Stearoyl Leucine

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  • Identifiers

    CAS number
    14379-43-2

    Molecular formula
    C24H47NO3

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(C)C)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 40.32%
    Odorless 37.11%
    Fatty 33.08%
    Savory 32.83%
    Meaty 27.84%
    Oily 27.28%
    Cooling 26.39%
    Woody 25.36%
    Herbal 25.09%
    Milky 23.61%

     

    Flavor
    Bland 38.89%
    Odorless 34.61%
    Mild 31.61%
    Faint 26.28%
    Slightly waxy 21.8%
    Herbal 20.77%
    Fatty 20.35%
    Bay oil 20.32%
    Delicate 20.2%
    Cedarleaf 19.46%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.3

    pKa est.
    7.41 (neutral)

    Molecular weight
    397.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    491°C

    Flash point

    • 226.83 ˚C est.

  • Synonyms

    • STEAROYL LEUCINE
    • RefChem:889162
    • Leucine, N-stearoyl-, L-
    • 14379-43-2
    • (2S)-4-methyl-2-(octadecanoylamino)pentanoic acid
    • N-Octadecanoylleucine
    • N-Stearoyl-L-leucine
    • N-octadecanoyl-L-leucine
    • L-Leucine, N-(1-oxooctadecyl)-
    • L-Leucine, N-stearoyl-
    • SCHEMBL2910119
    • DTXSID10162547
    • (S)-4-Methyl-2-stearamidopentanoic acid
    • NS00014118
    • 14379-43-2

  • Applications

    Stearoyl Leucine (CAS 14379-43-2) is an amphiphilic lipid-amino acid derivative used primarily as a surfactant and emulsifier in cosmetic and personal care formulations, where it helps stabilize oil-water mixtures and can improve texture and spreadability; it also serves as a conditioning agent in skincare products, contributing to a silky feel without a heavy residue. In addition, it is evaluated as a processing aid or lubricant in polymer and coating formulations, aiding dispersion and compatibility of lipid-soluble components; it may function as a surfactant or stabilizer in coatings and inks, improving wetting and film formation. It can be used in cleaning and household products as a mild surfactant or compatibility agent, helping to solubilize hydrophobic soils. In industrial manufacturing, stearoyl leucine derivatives are used as intermediates to synthesize other lipid-amino acid surfactants or specialty additives; overall, use is formulation-dependent and subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 35.08
    methanol 51.55
    isopropanol 33.73
    water 0.51
    ethyl acetate 63.73
    n-propanol 39.09
    acetone 72.74
    n-butanol 35.55
    acetonitrile 22.88
    DMF 153.66
    toluene 28.25
    isobutanol 34.54
    1,4-dioxane 85.39
    methyl acetate 58.63
    THF 286.05
    2-butanone 90.59
    n-pentanol 37.52
    sec-butanol 44.94
    n-hexane 7.35
    ethylene glycol 4.48
    NMP 386.54
    cyclohexane 21.36
    DMSO 201.49
    n-butyl acetate 87.29
    n-octanol 40.78
    chloroform 157.23
    n-propyl acetate 92.91
    acetic acid 68.86
    dichloromethane 157.43
    cyclohexanone 264.85
    propylene glycol 13.89
    isopropyl acetate 70.47
    DMAc 368.65
    2-ethoxyethanol 81.63
    isopentanol 44.94
    n-heptane 5.06
    ethyl formate 45.82
    1,2-dichloroethane 120.35
    n-hexanol 29.18
    2-methoxyethanol 80.16
    isobutyl acetate 69.21
    tetrachloromethane 43.91
    n-pentyl acetate 153.35
    transcutol 342.17
    n-heptanol 42.21
    ethylbenzene 26.05
    MIBK 76.46
    2-propoxyethanol 74.8
    tert-butanol 59.08
    MTBE 68.64
    2-butoxyethanol 118.83
    propionic acid 55.85
    o-xylene 31.98
    formic acid 24.15
    diethyl ether 35.48
    m-xylene 23.65
    p-xylene 39.34
    chlorobenzene 53.43
    dimethyl carbonate 31.86
    n-octane 4.33
    formamide 45.04
    cyclopentanone 268.75
    2-pentanone 80.49
    anisole 49.9
    cyclopentyl methyl ether 115.69
    gamma-butyrolactone 246.16
    1-methoxy-2-propanol 79.77
    pyridine 100.81
    3-pentanone 71.11
    furfural 171.47
    n-dodecane 2.43
    diethylene glycol 35.47
    diisopropyl ether 19.54
    tert-amyl alcohol 74.84
    acetylacetone 114.88
    n-hexadecane 2.82
    acetophenone 85.05
    methyl propionate 61.7
    isopentyl acetate 102.55
    trichloroethylene 204.33
    n-nonanol 40.51
    cyclohexanol 74.41
    benzyl alcohol 45.36
    2-ethylhexanol 29.57
    isooctanol 41.97
    dipropyl ether 36.09
    1,2-dichlorobenzene 65.22
    ethyl lactate 50.33
    propylene carbonate 149.46
    n-methylformamide 58.81
    2-pentanol 30.75
    n-pentane 4.62
    1-propoxy-2-propanol 76.73
    1-methoxy-2-propyl acetate 100.17
    2-(2-methoxypropoxy) propanol 95.44
    mesitylene 19.29
    ε-caprolactone 244.75
    p-cymene 20.47
    epichlorohydrin 219.16
    1,1,1-trichloroethane 130.93
    2-aminoethanol 18.4
    morpholine-4-carbaldehyde 214.57
    sulfolane 454.09
    2,2,4-trimethylpentane 7.1
    2-methyltetrahydrofuran 176.2
    n-hexyl acetate 139.21
    isooctane 3.28
    2-(2-butoxyethoxy)ethanol 135.28
    sec-butyl acetate 78.14
    tert-butyl acetate 108.7
    decalin 11.67
    glycerin 23.84
    diglyme 268.12
    acrylic acid 41.85
    isopropyl myristate 39.99
    n-butyric acid 101.36
    acetyl acetate 49.37
    di(2-ethylhexyl) phthalate 45.25
    ethyl propionate 72.92
    nitromethane 107.11
    1,2-diethoxyethane 111.16
    benzonitrile 47.97
    trioctyl phosphate 34.78
    1-bromopropane 61.72
    gamma-valerolactone 355.16
    n-decanol 24.79
    triethyl phosphate 50.78
    4-methyl-2-pentanol 26.44
    propionitrile 26.83
    vinylene carbonate 106.02
    1,1,2-trichlorotrifluoroethane 169.45
    DMS 73.04
    cumene 22.09
    2-octanol 38.1
    2-hexanone 91.94
    octyl acetate 55.96
    limonene 34.36
    1,2-dimethoxyethane 152.98
    ethyl orthosilicate 52.06
    tributyl phosphate 44.97
    diacetone alcohol 127.19
    N,N-dimethylaniline 46.96
    acrylonitrile 29.08
    aniline 37.97
    1,3-propanediol 33.98
    bromobenzene 54.38
    dibromomethane 101.43
    1,1,2,2-tetrachloroethane 221.71
    2-methyl-cyclohexyl acetate 84.51
    tetrabutyl urea 71.11
    diisobutyl methanol 22.78
    2-phenylethanol 41.64
    styrene 26.73
    dioctyl adipate 73.62
    dimethyl sulfate 83.21
    ethyl butyrate 74.0
    methyl lactate 43.43
    butyl lactate 118.65
    diethyl carbonate 44.35
    propanediol butyl ether 96.19
    triethyl orthoformate 66.61
    p-tert-butyltoluene 20.36
    methyl 4-tert-butylbenzoate 116.9
    morpholine 137.21
    tert-butylamine 33.5
    n-dodecanol 16.3
    dimethoxymethane 74.03
    ethylene carbonate 97.9
    cyrene 108.3
    2-ethoxyethyl acetate 161.64
    2-ethylhexyl acetate 84.51
    1,2,4-trichlorobenzene 88.32
    4-methylpyridine 94.11
    dibutyl ether 57.2
    2,6-dimethyl-4-heptanol 22.78
    DEF 126.96
    dimethyl isosorbide 192.73
    tetrachloroethylene 148.69
    eugenol 101.24
    triacetin 138.19
    span 80 91.79
    1,4-butanediol 18.61
    1,1-dichloroethane 94.23
    2-methyl-1-pentanol 49.55
    methyl formate 40.92
    2-methyl-1-butanol 45.62
    n-decane 5.66
    butyronitrile 33.19
    3,7-dimethyl-1-octanol 39.11
    1-chlorooctane 31.77
    1-chlorotetradecane 8.71
    n-nonane 5.31
    undecane 3.45
    tert-butylcyclohexane 8.86
    cyclooctane 5.46
    cyclopentanol 81.73
    tetrahydropyran 129.16
    tert-amyl methyl ether 67.23
    2,5,8-trioxanonane 147.77
    1-hexene 21.74
    2-isopropoxyethanol 71.17
    2,2,2-trifluoroethanol 40.85
    methyl butyrate 114.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction