Sodium Isethionate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1562-00-1

    Molecular formula
    C2H5NaO4S

    SMILES
    C(CS(=O)(=O)[O-])O.[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 82.35%
    Savory 21.38%
    Sulfurous 20.45%
    Cooked 18.9%
    Roasted 17.24%
    Pungent 16.76%
    Meaty 15.7%
    Fresh 13.78%
    Clean 12.71%
    Onion 12.54%

     

    Flavor
    Bitter 61.15%
    Odorless 40.43%
    Bland 26.67%
    Mild 21.9%
    Formyl 20.79%
    Nitrile 20.5%
    Taco 20.05%
    Roasted peanuts 19.89%
    Mousy 19.81%
    Yeast 19.81%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.39 (weak acid)

    Molecular weight
    148.12 g/mol

    Flash point

    • 134.09 ˚C est.

  • Synonyms

    • 1562-00-1
    • SODIUM ISETHIONATE
    • Isethionic acid sodium salt
    • Sodium 2-hydroxyethanesulfonate
    • 2-Hydroxyethanesulfonic acid sodium salt
    • Sodium hydroxyethylsulfonate
    • Ethanesulfonic acid, 2-hydroxy-, monosodium salt
    • Sodium 2-hydroxyethylsulfonate
    • Sodium beta-hydroxyethanesulfonate
    • Sodium 2-hydroxy-1-ethanesulfonate
    • 2-Hydroxyethanesulfonic acid, sodium salt
    • DTXSID7027413
    • 3R36J71C17
    • DTXCID007413
    • NSC-124283
    • RefChem:183946
    • 216-343-6
    • MFCD00007534
    • sodium;2-hydroxyethanesulfonate
    • C2H5NaO4S
    • Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1)
    • sodium 2-hydroxyethane-1-sulfonate
    • Sodium 1-hydroxy-2-ethanesulfonate; Sodium 2-hydroxy-1-ethanesulfonate; Sodium 2-hydroxyethanesulfonate
    • Sodium 2-hydroxyethanesulphonate
    • HSDB 5838
    • Sodium 1-hydroxy-2-ethanesulfonate
    • EINECS 216-343-6
    • NSC 124283
    • Isethionic acid, sodium salt
    • UNII-3R36J71C17
    • Ethanesulfonic acid, 2-hydroxy-, sodium salt
    • Hydroxyethylsulfonic Acid Sodium Salt
    • EC 216-343-6
    • 2-Hydroxyethanesulfonic acid sodium salt (SHES)
    • sodium hydroxyethyl sulfonate
    • SCHEMBL125497
    • CHEMBL172191
    • orb1301906
    • ISETHIONATE, SODIUM SALT
    • SCHEMBL11045429
    • SCHEMBL11786987
    • Sodium 2-Hydroxy-Ethanesulfonate
    • SODIUM ISETHIONATE [HSDB]
    • Isethionic acid sodium salt, 98%
    • HY-Y1173
    • Tox21_200227
    • AKOS015912506
    • EBC-616112
    • FH54885
    • NCGC00257781-01
    • SY008222
    • CAS-1562-00-1
    • SODIUM 2-HYDROXYETHANESULFONIC ACID
    • CS-0017163
    • H0241
    • NS00078178
    • G74509
    • F225614
    • F986792
    • Q1969744
    • F1905-7166
    • 1562-00-1

  • Applications

    Sodium Isethionate (CAS 1562-00-1) is a water-soluble, mild surfactant used as a building block and functional ingredient in various formulations. In cosmetics and personal care, it acts as a gentle cleansing surfactant with conditioning properties in shampoos, body washes, and facial cleansers. It is also a key intermediate for the production of other surfactants, such as sodium cocoyl isethionate, used in solid and liquid cleansers. In household and industrial cleaning products, it provides effective wetting and foaming while contributing to mildness. In coatings, inks, and plastics processing, it can serve as a dispersant or surfactant additive to improve wetting, stability, and formulation rheology. In pharmaceutical and topical formulations, it may be used as a surfactant excipient or solubilizing component, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 196.3
    methanol 384.77
    isopropanol 115.78
    water 239.33
    ethyl acetate 36.76
    n-propanol 110.68
    acetone 241.2
    n-butanol 90.53
    acetonitrile 150.61
    DMF 1112.19
    toluene 12.67
    isobutanol 59.86
    1,4-dioxane 72.65
    methyl acetate 58.85
    THF 127.47
    2-butanone 99.92
    n-pentanol 51.86
    sec-butanol 75.72
    n-hexane 3.38
    ethylene glycol 195.59
    NMP 686.43
    cyclohexane 6.18
    DMSO 905.93
    n-butyl acetate 21.46
    n-octanol 29.23
    chloroform 14.43
    n-propyl acetate 30.34
    acetic acid 193.73
    dichloromethane 31.38
    cyclohexanone 114.39
    propylene glycol 152.3
    isopropyl acetate 25.34
    DMAc 558.35
    2-ethoxyethanol 186.13
    isopentanol 56.91
    n-heptane 4.7
    ethyl formate 82.29
    1,2-dichloroethane 43.09
    n-hexanol 34.07
    2-methoxyethanol 401.68
    isobutyl acetate 12.8
    tetrachloromethane 2.85
    n-pentyl acetate 20.57
    transcutol 228.47
    n-heptanol 22.23
    ethylbenzene 8.75
    MIBK 46.37
    2-propoxyethanol 99.36
    tert-butanol 98.97
    MTBE 26.23
    2-butoxyethanol 58.78
    propionic acid 92.66
    o-xylene 17.96
    formic acid 291.33
    diethyl ether 33.63
    m-xylene 14.28
    p-xylene 10.6
    chlorobenzene 14.08
    dimethyl carbonate 50.79
    n-octane 2.28
    formamide 512.19
    cyclopentanone 147.12
    2-pentanone 84.92
    anisole 30.96
    cyclopentyl methyl ether 46.05
    gamma-butyrolactone 169.73
    1-methoxy-2-propanol 254.91
    pyridine 65.45
    3-pentanone 58.85
    furfural 226.58
    n-dodecane 2.04
    diethylene glycol 150.84
    diisopropyl ether 9.11
    tert-amyl alcohol 70.44
    acetylacetone 106.55
    n-hexadecane 2.19
    acetophenone 58.86
    methyl propionate 63.24
    isopentyl acetate 16.33
    trichloroethylene 45.17
    n-nonanol 26.6
    cyclohexanol 62.97
    benzyl alcohol 56.96
    2-ethylhexanol 17.58
    isooctanol 15.4
    dipropyl ether 20.61
    1,2-dichlorobenzene 17.57
    ethyl lactate 51.82
    propylene carbonate 70.28
    n-methylformamide 456.26
    2-pentanol 49.88
    n-pentane 5.88
    1-propoxy-2-propanol 65.8
    1-methoxy-2-propyl acetate 36.73
    2-(2-methoxypropoxy) propanol 88.6
    mesitylene 11.45
    ε-caprolactone 87.5
    p-cymene 9.61
    epichlorohydrin 108.16
    1,1,1-trichloroethane 12.22
    2-aminoethanol 205.46
    morpholine-4-carbaldehyde 438.0
    sulfolane 308.84
    2,2,4-trimethylpentane 2.22
    2-methyltetrahydrofuran 59.44
    n-hexyl acetate 31.76
    isooctane 1.79
    2-(2-butoxyethoxy)ethanol 108.64
    sec-butyl acetate 15.23
    tert-butyl acetate 28.96
    decalin 3.09
    glycerin 263.16
    diglyme 158.55
    acrylic acid 125.78
    isopropyl myristate 15.6
    n-butyric acid 81.56
    acetyl acetate 26.76
    di(2-ethylhexyl) phthalate 23.79
    ethyl propionate 33.13
    nitromethane 368.82
    1,2-diethoxyethane 34.88
    benzonitrile 46.05
    trioctyl phosphate 18.6
    1-bromopropane 17.22
    gamma-valerolactone 252.93
    n-decanol 21.37
    triethyl phosphate 17.51
    4-methyl-2-pentanol 24.86
    propionitrile 68.36
    vinylene carbonate 73.73
    1,1,2-trichlorotrifluoroethane 140.39
    DMS 27.25
    cumene 8.7
    2-octanol 16.73
    2-hexanone 44.45
    octyl acetate 22.36
    limonene 15.11
    1,2-dimethoxyethane 183.62
    ethyl orthosilicate 14.8
    tributyl phosphate 20.07
    diacetone alcohol 94.08
    N,N-dimethylaniline 42.38
    acrylonitrile 123.1
    aniline 38.13
    1,3-propanediol 191.55
    bromobenzene 8.78
    dibromomethane 19.26
    1,1,2,2-tetrachloroethane 40.29
    2-methyl-cyclohexyl acetate 22.23
    tetrabutyl urea 46.6
    diisobutyl methanol 12.57
    2-phenylethanol 36.76
    styrene 10.16
    dioctyl adipate 29.79
    dimethyl sulfate 126.83
    ethyl butyrate 24.77
    methyl lactate 109.65
    butyl lactate 37.32
    diethyl carbonate 16.43
    propanediol butyl ether 91.23
    triethyl orthoformate 18.07
    p-tert-butyltoluene 9.44
    methyl 4-tert-butylbenzoate 57.47
    morpholine 122.72
    tert-butylamine 44.27
    n-dodecanol 16.5
    dimethoxymethane 229.38
    ethylene carbonate 52.44
    cyrene 126.83
    2-ethoxyethyl acetate 30.43
    2-ethylhexyl acetate 12.31
    1,2,4-trichlorobenzene 22.08
    4-methylpyridine 71.25
    dibutyl ether 17.76
    2,6-dimethyl-4-heptanol 12.57
    DEF 163.31
    dimethyl isosorbide 108.72
    tetrachloroethylene 23.86
    eugenol 71.77
    triacetin 46.61
    span 80 70.65
    1,4-butanediol 94.12
    1,1-dichloroethane 19.62
    2-methyl-1-pentanol 35.27
    methyl formate 275.92
    2-methyl-1-butanol 54.77
    n-decane 3.01
    butyronitrile 62.07
    3,7-dimethyl-1-octanol 21.64
    1-chlorooctane 9.48
    1-chlorotetradecane 4.97
    n-nonane 2.93
    undecane 2.45
    tert-butylcyclohexane 2.34
    cyclooctane 2.88
    cyclopentanol 72.73
    tetrahydropyran 43.44
    tert-amyl methyl ether 28.02
    2,5,8-trioxanonane 140.57
    1-hexene 9.27
    2-isopropoxyethanol 83.72
    2,2,2-trifluoroethanol 101.78
    methyl butyrate 52.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction