Sodium Salicylate

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  • Identifiers

    CAS number
    54-21-7

    Molecular formula
    C7H5NaO3

    SMILES
    C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Phenolic 62.22%
    Sweet 52.4%
    Odorless 44.03%
    Balsamic 41.98%
    Bitter 36.6%
    Nutty 34.83%
    Medicinal 34.2%
    Aromatic 31.52%
    Almond 31.37%
    Vanilla 28.95%

     

    Flavor
    Phenolic 58.62%
    Nutty 42.37%
    Mild 40.11%
    Odorless 39.45%
    Bitter 32.22%
    Faint 29.83%
    Balsam 28.32%
    Balsamic 24.91%
    Urine 24.76%
    Honey 23.35%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.87 (weak acid)

    Molecular weight
    160.1 g/mol

    Flash point

    • 113.13 ˚C est.

  • Synonyms

    • Sodium salicylate
    • 54-21-7
    • Enterosalicyl
    • Kerasalicyl
    • Alysine
    • Benzoic acid, 2-hydroxy-, monosodium salt
    • Natrum salicylicum
    • salicylate sodium
    • Salicylic acid sodium salt
    • Monosodium 2-hydroxybenzoate
    • DTXSID5021708
    • Natrii salicylas
    • WIQ1H85SYP
    • Salicylate, sodium
    • NSC-202167
    • DTXCID701708
    • Benzoic acid, 2-hydroxy-, sodium salt (1:1)
    • NSC202167
    • Sod sal
    • Pro-Prin
    • SaliGard 60
    • RefChem:6246
    • UNI-SOL
    • UNI-SOL 60
    • Aspen Sodium Salicylate 48.6%
    • AquaPrime Liquid Sodium Salicylate
    • Aquasource Aqua-Prin Water Soluble Sodium Salicylate
    • 200-198-0
    • Sodium 2-hydroxybenzoate
    • Salsonin
    • Clin
    • Enterosalil
    • Entrosalyl
    • Glutosalyl
    • Kerosal
    • Magsalyl
    • Nadisal
    • Salisod
    • Aroall
    • Monosodium salicylate
    • Neo-salicyl
    • Diuretin
    • Parbocyl-rev
    • sodium;2-hydroxybenzoate
    • Salicylic acid, sodium salt
    • Sodium o-hydroxybenzoate
    • salicylic acid sodium
    • MFCD00002440
    • o-Hydroxybenzoic acid, sodium salt
    • Salicylic acid sodium salt;2-Hydroxybenzoic acid sodium salt
    • sodiumsalicylate
    • Natrium salicylat [German]
    • CCRIS 6715
    • EINECS 200-198-0
    • UNII-WIQ1H85SYP
    • NSC 202167
    • Sodium salicylate [USP:JAN]
    • Sodium salicylate CRS
    • sodium;2-carboxyphenolate
    • Sodium salicylate, 99%
    • Spectrum2_001945
    • Spectrum3_000900
    • Spectrum4_000995
    • Spectrum5_001120
    • EC 200-198-0
    • SCHEMBL4603
    • KBioGR_001429
    • Sodium Salicylate (Standard)
    • 90218-94-3
    • SPECTRUM1500533
    • SPBio_002009
    • CHEBI:9180
    • CHEMBL447868
    • HY-B0167AR
    • orb1310710
    • SODIUM SALICYLATE [JAN]
    • SCHEMBL29888959
    • Sodium salicylate (JP18/USP)
    • HY-B0167A
    • KBio3_001820
    • MSK3406
    • NATRUM SALICYLICUM [HPUS]
    • SODIUM SALICYLATE [VANDF]
    • SODIUM SALICYLATE [MART.]
    • HMS1920P16
    • HMS2092G17
    • SALICYLATE SODIUM [WHO-DD]
    • SODIUM SALICYLATE [USP-RS]
    • SODIUM SALICYLATE [WHO-IP]
    • Sodium salicylate, p.a., 99.5%
    • Tox21_200411
    • CCG-39474
    • AKOS003051698
    • AKOS005766021
    • CS-2008
    • CAS-54-21-7
    • NATRII SALICYLAS [WHO-IP LATIN]
    • SALICYLIC ACID SODIUM SALT [MI]
    • SODIUM SALICYLATE [EP MONOGRAPH]
    • NCGC00094780-01
    • NCGC00094780-02
    • NCGC00257965-01
    • SODIUM SALICYLATE [USP MONOGRAPH]
    • FS157080
    • SY010161
    • DB-052516
    • NS00074304
    • C07587
    • D00566
    • D83111
    • Sodium salicylate, ReagentPlus(R), >=99.5%
    • Sodium salicylate, SAJ first grade, >=99.5%
    • Sodium salicylate, tested according to Ph.Eur.
    • Sodium salicylate, SAJ special grade, >=99.5%
    • Q414547
    • Sodium salicylate, Vetec(TM) reagent grade, 99%
    • Sodium salicylate, meets USP testing specifications
    • Sodium salicylate, puriss. p.a., >=99.5% (NT)
    • Sodium salicylate, European Pharmacopoeia (EP) Reference Standard
    • Sodium salicylate, United States Pharmacopeia (USP) Reference Standard
    • Benzoic acid,2-hydroxy-,monosodium salt,coupled with 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid,diazotized 2-(4-aminophenyl)-1H-benzimidazol-5-amine and diazotized 4-nitrobenzenamine,sodium
    • 54-21-7

  • Applications

    Sodium Salicylate (CAS 54-21-7) is the sodium salt of salicylic acid and is primarily used as an intermediate in the synthesis of salicylates and salicylate esters; it can also serve as a source of salicylic acid for pharmaceutical synthesis. In the pharmaceutical industry, it is used as a precursor or salt form for producing salicylate derivatives. In cosmetics and personal care, it can act as a pH buffering agent and a solubilizer for phenolic actives. In cleaning and household formulations, sodium salicylate is used as a buffering and solubilizing additive to improve processing and compatibility of active ingredients. It may also be used as a starting material in polymer or coatings-related applications where salicylate functionality is desired, depending on formulation and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 935.25
    methanol 1465.24
    isopropanol 633.01
    water 2.69
    ethyl acetate 685.98
    n-propanol 675.38
    acetone 1182.6
    n-butanol 628.19
    acetonitrile 683.94
    DMF 3354.22
    toluene 52.55
    isobutanol 371.29
    1,4-dioxane 862.31
    methyl acetate 778.23
    THF 3502.3
    2-butanone 935.34
    n-pentanol 398.32
    sec-butanol 555.88
    n-hexane 9.12
    ethylene glycol 428.79
    NMP 1094.34
    cyclohexane 4.65
    DMSO 3833.51
    n-butyl acetate 202.15
    n-octanol 180.11
    chloroform 74.78
    n-propyl acetate 319.59
    acetic acid 331.4
    dichloromethane 107.77
    cyclohexanone 411.88
    propylene glycol 410.59
    isopropyl acetate 309.05
    DMAc 1223.3
    2-ethoxyethanol 1004.58
    isopentanol 448.38
    n-heptane 8.78
    ethyl formate 384.72
    1,2-dichloroethane 233.66
    n-hexanol 321.86
    2-methoxyethanol 2305.73
    isobutyl acetate 95.33
    tetrachloromethane 12.37
    n-pentyl acetate 138.08
    transcutol 2051.98
    n-heptanol 144.23
    ethylbenzene 38.79
    MIBK 345.8
    2-propoxyethanol 796.85
    tert-butanol 665.07
    MTBE 317.5
    2-butoxyethanol 343.36
    propionic acid 362.12
    o-xylene 42.57
    formic acid 301.43
    diethyl ether 491.7
    m-xylene 54.42
    p-xylene 38.15
    chlorobenzene 61.07
    dimethyl carbonate 344.4
    n-octane 5.4
    formamide 951.78
    cyclopentanone 1060.84
    2-pentanone 874.77
    anisole 190.76
    cyclopentyl methyl ether 556.77
    gamma-butyrolactone 1186.81
    1-methoxy-2-propanol 1535.06
    pyridine 270.52
    3-pentanone 400.73
    furfural 540.2
    n-dodecane 7.36
    diethylene glycol 803.65
    diisopropyl ether 92.97
    tert-amyl alcohol 495.09
    acetylacetone 662.3
    n-hexadecane 8.23
    acetophenone 154.16
    methyl propionate 670.09
    isopentyl acetate 141.17
    trichloroethylene 245.92
    n-nonanol 162.31
    cyclohexanol 244.98
    benzyl alcohol 161.55
    2-ethylhexanol 120.76
    isooctanol 98.64
    dipropyl ether 149.25
    1,2-dichlorobenzene 56.68
    ethyl lactate 199.13
    propylene carbonate 342.66
    n-methylformamide 1601.99
    2-pentanol 433.94
    n-pentane 10.56
    1-propoxy-2-propanol 436.54
    1-methoxy-2-propyl acetate 290.83
    2-(2-methoxypropoxy) propanol 320.84
    mesitylene 36.83
    ε-caprolactone 356.0
    p-cymene 29.08
    epichlorohydrin 1377.67
    1,1,1-trichloroethane 103.78
    2-aminoethanol 646.63
    morpholine-4-carbaldehyde 951.07
    sulfolane 1152.42
    2,2,4-trimethylpentane 7.59
    2-methyltetrahydrofuran 1087.95
    n-hexyl acetate 209.55
    isooctane 8.99
    2-(2-butoxyethoxy)ethanol 634.64
    sec-butyl acetate 167.16
    tert-butyl acetate 306.84
    decalin 7.33
    glycerin 557.21
    diglyme 882.16
    acrylic acid 294.27
    isopropyl myristate 96.58
    n-butyric acid 405.95
    acetyl acetate 218.9
    di(2-ethylhexyl) phthalate 58.85
    ethyl propionate 298.13
    nitromethane 1388.42
    1,2-diethoxyethane 365.57
    benzonitrile 146.87
    trioctyl phosphate 66.74
    1-bromopropane 125.12
    gamma-valerolactone 901.92
    n-decanol 129.07
    triethyl phosphate 70.0
    4-methyl-2-pentanol 195.34
    propionitrile 481.15
    vinylene carbonate 229.93
    1,1,2-trichlorotrifluoroethane 405.23
    DMS 176.04
    cumene 29.54
    2-octanol 107.13
    2-hexanone 385.32
    octyl acetate 127.66
    limonene 42.58
    1,2-dimethoxyethane 1041.47
    ethyl orthosilicate 61.04
    tributyl phosphate 74.54
    diacetone alcohol 570.76
    N,N-dimethylaniline 112.95
    acrylonitrile 626.73
    aniline 122.08
    1,3-propanediol 920.88
    bromobenzene 40.91
    dibromomethane 71.07
    1,1,2,2-tetrachloroethane 209.69
    2-methyl-cyclohexyl acetate 81.86
    tetrabutyl urea 111.68
    diisobutyl methanol 77.2
    2-phenylethanol 151.75
    styrene 42.95
    dioctyl adipate 115.56
    dimethyl sulfate 469.86
    ethyl butyrate 155.28
    methyl lactate 442.34
    butyl lactate 137.06
    diethyl carbonate 97.02
    propanediol butyl ether 377.47
    triethyl orthoformate 92.17
    p-tert-butyltoluene 30.59
    methyl 4-tert-butylbenzoate 149.33
    morpholine 1297.73
    tert-butylamine 244.75
    n-dodecanol 93.35
    dimethoxymethane 1675.32
    ethylene carbonate 204.31
    cyrene 226.37
    2-ethoxyethyl acetate 221.4
    2-ethylhexyl acetate 92.47
    1,2,4-trichlorobenzene 73.73
    4-methylpyridine 269.77
    dibutyl ether 137.75
    2,6-dimethyl-4-heptanol 77.2
    DEF 739.26
    dimethyl isosorbide 413.87
    tetrachloroethylene 105.83
    eugenol 179.98
    triacetin 159.47
    span 80 205.99
    1,4-butanediol 326.9
    1,1-dichloroethane 162.77
    2-methyl-1-pentanol 250.74
    methyl formate 1064.88
    2-methyl-1-butanol 388.24
    n-decane 10.72
    butyronitrile 448.93
    3,7-dimethyl-1-octanol 136.12
    1-chlorooctane 59.72
    1-chlorotetradecane 26.22
    n-nonane 9.14
    undecane 9.0
    tert-butylcyclohexane 8.45
    cyclooctane 3.17
    cyclopentanol 449.53
    tetrahydropyran 632.82
    tert-amyl methyl ether 255.15
    2,5,8-trioxanonane 633.67
    1-hexene 57.55
    2-isopropoxyethanol 480.05
    2,2,2-trifluoroethanol 144.9
    methyl butyrate 378.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction