Sodium Phosphate, Dibasic

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  • Identifiers

    CAS number
    7558-79-4

    Molecular formula
    HNa2O4P

    SMILES
    OP(=O)([O-])[O-].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 82.12%
    Clean 17.91%
    Sour 17.89%
    Sweet 15.18%
    Sharp 13.81%
    Bitter 12.85%
    Balsamic 12.23%
    Savory 12.21%
    Alcoholic 11.55%
    Milky 11.42%

     

    Flavor
    Odorless 70.05%
    Sour 33.87%
    Vinegar 25.11%
    Bland 22.95%
    Formyl 20.64%
    Pungent 20.52%
    Mousy 20.02%
    Soy 19.53%
    Acidic 19.26%
    Yeast 19.1%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    2.57 (strong acid)

    Molecular weight
    141.959 g/mol

    Melting point expt.

    • MP: loses H2O at 92.5 °C; Specific gravity: 2.066 at 15 °C /Disodium phosphate dihydrate/
    • Translucent crystals or granules; readily loses 5 mols of water on exposure to air at ordinary temp. Melting point 34-35 °C (when it contains the full 12 mols of H2O). Specific gravity 1.5. Soluble in 3 parts water; practically insoluble in alcohol. Aqueous solution is alkaline, pH=9.5. /Dodecahydrate/

    Flash point

    • 154.65 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Freely soluble in water. Insoluble in ethanol
    • Colorless crystals; 11.8 G sol in 100 cc water at 25 °C /Disodium phosphate heptahydrate/
    • 100 g sol in 100 ml water at 50 °C; 117 g sol in 100 ml water at 80 °C. /Disodium phosphate dihydrate/
    • 11.8 g sol in 100 ml water at 25 °C /Disodium phosphate dodecahydrate/
    • 11.8 g/100 g water at 25 °C
    • Soluble in 8 parts water, much more soluble in hot water. Solubility per 100 gal water increases from 14 lbs at slightly >0 °C to over 900 lbs at 95 °C. Insoluble in alcohol. /Anhydrous/
    • Solubility in water, g/100ml at 20 °C: 7.7

  • Synonyms

    • 7558-79-4
    • Sodium phosphate dibasic
    • DISODIUM PHOSPHATE
    • Disodium hydrogen phosphate
    • Disodium hydrogenorthophosphate
    • Sodium phosphate, dibasic
    • Dibasic sodium phosphate
    • Acetest
    • disodium hydrogenphosphate
    • Disodium acid phosphate
    • Soda phosphate
    • Disodium orthophosphate
    • Exsiccated sodium phosphate
    • Phosphoric acid, disodium salt
    • Sodium hydrogen phosphate
    • Phosphate of soda
    • Sodium monohydrogen phosphate
    • FEMA No. 2398
    • secondary Sodium phosphate
    • disodium;hydrogen phosphate
    • Natriumphosphat
    • Disodium acid orthophosphate
    • Caswell No. 778
    • Disodium hydrophosphate
    • Fleet enema
    • Disodium phosphate, anhydrous
    • Sodium hydrogenphosphate
    • Disodium phosphoric acid
    • Disodium monohydrogen phosphate
    • Na2HPO4
    • FEMA Number 2398
    • Natriumphosphat [German]
    • Disodium hydrogen phosphate, anhydrous
    • Hydrogen disodium phosphate
    • sec-Sodium phosphate
    • Sodium phosphate (NaHPO4)
    • Sodium phosphate, exsiccated
    • SODIUM PHOSPHATE, DIBASIC, ANHYDROUS
    • Sodium phosphate, dibasic (anhydrous)
    • CCRIS 5931
    • HSDB 376
    • Sodium orthophosphate, secondary
    • Sodium acid phosphate, anhydrous
    • Sodium Phosphate dibasic anhydrous
    • SODIUM PHOSPHATE, DIBASIC ANHYDROUS
    • EINECS 231-448-7
    • Phosphoric acid, sodium salt (1:2)
    • Disodium hydrogen monophosphate
    • EPA Pesticide Chemical Code 076403
    • Sodium monohydrogen phosphate (2:1:1)
    • 22ADO53M6F
    • Dibasic sodium phosphate anhydrous
    • dibasic sodium phosphate, anhydrous
    • MFCD00003496
    • phosphoric acid, disodium salt, anhydrous
    • INS NO.339(II)
    • DSP
    • DTXSID1026039
    • CHEBI:34683
    • INS-339(II)
    • DISODIUM PHOSPHATE [HSDB]
    • Sodium phosphate,dibasic,anhydrous
    • EC 231-448-7
    • disodium hydrogen phosphate anhydrous
    • E-339(II)
    • SODIUM PHOSPHATE, DIBASIC [MI]
    • DISODIUM PHOSPHATE [EP MONOGRAPH]
    • SODIUM PHOSPHATE DIBASIC [WHO-DD]
    • Disodium phosphate anhydrous
    • SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [II]
    • SODIUM PHOSPHATE,DIBASIC,ANHYDROUS [VANDF]
    • NATRIUMPHOSPHAT (GERMAN)
    • SODIUM PHOSPHATE, DIBASIC ANHYDROUS [ORANGE BOOK]
    • SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [ORANGE BOOK]
    • OSMOPREP COMPONENT SODIUM PHOSPHATE, DIBASIC ANHYDROUS
    • VISICOL COMPONENT SODIUM PHOSPHATE, DIBASIC ANHYDROUS
    • Sodium phosphate dibasic, anhydrous
    • SODIUM PHOSPHATE, (DIBASIC)
    • SODIUM PHOSPHATE, [DIBASIC]
    • SODIUM PHOSPHATE, DIBASIC (II)
    • SODIUM PHOSPHATE, DIBASIC [II]
    • DISODIUM PHOSPHATE (EP MONOGRAPH)
    • DIBASIC SODIUM PHOSPHATE (USP MONOGRAPH)
    • DIBASIC SODIUM PHOSPHATE [USP MONOGRAPH]
    • SODIUM PHOSPHATE, DIBASIC (USP IMPURITY)
    • SODIUM PHOSPHATE, DIBASIC [USP IMPURITY]
    • SODIUM PHOSPHATE, DIBASIC, ANHYDROUS (II)
    • UNII-22ADO53M6F
    • Disodium hydrogen orthophosphate
    • Disodium phospahte
    • Sodiumphosphatedibasic
    • Disodiumhydrogenphosphate
    • sodium hydrogen-phosphate
    • disodium hydrogen-phosphate
    • NAT. PHOS.
    • Sorensen's sodium phosphate
    • di-sodium hydrogen phosphate
    • di-Sodium hydrogen phosphate anhydrous, USP grade
    • phosphoric acid disodium salt
    • sodium hydrogen orthophosphate
    • Water Supply QC Check Sample: o-Phosphate Nutrients
    • FEMA NUMBER 2398.
    • SODIUM PHOSPHATE,DIBASIC
    • DTXCID106039
    • SODIUM PHOSPHATE [FHFI]
    • DISODIUM PHOSPHATE [INCI]
    • EXCICCATED SODIUM PHOSPHATE
    • BCP13559
    • SODIUM ORTHOPHOSPHATE DIBASIC
    • SODIUM PHOSPHATE (NA2HPO4)
    • Sodium hydrogen phosphate, anhydrous
    • Sodium phosphate dibasic, ACS grade
    • Disodium Hydrogen Phosphate Submicron
    • DISODIUM PHOSPHATE (NA2HPO4)
    • MONOHYDROGEN DISODIUM PHOSPHATE
    • AKOS015902440
    • AKOS015950661
    • ANHYDROUS SODIUM ACID PHOSPHATE
    • Sodium phosphate, dibasic, unspecified
    • CCG-266159
    • DB14502
    • di-Sodium hydrogen phosphate, anhydrous
    • FD30639
    • FS45392
    • SODIUM PHOSPHATE,DIBASIC [VANDF]
    • USEPA/OPP Pesticide Code: 076403
    • Sodium phosphate dibasic, ACS/HPLC grade
    • Sodium phosphate dibasic, biochemical grade

  • Applications

    Sodium Phosphate, Dibasic (CAS 7558-79-4) is used as a buffering and pH-control agent in pharmaceutical formulations and intravenous solutions; as a builder and water-softening component in household and industrial detergents and cleaners; as a buffering and chelating (sequestering) agent in food processing to regulate acidity, stabilize texture, and maintain color; in cosmetics/personal care as a buffering and chelating agent to stabilize formulations; in water treatment and industrial cleaning applications for pH adjustment and corrosion control; it may also serve as a phosphate source in some agricultural fertilizer formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 575.63
    methanol 1025.21
    isopropanol 455.03
    water 1459.1
    ethyl acetate 94.05
    n-propanol 355.75
    acetone 466.75
    n-butanol 265.18
    acetonitrile 238.17
    DMF 1721.38
    toluene 53.65
    isobutanol 224.86
    1,4-dioxane 377.04
    methyl acetate 159.22
    THF 487.79
    2-butanone 185.31
    n-pentanol 189.36
    sec-butanol 260.58
    n-hexane 35.66
    ethylene glycol 642.87
    NMP 603.49
    cyclohexane 45.73
    DMSO 1523.21
    n-butyl acetate 56.43
    n-octanol 89.1
    chloroform 59.84
    n-propyl acetate 76.45
    acetic acid 260.6
    dichloromethane 113.2
    cyclohexanone 153.59
    propylene glycol 397.72
    isopropyl acetate 70.76
    DMAc 851.27
    2-ethoxyethanol 472.12
    isopentanol 185.54
    n-heptane 33.71
    ethyl formate 153.86
    1,2-dichloroethane 137.25
    n-hexanol 123.15
    2-methoxyethanol 864.76
    isobutyl acetate 38.95
    tetrachloromethane 25.02
    n-pentyl acetate 56.34
    transcutol 329.33
    n-heptanol 90.2
    ethylbenzene 30.78
    MIBK 94.19
    2-propoxyethanol 311.44
    tert-butanol 428.28
    MTBE 163.97
    2-butoxyethanol 200.53
    propionic acid 169.31
    o-xylene 56.67
    formic acid 533.39
    diethyl ether 209.77
    m-xylene 46.59
    p-xylene 37.14
    chlorobenzene 31.83
    dimethyl carbonate 175.98
    n-octane 16.89
    formamide 772.47
    cyclopentanone 240.03
    2-pentanone 156.42
    anisole 92.83
    cyclopentyl methyl ether 189.14
    gamma-butyrolactone 235.14
    1-methoxy-2-propanol 572.02
    pyridine 146.84
    3-pentanone 119.82
    furfural 264.98
    n-dodecane 12.74
    diethylene glycol 445.27
    diisopropyl ether 61.51
    tert-amyl alcohol 242.66
    acetylacetone 153.5
    n-hexadecane 13.26
    acetophenone 80.13
    methyl propionate 145.19
    isopentyl acetate 40.21
    trichloroethylene 88.24
    n-nonanol 79.68
    cyclohexanol 155.86
    benzyl alcohol 109.25
    2-ethylhexanol 53.28
    isooctanol 62.15
    dipropyl ether 106.45
    1,2-dichlorobenzene 30.44
    ethyl lactate 99.29
    propylene carbonate 98.65
    n-methylformamide 730.8
    2-pentanol 179.4
    n-pentane 59.23
    1-propoxy-2-propanol 198.6
    1-methoxy-2-propyl acetate 85.81
    2-(2-methoxypropoxy) propanol 148.59
    mesitylene 40.94
    ε-caprolactone 117.74
    p-cymene 25.14
    epichlorohydrin 252.97
    1,1,1-trichloroethane 44.87
    2-aminoethanol 597.0
    morpholine-4-carbaldehyde 561.79
    sulfolane 358.45
    2,2,4-trimethylpentane 16.79
    2-methyltetrahydrofuran 203.79
    n-hexyl acetate 65.23
    isooctane 14.75
    2-(2-butoxyethoxy)ethanol 205.13
    sec-butyl acetate 44.53
    tert-butyl acetate 75.21
    decalin 14.96
    glycerin 611.89
    diglyme 341.33
    acrylic acid 179.98
    isopropyl myristate 39.05
    n-butyric acid 130.98
    acetyl acetate 55.32
    di(2-ethylhexyl) phthalate 41.92
    ethyl propionate 76.87
    nitromethane 436.26
    1,2-diethoxyethane 118.44
    benzonitrile 62.4
    trioctyl phosphate 40.76
    1-bromopropane 77.99
    gamma-valerolactone 316.62
    n-decanol 66.77
    triethyl phosphate 41.92
    4-methyl-2-pentanol 94.41
    propionitrile 148.47
    vinylene carbonate 98.47
    1,1,2-trichlorotrifluoroethane 211.72
    DMS 60.08
    cumene 28.48
    2-octanol 66.81
    2-hexanone 92.49
    octyl acetate 51.86
    limonene 34.25
    1,2-dimethoxyethane 599.5
    ethyl orthosilicate 41.82
    tributyl phosphate 39.83
    diacetone alcohol 156.36
    N,N-dimethylaniline 116.38
    acrylonitrile 186.59
    aniline 111.18
    1,3-propanediol 484.02
    bromobenzene 22.65
    dibromomethane 79.58
    1,1,2,2-tetrachloroethane 95.72
    2-methyl-cyclohexyl acetate 40.56
    tetrabutyl urea 76.86
    diisobutyl methanol 45.15
    2-phenylethanol 75.49
    styrene 35.21
    dioctyl adipate 55.15
    dimethyl sulfate 283.15
    ethyl butyrate 55.94
    methyl lactate 205.84
    butyl lactate 70.9
    diethyl carbonate 42.39
    propanediol butyl ether 173.06
    triethyl orthoformate 53.89
    p-tert-butyltoluene 26.69
    methyl 4-tert-butylbenzoate 94.7
    morpholine 416.48
    tert-butylamine 257.78
    n-dodecanol 56.49
    dimethoxymethane 757.73
    ethylene carbonate 95.54
    cyrene 144.89
    2-ethoxyethyl acetate 68.59
    2-ethylhexyl acetate 32.23
    1,2,4-trichlorobenzene 32.76
    4-methylpyridine 138.51
    dibutyl ether 61.25
    2,6-dimethyl-4-heptanol 45.15
    DEF 271.87
    dimethyl isosorbide 161.7
    tetrachloroethylene 79.06
    eugenol 125.58
    triacetin 66.5
    span 80 111.58
    1,4-butanediol 285.12
    1,1-dichloroethane 78.27
    2-methyl-1-pentanol 115.54
    methyl formate 508.08
    2-methyl-1-butanol 168.85
    n-decane 17.62
    butyronitrile 125.73
    3,7-dimethyl-1-octanol 57.51
    1-chlorooctane 34.78
    1-chlorotetradecane 21.26
    n-nonane 18.16
    undecane 14.69
    tert-butylcyclohexane 13.27
    cyclooctane 24.01
    cyclopentanol 230.07
    tetrahydropyran 193.17
    tert-amyl methyl ether 128.06
    2,5,8-trioxanonane 287.01
    1-hexene 58.75
    2-isopropoxyethanol 262.54
    2,2,2-trifluoroethanol 206.84
    methyl butyrate 99.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction