Sodium Thioglycolate

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  • Identifiers

    CAS number
    367-51-1

    Molecular formula
    C2H3NaO2S

    SMILES
    C(C(=O)[O-])S.[Na+]

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Sulfurous 61.37%
    Odorless 50.91%
    Meaty 49.41%
    Savory 37.66%
    Roasted 33.21%
    Cooked 26.85%
    Onion 25.69%
    Alliaceous 22.72%
    Garlic 20.86%
    Cheesy 20.48%

     

    Flavor
    Odorless 57.96%
    Sour 25.64%
    Mild 23.7%
    Sulfury 22.04%
    Mousy 21.2%
    Acidic 21.14%
    Cooked 21.1%
    Bland 20.82%
    Faint 20.51%
    Yeast 20.34%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    6.64 (neutral)

    Molecular weight
    114.1 g/mol

    Melting point expt.

    • greater than 572 °F (NTP, 1992)

    Flash point

    • 95.55 ˚C est.

    Solubility expt.

    • Very soluble (NTP, 1992)

  • Synonyms

    • SODIUM THIOGLYCOLATE
    • 367-51-1
    • Sodium mercaptoacetate
    • Mercaptoacetic acid sodium salt
    • Sodium thioglycollate
    • Thioglycolate sodium
    • Mercaptoacetic acid, sodium salt
    • sodium sulfanylacetate
    • Sodium 2-mercatoethanoate
    • Thioglycollic acid, sodium salt
    • Acetic acid, mercapto-, monosodium salt
    • Thioglycolic acid, sodium salt
    • CCRIS 4874
    • USAF EK-5199
    • EINECS 206-696-4
    • EINECS 253-166-3
    • Thioglycolic acid sodium salt
    • UNII-D94M78P69V
    • DTXSID3026142
    • CHEBI:86481
    • SODIUM THIOGLYCOLATE [II]
    • SODIUM THIOGLYCOLATE [MI]
    • EC 206-696-4
    • 36722-22-2
    • SODIUM THIOGLYCOLATE (II)
    • Sodium 2sulfanylacetate
    • Sodium 2mercatoethanoate
    • THIOGLYCOLATESODIUM
    • RefChem:184129
    • USAF EK5199
    • DTXCID806142
    • SODIUM 2-MERCAPTOETHANOATE
    • 2-mercaptoacetate, monosodium salt
    • SODIUM THIOGLYCOLATE [INCI]
    • Acetic acid, mercapto, monosodium salt
    • 2Mercaptoacetic acid sodium salt (1:1)
    • Acetic acid, 2mercapto, sodium salt (1:1)
    • 253-166-3
    • sodium 2-mercaptoacetate
    • Sodium 2-sulfanylacetate
    • sodium;2-sulfanylacetate
    • D94M78P69V
    • Mollescal SF
    • Acetic acid, mercapto-, sodium salt
    • MFCD00043386
    • Erhavit D
    • Thioglycolate (sodium)
    • Mercaptoacetic acid monosodium salt
    • C2H3NaO2S
    • SCHEMBL60834
    • Mercaptoacetic acid,sodium salt
    • orb1685372
    • sodium;2-hydroxy-2-oxoethanethiolate
    • AKOS015897598
    • CCG-214509
    • FM36434
    • HY-W115724
    • AS-58194
    • CS-0197966
    • M0053
    • NS00078303
    • Acetic acid, 2-mercapto-, sodium salt (1:1)
    • E78328
    • A823356
    • F987478
    • Q3991662
    • Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt
    • 367-51-1

  • Applications

    Sodium Thioglycolate (CAS 367-51-1) is primarily used as a reducing agent to cleave disulfide bonds in keratin, making it common in depilatory cosmetics and hair removal formulations. It is also employed as a processing aid and complexing/reducing agent in certain industrial formulations, including cleaners and metal surface pretreatment, due to its metal-binding and redox properties. As a thiol-containing compound, it is often used as an intermediate or a thiol-functional additive in polymer, adhesive, and formulation chemistry. Its use is formulation- and regulation-dependent, and it should be handled in accordance with local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 367.81
    methanol 707.14
    isopropanol 242.45
    water 396.28
    ethyl acetate 155.6
    n-propanol 211.61
    acetone 704.51
    n-butanol 169.24
    acetonitrile 555.42
    DMF 1436.49
    toluene 46.58
    isobutanol 137.48
    1,4-dioxane 326.57
    methyl acetate 285.43
    THF 242.92
    2-butanone 287.48
    n-pentanol 139.72
    sec-butanol 158.64
    n-hexane 25.06
    ethylene glycol 302.56
    NMP 769.12
    cyclohexane 18.76
    DMSO 1276.2
    n-butyl acetate 94.33
    n-octanol 104.19
    chloroform 107.08
    n-propyl acetate 136.19
    acetic acid 657.83
    dichloromethane 205.52
    cyclohexanone 234.14
    propylene glycol 161.38
    isopropyl acetate 90.91
    DMAc 925.78
    2-ethoxyethanol 378.59
    isopentanol 139.79
    n-heptane 15.64
    ethyl formate 247.54
    1,2-dichloroethane 179.85
    n-hexanol 85.78
    2-methoxyethanol 599.14
    isobutyl acetate 65.29
    tetrachloromethane 22.33
    n-pentyl acetate 90.97
    transcutol 834.78
    n-heptanol 58.9
    ethylbenzene 47.22
    MIBK 109.88
    2-propoxyethanol 204.4
    tert-butanol 258.29
    MTBE 131.02
    2-butoxyethanol 151.71
    propionic acid 285.11
    o-xylene 56.56
    formic acid 675.64
    diethyl ether 151.81
    m-xylene 43.02
    p-xylene 62.68
    chlorobenzene 61.24
    dimethyl carbonate 141.89
    n-octane 10.56
    formamide 943.3
    cyclopentanone 287.78
    2-pentanone 199.48
    anisole 145.2
    cyclopentyl methyl ether 102.05
    gamma-butyrolactone 359.69
    1-methoxy-2-propanol 337.69
    pyridine 221.38
    3-pentanone 159.23
    furfural 487.83
    n-dodecane 11.5
    diethylene glycol 284.43
    diisopropyl ether 40.98
    tert-amyl alcohol 175.25
    acetylacetone 289.43
    n-hexadecane 12.17
    acetophenone 197.33
    methyl propionate 184.58
    isopentyl acetate 69.65
    trichloroethylene 227.5
    n-nonanol 90.65
    cyclohexanol 109.26
    benzyl alcohol 147.65
    2-ethylhexanol 53.48
    isooctanol 46.55
    dipropyl ether 64.9
    1,2-dichlorobenzene 72.36
    ethyl lactate 99.21
    propylene carbonate 162.19
    n-methylformamide 771.07
    2-pentanol 113.58
    n-pentane 25.09
    1-propoxy-2-propanol 131.32
    1-methoxy-2-propyl acetate 97.14
    2-(2-methoxypropoxy) propanol 197.17
    mesitylene 35.06
    ε-caprolactone 207.23
    p-cymene 28.8
    epichlorohydrin 301.05
    1,1,1-trichloroethane 72.67
    2-aminoethanol 310.51
    morpholine-4-carbaldehyde 759.43
    sulfolane 442.41
    2,2,4-trimethylpentane 10.73
    2-methyltetrahydrofuran 152.68
    n-hexyl acetate 136.45
    isooctane 8.46
    2-(2-butoxyethoxy)ethanol 286.08
    sec-butyl acetate 69.32
    tert-butyl acetate 90.97
    decalin 13.65
    glycerin 275.62
    diglyme 479.52
    acrylic acid 357.94
    isopropyl myristate 60.29
    n-butyric acid 197.23
    acetyl acetate 126.4
    di(2-ethylhexyl) phthalate 67.38
    ethyl propionate 114.58
    nitromethane 1258.09
    1,2-diethoxyethane 196.92
    benzonitrile 155.0
    trioctyl phosphate 53.47
    1-bromopropane 79.55
    gamma-valerolactone 495.76
    n-decanol 72.39
    triethyl phosphate 49.28
    4-methyl-2-pentanol 64.85
    propionitrile 201.78
    vinylene carbonate 200.99
    1,1,2-trichlorotrifluoroethane 266.58
    DMS 129.83
    cumene 40.75
    2-octanol 53.66
    2-hexanone 161.0
    octyl acetate 82.49
    limonene 36.7
    1,2-dimethoxyethane 576.76
    ethyl orthosilicate 44.25
    tributyl phosphate 68.87
    diacetone alcohol 165.47
    N,N-dimethylaniline 145.07
    acrylonitrile 346.29
    aniline 103.25
    1,3-propanediol 320.68
    bromobenzene 44.98
    dibromomethane 116.85
    1,1,2,2-tetrachloroethane 155.77
    2-methyl-cyclohexyl acetate 60.17
    tetrabutyl urea 121.28
    diisobutyl methanol 37.13
    2-phenylethanol 93.72
    styrene 63.2
    dioctyl adipate 100.53
    dimethyl sulfate 267.84
    ethyl butyrate 80.77
    methyl lactate 158.14
    butyl lactate 99.87
    diethyl carbonate 59.33
    propanediol butyl ether 214.28
    triethyl orthoformate 57.76
    p-tert-butyltoluene 25.52
    methyl 4-tert-butylbenzoate 130.35
    morpholine 327.69
    tert-butylamine 133.72
    n-dodecanol 58.76
    dimethoxymethane 429.6
    ethylene carbonate 151.92
    cyrene 171.26
    2-ethoxyethyl acetate 149.71
    2-ethylhexyl acetate 51.9
    1,2,4-trichlorobenzene 83.97
    4-methylpyridine 231.3
    dibutyl ether 96.26
    2,6-dimethyl-4-heptanol 37.13
    DEF 326.73
    dimethyl isosorbide 205.0
    tetrachloroethylene 126.92
    eugenol 167.08
    triacetin 171.19
    span 80 153.02
    1,4-butanediol 178.48
    1,1-dichloroethane 102.27
    2-methyl-1-pentanol 118.37
    methyl formate 608.7
    2-methyl-1-butanol 125.61
    n-decane 16.32
    butyronitrile 161.32
    3,7-dimethyl-1-octanol 83.27
    1-chlorooctane 44.55
    1-chlorotetradecane 24.17
    n-nonane 16.12
    undecane 13.33
    tert-butylcyclohexane 12.94
    cyclooctane 9.01
    cyclopentanol 126.65
    tetrahydropyran 141.84
    tert-amyl methyl ether 102.01
    2,5,8-trioxanonane 363.49
    1-hexene 61.8
    2-isopropoxyethanol 202.59
    2,2,2-trifluoroethanol 307.57
    methyl butyrate 169.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction