Spiro[furan-3(2H),1a(2)(2a(2)H)-naphthalene]-5a(2)-acetic acid, 5a(2)-carboxy-4a(2)a,8a(2)a-diformyl-5-(3-furanyl)decahydro-2,4a(2),6a(2)-trihydroxy-2a(2)-(hydroxymethyl)-, (1a(2)R,2R,2a(2)R,4a(2)R,4a(2)aR,5S,5a(2)S,6a(2)R,8a(2)aR)-

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  • Identifiers

    CAS number
    143183-61-3

    Molecular formula
    C23H28O12

    SMILES
    C1CC2(C3(CC(OC3O)C4=COC=C4)C(CC(C2(C(C1O)(CC(=O)O)C(=O)O)C=O)O)CO)C=O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 74.68%
    Savory 19.1%
    Cooling 17.73%
    Milky 17.12%
    Nutty 16.51%
    Bitter 16.45%
    Roasted 16.43%
    Sweet 16.08%
    Popcorn 14.52%
    Burnt 14.17%

     

    Flavor
    Bitter 73.3%
    Odorless 36.27%
    Bland 25.09%
    Very mild 23.98%
    Sweet-like 23.44%
    Cedarleaf 20.25%
    Fenugreek 19.68%
    Cotton candy 19.64%
    Seedy 19.6%
    Leaves 19.46%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -2.1

    pKa est.
    2.08 (strong acid)

    Molecular weight
    496.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3580°C

    Flash point

    • 332.33 ˚C est.

  • Synonyms

    • DTXSID501098712
    • 143183-61-3
    • Spiro[furan-3(2H),1a(2)(2a(2)H)-naphthalene]-5a(2)-acetic acid, 5a(2)-carboxy-4a(2)a,8a(2)a-diformyl-5-(3-furanyl)decahydro-2,4a(2),6a(2)-trihydroxy-2a(2)-(hydroxymethyl)-, (1a(2)R,2R,2a(2)R,4a(2)R,4a(2)aR,5S,5a(2)S,6a(2)R,8a(2)aR)-
    • 143183-61-3

  • Applications

    Spiro[furan-3(2H),1a(2)(2a(2)H)-naphthalene]-5a(2)-acetic acid, 5a(2)-carboxy-4a(2)a,8a(2)a-diformyl-5-(3-furanyl)decahydro-2,4a(2),6a(2)-trihydroxy-2a(2)-(hydroxymethyl)-, (1a(2)R,2R,2a(2)R,4a(2)R,4a(2)aR,5S,5a(2)S,6a(2)R,8a(2)aR)- (CAS 143183-61-3) is a polyfunctional spiro-naphthalene-furan derivative that serves as a versatile intermediate in synthetic chemistry; its multiple functional groups (carboxyl, formyl, hydroxyl, hydroxymethyl) enable use as a building block for medicinal- and fine-chemical syntheses. In fragrance applications, the 3-furanyl moiety and rigid spiro framework make it a potential odorant precursor or fragrance fixative. In cosmetics/personal care, it may be evaluated as a fragrance component or formulation aid, subject to formulation constraints and regulatory considerations. In coatings, inks, and polymer chemistry, it can function as a reactive polyfunctional intermediate or crosslinking agent for specialty coatings and polymer networks. It may also be explored as a chiral building block in pharmaceutical and agrochemical process chemistry, where its stereocenters and functional groups support downstream transformations. Overall, applications depend on regulatory compliance, purity, and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.39
    methanol 34.87
    isopropanol 1.68
    water 1.8
    ethyl acetate 3.02
    n-propanol 2.47
    acetone 23.94
    n-butanol 1.08
    acetonitrile 7.01
    DMF 139.2
    toluene 0.41
    isobutanol 0.77
    1,4-dioxane 18.33
    methyl acetate 5.65
    THF 38.98
    2-butanone 6.02
    n-pentanol 0.69
    sec-butanol 0.66
    n-hexane 0.03
    ethylene glycol 16.25
    NMP 87.05
    cyclohexane 0.07
    DMSO 278.53
    n-butyl acetate 1.0
    n-octanol 0.45
    chloroform 1.95
    n-propyl acetate 1.31
    acetic acid 30.02
    dichloromethane 3.55
    cyclohexanone 8.74
    propylene glycol 5.0
    isopropyl acetate 1.15
    DMAc 78.55
    2-ethoxyethanol 12.9
    isopentanol 0.5
    n-heptane 0.03
    ethyl formate 5.87
    1,2-dichloroethane 2.95
    n-hexanol 0.58
    2-methoxyethanol 42.14
    isobutyl acetate 0.39
    tetrachloromethane 0.41
    n-pentyl acetate 0.91
    transcutol 4.66
    n-heptanol 0.6
    ethylbenzene 0.2
    MIBK 1.14
    2-propoxyethanol 8.81
    tert-butanol 1.0
    MTBE 0.4
    2-butoxyethanol 4.39
    propionic acid 4.39
    o-xylene 0.29
    formic acid 81.85
    diethyl ether 1.39
    m-xylene 0.25
    p-xylene 0.27
    chlorobenzene 0.52
    dimethyl carbonate 10.39
    n-octane 0.02
    formamide 105.87
    cyclopentanone 25.21
    2-pentanone 3.24
    anisole 1.12
    cyclopentyl methyl ether 2.72
    gamma-butyrolactone 35.3
    1-methoxy-2-propanol 12.72
    pyridine 8.77
    3-pentanone 2.58
    furfural 26.94
    n-dodecane 0.02
    diethylene glycol 16.79
    diisopropyl ether 0.15
    tert-amyl alcohol 0.49
    acetylacetone 10.07
    n-hexadecane 0.02
    acetophenone 2.05
    methyl propionate 5.53
    isopentyl acetate 0.59
    trichloroethylene 5.27
    n-nonanol 0.46
    cyclohexanol 0.76
    benzyl alcohol 1.58
    2-ethylhexanol 0.23
    isooctanol 0.31
    dipropyl ether 0.7
    1,2-dichlorobenzene 0.51
    ethyl lactate 2.29
    propylene carbonate 6.9
    n-methylformamide 61.23
    2-pentanol 0.32
    n-pentane 0.03
    1-propoxy-2-propanol 2.9
    1-methoxy-2-propyl acetate 2.73
    2-(2-methoxypropoxy) propanol 2.35
    mesitylene 0.15
    ε-caprolactone 6.32
    p-cymene 0.13
    epichlorohydrin 23.21
    1,1,1-trichloroethane 0.84
    2-aminoethanol 11.7
    morpholine-4-carbaldehyde 61.56
    sulfolane 64.0
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 4.39
    n-hexyl acetate 0.83
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.59
    sec-butyl acetate 0.49
    tert-butyl acetate 0.98
    decalin 0.02
    glycerin 21.57
    diglyme 8.95
    acrylic acid 9.53
    isopropyl myristate 0.26
    n-butyric acid 2.91
    acetyl acetate 3.03
    di(2-ethylhexyl) phthalate 0.59
    ethyl propionate 1.49
    nitromethane 100.03
    1,2-diethoxyethane 1.38
    benzonitrile 1.52
    trioctyl phosphate 0.48
    1-bromopropane 0.52
    gamma-valerolactone 53.67
    n-decanol 0.3
    triethyl phosphate 0.76
    4-methyl-2-pentanol 0.16
    propionitrile 2.41
    vinylene carbonate 8.02
    1,1,2-trichlorotrifluoroethane 24.05
    DMS 2.03
    cumene 0.11
    2-octanol 0.25
    2-hexanone 1.49
    octyl acetate 0.52
    limonene 0.17
    1,2-dimethoxyethane 18.18
    ethyl orthosilicate 0.56
    tributyl phosphate 0.41
    diacetone alcohol 3.3
    N,N-dimethylaniline 0.86
    acrylonitrile 6.66
    aniline 1.16
    1,3-propanediol 10.54
    bromobenzene 0.37
    dibromomethane 1.24
    1,1,2,2-tetrachloroethane 3.27
    2-methyl-cyclohexyl acetate 0.69
    tetrabutyl urea 1.1
    diisobutyl methanol 0.12
    2-phenylethanol 1.25
    styrene 0.24
    dioctyl adipate 0.63
    dimethyl sulfate 24.87
    ethyl butyrate 0.95
    methyl lactate 9.18
    butyl lactate 1.28
    diethyl carbonate 0.81
    propanediol butyl ether 2.8
    triethyl orthoformate 0.83
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 1.72
    morpholine 19.55
    tert-butylamine 0.21
    n-dodecanol 0.19
    dimethoxymethane 39.38
    ethylene carbonate 5.49
    cyrene 8.3
    2-ethoxyethyl acetate 2.35
    2-ethylhexyl acetate 0.45
    1,2,4-trichlorobenzene 0.77
    4-methylpyridine 3.77
    dibutyl ether 0.3
    2,6-dimethyl-4-heptanol 0.12
    DEF 7.76
    dimethyl isosorbide 5.6
    tetrachloroethylene 2.96
    eugenol 2.33
    triacetin 1.71
    span 80 1.9
    1,4-butanediol 3.52
    1,1-dichloroethane 0.94
    2-methyl-1-pentanol 0.34
    methyl formate 51.92
    2-methyl-1-butanol 0.48
    n-decane 0.03
    butyronitrile 1.42
    3,7-dimethyl-1-octanol 0.2
    1-chlorooctane 0.15
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.03
    cyclopentanol 2.08
    tetrahydropyran 3.88
    tert-amyl methyl ether 0.39
    2,5,8-trioxanonane 6.32
    1-hexene 0.11
    2-isopropoxyethanol 3.5
    2,2,2-trifluoroethanol 18.29
    methyl butyrate 2.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction