Span 40

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  • Identifiers

    CAS number
    26266-57-9

    Molecular formula
    C22H42O6

    SMILES
    CCCCCCCCCCCCCCCC(=O)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 59.3%
    Fatty 52.14%
    Oily 44.39%
    Odorless 40.57%
    Creamy 24.77%
    Milky 24.68%
    Buttery 24.25%
    Lactonic 23.43%
    Sweet 23.09%
    Peach 21.94%

     

    Flavor
    Waxy 45.14%
    Fatty 42.68%
    Mild 37.48%
    Bland 36.55%
    Oily 35.61%
    Odorless 32.2%
    Faint 24.16%
    Slightly waxy 23.32%
    Creamy 23.32%
    Coconut 23.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    6.45 (neutral)

    Molecular weight
    402.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    703°C

    Flash point

    • 220.26 ˚C est.

    Solubility expt.

    • Soluble at temperatures above its melting point in ethanol, methanol, ether, ethyl acetate, aniline, toluene, dioxane, petroleum ether and carbon tetrachloride. Insoluble in cold water but dispersible in warm water

  • Synonyms

    • Span 40
    • SORBITAN MONOPALMITATE
    • Arlacel 40
    • 26266-57-9
    • Palmitate de sorbitan
    • Sorbitani palmitas
    • Sorbitan palmitate
    • INS NO.495
    • INS-495
    • 77K6Z421KU
    • D-Glucitol, 1,4-anhydro-, 6-hexadecanoate
    • 1,4-Anhydro-D-glucitol, 6-hexadecanoate
    • E-495
    • RefChem:888279
    • 247-568-8
    • 2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl hexadecanoate
    • Sorbitan, monohexadecanoate
    • Sorbitan monohexadecanoate
    • Sorbitan palmitate [INN]
    • Glycomul P
    • Liposorb P
    • Protachem SMP
    • Sorbitan palmitas
    • Crill 2
    • Montane 40
    • Nikkol SP10
    • Nonion PP40
    • Sorgen 70
    • Nissan nonion PP40
    • Rheodol SP-P 10
    • Sorbitan, monopalmitate
    • Emsorb 2510
    • Nissan nonion PP 40R
    • MFCD00080946
    • [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate
    • Palmitato de sorbitano
    • UNII-77K6Z421KU
    • Sorbitani palmitas [INN-Latin]
    • Sorbitan monopalmitate [USAN:NF]
    • NCGC00181308-01
    • EINECS 247-568-8
    • Palmitate de sorbitan [INN-French]
    • Span 40 (=Sorbitan Monopalmitate)
    • Palmitato de sorbitan
    • Palmitato de sorbitano [INN-Spanish]
    • AI3-03901
    • DSSTox_CID_9335
    • EC 247-568-8
    • DSSTox_RID_78767
    • DSSTox_GSID_29335
    • CHEMBL3186294
    • SCHEMBL13700731
    • DTXSID90873164
    • (2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl hexadecanoate
    • (R)-2-((2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl palmitate
    • CHEBI:190605
    • IYFATESGLOUGBX-YVNJGZBMSA-N
    • SORBITAN MONOPALMITATE [II]
    • SORBITAN PALMITATE [MART.]
    • SORBITAN MONOPALMITATE [FCC]
    • Tox21_112783
    • SORBITAN MONOPALMITATE [USAN]
    • HY-W129513
    • SORBITAN PALMITATE [EP MONOGRAPH]
    • 1,4-Anhydro-6-O-hexadecanoyl-D-glucitol
    • DA-58030
    • CAS-26266-57-9
    • CS-0187643
    • S0061
    • [(2R)-2-[(2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] hexadecanoate
    • 26266-57-9

  • Applications

    Span 40 is a nonionic surfactant based on sorbitan monopalmitate, used as an emulsifier and stabilizer for oil-in-water emulsions in cosmetics and personal care; in pharmaceuticals for topical formulations; in household and cleaning products as an emulsifier and surfactant; as a dispersing and emulsifying agent in coatings, paints, and inks; and as an emulsification or processing aid in polymer and plastics manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.33
    methanol 56.49
    isopropanol 14.77
    water 2.37
    ethyl acetate 53.85
    n-propanol 21.83
    acetone 77.43
    n-butanol 18.15
    acetonitrile 25.15
    DMF 167.68
    toluene 12.47
    isobutanol 17.49
    1,4-dioxane 75.07
    methyl acetate 49.96
    THF 199.4
    2-butanone 56.67
    n-pentanol 18.83
    sec-butanol 20.0
    n-hexane 1.38
    ethylene glycol 8.86
    NMP 304.8
    cyclohexane 5.66
    DMSO 478.05
    n-butyl acetate 39.21
    n-octanol 25.95
    chloroform 103.97
    n-propyl acetate 56.12
    acetic acid 138.91
    dichloromethane 118.45
    cyclohexanone 165.97
    propylene glycol 14.89
    isopropyl acetate 56.4
    DMAc 318.84
    2-ethoxyethanol 83.88
    isopentanol 22.14
    n-heptane 1.91
    ethyl formate 44.89
    1,2-dichloroethane 79.89
    n-hexanol 14.86
    2-methoxyethanol 97.21
    isobutyl acetate 35.99
    tetrachloromethane 25.32
    n-pentyl acetate 85.8
    transcutol 312.56
    n-heptanol 26.64
    ethylbenzene 10.26
    MIBK 46.01
    2-propoxyethanol 61.69
    tert-butanol 31.46
    MTBE 31.43
    2-butoxyethanol 95.82
    propionic acid 61.39
    o-xylene 17.45
    formic acid 75.95
    diethyl ether 17.81
    m-xylene 12.5
    p-xylene 15.57
    chlorobenzene 26.59
    dimethyl carbonate 46.26
    n-octane 1.73
    formamide 117.92
    cyclopentanone 195.25
    2-pentanone 53.25
    anisole 28.69
    cyclopentyl methyl ether 73.45
    gamma-butyrolactone 243.74
    1-methoxy-2-propanol 75.93
    pyridine 61.93
    3-pentanone 46.72
    furfural 175.3
    n-dodecane 1.37
    diethylene glycol 47.99
    diisopropyl ether 10.7
    tert-amyl alcohol 35.15
    acetylacetone 130.25
    n-hexadecane 1.59
    acetophenone 57.59
    methyl propionate 57.44
    isopentyl acetate 46.74
    trichloroethylene 161.36
    n-nonanol 26.29
    cyclohexanol 42.21
    benzyl alcohol 32.21
    2-ethylhexanol 14.36
    isooctanol 25.2
    dipropyl ether 17.28
    1,2-dichlorobenzene 36.3
    ethyl lactate 49.9
    propylene carbonate 136.61
    n-methylformamide 76.94
    2-pentanol 14.81
    n-pentane 1.11
    1-propoxy-2-propanol 50.71
    1-methoxy-2-propyl acetate 70.62
    2-(2-methoxypropoxy) propanol 74.6
    mesitylene 10.11
    ε-caprolactone 171.65
    p-cymene 10.32
    epichlorohydrin 182.97
    1,1,1-trichloroethane 77.26
    2-aminoethanol 21.75
    morpholine-4-carbaldehyde 211.69
    sulfolane 474.63
    2,2,4-trimethylpentane 2.25
    2-methyltetrahydrofuran 97.61
    n-hexyl acetate 79.56
    isooctane 1.16
    2-(2-butoxyethoxy)ethanol 103.27
    sec-butyl acetate 43.4
    tert-butyl acetate 78.15
    decalin 3.78
    glycerin 39.66
    diglyme 239.14
    acrylic acid 60.11
    isopropyl myristate 22.8
    n-butyric acid 97.71
    acetyl acetate 67.53
    di(2-ethylhexyl) phthalate 28.71
    ethyl propionate 47.61
    nitromethane 225.8
    1,2-diethoxyethane 63.98
    benzonitrile 34.88
    trioctyl phosphate 23.81
    1-bromopropane 22.03
    gamma-valerolactone 290.38
    n-decanol 16.08
    triethyl phosphate 37.7
    4-methyl-2-pentanol 13.71
    propionitrile 18.32
    vinylene carbonate 109.39
    1,1,2-trichlorotrifluoroethane 216.76
    DMS 61.15
    cumene 9.51
    2-octanol 20.55
    2-hexanone 42.26
    octyl acetate 34.31
    limonene 15.79
    1,2-dimethoxyethane 116.27
    ethyl orthosilicate 35.76
    tributyl phosphate 30.38
    diacetone alcohol 100.3
    N,N-dimethylaniline 26.91
    acrylonitrile 30.14
    aniline 25.95
    1,3-propanediol 35.19
    bromobenzene 25.26
    dibromomethane 57.48
    1,1,2,2-tetrachloroethane 158.76
    2-methyl-cyclohexyl acetate 46.34
    tetrabutyl urea 43.56
    diisobutyl methanol 11.18
    2-phenylethanol 28.44
    styrene 11.15
    dioctyl adipate 46.53
    dimethyl sulfate 136.34
    ethyl butyrate 41.28
    methyl lactate 60.66
    butyl lactate 80.68
    diethyl carbonate 30.23
    propanediol butyl ether 77.64
    triethyl orthoformate 43.24
    p-tert-butyltoluene 10.66
    methyl 4-tert-butylbenzoate 89.59
    morpholine 107.09
    tert-butylamine 14.3
    n-dodecanol 10.64
    dimethoxymethane 84.63
    ethylene carbonate 99.41
    cyrene 97.49
    2-ethoxyethyl acetate 121.38
    2-ethylhexyl acetate 35.47
    1,2,4-trichlorobenzene 51.37
    4-methylpyridine 49.12
    dibutyl ether 26.1
    2,6-dimethyl-4-heptanol 11.18
    DEF 101.34
    dimethyl isosorbide 137.12
    tetrachloroethylene 110.16
    eugenol 75.38
    triacetin 133.47
    span 80 63.91
    1,4-butanediol 19.39
    1,1-dichloroethane 49.38
    2-methyl-1-pentanol 23.1
    methyl formate 61.41
    2-methyl-1-butanol 22.39
    n-decane 2.9
    butyronitrile 19.35
    3,7-dimethyl-1-octanol 23.05
    1-chlorooctane 15.51
    1-chlorotetradecane 4.86
    n-nonane 2.51
    undecane 1.87
    tert-butylcyclohexane 2.66
    cyclooctane 2.21
    cyclopentanol 52.12
    tetrahydropyran 67.48
    tert-amyl methyl ether 33.78
    2,5,8-trioxanonane 137.61
    1-hexene 4.98
    2-isopropoxyethanol 60.05
    2,2,2-trifluoroethanol 106.58
    methyl butyrate 73.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction