Sodium Gualenate

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  • Identifiers

    CAS number
    6223-35-4

    Molecular formula
    C15H17NaO3S

    SMILES
    CC1=C2C(=CC(=C2C=C(C=C1)C(C)C)C)S(=O)(=O)[O-].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 52.23%
    Fatty 23.27%
    Dry 20.78%
    Animal 19.69%
    Fresh 17.28%
    Green 17.28%
    Bitter 16.78%
    Citrus 16.3%
    Mint 16.19%
    Cooling 15.98%

     

    Flavor
    Bitter 73.17%
    Odorless 20.9%
    Nitrile 19.93%
    Lovage 19.09%
    Cedarleaf 19.06%
    Broom 18.6%
    Heather 18.57%
    Genet 18.36%
    Very strong 18.26%
    Indole 18.12%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.73 (weak acid)

    Molecular weight
    300.4 g/mol

    Flash point

    • 180.76 ˚C est.

  • Synonyms

    • Sodium gualenate
    • 6223-35-4
    • Gualenate de sodium
    • Natrii gualenas
    • Sodium guaiazulene-3-sulfonate
    • Sodium guaiazulenesulfonate
    • Sodium guaiazulene sulfonate
    • Oristar sgs
    • Sodium 7-isopropyl-1,4-dimethylazulene-3-sulfonate
    • 1-Azulenesulfonic acid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt
    • Guaiazulene 3-sulfonate sodium salt
    • Azunol ST
    • Soluble guaiazulene
    • Azulene sulfonate sodium
    • Sodium guaiazulenesulphonate
    • gualenato de sodio
    • 19WSH095WP
    • Sodium guaiazulene-3-sulphonate
    • Sodium 5-isopropyl-3,8-dimethyl-1-azulene sulfonate
    • GUAIAZULENE SOLUBLE
    • 1-AZULENESULFONIC ACID, 5-ISOPROPYL-3,8-DIMETHYL-, SODIUM SALT
    • DTXSID40211279
    • RefChem:183902
    • DTXCID90133770
    • 228-309-8
    • Sodium 5-isopropyl-3,8-dimethylazulene-1-sulfonate
    • Sodium Gualenate [INN]
    • Sodium guiazulene sulfonate
    • C15H17NaO3S
    • MFCD00866167
    • 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULFONATE SODIUM SALT
    • Sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate
    • sodium azulene sulfonate
    • Guaiazulenesulfonate sodium
    • sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
    • Azupromin
    • Sodium gualenate (INN)
    • Azulen SN
    • Gualenato sodidico
    • sodium 3,8-dimethyl-5-(propan-2-yl)azulene-1-sulfonate
    • Gualenato sodico
    • Natrii gualenas [INN-Latin]
    • CCRIS 3781
    • Gualenato sodico [INN-Spanish]
    • Gualenate de sodium [INN-French]
    • 1-AZULENESULFONIC ACID, 3,8-DIMETHYL-5-(1-METHYLETHYL)-, SODIUM SALT (1:1)
    • EINECS 228-309-8
    • Guajazulen-3-sulfonsaeure, natriumsalz
    • UNII-19WSH095WP
    • Natrium 7-isopropyl-1,4-dimethyl-3-azulensulfonat
    • Azunol ST (TN)
    • 3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid sodium salt
    • MLS006010128
    • orb1300057
    • SCHEMBL1648769
    • sodium,3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
    • AZULENE SULPHONATE SODIUM
    • CHEMBL1837010
    • SCHEMBL29611830
    • Sodium 3,8-dimethyl-5-(1-methylethyl)-1-azulenesulfonate
    • SODIUM GUALENATE [MART.]
    • GEYJUFBPCGDENK-UHFFFAOYSA-M
    • SODIUM GUALENATE [WHO-DD]
    • HMS5084G08
    • HY-B2191
    • Guaiazulenesulfonic Acid Sodium Salt
    • 3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid, sodium salt
    • AKOS015904358
    • AKOS022172033
    • CCG-267469
    • CS-7928
    • EBC-153128
    • FS40724
    • AS-14102
    • SMR003520030
    • SY108911
    • GUAIAZULENE 3-SULPHONATE SODIUM SALT
    • NS00014056
    • S0976
    • D02075
    • F17343
    • GUAIAZULENE 3-SULFONATE SODIUM SALT [MI]
    • EN300-18567290
    • Sodium5-isopropyl-3,8-dimethylazulene-1-sulfonate
    • Q27252130
    • sodium;5-isopropyl-3,8-dimethyl-azulene-1-sulfonate
    • Z3241251094
    • SODIUM 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULPHONATE
    • SODIUM 3-METHYL-5-ISOPROPYL-8-METHYLAZULENESULFONATE
    • SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENESULFONATE
    • SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENESULPHONATE
    • SODIUM 7-ISOPROPYL-1,4-DIMETHYLAZULENE-3-SULPHONATE
    • 5-Isopropyl-3,8-dimethylazulene-1-sulfonic Acid Sodium Salt
    • 7-Isopropyl-1,4-dimethyl-azulene-3-sulfonic Acid Sodium Salt
    • SODIUM 3-METHYL-5-ISOPROPYL-8-METHYLAZULENESULPHONATE
    • SODIUM 5-ISOPROPYL-3,8-DIMETHYL-1-AZULENE SULPHONATE
    • 6223-35-4

  • Applications

    Sodium Gualenate (CAS 6223-35-4) is used primarily as an antioxidant and stabilizer in a range of formulations, helping to inhibit oxidative degradation in polymers and plastics during processing and service, in coatings and inks to enhance aging resistance, and in cosmetic/personal care products to preserve product integrity. It may also serve as an intermediate or reagent in organic synthesis within industrial manufacturing. In cleaning formulations and household products, it can function as a stabilizing or chelating additive to improve formulation stability, depending on grade and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 144.59
    methanol 151.55
    isopropanol 108.35
    water 0.14
    ethyl acetate 90.69
    n-propanol 138.98
    acetone 229.64
    n-butanol 121.66
    acetonitrile 97.11
    DMF 652.81
    toluene 104.31
    isobutanol 80.29
    1,4-dioxane 195.48
    methyl acetate 121.51
    THF 457.91
    2-butanone 264.97
    n-pentanol 83.63
    sec-butanol 95.07
    n-hexane 0.95
    ethylene glycol 29.16
    NMP 285.61
    cyclohexane 3.43
    DMSO 223.69
    n-butyl acetate 80.11
    n-octanol 34.64
    chloroform 235.1
    n-propyl acetate 71.08
    acetic acid 38.57
    dichloromethane 229.37
    cyclohexanone 291.97
    propylene glycol 48.53
    isopropyl acetate 60.19
    DMAc 350.95
    2-ethoxyethanol 114.02
    isopentanol 77.27
    n-heptane 1.3
    ethyl formate 95.23
    1,2-dichloroethane 176.55
    n-hexanol 93.23
    2-methoxyethanol 216.92
    isobutyl acetate 49.07
    tetrachloromethane 16.37
    n-pentyl acetate 77.51
    transcutol 61.21
    n-heptanol 51.24
    ethylbenzene 33.73
    MIBK 82.95
    2-propoxyethanol 147.88
    tert-butanol 90.1
    MTBE 57.14
    2-butoxyethanol 90.59
    propionic acid 52.45
    o-xylene 38.59
    formic acid 23.55
    diethyl ether 64.89
    m-xylene 42.77
    p-xylene 41.36
    chlorobenzene 116.89
    dimethyl carbonate 56.18
    n-octane 1.4
    formamide 64.43
    cyclopentanone 429.49
    2-pentanone 179.96
    anisole 91.09
    cyclopentyl methyl ether 94.95
    gamma-butyrolactone 293.93
    1-methoxy-2-propanol 148.58
    pyridine 307.96
    3-pentanone 114.97
    furfural 250.42
    n-dodecane 1.65
    diethylene glycol 99.41
    diisopropyl ether 12.81
    tert-amyl alcohol 71.62
    acetylacetone 143.55
    n-hexadecane 2.02
    acetophenone 102.42
    methyl propionate 103.2
    isopentyl acetate 71.82
    trichloroethylene 334.72
    n-nonanol 32.64
    cyclohexanol 75.15
    benzyl alcohol 111.04
    2-ethylhexanol 42.04
    isooctanol 37.48
    dipropyl ether 24.59
    1,2-dichlorobenzene 85.53
    ethyl lactate 45.63
    propylene carbonate 120.36
    n-methylformamide 220.21
    2-pentanol 53.91
    n-pentane 1.55
    1-propoxy-2-propanol 80.42
    1-methoxy-2-propyl acetate 80.83
    2-(2-methoxypropoxy) propanol 51.26
    mesitylene 18.16
    ε-caprolactone 181.56
    p-cymene 20.16
    epichlorohydrin 371.97
    1,1,1-trichloroethane 92.53
    2-aminoethanol 69.48
    morpholine-4-carbaldehyde 254.7
    sulfolane 242.08
    2,2,4-trimethylpentane 1.29
    2-methyltetrahydrofuran 200.37
    n-hexyl acetate 69.87
    isooctane 1.0
    2-(2-butoxyethoxy)ethanol 61.18
    sec-butyl acetate 44.6
    tert-butyl acetate 61.71
    decalin 2.36
    glycerin 56.33
    diglyme 101.1
    acrylic acid 46.24
    isopropyl myristate 27.08
    n-butyric acid 85.2
    acetyl acetate 48.22
    di(2-ethylhexyl) phthalate 35.02
    ethyl propionate 56.02
    nitromethane 123.43
    1,2-diethoxyethane 49.79
    benzonitrile 136.69
    trioctyl phosphate 26.39
    1-bromopropane 78.42
    gamma-valerolactone 422.18
    n-decanol 25.28
    triethyl phosphate 25.24
    4-methyl-2-pentanol 28.62
    propionitrile 119.43
    vinylene carbonate 125.76
    1,1,2-trichlorotrifluoroethane 127.94
    DMS 58.95
    cumene 18.78
    2-octanol 36.82
    2-hexanone 102.36
    octyl acetate 39.13
    limonene 24.08
    1,2-dimethoxyethane 156.64
    ethyl orthosilicate 23.96
    tributyl phosphate 25.16
    diacetone alcohol 100.56
    N,N-dimethylaniline 54.3
    acrylonitrile 162.77
    aniline 110.92
    1,3-propanediol 106.39
    bromobenzene 113.01
    dibromomethane 143.08
    1,1,2,2-tetrachloroethane 213.25
    2-methyl-cyclohexyl acetate 48.75
    tetrabutyl urea 44.04
    diisobutyl methanol 19.24
    2-phenylethanol 113.82
    styrene 43.13
    dioctyl adipate 36.81
    dimethyl sulfate 74.14
    ethyl butyrate 48.69
    methyl lactate 60.96
    butyl lactate 56.28
    diethyl carbonate 34.66
    propanediol butyl ether 63.21
    triethyl orthoformate 31.87
    p-tert-butyltoluene 18.66
    methyl 4-tert-butylbenzoate 69.1
    morpholine 280.18
    tert-butylamine 37.73
    n-dodecanol 18.92
    dimethoxymethane 209.64
    ethylene carbonate 96.72
    cyrene 96.18
    2-ethoxyethyl acetate 92.45
    2-ethylhexyl acetate 57.35
    1,2,4-trichlorobenzene 99.32
    4-methylpyridine 289.21
    dibutyl ether 21.24
    2,6-dimethyl-4-heptanol 19.24
    DEF 161.14
    dimethyl isosorbide 104.11
    tetrachloroethylene 108.9
    eugenol 84.83
    triacetin 50.27
    span 80 50.95
    1,4-butanediol 48.98
    1,1-dichloroethane 140.23
    2-methyl-1-pentanol 65.67
    methyl formate 147.89
    2-methyl-1-butanol 75.89
    n-decane 2.57
    butyronitrile 127.76
    3,7-dimethyl-1-octanol 29.37
    1-chlorooctane 18.95
    1-chlorotetradecane 7.59
    n-nonane 1.99
    undecane 2.06
    tert-butylcyclohexane 2.02
    cyclooctane 0.91
    cyclopentanol 104.02
    tetrahydropyran 193.2
    tert-amyl methyl ether 42.85
    2,5,8-trioxanonane 78.43
    1-hexene 11.6
    2-isopropoxyethanol 75.09
    2,2,2-trifluoroethanol 19.54
    methyl butyrate 87.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction