Sphingolipid E

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  • Identifiers

    CAS number
    110483-07-3

    Molecular formula
    C37H75NO4

    SMILES
    CCCCCCCCCCCCCCCCOCC(CN(CCO)C(=O)CCCCCCCCCCCCCCC)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 56.1%
    Fatty 38.23%
    Oily 37.74%
    Odorless 34.24%
    Woody 25.02%
    Fresh 24.58%
    Fishy 23.95%
    Savory 21.91%
    Animal 21.36%
    Sweet 20.86%

     

    Flavor
    Bland 38.72%
    Mild 36.38%
    Waxy 32.03%
    Odorless 30.37%
    Fatty 30.32%
    Faint 27.97%
    Slightly waxy 23.09%
    Oily 22.6%
    Delicate 21.75%
    Bay oil 21.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    13.4

    pKa est.
    8.78 (weak base)

    Molecular weight
    598.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    904°C

    Flash point

    • 278.9 ˚C est.

  • Synonyms

    • 110483-07-3
    • Sphingolipid E
    • Hexadecanamide, N-(3-(hexadecyloxy)-2-hydroxypropyl)-N-(2-hydroxyethyl)-
    • CERAMIDE SL
    • ISA73Z2140
    • SPHINGOLIPID E66
    • DTXSID80869531
    • Hydroxyethyl Palmityl Oxyhydroxypropyl Palmitamide
    • N-(3-hexadecyloxy-2-hydroxyprop-1-yl)-N-(2-hydroxyethyl)palmitamide
    • Hexadecanamide, N-[3-(hexadecyloxy)-2-hydroxypropyl]-N-(2-hydroxyethyl)-
    • RefChem:789473
    • DTXCID30817502
    • 408-110-4
    • N-(3-hexadecoxy-2-hydroxypropyl)-N-(2-hydroxyethyl)hexadecanamide
    • CETYL-PG HYDROXYETHYL PALMITAMIDE
    • Hexadecanamide, N-3-(hexadecyloxy)-2-hydroxypropyl-N-(2-hydroxyethyl)-
    • N-(3-(Hexadecyloxy)-2-hydroxypropyl)-N-(2-hydroxyethyl)hexadecanamide
    • N-(3-(Hexadecyloxy)-2-hydroxypropyl)-N-(2-hydroxyethyl)palmitamide
    • N-[3-(HEXADECYLOXY)-2-HYDROXYPROPYL]-N-(2-HYDROXYETHYL)HEXADECANAMIDE
    • UNII-ISA73Z2140
    • SPHINGOLIPID-E
    • EC 408-110-4
    • SCHEMBL200278
    • PUGFCQQOYJMKOO-UHFFFAOYSA-N
    • EX-A11874
    • CETYL PG HYDROXYETHYL PALMITAMIDE
    • NS00008245
    • Q27280879
    • (+/-)-HYDROXYETHYL PALMITYL OXYHYDROXYPROPYL PALMITAMIDE
    • HYDROXYETHYL PALMITYL OXYHYDROXYPROPYL PALMITAMIDE, (+/-)-
    • n-(3-hexadecyloxy-2-hydroxypropyl)-n-2-hydroxyethylhexadecanamide
    • N-(3-HEXADECYLOXY-2-HYDROXYPROPYL)-N-2-HYDROXYETHYL-HEXADECANAMIDE
    • 110483-07-3

  • Applications

    Sphingolipid E (CAS number: 110483-07-3) is commonly employed as a skin-identical lipid in cosmetics and personal care, helping support barrier function and moisturization in formulations. It is often evaluated as a lipid-based excipient or carrier in pharmaceutical formulations, including liposome- and nanoparticle-delivery systems. In industrial manufacturing and polymer science, it can serve as a defined lipid component or model compound for studying lipid interactions, phase behavior, or as an intermediate in the synthesis of more complex sphingolipids. In research settings, it is used as a reference sphingolipid for membrane-model studies and analytical characterization. Its use is formulation- and regulation-dependent, and subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.44
    methanol 13.48
    isopropanol 6.49
    water 0.82
    ethyl acetate 79.47
    n-propanol 12.52
    acetone 44.51
    n-butanol 12.17
    acetonitrile 18.74
    DMF 105.93
    toluene 30.97
    isobutanol 11.92
    1,4-dioxane 71.92
    methyl acetate 58.13
    THF 168.89
    2-butanone 67.72
    n-pentanol 12.83
    sec-butanol 14.6
    n-hexane 5.46
    ethylene glycol 2.49
    NMP 421.52
    cyclohexane 24.12
    DMSO 133.4
    n-butyl acetate 67.24
    n-octanol 24.44
    chloroform 225.26
    n-propyl acetate 79.96
    acetic acid 62.14
    dichloromethane 229.87
    cyclohexanone 223.2
    propylene glycol 5.01
    isopropyl acetate 71.43
    DMAc 301.05
    2-ethoxyethanol 38.52
    isopentanol 14.54
    n-heptane 6.64
    ethyl formate 44.97
    1,2-dichloroethane 133.54
    n-hexanol 11.62
    2-methoxyethanol 36.51
    isobutyl acetate 48.99
    tetrachloromethane 65.59
    n-pentyl acetate 134.89
    transcutol 191.79
    n-heptanol 21.94
    ethylbenzene 22.8
    MIBK 52.23
    2-propoxyethanol 36.94
    tert-butanol 13.01
    MTBE 32.75
    2-butoxyethanol 69.91
    propionic acid 45.28
    o-xylene 36.41
    formic acid 22.77
    diethyl ether 26.23
    m-xylene 25.43
    p-xylene 32.7
    chlorobenzene 62.71
    dimethyl carbonate 48.62
    n-octane 4.27
    formamide 34.54
    cyclopentanone 232.82
    2-pentanone 62.37
    anisole 41.84
    cyclopentyl methyl ether 109.51
    gamma-butyrolactone 286.28
    1-methoxy-2-propanol 37.48
    pyridine 95.09
    3-pentanone 75.62
    furfural 206.7
    n-dodecane 2.29
    diethylene glycol 17.69
    diisopropyl ether 16.21
    tert-amyl alcohol 25.84
    acetylacetone 116.62
    n-hexadecane 2.7
    acetophenone 83.32
    methyl propionate 78.25
    isopentyl acetate 70.84
    trichloroethylene 279.27
    n-nonanol 26.23
    cyclohexanol 42.27
    benzyl alcohol 28.76
    2-ethylhexanol 18.11
    isooctanol 24.02
    dipropyl ether 38.16
    1,2-dichlorobenzene 88.33
    ethyl lactate 46.56
    propylene carbonate 182.49
    n-methylformamide 43.29
    2-pentanol 12.25
    n-pentane 3.92
    1-propoxy-2-propanol 44.29
    1-methoxy-2-propyl acetate 85.49
    2-(2-methoxypropoxy) propanol 64.2
    mesitylene 20.07
    ε-caprolactone 250.01
    p-cymene 21.41
    epichlorohydrin 209.56
    1,1,1-trichloroethane 176.34
    2-aminoethanol 7.44
    morpholine-4-carbaldehyde 205.4
    sulfolane 535.27
    2,2,4-trimethylpentane 6.3
    2-methyltetrahydrofuran 133.34
    n-hexyl acetate 111.52
    isooctane 2.24
    2-(2-butoxyethoxy)ethanol 75.7
    sec-butyl acetate 66.63
    tert-butyl acetate 92.31
    decalin 10.44
    glycerin 12.57
    diglyme 195.22
    acrylic acid 41.03
    isopropyl myristate 30.9
    n-butyric acid 76.64
    acetyl acetate 82.98
    di(2-ethylhexyl) phthalate 36.15
    ethyl propionate 79.75
    nitromethane 134.8
    1,2-diethoxyethane 80.99
    benzonitrile 43.35
    trioctyl phosphate 26.51
    1-bromopropane 57.19
    gamma-valerolactone 329.9
    n-decanol 15.58
    triethyl phosphate 68.31
    4-methyl-2-pentanol 10.52
    propionitrile 21.7
    vinylene carbonate 154.39
    1,1,2-trichlorotrifluoroethane 206.29
    DMS 82.67
    cumene 18.08
    2-octanol 21.42
    2-hexanone 60.46
    octyl acetate 44.15
    limonene 35.45
    1,2-dimethoxyethane 90.82
    ethyl orthosilicate 62.95
    tributyl phosphate 37.56
    diacetone alcohol 77.85
    N,N-dimethylaniline 40.57
    acrylonitrile 27.96
    aniline 31.13
    1,3-propanediol 11.7
    bromobenzene 72.6
    dibromomethane 128.18
    1,1,2,2-tetrachloroethane 258.17
    2-methyl-cyclohexyl acetate 76.35
    tetrabutyl urea 55.86
    diisobutyl methanol 13.94
    2-phenylethanol 24.99
    styrene 24.72
    dioctyl adipate 64.32
    dimethyl sulfate 149.25
    ethyl butyrate 81.37
    methyl lactate 46.39
    butyl lactate 98.43
    diethyl carbonate 55.8
    propanediol butyl ether 50.74
    triethyl orthoformate 82.27
    p-tert-butyltoluene 19.9
    methyl 4-tert-butylbenzoate 112.66
    morpholine 91.42
    tert-butylamine 9.42
    n-dodecanol 10.27
    dimethoxymethane 59.34
    ethylene carbonate 136.85
    cyrene 92.6
    2-ethoxyethyl acetate 157.22
    2-ethylhexyl acetate 66.51
    1,2,4-trichlorobenzene 123.01
    4-methylpyridine 81.88
    dibutyl ether 46.19
    2,6-dimethyl-4-heptanol 13.94
    DEF 123.21
    dimethyl isosorbide 154.02
    tetrachloroethylene 185.5
    eugenol 81.27
    triacetin 167.44
    span 80 59.52
    1,4-butanediol 7.21
    1,1-dichloroethane 95.96
    2-methyl-1-pentanol 17.89
    methyl formate 40.43
    2-methyl-1-butanol 17.69
    n-decane 5.63
    butyronitrile 21.81
    3,7-dimethyl-1-octanol 23.37
    1-chlorooctane 27.25
    1-chlorotetradecane 7.74
    n-nonane 5.31
    undecane 3.33
    tert-butylcyclohexane 6.9
    cyclooctane 8.16
    cyclopentanol 42.04
    tetrahydropyran 96.2
    tert-amyl methyl ether 48.01
    2,5,8-trioxanonane 107.1
    1-hexene 12.71
    2-isopropoxyethanol 33.75
    2,2,2-trifluoroethanol 52.85
    methyl butyrate 107.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction