Sphinganine

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  • Identifiers

    CAS number
    764-22-7

    Molecular formula
    C18H39NO2

    SMILES
    CCCCCCCCCCCCCCC[C@H]([C@H](CO)N)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 51.7%
    Oily 42.19%
    Fatty 34.79%
    Odorless 32.97%
    Fresh 29.8%
    Woody 28.7%
    Fishy 28.59%
    Citrus 26.97%
    Sweet 26.52%
    Animal 23.28%

     

    Flavor
    Mild 33.92%
    Bland 32.78%
    Odorless 29.41%
    Waxy 29.35%
    Fatty 25.56%
    Faint 25.12%
    Slightly waxy 22.65%
    Delicate 22.09%
    Bay oil 21.36%
    Leathery 20.7%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    6.44 (neutral)

    Molecular weight
    301.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    398°C

    Flash point

    • 192.45 ˚C est.

  • Synonyms

    • Sphinganine
    • 764-22-7
    • D-erythro-Sphinganine
    • Dihydrosphingosine
    • Octadecasphinganine
    • (2S,3R)-2-aminooctadecane-1,3-diol
    • C18-Dihydrosphingosine
    • D-erythro-2-Amino-1,3-octadecanediol
    • D-erythro-C18-Dihydrosphingosine
    • D-erythro-1,3-Dihydroxy-2-aminooctadecane
    • SPC 102860
    • 1,3-Octadecanediol, 2-amino-, (2S,3R)-
    • 2-Amino-1,3-dihydroxyoctadecane
    • YT0ZSD64HM
    • 1,3-Octadecanediol, 2-amino-, D-erythro-
    • 1,3-Octadecanediol, 2-amino-, (R-(R*,S*))-
    • CHEBI:16566
    • DTXSID501016568
    • d18:0
    • 1,3-Octadecanediol, 2-amino-, [R-(R*,S*)]-
    • RefChem:888505
    • DTXCID301474756
    • 212-116-0
    • D-erythro-Dihydrosphingosine
    • Dihydro-C18-sphingosine
    • Sphinganine (d18:0)
    • D-erythro-C18-Dihydro-D-sphingosine
    • D-erythro-Dihydro-D-sphingosine
    • erythro-Sphinganine
    • (2S,3R)-2-amino-1,3-octadecanediol
    • C18-Sphingosine, dihydro-
    • (R-(R*,S*))-2-Aminooctadecane-1,3-diol
    • CHEMBL448741
    • C18-sphinganine
    • 3102-56-5
    • EINECS 212-116-0
    • UNII-YT0ZSD64HM
    • dihydro-D-erythrosphingosine
    • phinganine
    • MFCD00079141
    • D-erythro-DHS
    • DIHYDROSPINGOSINE
    • Tocris-0749
    • C18-dihydro-Sphingosine
    • cid_3126
    • CBiol_002042
    • SCHEMBL40592
    • BSPBio_001288
    • KBioGR_000008
    • KBioSS_000008
    • Dihydro-D-erythro-Sphingosine
    • MLS001066334
    • (+)-erythro-dihydrosphingosine
    • BML3-D04
    • GTPL2453
    • orb1710787
    • Dihydrosphingosine (sphinganine)
    • BCBcMAP01_000225
    • KBio2_000008
    • KBio2_002576
    • KBio2_005144
    • KBio3_000015
    • KBio3_000016
    • MSK2578
    • Bio1_000328
    • Bio1_000817
    • Bio1_001306
    • Bio2_000008
    • Bio2_000488
    • D-erythro-Sphinganine, C18 chain
    • HMS1361A10
    • HMS1791A10
    • HMS1989A10
    • HMS2232G12
    • HMS3402A10
    • BDBM50244355
    • LMSP01020001
    • MFCD07371371
    • AKOS037645439
    • D-erythro-Dihydrosphingosine, >=98%
    • 2-amino-D-erythro-1,3-Octadecanediol
    • FS16403
    • HY-W019838
    • IDI1_033758
    • NCGC00024767-01
    • NCGC00024767-02
    • NCGC00024767-03
    • NCGC00024767-04
    • AS-60774
    • BP-42452
    • SMR000471878
    • SY351065
    • [R-(R*,S*)]-2-amino-1,3-Octadecanediol
    • CS-0031629
    • NS00014822
    • C00836
    • G13399
    • SR-01000597679
    • 1,3-Octadecanediol, 2-amino-, D-erythro- (8CI)
    • Sphinganine (d18:0), D-erythro-sphinganine, powder
    • SR-01000597679-1
    • 1,3-Octadecanediol, 2-amino-, (2S,3R)- (9CI)
    • BRD-K93944989-001-08-0
    • Q27088847
    • 82E0B6E3-6AE1-425F-A39E-5BED56511028
    • 764-22-7

  • Applications

    Sphinganine (dihydrosphingosine), CAS 764-22-7, is a core building block of sphingolipids and is commonly used as a precursor for synthesizing ceramides and related sphingolipids; in the cosmetics and personal care industry it is used indirectly as a lipid-building component for ceramide-based moisturizers and skin-conditioning formulations; it serves as a starting point for the synthesis of sphingolipids in pharmaceutical research and biomaterials development; it is employed as an analytical standard and reference in lipidomics for the quantification of sphingolipids in biological samples; it finds use in lipid-based drug delivery research, including liposome and lipid nanoparticle systems; and it may be used as a building block for synthetic sphingolipids in biomaterial or polymer research.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 37.54
    methanol 58.9
    isopropanol 32.94
    water 0.14
    ethyl acetate 57.51
    n-propanol 43.69
    acetone 57.33
    n-butanol 49.56
    acetonitrile 16.71
    DMF 104.84
    toluene 17.49
    isobutanol 40.97
    1,4-dioxane 102.61
    methyl acetate 39.49
    THF 351.63
    2-butanone 56.64
    n-pentanol 37.09
    sec-butanol 36.87
    n-hexane 6.2
    ethylene glycol 5.38
    NMP 259.5
    cyclohexane 30.21
    DMSO 346.94
    n-butyl acetate 104.37
    n-octanol 39.13
    chloroform 148.11
    n-propyl acetate 102.6
    acetic acid 78.1
    dichloromethane 130.32
    cyclohexanone 256.26
    propylene glycol 16.05
    isopropyl acetate 69.35
    DMAc 157.51
    2-ethoxyethanol 102.6
    isopentanol 64.59
    n-heptane 12.81
    ethyl formate 50.18
    1,2-dichloroethane 109.86
    n-hexanol 41.78
    2-methoxyethanol 122.07
    isobutyl acetate 73.42
    tetrachloromethane 49.66
    n-pentyl acetate 132.51
    transcutol 407.94
    n-heptanol 55.61
    ethylbenzene 16.67
    MIBK 74.42
    2-propoxyethanol 104.57
    tert-butanol 72.77
    MTBE 55.44
    2-butoxyethanol 140.7
    propionic acid 58.36
    o-xylene 22.83
    formic acid 22.33
    diethyl ether 34.65
    m-xylene 19.05
    p-xylene 24.36
    chlorobenzene 39.43
    dimethyl carbonate 25.47
    n-octane 5.33
    formamide 41.52
    cyclopentanone 286.25
    2-pentanone 67.31
    anisole 36.88
    cyclopentyl methyl ether 144.23
    gamma-butyrolactone 298.77
    1-methoxy-2-propanol 118.16
    pyridine 73.32
    3-pentanone 55.75
    furfural 204.3
    n-dodecane 2.61
    diethylene glycol 57.53
    diisopropyl ether 21.35
    tert-amyl alcohol 67.94
    acetylacetone 110.01
    n-hexadecane 3.08
    acetophenone 68.77
    methyl propionate 54.69
    isopentyl acetate 113.78
    trichloroethylene 199.3
    n-nonanol 39.45
    cyclohexanol 102.18
    benzyl alcohol 40.42
    2-ethylhexanol 46.62
    isooctanol 56.58
    dipropyl ether 79.93
    1,2-dichlorobenzene 58.02
    ethyl lactate 60.15
    propylene carbonate 175.9
    n-methylformamide 53.68
    2-pentanol 35.34
    n-pentane 5.04
    1-propoxy-2-propanol 125.12
    1-methoxy-2-propyl acetate 117.77
    2-(2-methoxypropoxy) propanol 83.14
    mesitylene 18.72
    ε-caprolactone 230.73
    p-cymene 25.79
    epichlorohydrin 227.57
    1,1,1-trichloroethane 109.33
    2-aminoethanol 21.59
    morpholine-4-carbaldehyde 199.15
    sulfolane 633.98
    2,2,4-trimethylpentane 7.14
    2-methyltetrahydrofuran 178.28
    n-hexyl acetate 101.66
    isooctane 4.62
    2-(2-butoxyethoxy)ethanol 138.09
    sec-butyl acetate 71.16
    tert-butyl acetate 121.34
    decalin 11.33
    glycerin 38.24
    diglyme 314.38
    acrylic acid 41.86
    isopropyl myristate 32.57
    n-butyric acid 141.28
    acetyl acetate 54.38
    di(2-ethylhexyl) phthalate 36.54
    ethyl propionate 68.92
    nitromethane 125.84
    1,2-diethoxyethane 116.76
    benzonitrile 44.87
    trioctyl phosphate 33.96
    1-bromopropane 44.57
    gamma-valerolactone 385.07
    n-decanol 24.25
    triethyl phosphate 64.68
    4-methyl-2-pentanol 34.25
    propionitrile 22.5
    vinylene carbonate 111.03
    1,1,2-trichlorotrifluoroethane 241.02
    DMS 56.3
    cumene 17.07
    2-octanol 36.97
    2-hexanone 73.15
    octyl acetate 44.19
    limonene 46.29
    1,2-dimethoxyethane 177.96
    ethyl orthosilicate 69.13
    tributyl phosphate 42.22
    diacetone alcohol 152.65
    N,N-dimethylaniline 36.21
    acrylonitrile 25.59
    aniline 34.76
    1,3-propanediol 55.09
    bromobenzene 41.39
    dibromomethane 87.68
    1,1,2,2-tetrachloroethane 226.54
    2-methyl-cyclohexyl acetate 99.91
    tetrabutyl urea 56.48
    diisobutyl methanol 38.9
    2-phenylethanol 45.03
    styrene 17.2
    dioctyl adipate 63.5
    dimethyl sulfate 84.49
    ethyl butyrate 107.25
    methyl lactate 50.71
    butyl lactate 117.83
    diethyl carbonate 57.78
    propanediol butyl ether 100.54
    triethyl orthoformate 102.15
    p-tert-butyltoluene 25.99
    methyl 4-tert-butylbenzoate 101.72
    morpholine 158.14
    tert-butylamine 42.14
    n-dodecanol 16.29
    dimethoxymethane 76.89
    ethylene carbonate 111.01
    cyrene 114.74
    2-ethoxyethyl acetate 132.33
    2-ethylhexyl acetate 90.48
    1,2,4-trichlorobenzene 73.33
    4-methylpyridine 57.82
    dibutyl ether 60.27
    2,6-dimethyl-4-heptanol 38.9
    DEF 113.84
    dimethyl isosorbide 196.87
    tetrachloroethylene 166.76
    eugenol 84.89
    triacetin 124.27
    span 80 85.11
    1,4-butanediol 21.31
    1,1-dichloroethane 67.33
    2-methyl-1-pentanol 45.78
    methyl formate 39.63
    2-methyl-1-butanol 53.5
    n-decane 6.02
    butyronitrile 35.06
    3,7-dimethyl-1-octanol 40.42
    1-chlorooctane 29.57
    1-chlorotetradecane 8.21
    n-nonane 5.93
    undecane 3.63
    tert-butylcyclohexane 9.18
    cyclooctane 8.84
    cyclopentanol 110.56
    tetrahydropyran 148.38
    tert-amyl methyl ether 53.52
    2,5,8-trioxanonane 168.17
    1-hexene 15.31
    2-isopropoxyethanol 83.65
    2,2,2-trifluoroethanol 49.02
    methyl butyrate 115.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction