Sodium propionate

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  • Identifiers

    CAS number
    137-40-6

    Molecular formula
    C3H5NaO2

    SMILES
    CCC(=O)[O-].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sour 54.24%
    Odorless 49.12%
    Cheesy 48.57%
    Buttery 39.79%
    Caramellic 37.36%
    Sharp 33.27%
    Milky 33.26%
    Pungent 31.99%
    Dairy 31.62%
    Fatty 30.3%

     

    Flavor
    Pungent 40.08%
    Cheese 37.8%
    Acidic 34.87%
    Sour 33.88%
    Sweet 31.66%
    Butter 30.75%
    Rancid 30.69%
    Odorless 30.48%
    Sharp 26.09%
    Caramel 25.87%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    4.02 (weak acid)

    Molecular weight
    96.06 g/mol

    Melting point expt.

    • 210 °C

    Flash point

    • 19.77 ˚C est.
    • >250 °C o.c.

    Solubility expt.

    • 1 g dissolves in about 1 ml water, in about 0.65 ml boiling water, in about 24 ml alcohol @ 25 °C
    • Soluble in water forming alkaline solutions. Slightly soluble in alcohol.
    • Solubility in water, g/100ml: 100 (good)

  • Synonyms

    • SODIUM PROPIONATE
    • 137-40-6
    • Sodium propanoate
    • Propionic acid sodium salt
    • Propanoic acid, sodium salt
    • SODIUMPROPIONATE
    • Propionic acid, sodium salt
    • sodium;propanoate
    • Propanoic acid, sodium salt (1:1)
    • Sodium propionate anhydrous
    • Natriumpropionat
    • Sodium hydrogen dipropionate
    • Sodium dipropionate
    • Propanoic acid, sodium salt (2:1)
    • DK6Y9P42IN
    • Mycoban; Napropion; Ocuseptine
    • Ocuseptine
    • DTXSID7021996
    • Napropion
    • 63785-15-9
    • EINECS 264-460-6
    • Deketon
    • E281
    • Impedex
    • Keenate
    • Propiofar
    • Propisol
    • Propi-ophtal
    • Whit-pro
    • Bioban-S
    • DTXCID001996
    • SODIUM PROPIONATE-2,3-13C2, 99 ATOM % 13 C
    • Caswell No. 707A
    • Propionan sodny
    • Propionan sodny [Czech]
    • Natriumpropionat [German]
    • CHEMBL500826
    • CAS-137-40-6
    • CCRIS 1896
    • HSDB 766
    • Propionic acid sodium
    • NCGC00159468-02
    • EINECS 205-290-4
    • EPA Pesticide Chemical Code 077703
    • Sodium propionate; Sodium propanoate; Propionic acid sodium salt
    • MFCD00002759
    • UNII-DK6Y9P42IN
    • SODIUM PROPIONATE [II]
    • SODIUM PROPIONATE [MI]
    • INS NO.281
    • SODIUM PROPIONATE [FCC]
    • HY-B1773A
    • INS-281
    • SODIUM PROPIONATE [VANDF]
    • ANHYDROUS SODIUM PROPIONATE
    • CHEBI:132106
    • SODIUM PROPIONATE [MART.]
    • 391O0PO49R
    • SODIUM PROPIONATE [USP-RS]
    • SODIUM PROPIONATE [WHO-DD]
    • Natriumpropionat [veterinary] (TN)
    • Tox21_113044
    • Tox21_202735
    • AKOS003051488
    • AKOS015892835
    • SODIUM PROPIONATE [EP MONOGRAPH]
    • NCGC00260283-01
    • SODIUM PROPIONATE ANHYDROUS [HSDB]
    • ANHYDROUS SODIUM PROPIONATE [MART.]
    • CS-0013802
    • E-281
    • NS00079169
    • P0512
    • D08440
    • EN300-7399958
    • A807253
    • Q420130

  • Applications

    Sodium propionate (CAS 137-40-6) is a versatile carboxylate salt valued for its strong antifungal and antibacterial activity: in the food industry it is labeled E281 and extends the shelf life of bread, pastries, cheese, processed meats and fermented drinks by preventing mold growth and mycotoxin formation; in animal nutrition it protects cereals and bran from spoilage and helps stabilize gut pH in livestock; in pharmaceuticals it appears in topical antifungal creams and mouthwashes; in cosmetics and personal-care products it serves as a pH buffer and microbial inhibitor for lotions, rinses and hand cleansers; it is also applied in warehouse fumigation, metal-corrosion inhibitors and biodegradable plastic additives thanks to its water solubility, low toxicity, ease of formulation and compliance with international safety regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 607.64
    methanol 971.01
    isopropanol 443.51
    water 199.46
    ethyl acetate 339.62
    n-propanol 382.01
    acetone 852.17
    n-butanol 351.83
    acetonitrile 903.67
    DMF 1535.96
    toluene 105.47
    isobutanol 307.31
    1,4-dioxane 521.8
    methyl acetate 572.41
    THF 388.86
    2-butanone 529.58
    n-pentanol 302.27
    sec-butanol 395.67
    n-hexane 50.79
    ethylene glycol 300.53
    NMP 1265.84
    cyclohexane 31.03
    DMSO 1360.57
    n-butyl acetate 222.77
    n-octanol 179.59
    chloroform 443.17
    n-propyl acetate 272.81
    acetic acid 1355.43
    dichloromethane 607.41
    cyclohexanone 478.53
    propylene glycol 273.35
    isopropyl acetate 205.48
    DMAc 1265.93
    2-ethoxyethanol 524.08
    isopentanol 318.87
    n-heptane 21.38
    ethyl formate 447.44
    1,2-dichloroethane 449.2
    n-hexanol 192.88
    2-methoxyethanol 730.55
    isobutyl acetate 131.47
    tetrachloromethane 74.16
    n-pentyl acetate 202.23
    transcutol 1119.68
    n-heptanol 119.12
    ethylbenzene 119.91
    MIBK 212.43
    2-propoxyethanol 333.37
    tert-butanol 526.76
    MTBE 341.93
    2-butoxyethanol 244.26
    propionic acid 648.46
    o-xylene 131.31
    formic acid 933.64
    diethyl ether 248.23
    m-xylene 95.87
    p-xylene 187.63
    chlorobenzene 227.2
    dimethyl carbonate 210.02
    n-octane 16.45
    formamide 1164.18
    cyclopentanone 565.17
    2-pentanone 336.86
    anisole 314.58
    cyclopentyl methyl ether 210.68
    gamma-butyrolactone 813.44
    1-methoxy-2-propanol 474.26
    pyridine 457.31
    3-pentanone 276.88
    furfural 964.89
    n-dodecane 17.43
    diethylene glycol 326.99
    diisopropyl ether 81.99
    tert-amyl alcohol 504.01
    acetylacetone 474.71
    n-hexadecane 18.5
    acetophenone 366.79
    methyl propionate 329.18
    isopentyl acetate 193.16
    trichloroethylene 750.9
    n-nonanol 150.6
    cyclohexanol 246.42
    benzyl alcohol 291.17
    2-ethylhexanol 124.45
    isooctanol 101.6
    dipropyl ether 99.09
    1,2-dichlorobenzene 269.57
    ethyl lactate 160.47
    propylene carbonate 445.36
    n-methylformamide 957.82
    2-pentanol 252.45
    n-pentane 42.69
    1-propoxy-2-propanol 214.35
    1-methoxy-2-propyl acetate 201.21
    2-(2-methoxypropoxy) propanol 304.71
    mesitylene 69.75
    ε-caprolactone 494.29
    p-cymene 65.74
    epichlorohydrin 652.78
    1,1,1-trichloroethane 269.36
    2-aminoethanol 430.14
    morpholine-4-carbaldehyde 1077.5
    sulfolane 923.07
    2,2,4-trimethylpentane 35.86
    2-methyltetrahydrofuran 377.57
    n-hexyl acetate 300.68
    isooctane 20.06
    2-(2-butoxyethoxy)ethanol 415.65
    sec-butyl acetate 162.24
    tert-butyl acetate 228.04
    decalin 33.01
    glycerin 368.28
    diglyme 638.12
    acrylic acid 732.47
    isopropyl myristate 101.8
    n-butyric acid 500.39
    acetyl acetate 295.52
    di(2-ethylhexyl) phthalate 130.64
    ethyl propionate 225.71
    nitromethane 1994.79
    1,2-diethoxyethane 322.7
    benzonitrile 382.64
    trioctyl phosphate 86.81
    1-bromopropane 204.67
    gamma-valerolactone 865.33
    n-decanol 113.59
    triethyl phosphate 97.15
    4-methyl-2-pentanol 149.29
    propionitrile 405.0
    vinylene carbonate 512.59
    1,1,2-trichlorotrifluoroethane 537.14
    DMS 278.82
    cumene 98.83
    2-octanol 112.46
    2-hexanone 282.78
    octyl acetate 145.63
    limonene 86.18
    1,2-dimethoxyethane 735.29
    ethyl orthosilicate 93.7
    tributyl phosphate 126.95
    diacetone alcohol 322.68
    N,N-dimethylaniline 259.07
    acrylonitrile 673.63
    aniline 220.19
    1,3-propanediol 466.49
    bromobenzene 196.38
    dibromomethane 341.64
    1,1,2,2-tetrachloroethane 526.38
    2-methyl-cyclohexyl acetate 132.7
    tetrabutyl urea 166.52
    diisobutyl methanol 77.23
    2-phenylethanol 201.54
    styrene 156.81
    dioctyl adipate 163.27
    dimethyl sulfate 424.37
    ethyl butyrate 164.45
    methyl lactate 240.62
    butyl lactate 180.84
    diethyl carbonate 129.2
    propanediol butyl ether 327.69
    triethyl orthoformate 111.98
    p-tert-butyltoluene 61.71
    methyl 4-tert-butylbenzoate 247.77
    morpholine 550.33
    tert-butylamine 304.52
    n-dodecanol 86.05
    dimethoxymethane 443.67
    ethylene carbonate 363.3
    cyrene 260.69
    2-ethoxyethyl acetate 296.43
    2-ethylhexyl acetate 147.38
    1,2,4-trichlorobenzene 300.34
    4-methylpyridine 549.84
    dibutyl ether 160.19
    2,6-dimethyl-4-heptanol 77.23
    DEF 597.59
    dimethyl isosorbide 360.32
    tetrachloroethylene 373.93
    eugenol 279.51
    triacetin 323.1
    span 80 240.31
    1,4-butanediol 268.96
    1,1-dichloroethane 352.52
    2-methyl-1-pentanol 301.3
    methyl formate 754.7
    2-methyl-1-butanol 318.27
    n-decane 25.71
    butyronitrile 358.23
    3,7-dimethyl-1-octanol 168.61
    1-chlorooctane 90.49
    1-chlorotetradecane 41.95
    n-nonane 25.41
    undecane 20.59
    tert-butylcyclohexane 35.3
    cyclooctane 13.07
    cyclopentanol 287.09
    tetrahydropyran 286.77
    tert-amyl methyl ether 297.11
    2,5,8-trioxanonane 462.72
    1-hexene 136.45
    2-isopropoxyethanol 322.38
    2,2,2-trifluoroethanol 520.26
    methyl butyrate 346.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction