Sodium 4-hydroxybenzoate

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  • Identifiers

    CAS number
    114-63-6

    Molecular formula
    C7H5NaO3

    SMILES
    C1=CC(=CC=C1C(=O)[O-])O.[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 66.0%
    Odorless 48.22%
    Balsamic 40.58%
    Nutty 40.35%
    Sweet 40.16%
    Vanilla 34.75%
    Medicinal 34.69%
    Bitter 33.08%
    Burnt 32.52%
    Aromatic 28.69%

     

    Flavor
    Phenolic 52.48%
    Nutty 44.43%
    Mild 39.13%
    Odorless 39.09%
    Bitter 35.64%
    Balsam 33.02%
    Faint 31.12%
    Balsamic 27.75%
    Powdery 24.97%
    Urine 24.67%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.98 (neutral)

    Molecular weight
    160.1 g/mol

    Flash point

    • 143.15 ˚C est.

  • Synonyms

    • Sodium 4-hydroxybenzoate
    • Sodium p-hydroxybenzoate
    • 4-Hydroxybenzoic acid sodium salt
    • sodium paraben
    • Benzoic acid, 4-hydroxy-, monosodium salt
    • p-Hydroxybenzoic acid sodium salt
    • Monosodium p-hydroxybenzoate
    • Monosodium 4-hydroxybenzoate
    • Benzoic acid, 4-hydroxy-, sodium salt (1:1)
    • EINECS 204-051-1
    • p-hydroxybenzoic acid monosodium salt
    • V6102T509B
    • DTXSID3059426
    • BENZOIC ACID, p-HYDROXY-, SODIUM SALT
    • CHEBI:113449
    • SODIUM 4-HYDROXYBENZOIC ACID
    • BENZOIC ACID, P-HYDROXY-, MONOSODIUM SALT
    • RefChem:887100
    • SODIUM PARABEN [INCI]
    • DTXCID5033337
    • 114-63-6
    • sodium;4-hydroxybenzoate
    • C7H5NaO3
    • CHEMBL1762656
    • UNII-V6102T509B
    • sodium parahydroxybenzoate
    • 4-Hydroxybenzoic acid sodium
    • SCHEMBL381913
    • SODIUM4-HYDROXYBENZOATE
    • orb2941099
    • MSK40175
    • AKOS003051801
    • AKOS015888195
    • AKOS022190835
    • CS-W010880
    • FH46993
    • HY-W010164
    • AS-65704
    • H0221
    • NS00079031
    • Sodium 4-hydroxybenzoate, analytical standard
    • D71249
    • Q27194146
    • 114-63-6

  • Applications

    Sodium 4-hydroxybenzoate (CAS 114-63-6) is widely used as a preservative in cosmetics and personal care products, and is also used as a preservative in pharmaceutical formulations; it is present in household cleaning products with a preservative function as well. In industrial manufacturing, it can serve as an intermediate for the synthesis of other parabens or related ester derivatives. These applications depend on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 132.69
    methanol 176.42
    isopropanol 111.36
    water 1.69
    ethyl acetate 148.35
    n-propanol 89.67
    acetone 241.99
    n-butanol 88.87
    acetonitrile 82.03
    DMF 441.14
    toluene 7.85
    isobutanol 62.96
    1,4-dioxane 302.8
    methyl acetate 168.55
    THF 492.68
    2-butanone 163.4
    n-pentanol 76.14
    sec-butanol 93.52
    n-hexane 0.83
    ethylene glycol 74.82
    NMP 517.8
    cyclohexane 0.62
    DMSO 469.33
    n-butyl acetate 94.26
    n-octanol 120.36
    chloroform 7.04
    n-propyl acetate 82.0
    acetic acid 196.1
    dichloromethane 21.44
    cyclohexanone 112.55
    propylene glycol 83.79
    isopropyl acetate 101.66
    DMAc 351.35
    2-ethoxyethanol 236.68
    isopentanol 94.35
    n-heptane 2.74
    ethyl formate 83.24
    1,2-dichloroethane 39.08
    n-hexanol 81.54
    2-methoxyethanol 343.19
    isobutyl acetate 38.24
    tetrachloromethane 1.22
    n-pentyl acetate 112.76
    transcutol 1339.65
    n-heptanol 80.22
    ethylbenzene 7.3
    MIBK 96.21
    2-propoxyethanol 204.34
    tert-butanol 172.9
    MTBE 106.31
    2-butoxyethanol 170.49
    propionic acid 124.88
    o-xylene 11.19
    formic acid 171.31
    diethyl ether 103.67
    m-xylene 11.31
    p-xylene 8.64
    chlorobenzene 12.86
    dimethyl carbonate 103.03
    n-octane 1.96
    formamide 347.88
    cyclopentanone 269.4
    2-pentanone 147.01
    anisole 60.09
    cyclopentyl methyl ether 128.44
    gamma-butyrolactone 375.11
    1-methoxy-2-propanol 287.05
    pyridine 91.9
    3-pentanone 84.12
    furfural 248.99
    n-dodecane 3.53
    diethylene glycol 216.54
    diisopropyl ether 30.8
    tert-amyl alcohol 138.46
    acetylacetone 196.92
    n-hexadecane 4.07
    acetophenone 75.81
    methyl propionate 142.54
    isopentyl acetate 89.19
    trichloroethylene 53.97
    n-nonanol 104.25
    cyclohexanol 54.09
    benzyl alcohol 63.6
    2-ethylhexanol 46.34
    isooctanol 61.56
    dipropyl ether 46.18
    1,2-dichlorobenzene 15.61
    ethyl lactate 68.34
    propylene carbonate 143.35
    n-methylformamide 227.84
    2-pentanol 86.84
    n-pentane 1.29
    1-propoxy-2-propanol 156.0
    1-methoxy-2-propyl acetate 155.12
    2-(2-methoxypropoxy) propanol 208.83
    mesitylene 9.08
    ε-caprolactone 164.46
    p-cymene 14.13
    epichlorohydrin 348.86
    1,1,1-trichloroethane 11.89
    2-aminoethanol 106.89
    morpholine-4-carbaldehyde 461.88
    sulfolane 440.18
    2,2,4-trimethylpentane 2.0
    2-methyltetrahydrofuran 246.37
    n-hexyl acetate 190.99
    isooctane 2.02
    2-(2-butoxyethoxy)ethanol 355.63
    sec-butyl acetate 60.56
    tert-butyl acetate 136.42
    decalin 1.48
    glycerin 165.85
    diglyme 468.67
    acrylic acid 143.32
    isopropyl myristate 65.9
    n-butyric acid 112.87
    acetyl acetate 88.5
    di(2-ethylhexyl) phthalate 52.62
    ethyl propionate 74.47
    nitromethane 471.72
    1,2-diethoxyethane 204.39
    benzonitrile 49.49
    trioctyl phosphate 46.45
    1-bromopropane 11.98
    gamma-valerolactone 350.57
    n-decanol 76.64
    triethyl phosphate 38.48
    4-methyl-2-pentanol 55.39
    propionitrile 54.3
    vinylene carbonate 104.06
    1,1,2-trichlorotrifluoroethane 191.66
    DMS 135.16
    cumene 7.48
    2-octanol 65.39
    2-hexanone 82.83
    octyl acetate 95.38
    limonene 22.0
    1,2-dimethoxyethane 227.85
    ethyl orthosilicate 34.36
    tributyl phosphate 53.46
    diacetone alcohol 228.12
    N,N-dimethylaniline 39.17
    acrylonitrile 87.92
    aniline 35.13
    1,3-propanediol 156.51
    bromobenzene 7.63
    dibromomethane 6.99
    1,1,2,2-tetrachloroethane 41.16
    2-methyl-cyclohexyl acetate 54.95
    tetrabutyl urea 73.06
    diisobutyl methanol 34.32
    2-phenylethanol 68.94
    styrene 8.51
    dioctyl adipate 90.11
    dimethyl sulfate 195.97
    ethyl butyrate 61.34
    methyl lactate 127.47
    butyl lactate 95.07
    diethyl carbonate 41.72
    propanediol butyl ether 241.09
    triethyl orthoformate 47.8
    p-tert-butyltoluene 14.59
    methyl 4-tert-butylbenzoate 119.05
    morpholine 309.18
    tert-butylamine 55.18
    n-dodecanol 52.27
    dimethoxymethane 257.4
    ethylene carbonate 80.5
    cyrene 159.67
    2-ethoxyethyl acetate 210.27
    2-ethylhexyl acetate 58.92
    1,2,4-trichlorobenzene 28.06
    4-methylpyridine 73.52
    dibutyl ether 83.72
    2,6-dimethyl-4-heptanol 34.32
    DEF 176.17
    dimethyl isosorbide 259.1
    tetrachloroethylene 23.33
    eugenol 119.98
    triacetin 199.02
    span 80 164.63
    1,4-butanediol 71.56
    1,1-dichloroethane 16.85
    2-methyl-1-pentanol 70.05
    methyl formate 196.7
    2-methyl-1-butanol 75.21
    n-decane 5.51
    butyronitrile 49.36
    3,7-dimethyl-1-octanol 80.3
    1-chlorooctane 33.03
    1-chlorotetradecane 13.39
    n-nonane 4.28
    undecane 4.5
    tert-butylcyclohexane 1.79
    cyclooctane 0.57
    cyclopentanol 95.65
    tetrahydropyran 128.24
    tert-amyl methyl ether 91.2
    2,5,8-trioxanonane 351.47
    1-hexene 5.59
    2-isopropoxyethanol 163.24
    2,2,2-trifluoroethanol 97.12
    methyl butyrate 83.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction