Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2)

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  • Identifiers

    CAS number
    16423-68-0

    Molecular formula
    C20H6I4Na2O5

    SMILES
    C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C(=C4OC5=C(C(=C(C=C35)I)[O-])I)I)[O-])I.[Na+].[Na+]

  • Odor profile

    Fragrance
    Odorless 55.34%
    Phenolic 34.51%
    Burnt 26.5%
    Smoky 19.55%
    Dry 18.29%
    Animal 17.24%
    Spicy 16.68%
    Bitter 16.28%
    Savory 16.22%
    Powdery 15.34%

     

    Flavor
    Bitter 95.55%
    Odorless 27.2%
    Bland 21.2%
    Sweet-like 19.8%
    Cedarleaf 18.97%
    Very strong 18.82%
    Indole 18.72%
    Nitrile 18.52%
    Rotten 17.84%
    Parsley 17.67%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.58 (weak acid)

    Molecular weight
    879.9 g/mol

    Flash point

    • 304.92 ˚C est.

  • Synonyms

    • 16423-68-0
    • Erythrosin B
    • Erythrosine B
    • ERYTHROSINE
    • C.I. Acid Red 51
    • Erythrosine sodium (close form)
    • Food Red No. 3
    • Sodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)
    • MFCD00144257
    • Erythrosin B disodium
    • C.I. Food Red 14
    • FD & C red no. 3
    • FD&C Red 3
    • DTXSID7021233
    • Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt
    • Erythrosine I
    • Erythrosine BS
    • Erythrosine TB
    • Erythrosine Lake
    • Erythrosine 3B
    • Maple erythrosine
    • Sodium erythrosin
    • Erythrosine Extra
    • Cilefa Pink B
    • Erythrosine Bluish
    • Erythrosine B Disodium Salt
    • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt
    • disodium;2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
    • Dolkwal erythrosine
    • Food Dye Red 3
    • Erythrosine TB Extra
    • FDC Red 3 dye
    • Usacert Red No. 3
    • Calcocid erythrosine N
    • Schultz No. 887
    • Erythrosin B disodium 100 microg/mL in Acetonitrile/Water
    • Hexacert Red No. 3
    • Hexacol erythrosine BS
    • FD and C Red 3
    • Erythrosin B, soldium salt
    • New Pink Bluish Geigy
    • Red Dye No. 3
    • Canacert erythrosine BS
    • DTXCID301030411
    • Erythrosine (indicator)
    • Caswell No. 425AB
    • FDC Red 3
    • Erythrosine Extra Bluish
    • LB-Rot 1
    • Erythrosine Extra Pure A
    • D&C Red No. 3
    • Edicol Supra Erythrosin AS
    • Edicol Supra Erythrosine A
    • Benzoic acid, 2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-j9-yl)-, disodium salt
    • Cerven kysela 51 [Czech]
    • Cerven kysela 51
    • Sodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro-[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)
    • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2)
    • CCRIS 892
    • Dye FD and C Red No. 3
    • CAS-16423-68-0
    • Erythrosine B Disodium Salt (Technical Grade)
    • Erythrosine B (biological stain)
    • Cerven potravinarska 14 [Czech]
    • Erythrosine Extra Conc. A Export
    • Cerven potravinarska 14
    • EINECS 240-474-8
    • Erythrosine B-FO (biological stain)
    • Erythrosine K-FO (biological stain)
    • Erythrosine bluish (biological stain)
    • UNII-8TL7LH93FM
    • EPA Pesticide Chemical Code 120901
    • Eritrosina
    • Erythrosine sodium (close form) [USAN]
    • AI3-09094
    • Disodium 2',4',5',7'-tetraiodofluorescein
    • E 127
    • HSDB 7974
    • Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2)
    • 9-(o-Carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3H-xanthene-3-one disodium salt monohydrate
    • Disodium 9-(O-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3H-xanthen-3-one monohydrate
    • SCHEMBL19080
    • Disodium 3',6'-dihydroxy-2',4',5',7'-tetraiodospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one
    • Erythrosin B, analytical standard
    • MSK2415
    • RAGZEDHHTPQLAI-UHFFFAOYSA-L
    • Tox21_202932
    • Tox21_302085
    • NSC 36685
    • AKOS015904033
    • AKOS016010498
    • ERYTHROSINE SODIUM (OPEN FORM)
    • FE44544
    • NSC 759227
    • Erythrosine sodium (open form) [USAN]
    • NCGC00255371-01
    • NCGC00260478-01
    • 3',6'-Dihydroxy-2',4',5',7'-tetraiodospiro(isobenzofuran-1(3H),9'- -(9H)xanthen)-3-one, disodium salt
    • DA-73197
    • Erythrosin extra bluish (C.I. 45430)
    • Erythrosin extra bluish, 87.0-100.0%
    • D92361
    • SBI-0654215.0001
    • 2-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate
    • Erythrosin extra bluish, certified by the Biological Stain Commission
    • Benzoic acid, 2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-, disodium salt
    • Erythrosin B, certified by the Biological Stain Commission, Dye content 90 %
    • Erythrosin extra bluish, for microscopy (Bact., Hist.), adsorption and fluorescent indicator
    • Fluorescein, 2',4',5',7'-tetraiodo-, disodium salt (Benzoic acid tautomeric form)
    • Red No. 3;2-(6-Hydroxy-2,4,5,7-tetraiodo-3-oxo-xanthen-9-yl)benzoic acid

  • Applications

    Chemical name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2); CAS number: 16423-68-0. This xanthene-based dye is used as a colorant and fluorescent probe with established utility in laboratory staining and optical imaging. Practical applications include histology/cytochemistry staining, fluorescence labeling for microscopy, analytical chemistry and sensing as a pH or redox indicator, colorant in inks and coatings, and as a tracer or pigment in polymers and plastics. Its properties may be exploited in research and development as a fluorescent probe; use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.94
    methanol 1.71
    isopropanol 1.0
    water 0.04
    ethyl acetate 5.66
    n-propanol 2.02
    acetone 4.39
    n-butanol 1.69
    acetonitrile 3.82
    DMF 23.95
    toluene 5.86
    isobutanol 1.58
    1,4-dioxane 10.39
    methyl acetate 5.1
    THF 30.47
    2-butanone 6.02
    n-pentanol 2.56
    sec-butanol 1.28
    n-hexane 0.3
    ethylene glycol 1.77
    NMP 39.08
    cyclohexane 0.36
    DMSO 6.8
    n-butyl acetate 12.45
    n-octanol 5.98
    chloroform 10.49
    n-propyl acetate 9.18
    acetic acid 4.3
    dichloromethane 9.2
    cyclohexanone 14.28
    propylene glycol 1.57
    isopropyl acetate 5.82
    DMAc 24.13
    2-ethoxyethanol 8.74
    isopentanol 1.82
    n-heptane 0.88
    ethyl formate 5.65
    1,2-dichloroethane 5.3
    n-hexanol 4.47
    2-methoxyethanol 10.47
    isobutyl acetate 8.12
    tetrachloromethane 1.17
    n-pentyl acetate 15.79
    transcutol 31.67
    n-heptanol 5.3
    ethylbenzene 3.98
    MIBK 6.52
    2-propoxyethanol 18.34
    tert-butanol 1.13
    MTBE 1.95
    2-butoxyethanol 14.94
    propionic acid 3.42
    o-xylene 4.06
    formic acid 3.91
    diethyl ether 2.79
    m-xylene 5.15
    p-xylene 4.61
    chlorobenzene 6.67
    dimethyl carbonate 9.79
    n-octane 0.75
    formamide 6.49
    cyclopentanone 23.49
    2-pentanone 6.83
    anisole 9.63
    cyclopentyl methyl ether 13.38
    gamma-butyrolactone 25.14
    1-methoxy-2-propanol 8.79
    pyridine 18.02
    3-pentanone 5.66
    furfural 28.58
    n-dodecane 0.93
    diethylene glycol 12.38
    diisopropyl ether 1.51
    tert-amyl alcohol 1.47
    acetylacetone 10.84
    n-hexadecane 1.08
    acetophenone 13.62
    methyl propionate 7.76
    isopentyl acetate 11.59
    trichloroethylene 14.55
    n-nonanol 6.8
    cyclohexanol 2.84
    benzyl alcohol 8.35
    2-ethylhexanol 5.34
    isooctanol 4.9
    dipropyl ether 8.27
    1,2-dichlorobenzene 7.12
    ethyl lactate 8.36
    propylene carbonate 14.77
    n-methylformamide 9.49
    2-pentanol 1.39
    n-pentane 0.23
    1-propoxy-2-propanol 15.93
    1-methoxy-2-propyl acetate 19.6
    2-(2-methoxypropoxy) propanol 20.29
    mesitylene 3.13
    ε-caprolactone 16.67
    p-cymene 5.94
    epichlorohydrin 22.97
    1,1,1-trichloroethane 3.79
    2-aminoethanol 2.75
    morpholine-4-carbaldehyde 39.6
    sulfolane 26.34
    2,2,4-trimethylpentane 0.23
    2-methyltetrahydrofuran 11.15
    n-hexyl acetate 15.38
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 22.58
    sec-butyl acetate 6.76
    tert-butyl acetate 6.97
    decalin 0.58
    glycerin 4.01
    diglyme 31.12
    acrylic acid 5.2
    isopropyl myristate 9.26
    n-butyric acid 4.57
    acetyl acetate 4.95
    di(2-ethylhexyl) phthalate 11.53
    ethyl propionate 8.41
    nitromethane 9.24
    1,2-diethoxyethane 15.77
    benzonitrile 14.03
    trioctyl phosphate 8.22
    1-bromopropane 3.11
    gamma-valerolactone 38.34
    n-decanol 5.51
    triethyl phosphate 7.5
    4-methyl-2-pentanol 1.61
    propionitrile 4.53
    vinylene carbonate 16.96
    1,1,2-trichlorotrifluoroethane 22.3
    DMS 15.04
    cumene 3.42
    2-octanol 4.64
    2-hexanone 9.04
    octyl acetate 10.97
    limonene 6.32
    1,2-dimethoxyethane 16.81
    ethyl orthosilicate 7.42
    tributyl phosphate 9.2
    diacetone alcohol 8.43
    N,N-dimethylaniline 10.49
    acrylonitrile 8.18
    aniline 7.05
    1,3-propanediol 3.01
    bromobenzene 6.54
    dibromomethane 5.59
    1,1,2,2-tetrachloroethane 10.49
    2-methyl-cyclohexyl acetate 13.84
    tetrabutyl urea 16.68
    diisobutyl methanol 3.52
    2-phenylethanol 12.04
    styrene 4.45
    dioctyl adipate 13.77
    dimethyl sulfate 12.8
    ethyl butyrate 11.33
    methyl lactate 8.78
    butyl lactate 16.75
    diethyl carbonate 7.62
    propanediol butyl ether 14.04
    triethyl orthoformate 11.67
    p-tert-butyltoluene 5.39
    methyl 4-tert-butylbenzoate 18.29
    morpholine 14.27
    tert-butylamine 0.76
    n-dodecanol 4.49
    dimethoxymethane 19.66
    ethylene carbonate 11.49
    cyrene 23.79
    2-ethoxyethyl acetate 20.98
    2-ethylhexyl acetate 11.57
    1,2,4-trichlorobenzene 9.79
    4-methylpyridine 14.99
    dibutyl ether 8.5
    2,6-dimethyl-4-heptanol 3.52
    DEF 13.58
    dimethyl isosorbide 44.89
    tetrachloroethylene 7.12
    eugenol 23.31
    triacetin 18.75
    span 80 16.98
    1,4-butanediol 2.18
    1,1-dichloroethane 3.44
    2-methyl-1-pentanol 2.57
    methyl formate 8.75
    2-methyl-1-butanol 1.85
    n-decane 1.37
    butyronitrile 4.67
    3,7-dimethyl-1-octanol 5.7
    1-chlorooctane 4.5
    1-chlorotetradecane 2.58
    n-nonane 1.1
    undecane 1.11
    tert-butylcyclohexane 0.5
    cyclooctane 0.32
    cyclopentanol 4.5
    tetrahydropyran 7.14
    tert-amyl methyl ether 3.0
    2,5,8-trioxanonane 27.42
    1-hexene 1.41
    2-isopropoxyethanol 7.21
    2,2,2-trifluoroethanol 3.9
    methyl butyrate 10.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction