Stearoyl Glutamic Acid

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  • Identifiers

    CAS number
    3397-16-8

    Molecular formula
    C23H43NO5

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 44.18%
    Fatty 37.2%
    Waxy 35.96%
    Savory 34.08%
    Meaty 28.63%
    Oily 25.42%
    Milky 24.4%
    Citrus 20.07%
    Lactonic 19.72%
    Cooling 19.5%

     

    Flavor
    Odorless 46.96%
    Bland 38.83%
    Mild 36.49%
    Fatty 31.94%
    Faint 27.09%
    Waxy 26.29%
    Slightly waxy 22.45%
    Bay oil 21.97%
    Cultured dairy 21.0%
    Beer 20.15%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.4

    pKa est.
    6.23 (neutral)

    Molecular weight
    413.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    540°C

    Flash point

    • 270.93 ˚C est.

  • Synonyms

    • Stearoyl glutamic acid
    • 3397-16-8
    • N-Stearoyl-L-glutamic acid
    • Glutamic acid, N-stearoyl-
    • Amisoft HA
    • Stearoylglutaminic acid
    • n-stearoylglutamic acid
    • N-octadecanoyl-L-glutamic acid
    • Acide stearoylglutaminique
    • Glutamic acid, N-stearoyl-, L-
    • Stearoylglutamic acid
    • L-Glutamic acid, N-(1-oxooctadecyl)-
    • EINECS 222-252-2
    • 4R4O71786G
    • DTXSID101019641
    • RefChem:889159
    • DTXCID401477591
    • STEAROYL GLUTAMIC ACID [INCI]
    • L-Glutamic acid, N-(1-oxooctadecyl)-(9CI)
    • N-(1-Oxooctadecyl)-L-glutamic acid
    • N-Octadecanoylglutamic acid
    • N-stearoyl glutamic acid
    • (2S)-2-(octadecanoylamino)pentanedioic acid
    • L-Glutamic acid,N-(1-oxooctadecyl)-
    • stearoyl-l-glutamic acid
    • N-octadecanoyl-glutamic acid
    • UNII-4R4O71786G
    • SCHEMBL308197
    • orb1697093
    • ATFFFUXLAJBBDE-FQEVSTJZSA-N
    • CHEBI:165566
    • (S)-2-Stearamidopentanedioic acid
    • LMFA08020090
    • AKOS030607142
    • DB-230870
    • NS00083214
    • Q27260391
    • 3397-16-8

  • Applications

    Stearoyl glutamic acid (CAS 3397-16-8) is used primarily as an amphiphilic surfactant and emulsifier in cosmetics and personal care, where it helps stabilize emulsions and provides mild cleansing and conditioning. It also serves as a thickener and texture modifier in formulations for skincare and haircare products. In industrial contexts it can function as an intermediate for the synthesis of other glutamate-based surfactants and as a stabilizer in polymer or biopolymer systems. It may also appear in household and cleaning products as a surfactant component or additive to improve dispersion and film-forming performance in coatings or inks. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.14
    methanol 11.28
    isopropanol 3.5
    water 0.42
    ethyl acetate 4.75
    n-propanol 5.29
    acetone 9.05
    n-butanol 3.95
    acetonitrile 2.21
    DMF 69.05
    toluene 2.25
    isobutanol 3.51
    1,4-dioxane 10.38
    methyl acetate 6.38
    THF 36.04
    2-butanone 10.17
    n-pentanol 4.97
    sec-butanol 4.98
    n-hexane 0.63
    ethylene glycol 1.96
    NMP 148.79
    cyclohexane 0.77
    DMSO 101.36
    n-butyl acetate 6.64
    n-octanol 4.86
    chloroform 11.48
    n-propyl acetate 8.22
    acetic acid 17.94
    dichloromethane 12.08
    cyclohexanone 27.7
    propylene glycol 4.52
    isopropyl acetate 5.55
    DMAc 161.64
    2-ethoxyethanol 18.94
    isopentanol 3.87
    n-heptane 0.44
    ethyl formate 6.14
    1,2-dichloroethane 8.71
    n-hexanol 3.1
    2-methoxyethanol 19.46
    isobutyl acetate 5.38
    tetrachloromethane 3.31
    n-pentyl acetate 13.09
    transcutol 75.49
    n-heptanol 4.77
    ethylbenzene 2.76
    MIBK 6.24
    2-propoxyethanol 14.52
    tert-butanol 5.72
    MTBE 5.68
    2-butoxyethanol 20.46
    propionic acid 11.34
    o-xylene 3.88
    formic acid 12.84
    diethyl ether 2.59
    m-xylene 2.33
    p-xylene 3.97
    chlorobenzene 3.08
    dimethyl carbonate 6.81
    n-octane 0.36
    formamide 19.37
    cyclopentanone 36.72
    2-pentanone 7.42
    anisole 5.85
    cyclopentyl methyl ether 11.89
    gamma-butyrolactone 43.91
    1-methoxy-2-propanol 17.85
    pyridine 11.39
    3-pentanone 7.98
    furfural 34.93
    n-dodecane 0.23
    diethylene glycol 10.38
    diisopropyl ether 1.51
    tert-amyl alcohol 8.71
    acetylacetone 13.71
    n-hexadecane 0.26
    acetophenone 12.35
    methyl propionate 8.07
    isopentyl acetate 7.51
    trichloroethylene 18.21
    n-nonanol 5.06
    cyclohexanol 7.26
    benzyl alcohol 6.94
    2-ethylhexanol 2.88
    isooctanol 4.43
    dipropyl ether 3.88
    1,2-dichlorobenzene 5.23
    ethyl lactate 10.08
    propylene carbonate 22.29
    n-methylformamide 19.42
    2-pentanol 2.92
    n-pentane 0.33
    1-propoxy-2-propanol 13.05
    1-methoxy-2-propyl acetate 12.45
    2-(2-methoxypropoxy) propanol 23.67
    mesitylene 1.87
    ε-caprolactone 31.6
    p-cymene 2.23
    epichlorohydrin 25.94
    1,1,1-trichloroethane 7.98
    2-aminoethanol 5.39
    morpholine-4-carbaldehyde 64.15
    sulfolane 130.01
    2,2,4-trimethylpentane 0.61
    2-methyltetrahydrofuran 16.69
    n-hexyl acetate 13.99
    isooctane 0.23
    2-(2-butoxyethoxy)ethanol 28.61
    sec-butyl acetate 6.45
    tert-butyl acetate 10.18
    decalin 0.9
    glycerin 10.87
    diglyme 56.39
    acrylic acid 11.35
    isopropyl myristate 4.14
    n-butyric acid 12.43
    acetyl acetate 5.13
    di(2-ethylhexyl) phthalate 7.15
    ethyl propionate 7.62
    nitromethane 25.16
    1,2-diethoxyethane 13.06
    benzonitrile 4.97
    trioctyl phosphate 5.08
    1-bromopropane 3.47
    gamma-valerolactone 63.48
    n-decanol 3.08
    triethyl phosphate 8.61
    4-methyl-2-pentanol 2.38
    propionitrile 2.61
    vinylene carbonate 16.64
    1,1,2-trichlorotrifluoroethane 41.15
    DMS 11.78
    cumene 2.66
    2-octanol 3.72
    2-hexanone 9.56
    octyl acetate 6.2
    limonene 3.35
    1,2-dimethoxyethane 30.0
    ethyl orthosilicate 8.31
    tributyl phosphate 6.79
    diacetone alcohol 18.63
    N,N-dimethylaniline 8.39
    acrylonitrile 3.95
    aniline 4.24
    1,3-propanediol 6.98
    bromobenzene 2.93
    dibromomethane 6.59
    1,1,2,2-tetrachloroethane 21.85
    2-methyl-cyclohexyl acetate 9.98
    tetrabutyl urea 12.51
    diisobutyl methanol 2.29
    2-phenylethanol 5.53
    styrene 2.53
    dioctyl adipate 9.94
    dimethyl sulfate 28.69
    ethyl butyrate 7.14
    methyl lactate 12.4
    butyl lactate 18.2
    diethyl carbonate 5.08
    propanediol butyl ether 21.04
    triethyl orthoformate 9.12
    p-tert-butyltoluene 2.28
    methyl 4-tert-butylbenzoate 22.49
    morpholine 18.74
    tert-butylamine 3.04
    n-dodecanol 1.96
    dimethoxymethane 17.27
    ethylene carbonate 13.21
    cyrene 30.06
    2-ethoxyethyl acetate 19.21
    2-ethylhexyl acetate 6.51
    1,2,4-trichlorobenzene 8.19
    4-methylpyridine 9.75
    dibutyl ether 5.51
    2,6-dimethyl-4-heptanol 2.29
    DEF 21.0
    dimethyl isosorbide 42.69
    tetrachloroethylene 15.02
    eugenol 19.99
    triacetin 24.74
    span 80 18.26
    1,4-butanediol 4.48
    1,1-dichloroethane 5.28
    2-methyl-1-pentanol 5.49
    methyl formate 11.3
    2-methyl-1-butanol 4.83
    n-decane 0.52
    butyronitrile 2.79
    3,7-dimethyl-1-octanol 4.13
    1-chlorooctane 2.73
    1-chlorotetradecane 0.8
    n-nonane 0.47
    undecane 0.32
    tert-butylcyclohexane 0.74
    cyclooctane 0.34
    cyclopentanol 9.66
    tetrahydropyran 9.26
    tert-amyl methyl ether 7.58
    2,5,8-trioxanonane 37.66
    1-hexene 1.89
    2-isopropoxyethanol 12.93
    2,2,2-trifluoroethanol 12.63
    methyl butyrate 12.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction