Spirodiclofen

Overview IFRA Request a quote

  • Identifiers

    CAS number
    148477-71-8

    Molecular formula
    C21H24Cl2O4

    SMILES
    CCC(C)(C)C(=O)OC1=C(C(=O)OC12CCCCC2)C3=C(C=C(C=C3)Cl)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 47.17%
    Floral 35.15%
    Musk 33.07%
    Powdery 27.79%
    Dry 27.22%
    Sweet 27.22%
    Animal 26.13%
    Woody 25.44%
    Grape 24.45%
    Berry 24.44%

     

    Flavor
    Bitter 79.84%
    Odorless 22.75%
    Bland 21.66%
    Cedarleaf 20.9%
    Parsley 20.38%
    Lovage 20.06%
    Ripe apricot 19.64%
    Heather 19.61%
    Red fruit 19.53%
    Broom 19.47%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.9

    pKa est.
    5.66 (weak acid)

    Molecular weight
    411.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    497°C

    Melting point expt.

    • 94.8 °C

    Flash point

    • 172.36 ˚C est.

    Solubility expt.

    • In n-heptane 20, polyethylene glycol 24, n-octanol 44, isopropanol 47, DMSO 75, acetone, dichlormethane, ethyl acetate, acetonitrile and xylene >250 (all in g/L, 20 °C)
    • In water, 50 (pH 4); 190 (pH 7); both in ug/L at 20 °C

  • Synonyms

    • spirodiclofen
    • 148477-71-8
    • Envidor
    • Spirodiclofen [ISO]
    • [3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl] 2,2-dimethylbutanoate
    • 3X7G31F5MX
    • DTXSID6034928
    • CHEBI:38639
    • HSDB 7940
    • BAJ2740
    • BAJ 2740
    • BAJ-2740
    • SPIRODICLOFEN [MI]
    • DTXCID201334167
    • 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate
    • Spirodiclofen 1000 microg/mL in Acetone
    • Spirodiclofen 10 microg/mL in Cyclohexane
    • 3-(2,4-DICHLOROPHENYL)-2-OXO-1-OXASPIRO(4.5)DEC-3-EN-4-YL 2,2-DIMETHYLBUTANOATE
    • 3-(2,4-DICHLOROPHENYL)-2-OXO-1-OXASPIRO(4.5)DEC-3-EN-4-YL 2,2-DIMETHYLBUTYRATE
    • 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutyrate
    • Butanoic acid, 2,2-dimethyl-, 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro(4.5)dec-3-en-4-yl ester
    • UNII-3X7G31F5MX
    • 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro(4.5)dec-3-en-4-yl 2,2-dimethylbutyrate, 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro(4.5)dec-3-en-4-yl 2,2-dimethylbutanoate
    • 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutyrate, 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate
    • spirodiclofen (ISO);3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro(4.5)dec-3-en-4-yl 2,2-dimethylbutyrate
    • spirodiclofen (ISO);3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutyrate
    • Spirodiclofen (Standard)
    • SCHEMBL27234
    • CHEMBL2227839
    • HY-B0826R
    • BCP21407
    • HY-B0826
    • MSK20385
    • YFA47771
    • Tox21_301133
    • AKOS015895782
    • CS-5165
    • 3-(2,4-Dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl) 2,2-dimethylbutyrate
    • USEPA/OPP Pesticide Code: 124871
    • NCGC00182605-01
    • NCGC00255032-01
    • MS-27098
    • CAS-148477-71-8
    • NS00006322
    • Spirodiclofen 100 microg/mL in Acetonitrile
    • C18553
    • G13297
    • Spirodiclofen, PESTANAL(R), analytical standard
    • Q425807
    • 2,2-Dimethylbutanoic acid, 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro
    • 604-636-5
    • Pesticide7_Spirodiclofen_C21H24Cl2O4_Butanoic acid, 2,2-dimethyl-, 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl ester

  • Applications

    Spirodiclofen is an acaricide used in agriculture to control mites on crops such as citrus, grapes, pome fruits, and vegetables; it is applied in both greenhouse and open-field production and is commonly formulated as emulsifiable concentrates (EC) or suspension concentrates (SC); it is often used as part of integrated pest management (IPM) programs; its mode of action is inhibition of acetyl-CoA carboxylase in mites, disrupting lipid biosynthesis and reducing mite populations; it is employed as a miticide in crop protection programs, including use on ornamentals within IPM.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 123.17
    methanol 72.55
    isopropanol 97.85
    water 0.02
    ethyl acetate 732.28
    n-propanol 186.6
    acetone 475.16
    n-butanol 213.61
    acetonitrile 215.62
    DMF 724.91
    toluene 1734.33
    isobutanol 161.73
    1,4-dioxane 631.32
    methyl acetate 559.23
    THF 1262.33
    2-butanone 887.87
    n-pentanol 194.77
    sec-butanol 229.33
    n-hexane 20.72
    ethylene glycol 8.83
    NMP 1292.52
    cyclohexane 49.31
    DMSO 211.08
    n-butyl acetate 484.2
    n-octanol 105.92
    chloroform 2256.22
    n-propyl acetate 464.04
    acetic acid 274.82
    dichloromethane 1787.07
    cyclohexanone 1521.57
    propylene glycol 25.59
    isopropyl acetate 538.88
    DMAc 1382.03
    2-ethoxyethanol 285.5
    isopentanol 250.35
    n-heptane 12.32
    ethyl formate 265.31
    1,2-dichloroethane 1025.05
    n-hexanol 206.52
    2-methoxyethanol 313.91
    isobutyl acetate 317.23
    tetrachloromethane 167.08
    n-pentyl acetate 411.01
    transcutol 883.34
    n-heptanol 132.67
    ethylbenzene 531.94
    MIBK 486.81
    2-propoxyethanol 434.5
    tert-butanol 118.84
    MTBE 358.13
    2-butoxyethanol 329.05
    propionic acid 209.74
    o-xylene 652.79
    formic acid 56.62
    diethyl ether 376.96
    m-xylene 684.98
    p-xylene 664.61
    chlorobenzene 1232.84
    dimethyl carbonate 299.79
    n-octane 7.31
    formamide 132.61
    cyclopentanone 1174.11
    2-pentanone 824.65
    anisole 840.5
    cyclopentyl methyl ether 790.46
    gamma-butyrolactone 1019.09
    1-methoxy-2-propanol 299.34
    pyridine 1668.31
    3-pentanone 683.08
    furfural 1027.06
    n-dodecane 6.77
    diethylene glycol 152.61
    diisopropyl ether 127.87
    tert-amyl alcohol 239.02
    acetylacetone 829.58
    n-hexadecane 8.74
    acetophenone 904.1
    methyl propionate 640.37
    isopentyl acetate 494.0
    trichloroethylene 2933.49
    n-nonanol 113.63
    cyclohexanol 398.12
    benzyl alcohol 570.35
    2-ethylhexanol 173.54
    isooctanol 130.14
    dipropyl ether 167.11
    1,2-dichlorobenzene 977.54
    ethyl lactate 185.94
    propylene carbonate 730.99
    n-methylformamide 241.57
    2-pentanol 197.46
    n-pentane 20.33
    1-propoxy-2-propanol 280.4
    1-methoxy-2-propyl acetate 586.81
    2-(2-methoxypropoxy) propanol 356.01
    mesitylene 270.32
    ε-caprolactone 1361.45
    p-cymene 166.9
    epichlorohydrin 1685.38
    1,1,1-trichloroethane 1162.52
    2-aminoethanol 43.69
    morpholine-4-carbaldehyde 1185.65
    sulfolane 813.52
    2,2,4-trimethylpentane 26.26
    2-methyltetrahydrofuran 1128.55
    n-hexyl acetate 462.56
    isooctane 13.47
    2-(2-butoxyethoxy)ethanol 427.09
    sec-butyl acetate 438.38
    tert-butyl acetate 522.79
    decalin 44.5
    glycerin 43.5
    diglyme 769.39
    acrylic acid 185.38
    isopropyl myristate 156.16
    n-butyric acid 457.66
    acetyl acetate 497.53
    di(2-ethylhexyl) phthalate 202.93
    ethyl propionate 461.18
    nitromethane 602.93
    1,2-diethoxyethane 424.29
    benzonitrile 732.15
    trioctyl phosphate 109.3
    1-bromopropane 686.39
    gamma-valerolactone 1723.1
    n-decanol 77.2
    triethyl phosphate 181.13
    4-methyl-2-pentanol 137.3
    propionitrile 292.82
    vinylene carbonate 683.55
    1,1,2-trichlorotrifluoroethane 767.38
    DMS 439.03
    cumene 258.94
    2-octanol 106.14
    2-hexanone 556.61
    octyl acetate 213.87
    limonene 228.07
    1,2-dimethoxyethane 567.95
    ethyl orthosilicate 172.07
    tributyl phosphate 140.82
    diacetone alcohol 443.78
    N,N-dimethylaniline 511.51
    acrylonitrile 388.41
    aniline 909.94
    1,3-propanediol 101.6
    bromobenzene 1461.01
    dibromomethane 1133.53
    1,1,2,2-tetrachloroethane 1920.95
    2-methyl-cyclohexyl acetate 356.26
    tetrabutyl urea 204.98
    diisobutyl methanol 86.23
    2-phenylethanol 521.22
    styrene 694.17
    dioctyl adipate 256.33
    dimethyl sulfate 407.78
    ethyl butyrate 371.48
    methyl lactate 218.22
    butyl lactate 250.77
    diethyl carbonate 244.71
    propanediol butyl ether 198.91
    triethyl orthoformate 245.85
    p-tert-butyltoluene 146.5
    methyl 4-tert-butylbenzoate 440.78
    morpholine 926.93
    tert-butylamine 70.74
    n-dodecanol 55.36
    dimethoxymethane 512.35
    ethylene carbonate 534.7
    cyrene 431.99
    2-ethoxyethyl acetate 571.33
    2-ethylhexyl acetate 430.33
    1,2,4-trichlorobenzene 1179.4
    4-methylpyridine 2308.21
    dibutyl ether 166.39
    2,6-dimethyl-4-heptanol 86.23
    DEF 1045.06
    dimethyl isosorbide 671.6
    tetrachloroethylene 1021.46
    eugenol 405.03
    triacetin 438.6
    span 80 294.31
    1,4-butanediol 42.32
    1,1-dichloroethane 1108.03
    2-methyl-1-pentanol 298.16
    methyl formate 187.98
    2-methyl-1-butanol 321.78
    n-decane 12.35
    butyronitrile 362.62
    3,7-dimethyl-1-octanol 157.37
    1-chlorooctane 99.87
    1-chlorotetradecane 38.85
    n-nonane 9.72
    undecane 8.71
    tert-butylcyclohexane 35.55
    cyclooctane 17.03
    cyclopentanol 271.55
    tetrahydropyran 869.28
    tert-amyl methyl ether 448.3
    2,5,8-trioxanonane 521.9
    1-hexene 162.28
    2-isopropoxyethanol 262.49
    2,2,2-trifluoroethanol 104.85
    methyl butyrate 603.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction