Sodium ethoxide

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  • Identifiers

    CAS number
    141-52-6

    Molecular formula
    C2H5NaO

    SMILES
    CC[O-].[Na+]

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Alcoholic 59.07%
    Sweet 58.09%
    Fermented 47.22%
    Solvent 46.67%
    Ethereal 46.29%
    Oily 38.87%
    Fishy 37.31%
    Musty 35.02%
    Winey 28.26%
    Cheesy 27.58%

     

    Flavor
    Fishy 37.58%
    Alcoholic 27.72%
    Fruity 23.3%
    Ammoniacal 23.26%
    Onion 23.05%
    Rotten 23.04%
    Decomposing cabbage 22.51%
    Sweet 22.21%
    Egg 22.03%
    Ethereal 21.44%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    6.72 (neutral)

    Molecular weight
    68.05 g/mol

    Flash point

    • -33.59 ˚C est.

    Solubility expt.

    • SOL IN ABSOLUTE ALCOHOL

  • Synonyms

    • Sodium ethoxide
    • 141-52-6
    • Sodium ethylate
    • SODIUM ETHANOLATE
    • Ethoxysodium
    • Caustic alcohol
    • Ethanol, sodium salt
    • Ethyl alcohol, sodium salt
    • 1I9504387J
    • DTXSID3027089
    • CHEBI:52096
    • RefChem:183880
    • DTXCID707089
    • 205-487-5
    • sodiumethoxide
    • sodium;ethanolate
    • NaOEt
    • C2H5NaO
    • MFCD00012417
    • Sodium Ethoxide (>85%)
    • EtONa
    • sodiumethylate
    • sodiumethanolate
    • ethoxy sodium
    • sodium-ethoxide
    • HSDB 5637
    • natrium ethanolate
    • UNII-1I9504387J
    • EINECS 205-487-5
    • NaOC2H5
    • AI3-52660
    • SCHEMBL677
    • EC 205-487-5
    • SODIUM ETHOXIDE [MI]
    • SCHEMBL6679559
    • SODIUM ETHANOLATE [HSDB]
    • AKOS009156827
    • NS00041642
    • A807773
    • Q412779
    • F0001-0487
    • 141-52-6

  • Applications

    Sodium ethoxide (CAS 141-52-6) is a strong base and alkoxide source used in organic synthesis. It is commonly employed to deprotonate substrates and generate enolates for carbon–carbon bond-forming reactions. In industrial contexts, it serves as a catalyst/base in the transesterification of triglycerides with ethanol to produce fatty ethyl esters (biodiesel). It is also used in Williamson ether synthesis to prepare alkyl ethers by SN2 reactions of ethoxide with appropriate alkyl halides. Additionally, sodium ethoxide is used as a base in pharmaceutical synthesis and for preparing key intermediates in industrial sequences.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 515.93
    methanol 934.44
    isopropanol 323.48
    water 92.67
    ethyl acetate 191.69
    n-propanol 311.32
    acetone 482.69
    n-butanol 247.04
    acetonitrile 563.14
    DMF 835.79
    toluene 59.89
    isobutanol 192.59
    1,4-dioxane 371.53
    methyl acetate 258.4
    THF 340.12
    2-butanone 237.39
    n-pentanol 132.87
    sec-butanol 221.29
    n-hexane 36.96
    ethylene glycol 364.13
    NMP 646.54
    cyclohexane 60.43
    DMSO 665.64
    n-butyl acetate 95.68
    n-octanol 100.45
    chloroform 576.46
    n-propyl acetate 93.42
    acetic acid 1210.82
    dichloromethane 555.1
    cyclohexanone 299.17
    propylene glycol 264.9
    isopropyl acetate 84.68
    DMAc 523.93
    2-ethoxyethanol 238.18
    isopentanol 147.02
    n-heptane 29.84
    ethyl formate 189.58
    1,2-dichloroethane 266.73
    n-hexanol 119.16
    2-methoxyethanol 527.36
    isobutyl acetate 48.48
    tetrachloromethane 121.87
    n-pentyl acetate 77.28
    transcutol 680.96
    n-heptanol 60.29
    ethylbenzene 37.17
    MIBK 67.25
    2-propoxyethanol 220.76
    tert-butanol 281.78
    MTBE 126.66
    2-butoxyethanol 118.05
    propionic acid 456.63
    o-xylene 51.35
    formic acid 628.69
    diethyl ether 155.43
    m-xylene 39.51
    p-xylene 53.03
    chlorobenzene 142.54
    dimethyl carbonate 91.98
    n-octane 12.92
    formamide 563.82
    cyclopentanone 372.34
    2-pentanone 154.54
    anisole 102.92
    cyclopentyl methyl ether 140.32
    gamma-butyrolactone 443.71
    1-methoxy-2-propanol 304.5
    pyridine 314.04
    3-pentanone 131.5
    furfural 471.8
    n-dodecane 12.23
    diethylene glycol 300.52
    diisopropyl ether 33.24
    tert-amyl alcohol 201.58
    acetylacetone 192.46
    n-hexadecane 13.05
    acetophenone 107.62
    methyl propionate 178.5
    isopentyl acetate 77.87
    trichloroethylene 502.73
    n-nonanol 81.46
    cyclohexanol 209.16
    benzyl alcohol 126.49
    2-ethylhexanol 71.18
    isooctanol 46.38
    dipropyl ether 76.38
    1,2-dichlorobenzene 139.36
    ethyl lactate 78.96
    propylene carbonate 200.43
    n-methylformamide 489.73
    2-pentanol 130.9
    n-pentane 38.4
    1-propoxy-2-propanol 148.75
    1-methoxy-2-propyl acetate 95.85
    2-(2-methoxypropoxy) propanol 160.46
    mesitylene 27.05
    ε-caprolactone 257.32
    p-cymene 33.72
    epichlorohydrin 323.46
    1,1,1-trichloroethane 231.48
    2-aminoethanol 389.43
    morpholine-4-carbaldehyde 533.93
    sulfolane 495.1
    2,2,4-trimethylpentane 16.95
    2-methyltetrahydrofuran 237.83
    n-hexyl acetate 133.91
    isooctane 9.16
    2-(2-butoxyethoxy)ethanol 210.09
    sec-butyl acetate 52.01
    tert-butyl acetate 75.37
    decalin 20.25
    glycerin 385.77
    diglyme 330.34
    acrylic acid 554.3
    isopropyl myristate 52.39
    n-butyric acid 359.51
    acetyl acetate 153.14
    di(2-ethylhexyl) phthalate 63.65
    ethyl propionate 94.33
    nitromethane 976.45
    1,2-diethoxyethane 149.17
    benzonitrile 185.42
    trioctyl phosphate 43.12
    1-bromopropane 133.72
    gamma-valerolactone 450.69
    n-decanol 58.72
    triethyl phosphate 51.11
    4-methyl-2-pentanol 56.4
    propionitrile 271.62
    vinylene carbonate 223.54
    1,1,2-trichlorotrifluoroethane 417.35
    DMS 128.25
    cumene 29.63
    2-octanol 47.65
    2-hexanone 93.91
    octyl acetate 69.4
    limonene 55.09
    1,2-dimethoxyethane 315.28
    ethyl orthosilicate 45.23
    tributyl phosphate 60.56
    diacetone alcohol 125.69
    N,N-dimethylaniline 75.82
    acrylonitrile 412.17
    aniline 148.8
    1,3-propanediol 383.4
    bromobenzene 118.08
    dibromomethane 326.36
    1,1,2,2-tetrachloroethane 358.5
    2-methyl-cyclohexyl acetate 64.06
    tetrabutyl urea 86.37
    diisobutyl methanol 40.68
    2-phenylethanol 95.84
    styrene 60.8
    dioctyl adipate 90.58
    dimethyl sulfate 170.28
    ethyl butyrate 81.56
    methyl lactate 156.81
    butyl lactate 84.22
    diethyl carbonate 63.52
    propanediol butyl ether 180.58
    triethyl orthoformate 61.3
    p-tert-butyltoluene 31.6
    methyl 4-tert-butylbenzoate 102.67
    morpholine 423.4
    tert-butylamine 174.73
    n-dodecanol 45.84
    dimethoxymethane 239.12
    ethylene carbonate 163.55
    cyrene 119.21
    2-ethoxyethyl acetate 112.98
    2-ethylhexyl acetate 60.41
    1,2,4-trichlorobenzene 168.57
    4-methylpyridine 245.43
    dibutyl ether 87.86
    2,6-dimethyl-4-heptanol 40.68
    DEF 266.67
    dimethyl isosorbide 179.14
    tetrachloroethylene 318.37
    eugenol 119.5
    triacetin 166.73
    span 80 162.01
    1,4-butanediol 152.01
    1,1-dichloroethane 269.12
    2-methyl-1-pentanol 93.65
    methyl formate 327.39
    2-methyl-1-butanol 156.65
    n-decane 19.35
    butyronitrile 220.95
    3,7-dimethyl-1-octanol 85.89
    1-chlorooctane 56.36
    1-chlorotetradecane 25.17
    n-nonane 19.89
    undecane 14.68
    tert-butylcyclohexane 18.75
    cyclooctane 15.04
    cyclopentanol 259.96
    tetrahydropyran 251.28
    tert-amyl methyl ether 96.06
    2,5,8-trioxanonane 255.71
    1-hexene 82.21
    2-isopropoxyethanol 126.42
    2,2,2-trifluoroethanol 369.87
    methyl butyrate 132.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction