecular weight
    804.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    3394°C

    Melting point expt.

    • 238 - 239 °C

    Flash point

    • 250.65 ˚C est.

    Solubility expt.

    • 1.25 mg/mL

  • Synonyms

    • Stevioside
    • Steviosin
    • 57817-89-7
    • 0YON5MXJ9P
    • CHEBI:9271
    • INS NO.960
    • DTXSID7021281
    • FEMA NO. 4763
    • INS-960
    • E-960
    • ((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl) (1R,4S,5R,9S,10R,13S)-13-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxan-2-yl)oxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylate
    • (4bS,8aS)-1-hydroxy-2-isopropyl-4b,8,8-trimethyl-5,6,7,8a,9,10-hexahydrophenanthrene-3,4-dione
    • [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate
    • RefChem:51134
    • DTXCID301281
    • 260-975-5
    • Rebaudin
    • Diterpene glycoside
    • STEVIBIOSIDE
    • .ALPHA.-G-SWEET
    • (-)-STEVIOSIDE
    • STEVIAN 50
    • Kaur-16-en-18-oic acid,13-[(2-O-b-D-glucopyranosyl-b-D-glucopyranosyl)oxy]-,b-D-glucopyranosyl ester, (4a)-
    • Stevioside hydrate
    • C38H60O18
    • 1-O-{13alpha-[(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-18-oxo-5beta,8alpha,9beta,10alpha-kaur-16-en-18-yl}-beta-D-glucopyranose
    • 13-[(2-O-.beta.-D-Glucopyranosyl-.alpha.-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid .beta.-D-glucopyranosyl ester
    • C09189
    • UNII-0YON5MXJ9P
    • CHEMBL444122
    • CCRIS 6116
    • Eupatorin?
    • Stevin?
    • (4a)-13-[(2-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid b-D-glucopyranosyl ester
    • EINECS 260-975-5
    • Stevioside (Standard)
    • BRN 0077427
    • STEVIOSIDE [MI]
    • Stevioside - min 75%
    • Stevioside - min 95%
    • Stevioside - min 98%
    • STEVIOSIDE [MART.]
    • STEVIOSIDE [USP-RS]
    • SCHEMBL33428
    • 4-17-00-03618 (Beilstein Handbook Reference)
    • GTPL12423
    • HY-N0669R
    • MSK5110
    • HY-N0669
    • BDBM50480264
    • AKOS015895872
    • CS-W019786
    • DS-6711
    • EBC-618436
    • FS76720
    • OS09396
    • OS46367
    • 13-[(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid beta-D-glucopyranosyl ester
    • XS165242
    • Q415043
    • (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl (1R,4S,5R,9S,10R,13S)-13-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carboxylate
    • (4.ALPHA.)-13-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)KAUR-16-EN-18-OIC ACID .BETA.-D-GLUCOPYRANOSYL ESTER
    • (4alpha)-beta-D-Glucopyranosyl 13-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)kaur-16-en-18-oate
    • [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5,9-dimethyl-14-methylene-tetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate
    • [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl] [(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-dimethyl-methylene-[?]carboxylate
    • 1-O-{(5beta,8alpha,9beta,10alpha,13alpha)-13-[(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-18-oxokaur-16-en-18-yl}-beta-D-glucopyranose
    • KAUR-16-EN-18-OIC ACID, 13-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-, .BETA.-D-GLUCOPYRANOSYL ESTER, (4.ALPHA.)-
    • Kaur-16-en-18-oic acid, 13-((2-O-beta-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy)-, beta-D-glucopyranosyl ester
    • 57817-89-7

  • Applications

    Stevioside is widely used as a non-nutritive sweetener in food processing and in beverage formulations, providing sweetness with minimal calories. It is also employed in tabletop sweeteners and in dietary/nutritional products as a sugar substitute. In pharmaceutical formulations, stevioside is used to improve palatability of syrups, chewable tablets, and oral solutions. Its use is commonly evaluated for use in functional foods and nutraceuticals, but remains subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.29
    methanol 41.37
    isopropanol 1.48
    water 0.38
    ethyl acetate 4.76
    n-propanol 2.85
    acetone 6.31
    n-butanol 1.5
    acetonitrile 2.53
    DMF 68.32
    toluene 0.81
    isobutanol 0.97
    1,4-dioxane 12.47
    methyl acetate 4.9
    THF 28.72
    2-butanone 4.33
    n-pentanol 0.82
    sec-butanol 1.01
    n-hexane 0.02
    ethylene glycol 11.78
    NMP 90.13
    cyclohexane 0.06
    DMSO 76.71
    n-butyl acetate 1.39
    n-octanol 0.82
    chloroform 5.92
    n-propyl acetate 1.51
    acetic acid 74.49
    dichloromethane 6.12
    cyclohexanone 6.57
    propylene glycol 9.85
    isopropyl acetate 2.38
    DMAc 55.06
    2-ethoxyethanol 13.17
    isopentanol 0.71
    n-heptane 0.04
    ethyl formate 5.74
    1,2-dichloroethane 2.8
    n-hexanol 0.72
    2-methoxyethanol 45.65
    isobutyl acetate 0.65
    tetrachloromethane 0.7
    n-pentyl acetate 2.16
    transcutol 19.49
    n-heptanol 1.08
    ethylbenzene 0.22
    MIBK 1.36
    2-propoxyethanol 12.45
    tert-butanol 0.86
    MTBE 0.7
    2-butoxyethanol 8.39
    propionic acid 8.11
    o-xylene 0.51
    formic acid 106.62
    diethyl ether 1.37
    m-xylene 0.5
    p-xylene 0.23
    chlorobenzene 0.94
    dimethyl carbonate 12.99
    n-octane 0.03
    formamide 69.29
    cyclopentanone 18.76
    2-pentanone 3.37
    anisole 1.42
    cyclopentyl methyl ether 3.95
    gamma-butyrolactone 34.51
    1-methoxy-2-propanol 20.42
    pyridine 8.68
    3-pentanone 2.62
    furfural 36.27
    n-dodecane 0.02
    diethylene glycol 19.31
    diisopropyl ether 0.23
    tert-amyl alcohol 0.75
    acetylacetone 12.02
    n-hexadecane 0.02
    acetophenone 2.45
    methyl propionate 7.19
    isopentyl acetate 1.01
    trichloroethylene 10.05
    n-nonanol 0.86
    cyclohexanol 1.06
    benzyl alcohol 2.41
    2-ethylhexanol 0.33
    isooctanol 0.6
    dipropyl ether 0.83
    1,2-dichlorobenzene 1.06
    ethyl lactate 3.74
    propylene carbonate 13.14
    n-methylformamide 39.47
    2-pentanol 0.61
    n-pentane 0.04
    1-propoxy-2-propanol 5.76
    1-methoxy-2-propyl acetate 6.25
    2-(2-methoxypropoxy) propanol 5.17
    mesitylene 0.26
    ε-caprolactone 9.46
    p-cymene 0.21
    epichlorohydrin 23.9
    1,1,1-trichloroethane 1.45
    2-aminoethanol 12.76
    morpholine-4-carbaldehyde 69.63
    sulfolane 70.86
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 5.02
    n-hexyl acetate 2.12
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 8.12
    sec-butyl acetate 0.82
    tert-butyl acetate 2.05
    decalin 0.03
    glycerin 36.04
    diglyme 18.26
    acrylic acid 19.5
    isopropyl myristate 0.45
    n-butyric acid 8.3
    acetyl acetate 6.66
    di(2-ethylhexyl) phthalate 0.98
    ethyl propionate 1.77
    nitromethane 80.26
    1,2-diethoxyethane 2.54
    benzonitrile 1.57
    trioctyl phosphate 0.71
    1-bromopropane 0.59
    gamma-valerolactone 59.52
    n-decanol 0.47
    triethyl phosphate 1.09
    4-methyl-2-pentanol 0.34
    propionitrile 1.39
    vinylene carbonate 15.08
    1,1,2-trichlorotrifluoroethane 51.34
    DMS 3.83
    cumene 0.14
    2-octanol 0.47
    2-hexanone 1.2
    octyl acetate 0.95
    limonene 0.31
    1,2-dimethoxyethane 12.2
    ethyl orthosilicate 0.89
    tributyl phosphate 0.63
    diacetone alcohol 5.94
    N,N-dimethylaniline 1.12
    acrylonitrile 4.07
    aniline 2.2
    1,3-propanediol 12.16
    bromobenzene 0.76
    dibromomethane 2.12
    1,1,2,2-tetrachloroethane 6.29
    2-methyl-cyclohexyl acetate 1.11
    tetrabutyl urea 1.14
    diisobutyl methanol 0.22
    2-phenylethanol 1.9
    styrene 0.31
    dioctyl adipate 1.14
    dimethyl sulfate 32.04
    ethyl butyrate 1.42
    methyl lactate 19.62
    butyl lactate 3.47
    diethyl carbonate 1.03
    propanediol butyl ether 8.34
    triethyl orthoformate 1.49
    p-tert-butyltoluene 0.22
    methyl 4-tert-butylbenzoate 4.43
    morpholine 17.07
    tert-butylamine 0.23
    n-dodecanol 0.26
    dimethoxymethane 32.7
    ethylene carbonate 8.54
    cyrene 12.52
    2-ethoxyethyl acetate 6.53
    2-ethylhexyl acetate 0.74
    1,2,4-trichlorobenzene 1.82
    4-methylpyridine 4.23
    dibutyl ether 0.4
    2,6-dimethyl-4-heptanol 0.22
    DEF 8.33
    dimethyl isosorbide 10.31
    tetrachloroethylene 4.98
    eugenol 4.48
    triacetin 6.05
    span 80 5.28
    1,4-butanediol 3.16
    1,1-dichloroethane 1.44
    2-methyl-1-pentanol 0.45
    methyl formate 33.05
    2-methyl-1-butanol 0.77
    n-decane 0.04
    butyronitrile 0.98
    3,7-dimethyl-1-octanol 0.42
    1-chlorooctane 0.22
    1-chlorotetradecane 0.06
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 2.58
    tetrahydropyran 3.38
    tert-amyl methyl ether 0.78
    2,5,8-trioxanonane 10.47
    1-hexene 0.09
    2-isopropoxyethanol 4.31
    2,2,2-trifluoroethanol 28.15
    methyl butyrate 2.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction