Sodium Starch Glycolate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    9063-38-1

    Molecular formula
    C11H14FNO3S

    SMILES
    CCCS(=O)(=O)CC(=O)NC1=CC=C(C=C1)F

    Safety labels

  • Odor profile

    Fragrance
    Odorless 39.94%
    Meaty 38.04%
    Roasted 35.23%
    Cooked 32.67%
    Savory 32.24%
    Fruity 28.86%
    Grape 26.71%
    Sulfurous 20.54%
    Citrus 19.94%
    Burnt 19.56%

     

    Flavor
    Bitter 51.72%
    Odorless 32.05%
    Mild 26.39%
    Bland 22.38%
    Roasted 21.88%
    Cooked 21.57%
    Nitrile 20.91%
    Taco 20.71%
    Roasted peanuts 20.68%
    Bread crust 20.1%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    6.58 (neutral)

    Molecular weight
    259.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    506°C

    Flash point

    • 212.42 ˚C est.

  • Synonyms

    • SODIUM STARCH GLYCOLATE (II)
    • SODIUM STARCH GLYCOLATE [II]
    • SODIUM STARCH GLYCOLATE (MART.)
    • SODIUM STARCH GLYCOLATE [MART.]
    • Sodium starch glycolate type a
    • SODIUM STARCH GLYCOLATE TYPE A (USP-RS)
    • SODIUM STARCH GLYCOLATE TYPE A [USP-RS]
    • SODIUM STARCH GLYCOLATE TYPE A POTATO (II)
    • SODIUM STARCH GLYCOLATE TYPE A POTATO [II]
    • SODIUM STARCH GLYCOLATE (TYPE A) (EP MONOGRAPH)
    • SODIUM STARCH GLYCOLATE (TYPE A) [EP MONOGRAPH]
    • Covagel
    • Explotab
    • Glycolys
    • Primojel
    • Explotab (TN)
    • Sodium starch glycollate
    • RefChem:887881
    • H8AV0SQX4D
    • Carboxymethyl starch sodium salt
    • DTXSID6051271
    • Sodium starch glycolate (type a)
    • dium starch glycolate type A potato
    • SODIUM STARCH GLYCOLATE [JAN]
    • 5856J3G2A2
    • SODIUM STARCH GLYCOLATE [VANDF]
    • Starch, carboxymethyl ether, sodium salt
    • SODIUM STARCH GLYCOLLATE [WHO-DD]
    • SODIUM STARCH GLYCOLATE TYPE A POTATO
    • Starch, carboxymethyl ether, monosodium salt
    • SODIUM STARCH GLYCOLATE TYPE A, UNSPECIFIED SOURCE
    • 618-597-7
    • 9063-38-1
    • Carboxy methyl starch sodium
    • SODIUM CARBOXYL METHYLSTARCH
    • Sodium carboxyl methylstarch, CMS-Na
    • 9063-38-1

  • Applications

    Chemical name: Sodium Starch Glycolate; CAS number: 9063-38-1. Sodium Starch Glycolate is a widely used pharmaceutical excipient that functions as a superdisintegrant in solid oral dosage forms, promoting rapid tablet or capsule disintegration by absorbing water and swelling in the gastrointestinal environment. It is commonly employed in tablet and capsule formulations across direct compression and wet granulation processes to improve disintegration, dissolution performance, and content uniformity. It is also valued in fast-dissolving or chewable dosage forms for faster onset and in low-dose formulations as a bulk excipient that contributes disintegration efficiency. In formulation development, SSG is routinely evaluated for swelling, wetting behavior, and compatibility with active ingredients and other excipients, and its use is typically guided by pharmacopeial standards and regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 46.29
    methanol 80.9
    isopropanol 23.07
    water 0.15
    ethyl acetate 48.43
    n-propanol 27.52
    acetone 229.55
    n-butanol 23.84
    acetonitrile 102.88
    DMF 473.0
    toluene 4.29
    isobutanol 15.19
    1,4-dioxane 73.76
    methyl acetate 62.32
    THF 216.11
    2-butanone 114.54
    n-pentanol 16.59
    sec-butanol 20.06
    n-hexane 0.25
    ethylene glycol 14.0
    NMP 319.63
    cyclohexane 0.64
    DMSO 619.45
    n-butyl acetate 27.46
    n-octanol 5.38
    chloroform 52.62
    n-propyl acetate 29.87
    acetic acid 75.13
    dichloromethane 60.6
    cyclohexanone 123.59
    propylene glycol 27.53
    isopropyl acetate 31.33
    DMAc 396.86
    2-ethoxyethanol 78.64
    isopentanol 20.31
    n-heptane 0.35
    ethyl formate 54.71
    1,2-dichloroethane 50.94
    n-hexanol 11.01
    2-methoxyethanol 195.97
    isobutyl acetate 14.43
    tetrachloromethane 1.96
    n-pentyl acetate 11.47
    transcutol 301.41
    n-heptanol 4.7
    ethylbenzene 4.33
    MIBK 38.97
    2-propoxyethanol 61.86
    tert-butanol 28.44
    MTBE 13.48
    2-butoxyethanol 22.21
    propionic acid 35.15
    o-xylene 4.67
    formic acid 55.85
    diethyl ether 17.91
    m-xylene 3.93
    p-xylene 5.63
    chlorobenzene 13.06
    dimethyl carbonate 37.59
    n-octane 0.15
    formamide 146.33
    cyclopentanone 181.13
    2-pentanone 76.93
    anisole 33.69
    cyclopentyl methyl ether 34.65
    gamma-butyrolactone 174.87
    1-methoxy-2-propanol 120.57
    pyridine 59.17
    3-pentanone 52.96
    furfural 185.21
    n-dodecane 0.24
    diethylene glycol 74.27
    diisopropyl ether 3.67
    tert-amyl alcohol 21.96
    acetylacetone 142.29
    n-hexadecane 0.28
    acetophenone 47.4
    methyl propionate 50.85
    isopentyl acetate 24.81
    trichloroethylene 101.0
    n-nonanol 5.48
    cyclohexanol 17.96
    benzyl alcohol 29.57
    2-ethylhexanol 7.59
    isooctanol 4.34
    dipropyl ether 10.58
    1,2-dichlorobenzene 16.69
    ethyl lactate 30.69
    propylene carbonate 91.28
    n-methylformamide 148.94
    2-pentanol 11.08
    n-pentane 0.24
    1-propoxy-2-propanol 40.62
    1-methoxy-2-propyl acetate 57.08
    2-(2-methoxypropoxy) propanol 63.85
    mesitylene 2.76
    ε-caprolactone 86.56
    p-cymene 4.6
    epichlorohydrin 186.25
    1,1,1-trichloroethane 19.97
    2-aminoethanol 31.99
    morpholine-4-carbaldehyde 231.0
    sulfolane 279.76
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 62.71
    n-hexyl acetate 18.71
    isooctane 0.23
    2-(2-butoxyethoxy)ethanol 69.94
    sec-butyl acetate 18.46
    tert-butyl acetate 38.74
    decalin 0.63
    glycerin 60.87
    diglyme 139.95
    acrylic acid 41.62
    isopropyl myristate 8.76
    n-butyric acid 46.34
    acetyl acetate 45.13
    di(2-ethylhexyl) phthalate 15.58
    ethyl propionate 32.18
    nitromethane 282.08
    1,2-diethoxyethane 39.98
    benzonitrile 37.69
    trioctyl phosphate 8.48
    1-bromopropane 12.6
    gamma-valerolactone 255.61
    n-decanol 4.29
    triethyl phosphate 19.27
    4-methyl-2-pentanol 7.84
    propionitrile 41.39
    vinylene carbonate 75.35
    1,1,2-trichlorotrifluoroethane 127.88
    DMS 33.49
    cumene 3.63
    2-octanol 2.82
    2-hexanone 43.31
    octyl acetate 11.31
    limonene 6.87
    1,2-dimethoxyethane 175.08
    ethyl orthosilicate 15.33
    tributyl phosphate 14.34
    diacetone alcohol 75.5
    N,N-dimethylaniline 23.86
    acrylonitrile 67.57
    aniline 19.87
    1,3-propanediol 50.52
    bromobenzene 9.53
    dibromomethane 27.72
    1,1,2,2-tetrachloroethane 78.73
    2-methyl-cyclohexyl acetate 27.21
    tetrabutyl urea 27.12
    diisobutyl methanol 5.58
    2-phenylethanol 24.28
    styrene 6.11
    dioctyl adipate 23.89
    dimethyl sulfate 90.46
    ethyl butyrate 29.27
    methyl lactate 60.93
    butyl lactate 21.42
    diethyl carbonate 23.5
    propanediol butyl ether 36.39
    triethyl orthoformate 21.46
    p-tert-butyltoluene 3.91
    methyl 4-tert-butylbenzoate 34.69
    morpholine 107.0
    tert-butylamine 9.84
    n-dodecanol 3.38
    dimethoxymethane 149.53
    ethylene carbonate 56.26
    cyrene 77.97
    2-ethoxyethyl acetate 29.53
    2-ethylhexyl acetate 17.31
    1,2,4-trichlorobenzene 25.23
    4-methylpyridine 53.89
    dibutyl ether 8.87
    2,6-dimethyl-4-heptanol 5.58
    DEF 97.33
    dimethyl isosorbide 118.28
    tetrachloroethylene 27.41
    eugenol 37.06
    triacetin 40.67
    span 80 34.92
    1,4-butanediol 17.17
    1,1-dichloroethane 26.5
    2-methyl-1-pentanol 15.4
    methyl formate 108.42
    2-methyl-1-butanol 17.57
    n-decane 0.34
    butyronitrile 43.72
    3,7-dimethyl-1-octanol 7.52
    1-chlorooctane 2.32
    1-chlorotetradecane 1.18
    n-nonane 0.27
    undecane 0.28
    tert-butylcyclohexane 0.45
    cyclooctane 0.19
    cyclopentanol 28.02
    tetrahydropyran 41.2
    tert-amyl methyl ether 14.41
    2,5,8-trioxanonane 116.84
    1-hexene 2.16
    2-isopropoxyethanol 37.11
    2,2,2-trifluoroethanol 35.15
    methyl butyrate 48.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction