Steviol

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  • Identifiers

    CAS number
    471-80-7

    Molecular formula
    C20H30O3

    SMILES
    C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@](C3)(C(=C)C4)O)(C)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 68.22%
    Balsamic 40.8%
    Cedar 39.97%
    Amber 39.36%
    Dry 36.1%
    Camphoreous 34.91%
    Spicy 34.8%
    Animal 31.58%
    Earthy 31.31%
    Herbal 31.29%

     

    Flavor
    Bitter 43.2%
    Woody 26.78%
    Minty 26.29%
    Spicy 24.79%
    Camphor 24.71%
    Soil 23.04%
    Fruity 22.97%
    Beet 22.96%
    Ripe apricot 22.76%
    Earthy 22.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    7.93 (neutral)

    Molecular weight
    318.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    459°C

    Flash point

    • 219.85 ˚C est.

  • Synonyms

    • Steviol
    • 471-80-7
    • Hydroxydehydrostevic acid
    • (-)-Steviol
    • 4741LYX6RT
    • DTXSID50897427
    • (14-alpha)-13-Hydroxykaur-16-en-18-oic acid
    • CHEBI:145024
    • NSC-226902
    • (1R,4S,5R,9S,10R,13S)-13-hydroxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
    • Kaur-16-en-18-oic acid, 13-hydroxy-, (4alpha)-
    • (1R,4S,5R,9S,10R,13S)-13-hydroxy-5,9-dimethyl-14-methylidenetetracyclo(11.2.1.01,10.04,9)hexadecane-5-carboxylic acid
    • RefChem:185727
    • DTXCID401326770
    • (4R,4aS,6aR,9S,11aR,11bS)-9-Hydroxy-4,11b-dimethyl-8-methylidenetetradecahydro-6a,9-methanocyclohepta(a)naphthalene-4-carboxylic acid
    • MFCD00210558
    • (4R,4aS,6aR,9S,11aR,11bS)-9-hydroxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
    • Kaur-16-en-18-oic acid, 13-hydroxy-, (4.alpha.)-
    • 13-Hydroxykaurenoic acid
    • 13alpha-hydroxy-5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid
    • Steviol hydrate
    • UNII-4741LYX6RT
    • CCRIS 2588
    • 13-Hydroxykaur-16-en-18-oic acid
    • Steviol (Standard)
    • NSC 226902
    • STEVIOL(P)
    • STEVIOSIDE AGLYCON
    • STEVIOL [MI]
    • ent-13-Hydroxy-kauran-16-en-19-oic acid
    • REBAUDIOSIDES AGLYCON
    • Steviol, analytical standard
    • SCHEMBL28608
    • CHEMBL463996
    • HY-N2057R
    • HMS3263G10
    • Steviol (Hydroxydehydrostevic acid)
    • HY-N2057
    • Tox21_501074
    • BDBM50480263
    • s3272
    • AKOS037514919
    • CCG-222378
    • EBC-618489
    • FS65877
    • LP01074
    • SDCCGSBI-0633785.P001
    • NCGC00186036-01
    • NCGC00186036-04
    • NCGC00261759-01
    • DA-58111
    • SY075770
    • (4?)-13-Hydroxykaur-16-en-18-oic acid
    • CS-0018546
    • NS00124653
    • C20212
    • 471H807
    • Q426852
    • (4.ALPHA.)-13-HYDROXYKAUR-16-EN-18-OIC ACID
    • Kaur-16-en-18-oic acid, 13-hydroxy-, (14-alpha)-
    • (1R,4S,5R,9S,10R,13S)-13-hydroxy-5,9-dimethyl-14-methylene-tetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
    • (1R,4S,5R,9S,10R,13S)-13-hydroxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carboxylic acid
    • 471-80-7

  • Applications

    Steviol (CAS 471-80-7) is primarily used as a building block for the industrial production of steviol glycosides, natural high‑intensity sweeteners widely utilized in the food and beverage industry. It serves as a starting material for glycosylation to generate stevioside, rebaudioside A and related derivatives, enabling supply of widely used sweeteners. In research and development, steviol is utilized in the synthesis of diterpene glycoside derivatives and as a scaffold for glycosylation studies in pharmaceutical and cosmetic R&D. It also functions as an analytical reference standard for quality control and method development in sweetener manufacture and analytics. Additionally, exploratory biocatalytic or chemical transformations of steviol are investigated to broaden the range of natural product–derived sweeteners.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 91.23
    methanol 144.11
    isopropanol 124.78
    water 0.33
    ethyl acetate 47.99
    n-propanol 110.44
    acetone 66.13
    n-butanol 101.48
    acetonitrile 28.36
    DMF 326.19
    toluene 56.08
    isobutanol 59.78
    1,4-dioxane 167.59
    methyl acetate 31.97
    THF 639.62
    2-butanone 54.64
    n-pentanol 24.22
    sec-butanol 34.31
    n-hexane 0.45
    ethylene glycol 20.06
    NMP 68.47
    cyclohexane 1.25
    DMSO 115.28
    n-butyl acetate 32.91
    n-octanol 9.76
    chloroform 114.15
    n-propyl acetate 20.71
    acetic acid 38.21
    dichloromethane 63.33
    cyclohexanone 77.85
    propylene glycol 28.36
    isopropyl acetate 50.93
    DMAc 97.2
    2-ethoxyethanol 63.98
    isopentanol 66.04
    n-heptane 0.51
    ethyl formate 25.68
    1,2-dichloroethane 38.79
    n-hexanol 40.3
    2-methoxyethanol 227.1
    isobutyl acetate 18.28
    tetrachloromethane 10.93
    n-pentyl acetate 25.89
    transcutol 140.56
    n-heptanol 20.75
    ethylbenzene 12.8
    MIBK 51.45
    2-propoxyethanol 171.25
    tert-butanol 88.09
    MTBE 27.65
    2-butoxyethanol 70.08
    propionic acid 29.39
    o-xylene 18.42
    formic acid 31.93
    diethyl ether 39.55
    m-xylene 35.87
    p-xylene 12.84
    chlorobenzene 35.19
    dimethyl carbonate 44.01
    n-octane 0.28
    formamide 59.83
    cyclopentanone 163.63
    2-pentanone 67.2
    anisole 37.81
    cyclopentyl methyl ether 88.1
    gamma-butyrolactone 148.86
    1-methoxy-2-propanol 238.06
    pyridine 120.15
    3-pentanone 31.67
    furfural 112.18
    n-dodecane 0.19
    diethylene glycol 123.01
    diisopropyl ether 10.5
    tert-amyl alcohol 25.56
    acetylacetone 83.16
    n-hexadecane 0.25
    acetophenone 32.19
    methyl propionate 51.07
    isopentyl acetate 35.62
    trichloroethylene 100.95
    n-nonanol 10.98
    cyclohexanol 40.14
    benzyl alcohol 42.12
    2-ethylhexanol 13.31
    isooctanol 15.87
    dipropyl ether 15.79
    1,2-dichlorobenzene 27.63
    ethyl lactate 23.96
    propylene carbonate 53.25
    n-methylformamide 123.73
    2-pentanol 39.22
    n-pentane 0.97
    1-propoxy-2-propanol 98.41
    1-methoxy-2-propyl acetate 84.7
    2-(2-methoxypropoxy) propanol 45.31
    mesitylene 16.12
    ε-caprolactone 62.3
    p-cymene 7.59
    epichlorohydrin 177.94
    1,1,1-trichloroethane 30.29
    2-aminoethanol 62.65
    morpholine-4-carbaldehyde 136.32
    sulfolane 126.16
    2,2,4-trimethylpentane 0.52
    2-methyltetrahydrofuran 97.99
    n-hexyl acetate 27.02
    isooctane 0.83
    2-(2-butoxyethoxy)ethanol 69.52
    sec-butyl acetate 18.7
    tert-butyl acetate 56.66
    decalin 0.77
    glycerin 61.02
    diglyme 119.55
    acrylic acid 28.87
    isopropyl myristate 9.69
    n-butyric acid 67.86
    acetyl acetate 33.61
    di(2-ethylhexyl) phthalate 16.22
    ethyl propionate 24.12
    nitromethane 70.95
    1,2-diethoxyethane 33.69
    benzonitrile 36.4
    trioctyl phosphate 12.08
    1-bromopropane 17.09
    gamma-valerolactone 212.99
    n-decanol 6.78
    triethyl phosphate 13.22
    4-methyl-2-pentanol 26.61
    propionitrile 42.33
    vinylene carbonate 54.66
    1,1,2-trichlorotrifluoroethane 93.75
    DMS 30.91
    cumene 7.47
    2-octanol 9.56
    2-hexanone 20.09
    octyl acetate 12.55
    limonene 7.2
    1,2-dimethoxyethane 103.03
    ethyl orthosilicate 13.21
    tributyl phosphate 11.15
    diacetone alcohol 81.63
    N,N-dimethylaniline 22.9
    acrylonitrile 58.29
    aniline 69.67
    1,3-propanediol 118.19
    bromobenzene 31.04
    dibromomethane 34.43
    1,1,2,2-tetrachloroethane 78.26
    2-methyl-cyclohexyl acetate 22.63
    tetrabutyl urea 15.59
    diisobutyl methanol 10.64
    2-phenylethanol 56.65
    styrene 14.14
    dioctyl adipate 16.14
    dimethyl sulfate 61.92
    ethyl butyrate 22.21
    methyl lactate 54.96
    butyl lactate 33.33
    diethyl carbonate 15.0
    propanediol butyl ether 47.86
    triethyl orthoformate 20.8
    p-tert-butyltoluene 8.37
    methyl 4-tert-butylbenzoate 41.97
    morpholine 225.81
    tert-butylamine 26.71
    n-dodecanol 3.9
    dimethoxymethane 268.88
    ethylene carbonate 46.23
    cyrene 48.85
    2-ethoxyethyl acetate 48.29
    2-ethylhexyl acetate 22.91
    1,2,4-trichlorobenzene 34.17
    4-methylpyridine 97.58
    dibutyl ether 7.06
    2,6-dimethyl-4-heptanol 10.64
    DEF 47.45
    dimethyl isosorbide 85.8
    tetrachloroethylene 48.17
    eugenol 48.81
    triacetin 31.7
    span 80 35.86
    1,4-butanediol 22.13
    1,1-dichloroethane 38.95
    2-methyl-1-pentanol 16.81
    methyl formate 66.02
    2-methyl-1-butanol 37.9
    n-decane 0.43
    butyronitrile 44.61
    3,7-dimethyl-1-octanol 11.26
    1-chlorooctane 3.16
    1-chlorotetradecane 0.93
    n-nonane 0.34
    undecane 0.28
    tert-butylcyclohexane 0.76
    cyclooctane 0.56
    cyclopentanol 60.45
    tetrahydropyran 119.77
    tert-amyl methyl ether 14.94
    2,5,8-trioxanonane 68.76
    1-hexene 2.85
    2-isopropoxyethanol 40.44
    2,2,2-trifluoroethanol 21.95
    methyl butyrate 27.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction