Sodium 2-(methylamino)ethanesulfonate

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  • Identifiers

    CAS number
    4316-74-9

    Molecular formula
    C3H8NNaO3S

    SMILES
    CNCCS(=O)(=O)[O-].[Na+]

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 79.87%
    Savory 26.96%
    Fishy 20.51%
    Meaty 19.77%
    Cooked 19.66%
    Pungent 18.74%
    Sulfurous 17.7%
    Roasted 14.65%
    Cheesy 13.04%
    Onion 11.19%

     

    Flavor
    Bitter 63.48%
    Odorless 35.09%
    Bland 28.03%
    Mild 21.22%
    Nitrile 20.65%
    Taco 19.64%
    Scallion 19.19%
    Roasted peanuts 19.19%
    Cooked 19.07%
    Sweet-like 18.98%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.43 (weak acid)

    Molecular weight
    161.16 g/mol

    Flash point

    • 109.93 ˚C est.

  • Synonyms

    • 4316-74-9
    • sodium 2-(methylamino)ethanesulfonate
    • N-Methyltaurine Sodium Salt
    • Sodium methyltaurate
    • Ethanesulfonic acid, 2-(methylamino)-, monosodium salt
    • sodium;2-(methylamino)ethanesulfonate
    • FXG7384HSN
    • DTXSID5029263
    • Ethanesulfonic acid, 2-(methylamino)-, sodium salt (1:1)
    • N-Methyltaurine Sodium Salt (>50% in Water)
    • Sodium 2-(methylamino)ethanesulfonate, 60% in water
    • Sodium N-methyltaurinate
    • Sodium coco methyl tauride
    • Ethanesulfonic acid,2-(methylamino)-, N-coco acyl derivs., sodium salts
    • EINECS 263-174-9
    • UNII-FXG7384HSN
    • Sodium cocomethylaminoethyl-2-sulfonate
    • sodium-n-coconut acid n-methyl taurate
    • 61791-43-3
    • EINECS 224-339-0
    • EINECS 263-175-4
    • Taurine, N-methyl-, monosodium salt
    • MFCD00066598
    • N-Methyltaurine Sodium Salt Anhydrous
    • sodium n-methyltaurine
    • EC 224-339-0
    • EC 263-174-9
    • SCHEMBL646481
    • DTXCID309263
    • Ethanesulfonic acid, 2-(cocomethylamino), sodium salt
    • CHEMBL3182439
    • sodium2-(methylamino)ethanesulfonate
    • Tox21_200996
    • AKOS015897511
    • CS-W022955
    • N-METHYLTAURINE SODIUM SALT [MI]
    • NCGC00258549-01
    • FM179483
    • CAS-4316-74-9
    • M0434
    • NS00078322
    • N-Methyltaurine sodium, 60% aqueous solution
    • E76159
    • Sodium 2-(methylamino)ethanesulfonate, AldrichCPR
    • 2-(METHYLAMINO)ETHANESULFONIC ACID SODIUM SALT
    • Q27278259
    • N-Methyltaurine Sodium Salt (60-66per cent in Water)
    • Sodium 2-(methylamino)ethanesulfonate (60-66% in water)

  • Applications

    Sodium 2-(methylamino)ethanesulfonate (CAS 4316-74-9) is primarily used as an aqueous buffer and as a synthetic intermediate in biological and analytical systems, helping to maintain stable pH in solutions containing enzymes, proteins, and purification workflows. It also serves as a precursor for sulfonated amine-containing compounds, supporting the production of polymers, specialty chemicals, and related actives. With good water solubility in its salt form, it can function as a pH-adjusting component in pharmaceutical and analytical formulations, and it provides a building block for polyamino sulfonates and other sulfonated derivatives in industrial applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 33.23
    methanol 94.07
    isopropanol 14.48
    water 74.72
    ethyl acetate 9.99
    n-propanol 16.82
    acetone 41.44
    n-butanol 13.28
    acetonitrile 19.35
    DMF 192.47
    toluene 3.64
    isobutanol 8.62
    1,4-dioxane 22.91
    methyl acetate 14.69
    THF 39.49
    2-butanone 15.74
    n-pentanol 6.59
    sec-butanol 9.59
    n-hexane 0.42
    ethylene glycol 60.28
    NMP 151.05
    cyclohexane 1.34
    DMSO 164.63
    n-butyl acetate 7.27
    n-octanol 5.58
    chloroform 8.14
    n-propyl acetate 5.59
    acetic acid 31.29
    dichloromethane 11.22
    cyclohexanone 28.94
    propylene glycol 35.62
    isopropyl acetate 5.85
    DMAc 135.6
    2-ethoxyethanol 28.85
    isopentanol 8.8
    n-heptane 0.79
    ethyl formate 27.7
    1,2-dichloroethane 12.29
    n-hexanol 8.51
    2-methoxyethanol 95.87
    isobutyl acetate 2.85
    tetrachloromethane 2.22
    n-pentyl acetate 4.8
    transcutol 43.57
    n-heptanol 5.13
    ethylbenzene 2.46
    MIBK 7.89
    2-propoxyethanol 28.25
    tert-butanol 13.74
    MTBE 4.1
    2-butoxyethanol 14.7
    propionic acid 20.51
    o-xylene 5.54
    formic acid 100.89
    diethyl ether 5.06
    m-xylene 3.93
    p-xylene 3.14
    chlorobenzene 5.56
    dimethyl carbonate 13.07
    n-octane 0.37
    formamide 114.73
    cyclopentanone 39.82
    2-pentanone 13.22
    anisole 7.81
    cyclopentyl methyl ether 9.2
    gamma-butyrolactone 46.45
    1-methoxy-2-propanol 41.84
    pyridine 18.31
    3-pentanone 9.39
    furfural 74.57
    n-dodecane 0.39
    diethylene glycol 54.98
    diisopropyl ether 1.39
    tert-amyl alcohol 10.08
    acetylacetone 24.51
    n-hexadecane 0.44
    acetophenone 14.09
    methyl propionate 14.48
    isopentyl acetate 6.59
    trichloroethylene 15.84
    n-nonanol 5.18
    cyclohexanol 11.14
    benzyl alcohol 13.7
    2-ethylhexanol 4.91
    isooctanol 3.75
    dipropyl ether 3.77
    1,2-dichlorobenzene 7.46
    ethyl lactate 11.78
    propylene carbonate 24.44
    n-methylformamide 89.06
    2-pentanol 5.46
    n-pentane 0.71
    1-propoxy-2-propanol 15.93
    1-methoxy-2-propyl acetate 13.48
    2-(2-methoxypropoxy) propanol 24.51
    mesitylene 3.14
    ε-caprolactone 23.36
    p-cymene 3.53
    epichlorohydrin 32.58
    1,1,1-trichloroethane 4.78
    2-aminoethanol 52.18
    morpholine-4-carbaldehyde 96.85
    sulfolane 81.28
    2,2,4-trimethylpentane 0.38
    2-methyltetrahydrofuran 14.73
    n-hexyl acetate 6.65
    isooctane 0.26
    2-(2-butoxyethoxy)ethanol 25.57
    sec-butyl acetate 3.26
    tert-butyl acetate 6.72
    decalin 0.62
    glycerin 80.53
    diglyme 42.19
    acrylic acid 29.37
    isopropyl myristate 3.64
    n-butyric acid 19.08
    acetyl acetate 8.84
    di(2-ethylhexyl) phthalate 8.05
    ethyl propionate 6.2
    nitromethane 63.45
    1,2-diethoxyethane 7.45
    benzonitrile 13.74
    trioctyl phosphate 5.45
    1-bromopropane 3.88
    gamma-valerolactone 65.92
    n-decanol 4.2
    triethyl phosphate 6.77
    4-methyl-2-pentanol 3.5
    propionitrile 11.44
    vinylene carbonate 25.77
    1,1,2-trichlorotrifluoroethane 50.91
    DMS 9.83
    cumene 2.33
    2-octanol 2.96
    2-hexanone 6.12
    octyl acetate 5.28
    limonene 4.8
    1,2-dimethoxyethane 41.28
    ethyl orthosilicate 5.43
    tributyl phosphate 6.01
    diacetone alcohol 19.4
    N,N-dimethylaniline 9.28
    acrylonitrile 23.06
    aniline 10.39
    1,3-propanediol 45.99
    bromobenzene 4.04
    dibromomethane 6.93
    1,1,2,2-tetrachloroethane 16.27
    2-methyl-cyclohexyl acetate 7.66
    tetrabutyl urea 12.61
    diisobutyl methanol 3.46
    2-phenylethanol 12.61
    styrene 2.78
    dioctyl adipate 7.75
    dimethyl sulfate 31.83
    ethyl butyrate 7.09
    methyl lactate 29.46
    butyl lactate 10.04
    diethyl carbonate 6.36
    propanediol butyl ether 20.44
    triethyl orthoformate 6.2
    p-tert-butyltoluene 3.4
    methyl 4-tert-butylbenzoate 15.85
    morpholine 29.88
    tert-butylamine 6.22
    n-dodecanol 3.32
    dimethoxymethane 45.21
    ethylene carbonate 18.38
    cyrene 32.08
    2-ethoxyethyl acetate 8.3
    2-ethylhexyl acetate 4.92
    1,2,4-trichlorobenzene 9.2
    4-methylpyridine 17.64
    dibutyl ether 2.93
    2,6-dimethyl-4-heptanol 3.46
    DEF 31.02
    dimethyl isosorbide 33.81
    tetrachloroethylene 13.03
    eugenol 21.58
    triacetin 11.6
    span 80 18.11
    1,4-butanediol 16.61
    1,1-dichloroethane 5.47
    2-methyl-1-pentanol 5.33
    methyl formate 69.24
    2-methyl-1-butanol 8.13
    n-decane 0.55
    butyronitrile 11.28
    3,7-dimethyl-1-octanol 5.3
    1-chlorooctane 2.05
    1-chlorotetradecane 1.1
    n-nonane 0.48
    undecane 0.45
    tert-butylcyclohexane 0.45
    cyclooctane 0.61
    cyclopentanol 16.25
    tetrahydropyran 9.57
    tert-amyl methyl ether 4.48
    2,5,8-trioxanonane 38.97
    1-hexene 1.22
    2-isopropoxyethanol 12.57
    2,2,2-trifluoroethanol 29.32
    methyl butyrate 10.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction