Sodium Palmitoyl Proline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    58725-33-0

    Molecular formula
    C21H38NNaO3

    SMILES
    CCCCCCCCCCCCCCCC(=O)N1CCC[C@H]1C(=O)[O-].[Na+]

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Waxy 38.71%
    Odorless 37.07%
    Fatty 29.56%
    Oily 28.63%
    Woody 28.55%
    Animal 26.58%
    Herbal 26.37%
    Savory 26.25%
    Fresh 25.56%
    Milky 24.22%

     

    Flavor
    Bland 32.95%
    Odorless 31.73%
    Mild 27.64%
    Herbal 27.42%
    Waxy 21.71%
    Faint 21.59%
    Slightly waxy 21.35%
    Fatty 20.79%
    Cedarleaf 20.35%
    Bay oil 20.15%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.24 (weak acid)

    Molecular weight
    375.5 g/mol

    Flash point

    • 211.79 ˚C est.

  • Synonyms

    • 58725-33-0
    • sodium palmitoyl proline
    • UNII-64L053FRFO
    • Sodium 5-oxo-1-palmitoyl-L-prolinate
    • 64L053FRFO
    • N-Palmitoyl-L-proline sodium salt
    • EINECS 261-406-3
    • SODIUM PALMITOYL PROLINE [WHO-DD]
    • RefChem:184056
    • SODIUM PALMITOYL PROLINE [INCI]
    • 1-(1-Oxohexadecyl)-L-proline sodium salt
    • N-Hexadecanoyl-proline mono sodium salt
    • MFCD09751056
    • sodium;(2S)-1-hexadecanoylpyrrolidine-2-carboxylate
    • L-Proline, 1-(1-oxohexadecyl)-, sodium salt
    • C21H38NNaO3
    • sodium palmitoyl-L-prolinate
    • Sodium (2S)-1-palmitoylpyrrolidine-2-carboxylate
    • SCHEMBL245579
    • sodium (2S)-1-hexadecanoylpyrrolidine-2-carboxylate
    • sodium N-palmitoyl-l-prolinate
    • GJIFNLAZXVYJDI-FYZYNONXSA-M
    • AKOS015919471
    • DS-0327
    • 1-(1-Oxohexadecyl)-L-prolinesodiumsalt
    • CS-0362630
    • Q27263761
    • L-PROLINE, 1-(1-OXOHEXADECYL)-, SODIUM SALT (1:1)
    • 58725-33-0

  • Applications

    Sodium Palmitoyl Proline (CAS 58725-33-0) is a fatty-acid–modified amino acid derivative that functions as a surfactant and skin-conditioning agent in cosmetics and personal care; it can act as a mild surfactant/emulsifier in household cleaners; in polymer and plastics formulations it may serve as a processing aid or stabilizer affecting rheology and film properties; it can be used as an excipient in topical pharmaceutical formulations; in coatings, inks, and dispersion systems it may improve wetting and pigment dispersion.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 185.1
    methanol 274.91
    isopropanol 171.77
    water 0.94
    ethyl acetate 481.36
    n-propanol 187.16
    acetone 454.0
    n-butanol 182.91
    acetonitrile 276.75
    DMF 715.75
    toluene 176.82
    isobutanol 162.23
    1,4-dioxane 372.82
    methyl acetate 379.25
    THF 914.99
    2-butanone 453.35
    n-pentanol 135.28
    sec-butanol 186.08
    n-hexane 13.05
    ethylene glycol 21.41
    NMP 1191.9
    cyclohexane 55.56
    DMSO 721.21
    n-butyl acetate 370.06
    n-octanol 80.69
    chloroform 1113.07
    n-propyl acetate 460.12
    acetic acid 336.35
    dichloromethane 1342.77
    cyclohexanone 1112.01
    propylene glycol 48.05
    isopropyl acetate 411.67
    DMAc 1071.75
    2-ethoxyethanol 294.3
    isopentanol 187.06
    n-heptane 7.24
    ethyl formate 298.86
    1,2-dichloroethane 888.33
    n-hexanol 87.71
    2-methoxyethanol 337.92
    isobutyl acetate 282.53
    tetrachloromethane 214.54
    n-pentyl acetate 483.9
    transcutol 826.24
    n-heptanol 85.26
    ethylbenzene 97.7
    MIBK 311.84
    2-propoxyethanol 242.81
    tert-butanol 199.64
    MTBE 250.24
    2-butoxyethanol 277.72
    propionic acid 282.84
    o-xylene 139.24
    formic acid 116.77
    diethyl ether 187.43
    m-xylene 119.33
    p-xylene 152.1
    chlorobenzene 406.14
    dimethyl carbonate 162.65
    n-octane 6.14
    formamide 267.21
    cyclopentanone 1074.11
    2-pentanone 426.77
    anisole 223.33
    cyclopentyl methyl ether 400.21
    gamma-butyrolactone 1167.4
    1-methoxy-2-propanol 302.02
    pyridine 655.24
    3-pentanone 324.7
    furfural 855.85
    n-dodecane 4.95
    diethylene glycol 131.88
    diisopropyl ether 73.77
    tert-amyl alcohol 216.16
    acetylacetone 580.38
    n-hexadecane 5.95
    acetophenone 355.72
    methyl propionate 348.77
    isopentyl acetate 355.82
    trichloroethylene 1507.02
    n-nonanol 79.58
    cyclohexanol 294.01
    benzyl alcohol 217.28
    2-ethylhexanol 75.09
    isooctanol 85.36
    dipropyl ether 100.1
    1,2-dichlorobenzene 433.69
    ethyl lactate 188.78
    propylene carbonate 716.46
    n-methylformamide 355.51
    2-pentanol 131.62
    n-pentane 12.09
    1-propoxy-2-propanol 195.79
    1-methoxy-2-propyl acetate 350.81
    2-(2-methoxypropoxy) propanol 205.21
    mesitylene 78.95
    ε-caprolactone 1045.09
    p-cymene 60.1
    epichlorohydrin 1174.06
    1,1,1-trichloroethane 790.99
    2-aminoethanol 82.32
    morpholine-4-carbaldehyde 801.64
    sulfolane 1371.46
    2,2,4-trimethylpentane 14.82
    2-methyltetrahydrofuran 665.69
    n-hexyl acetate 387.96
    isooctane 7.18
    2-(2-butoxyethoxy)ethanol 283.6
    sec-butyl acetate 336.01
    tert-butyl acetate 396.67
    decalin 27.12
    glycerin 80.23
    diglyme 659.63
    acrylic acid 227.43
    isopropyl myristate 100.6
    n-butyric acid 545.44
    acetyl acetate 356.88
    di(2-ethylhexyl) phthalate 115.87
    ethyl propionate 363.82
    nitromethane 732.31
    1,2-diethoxyethane 325.85
    benzonitrile 338.41
    trioctyl phosphate 76.64
    1-bromopropane 391.47
    gamma-valerolactone 1384.78
    n-decanol 49.1
    triethyl phosphate 147.14
    4-methyl-2-pentanol 84.21
    propionitrile 255.66
    vinylene carbonate 582.02
    1,1,2-trichlorotrifluoroethane 693.51
    DMS 286.09
    cumene 69.4
    2-octanol 76.47
    2-hexanone 331.03
    octyl acetate 145.46
    limonene 97.09
    1,2-dimethoxyethane 538.15
    ethyl orthosilicate 134.36
    tributyl phosphate 111.13
    diacetone alcohol 352.25
    N,N-dimethylaniline 150.68
    acrylonitrile 319.57
    aniline 239.29
    1,3-propanediol 150.08
    bromobenzene 436.36
    dibromomethane 776.35
    1,1,2,2-tetrachloroethane 1219.75
    2-methyl-cyclohexyl acetate 228.77
    tetrabutyl urea 152.61
    diisobutyl methanol 49.52
    2-phenylethanol 161.42
    styrene 132.68
    dioctyl adipate 185.47
    dimethyl sulfate 348.33
    ethyl butyrate 277.06
    methyl lactate 177.81
    butyl lactate 297.01
    diethyl carbonate 178.35
    propanediol butyl ether 200.29
    triethyl orthoformate 182.44
    p-tert-butyltoluene 53.69
    methyl 4-tert-butylbenzoate 293.57
    morpholine 560.39
    tert-butylamine 114.73
    n-dodecanol 32.97
    dimethoxymethane 309.71
    ethylene carbonate 541.41
    cyrene 261.94
    2-ethoxyethyl acetate 547.74
    2-ethylhexyl acetate 278.82
    1,2,4-trichlorobenzene 517.15
    4-methylpyridine 611.53
    dibutyl ether 129.14
    2,6-dimethyl-4-heptanol 49.52
    DEF 600.16
    dimethyl isosorbide 409.48
    tetrachloroethylene 836.93
    eugenol 259.04
    triacetin 414.09
    span 80 181.92
    1,4-butanediol 74.89
    1,1-dichloroethane 713.68
    2-methyl-1-pentanol 153.37
    methyl formate 227.56
    2-methyl-1-butanol 187.66
    n-decane 9.92
    butyronitrile 286.9
    3,7-dimethyl-1-octanol 82.74
    1-chlorooctane 73.72
    1-chlorotetradecane 21.54
    n-nonane 8.5
    undecane 6.58
    tert-butylcyclohexane 17.28
    cyclooctane 12.23
    cyclopentanol 302.9
    tetrahydropyran 517.81
    tert-amyl methyl ether 214.85
    2,5,8-trioxanonane 350.86
    1-hexene 65.97
    2-isopropoxyethanol 228.61
    2,2,2-trifluoroethanol 216.34
    methyl butyrate 547.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction