Sodium Methoxide

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  • Identifiers

    CAS number
    124-41-4

    Molecular formula
    CH3NaO

    SMILES
    C[O-].[Na+]

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Alcoholic 60.6%
    Fermented 49.61%
    Ethereal 49.49%
    Sweet 45.8%
    Solvent 43.54%
    Oily 33.94%
    Odorless 33.77%
    Musty 33.04%
    Winey 32.2%
    Fishy 32.16%

     

    Flavor
    Egg 31.25%
    Gasoline 30.92%
    Alcoholic 30.22%
    Sulfur 28.86%
    Rotten 28.78%
    Fishy 27.65%
    Decomposing cabbage 27.13%
    Pungent 26.8%
    Garlic 24.27%
    Bitter 23.0%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    5.41 (weak acid)

    Molecular weight
    54.024 g/mol

    Melting point expt.

    • Melting point (decomposes) = 127 °C
    • Melting point: decomp. Soluble in cold water. Soluble in methanol. /Solvated form/
    • No melting point; decomposes at >50 °C

    Flash point

    • -50.5 ˚C est.

    Solubility expt.

    • Soluble in ethanol, methanol
    • Soluble in fats, esters
    • Insoluble in hydrocarbons and most common organic solvents
    • Solubility in water: reaction

  • Synonyms

    • Sodium methanolate
    • SODIUM METHOXIDE
    • 124-41-4
    • Sodium methylate
    • Methoxysodium
    • Methanol, sodium salt
    • Feldalat NM
    • Metilato sodico
    • Methylate de sodium
    • IG663U5EMC
    • DTXSID8027030
    • RefChem:6240
    • SODIUM METHYLATE, DRY
    • DTXCID607030
    • 204-699-5
    • Methanol, sodium salt (1:1)
    • sodium;methanolate
    • MFCD00012179
    • Sodium methoxide, 25% in methanol
    • sodiummethanolate
    • Metilato sodico [Spanish]
    • Sodium Methoxide [5M(28%) in MeOH]
    • Methylate de sodium [French]
    • HSDB 755
    • EINECS 204-699-5
    • UN1289
    • UN1431
    • UNII-IG663U5EMC
    • sodiummethylate
    • sodium methyate
    • Sodium methylat
    • sodium mehtylate
    • sodium-methoxide
    • sodium-methylate
    • AI3-52659
    • natrium methoxide
    • sodium methanolat
    • MeONa
    • NaOMe
    • sodium -methoxide
    • sodium meth-oxide
    • sodium methox-ide
    • CH3NaO
    • CH3ONa
    • NaOCH3
    • MeO-Na+
    • 0.1M Sodium methoxide
    • SCHEMBL81
    • EC 204-699-5
    • SODIUM METHOXIDE [MI]
    • SODIUM METHYLATE [FCC]
    • SODIUM METHOXIDE [HSDB]
    • Sodium methoxide, 30% in methanol
    • STL483237
    • AKOS009031299
    • Sodium methoxide, 25 wt.% in methanol
    • Sodium methoxide, ca 25% w/w in methanol
    • Sodium methoxide, 0.5 M Methanolic Solution
    • A805230
    • F076023
    • Q414384
    • Sodium methylate [UN1431] [Spontaneously combustible]
    • 0.1M Sodium Methoxide according to European Pharmacopoeia 4.2.2.
    • 124-41-4

  • Applications

    Sodium Methoxide (CAS 124-41-4) is a strong base and methoxide reagent widely used as a catalyst for base-catalyzed transesterification in biodiesel production from vegetable or animal oils with methanol. It is also employed as a catalyst for methanolysis and transesterification in polyester processing and chemical recycling, including PET glycolysis. In organic synthesis, Sodium Methoxide serves as a strong base and nucleophile for deprotonation and carbon–carbon bond-forming reactions, enabling Knoevenagel and Claisen-type condensations and the preparation of methyl esters. The reagent is commonly used as a methoxide source for the preparation of various esters and other specialty chemicals in fine chemical manufacturing, within the limits of formulation and local regulations. In industrial contexts, it functions as a reagent for polymer and chemical production, with handling and safety requirements governed by applicable standards.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 307.28
    methanol 697.19
    isopropanol 166.23
    water 383.16
    ethyl acetate 69.82
    n-propanol 166.12
    acetone 146.25
    n-butanol 112.8
    acetonitrile 252.03
    DMF 403.94
    toluene 10.58
    isobutanol 97.85
    1,4-dioxane 159.57
    methyl acetate 127.67
    THF 112.78
    2-butanone 75.4
    n-pentanol 43.51
    sec-butanol 106.52
    n-hexane 6.14
    ethylene glycol 407.17
    NMP 268.52
    cyclohexane 14.36
    DMSO 251.85
    n-butyl acetate 22.78
    n-octanol 23.55
    chloroform 235.61
    n-propyl acetate 25.14
    acetic acid 850.44
    dichloromethane 251.12
    cyclohexanone 79.63
    propylene glycol 175.87
    isopropyl acetate 22.87
    DMAc 245.95
    2-ethoxyethanol 124.45
    isopentanol 53.76
    n-heptane 7.34
    ethyl formate 92.7
    1,2-dichloroethane 104.04
    n-hexanol 34.09
    2-methoxyethanol 375.46
    isobutyl acetate 11.0
    tetrachloromethane 73.23
    n-pentyl acetate 16.04
    transcutol 165.42
    n-heptanol 20.49
    ethylbenzene 6.25
    MIBK 14.53
    2-propoxyethanol 83.42
    tert-butanol 139.61
    MTBE 39.92
    2-butoxyethanol 46.08
    propionic acid 269.35
    o-xylene 12.24
    formic acid 911.84
    diethyl ether 56.58
    m-xylene 7.13
    p-xylene 10.09
    chlorobenzene 32.65
    dimethyl carbonate 36.87
    n-octane 3.07
    formamide 701.5
    cyclopentanone 103.2
    2-pentanone 38.38
    anisole 25.44
    cyclopentyl methyl ether 40.29
    gamma-butyrolactone 168.27
    1-methoxy-2-propanol 147.94
    pyridine 125.57
    3-pentanone 38.62
    furfural 192.56
    n-dodecane 2.53
    diethylene glycol 158.74
    diisopropyl ether 8.61
    tert-amyl alcohol 92.05
    acetylacetone 41.94
    n-hexadecane 2.64
    acetophenone 27.08
    methyl propionate 71.46
    isopentyl acetate 16.37
    trichloroethylene 193.07
    n-nonanol 19.39
    cyclohexanol 86.26
    benzyl alcohol 38.84
    2-ethylhexanol 18.81
    isooctanol 14.88
    dipropyl ether 21.23
    1,2-dichlorobenzene 38.4
    ethyl lactate 28.77
    propylene carbonate 69.29
    n-methylformamide 337.51
    2-pentanol 49.85
    n-pentane 10.68
    1-propoxy-2-propanol 46.14
    1-methoxy-2-propyl acetate 25.82
    2-(2-methoxypropoxy) propanol 46.75
    mesitylene 5.41
    ε-caprolactone 79.89
    p-cymene 8.66
    epichlorohydrin 129.32
    1,1,1-trichloroethane 77.8
    2-aminoethanol 336.8
    morpholine-4-carbaldehyde 237.08
    sulfolane 151.55
    2,2,4-trimethylpentane 4.9
    2-methyltetrahydrofuran 78.0
    n-hexyl acetate 25.45
    isooctane 2.01
    2-(2-butoxyethoxy)ethanol 59.39
    sec-butyl acetate 12.22
    tert-butyl acetate 17.72
    decalin 3.98
    glycerin 310.01
    diglyme 108.12
    acrylic acid 335.13
    isopropyl myristate 9.69
    n-butyric acid 170.24
    acetyl acetate 49.8
    di(2-ethylhexyl) phthalate 15.91
    ethyl propionate 26.87
    nitromethane 601.22
    1,2-diethoxyethane 31.22
    benzonitrile 44.51
    trioctyl phosphate 10.85
    1-bromopropane 41.44
    gamma-valerolactone 144.37
    n-decanol 13.88
    triethyl phosphate 16.57
    4-methyl-2-pentanol 16.21
    propionitrile 109.41
    vinylene carbonate 82.66
    1,1,2-trichlorotrifluoroethane 230.91
    DMS 31.63
    cumene 6.21
    2-octanol 12.21
    2-hexanone 17.35
    octyl acetate 15.49
    limonene 14.11
    1,2-dimethoxyethane 119.65
    ethyl orthosilicate 15.29
    tributyl phosphate 13.02
    diacetone alcohol 40.73
    N,N-dimethylaniline 21.91
    acrylonitrile 181.53
    aniline 55.58
    1,3-propanediol 293.27
    bromobenzene 23.8
    dibromomethane 128.16
    1,1,2,2-tetrachloroethane 135.74
    2-methyl-cyclohexyl acetate 16.31
    tetrabutyl urea 20.73
    diisobutyl methanol 10.76
    2-phenylethanol 25.39
    styrene 10.2
    dioctyl adipate 19.67
    dimethyl sulfate 69.01
    ethyl butyrate 22.72
    methyl lactate 69.51
    butyl lactate 21.23
    diethyl carbonate 18.91
    propanediol butyl ether 47.21
    triethyl orthoformate 18.71
    p-tert-butyltoluene 8.2
    methyl 4-tert-butylbenzoate 30.17
    morpholine 211.49
    tert-butylamine 78.76
    n-dodecanol 10.92
    dimethoxymethane 105.14
    ethylene carbonate 58.7
    cyrene 44.75
    2-ethoxyethyl acetate 26.09
    2-ethylhexyl acetate 13.23
    1,2,4-trichlorobenzene 48.49
    4-methylpyridine 69.41
    dibutyl ether 16.14
    2,6-dimethyl-4-heptanol 10.76
    DEF 97.33
    dimethyl isosorbide 50.11
    tetrachloroethylene 153.72
    eugenol 37.19
    triacetin 35.79
    span 80 42.1
    1,4-butanediol 90.66
    1,1-dichloroethane 87.58
    2-methyl-1-pentanol 26.92
    methyl formate 209.59
    2-methyl-1-butanol 65.24
    n-decane 3.98
    butyronitrile 77.97
    3,7-dimethyl-1-octanol 18.01
    1-chlorooctane 11.95
    1-chlorotetradecane 5.25
    n-nonane 4.09
    undecane 3.0
    tert-butylcyclohexane 3.89
    cyclooctane 3.83
    cyclopentanol 112.68
    tetrahydropyran 79.56
    tert-amyl methyl ether 31.6
    2,5,8-trioxanonane 77.18
    1-hexene 13.38
    2-isopropoxyethanol 54.96
    2,2,2-trifluoroethanol 394.37
    methyl butyrate 37.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction