Sennosides

Overview IFRA Request a quote

  • Identifiers

    Molecular formula
    C42H38O20

    SMILES
    C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 77.68%
    Vanilla 26.7%
    Sweet 25.75%
    Balsamic 22.47%
    Phenolic 21.68%
    Milky 21.68%
    Bitter 20.27%
    Savory 18.2%
    Clean 18.02%
    Spicy 17.71%

     

    Flavor
    Bitter 89.47%
    Odorless 36.37%
    Bland 33.18%
    Sweet-like 24.54%
    Very mild 20.57%
    Cedarleaf 20.02%
    Lovage 19.08%
    Nitrile 18.94%
    Parsley 18.77%
    Heather 18.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    1.48 (strong acid)

    Molecular weight
    862.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    6935°C

    Flash point

    • 371.87 ˚C est.

  • Synonyms

    • Sennosides
    • Glysennid
    • Laxative
    • Sennoside Ca
    • Colonorm
    • Nytilax
    • Sankaijo
    • Exchange select
    • Docuset Sodium
    • Laxative Pills
    • Laxative Senna
    • Senna Glycoside
    • Colistat Plus
    • Gentle Nature
    • Senna Liquid
    • Colon Detox
    • Geri-kot
    • Senna Plus
    • Senna-Tabs
    • Nature's Remedy
    • Senna Lax
    • Senna-Doc
    • Senokot-S
    • Senna S Orange
    • Senna S Laxative
    • Chocolate Laxative
    • Senna S
    • Vegetable Laxative
    • Senna UD
    • Plus Pharma Senna
    • Sennoside 25 mg
    • Chocolated Laxative
    • Sennosides 15 mg
    • Sennosides 25 mg
    • Sennosides 8.6mg
    • CVS Senna Laxative
    • Laxative Preparation
    • Super Colon Cleanse
    • CAREMOTION
    • DOCUZEN
    • Preferred Plus Senna
    • Senna 8.6mg
    • Senna Natural Relief
    • Sennosides, 25 mg
    • GeriCare Senna Syrup
    • Senna S Dual Action
    • Genexa Senna Laxative
    • Kroger Senna Laxative
    • Meijer Senna Laxative
    • Senna/Docusate Sodium
    • MEDI-LAXX
    • SENNA-PLUS
    • Sool Softener Laxative
    • Laxative Stool Softener
    • Stimulant Laxative Plus
    • RefChem:48717
    • Chocolate Flavored Senna
    • Walgreens Senna Laxative
    • Calcium Sennosides 20%
    • Calcium Sennosides 60%
    • Laxative Maximum Strength
    • Laxative Regular Strength
    • Maximum Strength Laxative
    • Regular Strength Laxative
    • Docusate sodium-sennosides
    • Senna and Docusate Sodium
    • 3FYP5M0IJX
    • Docusate Sodium Sennosides
    • Docusate Sodium/Sennosides
    • Natural Vegetable Laxative
    • Genexa Kids Senna Laxative
    • Sennosides Natural Laxative
    • Docusate Sodium, Sennosides
    • Docusate Sodium; Sennosides
    • Laxative and Stool Softener
    • Sennosides, Docusate Sodium
    • Stool Softener and Laxative
    • Sennosides 8.6 mg Tablets
    • SENNOSIDES, 8.6 mg
    • Stool Softener plus Laxative
    • Stool Softener with Laxative
    • Sennosides Stimulant Laxative
    • NATURAL SENNA LAXATIVE
    • Standardized senna concentrate
    • Stool Softener Plus Stimulant
    • Sennosides, stimulant laxative
    • Sennosides and Docusate Sodium
    • Laxative Pills Maximum Strength
    • Maximum Strength Senna Laxative
    • Senna laxative Regular Strength
    • VALUMEDS NATURAL LAXATIVE
    • CHEBI:50503
    • CHEBI:84154
    • DOCUSATE SODIUM AND SENNA
    • DOCUSATE SODIUM,SENNOSIDES
    • Only For STIMULANT LAXATIVE
    • Stool Softener Stimulant laxative
    • HEB Maximum strength Laxative pills
    • Laxative Docusate Sodium with Senna
    • DOCUSATE SODIUM and SENNOSIDES
    • Vegetable Laxative and Stool Softner
    • Stool Softener and Stimulant Laxative
    • Kroger Senna Laxative Regular Strength
    • MAXIMUM STRENGTH LAXATIVE PILLS
    • Meijer Senna Laxative Regular Strength
    • Stimulant Laxative Plus Stool Softener
    • Stool Softener Laxative Plus Stimulant
    • Stool Softener Plus Stimulant Laxative
    • Stool Softener with Stimulant Laxative
    • STOOL SOFTENER-STIMULANT LAXATIVE
    • Vegetable Laxative From Senna Concentrate
    • Docusate Sodium 50 mg Sennosides 8.6 mg
    • Docusate Sodium 50mg and Sennosides 8.6mg
    • Senna and Docusate Sodium Tablets, 8.6 mg
    • SENNA-S LAXATIVE WITH STOOL SOFTENER
    • Sennosides 8.6mg and Docusate Sodium 50mg
    • Little Remedies Little Tummys Laxative Drops
    • MEDI-LAXX STOOL SOFTENER AND LAXATIVE
    • Docusate Sodium 50 mg and Sennosides 8.6 mg
    • Docusate Sodium, 50 mg Sennosides, 8.6 mg
    • Natural Vegetable Laxative and Stool Softener
    • Sennosides 8.6 mg and Docusate Sodium 50 mg
    • Drug Mart Stool Softener plus Stimulant Laxative
    • Drug Mart Vegetable Laxative plus Stool Softener
    • LEADER Regular Strength Senna Laxative SOFTGEL
    • EX-LAX MAXIMUM STRENGTH STIMULANT LAXATIVE
    • EX-LAX REGULAR STRENGTH STIMULANT LAXATIVE
    • 85085-71-8

  • Applications

    Sennosides are natural anthraquinone glycosides used primarily as stimulant laxatives in pharmaceutical formulations; they also occur as key constituents of senna-based herbal medicines and dietary supplements, where senna extracts provide the laxative activity. In pharmaceutical manufacturing and pharmacognosy, sennosides serve as reference materials for extraction, isolation, and standardization workflows, and they are commonly quantified by HPLC in quality-control analyses. They may be used as analytical standards in method development and routine assays to ensure batch-to-batch consistency, while formulations and labeling are subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.88
    methanol 10.18
    isopropanol 3.43
    water 0.14
    ethyl acetate 2.25
    n-propanol 5.25
    acetone 5.07
    n-butanol 2.56
    acetonitrile 1.04
    DMF 34.63
    toluene 0.49
    isobutanol 1.5
    1,4-dioxane 10.14
    methyl acetate 3.35
    THF 22.31
    2-butanone 5.43
    n-pentanol 1.13
    sec-butanol 2.64
    n-hexane 0.03
    ethylene glycol 8.29
    NMP 30.58
    cyclohexane 0.06
    DMSO 37.66
    n-butyl acetate 0.68
    n-octanol 0.73
    chloroform 0.95
    n-propyl acetate 0.82
    acetic acid 16.68
    dichloromethane 1.13
    cyclohexanone 5.48
    propylene glycol 10.33
    isopropyl acetate 0.99
    DMAc 36.44
    2-ethoxyethanol 11.27
    isopentanol 0.9
    n-heptane 0.04
    ethyl formate 3.15
    1,2-dichloroethane 0.97
    n-hexanol 0.55
    2-methoxyethanol 33.8
    isobutyl acetate 0.2
    tetrachloromethane 0.18
    n-pentyl acetate 0.99
    transcutol 9.41
    n-heptanol 0.76
    ethylbenzene 0.13
    MIBK 0.69
    2-propoxyethanol 7.26
    tert-butanol 1.35
    MTBE 0.73
    2-butoxyethanol 4.65
    propionic acid 6.18
    o-xylene 0.25
    formic acid 18.95
    diethyl ether 1.82
    m-xylene 0.2
    p-xylene 0.11
    chlorobenzene 0.2
    dimethyl carbonate 3.81
    n-octane 0.03
    formamide 20.89
    cyclopentanone 12.34
    2-pentanone 2.84
    anisole 0.51
    cyclopentyl methyl ether 2.26
    gamma-butyrolactone 14.16
    1-methoxy-2-propanol 19.47
    pyridine 5.54
    3-pentanone 2.03
    furfural 8.15
    n-dodecane 0.02
    diethylene glycol 9.49
    diisopropyl ether 0.15
    tert-amyl alcohol 1.33
    acetylacetone 3.75
    n-hexadecane 0.02
    acetophenone 0.78
    methyl propionate 4.08
    isopentyl acetate 0.36
    trichloroethylene 1.72
    n-nonanol 0.74
    cyclohexanol 1.52
    benzyl alcohol 1.24
    2-ethylhexanol 0.23
    isooctanol 0.39
    dipropyl ether 0.74
    1,2-dichlorobenzene 0.14
    ethyl lactate 1.66
    propylene carbonate 2.85
    n-methylformamide 18.64
    2-pentanol 1.13
    n-pentane 0.06
    1-propoxy-2-propanol 3.99
    1-methoxy-2-propyl acetate 2.11
    2-(2-methoxypropoxy) propanol 2.59
    mesitylene 0.08
    ε-caprolactone 5.57
    p-cymene 0.07
    epichlorohydrin 8.79
    1,1,1-trichloroethane 0.27
    2-aminoethanol 10.44
    morpholine-4-carbaldehyde 29.56
    sulfolane 21.24
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 4.64
    n-hexyl acetate 0.95
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 4.27
    sec-butyl acetate 0.37
    tert-butyl acetate 0.74
    decalin 0.01
    glycerin 24.47
    diglyme 7.43
    acrylic acid 8.22
    isopropyl myristate 0.25
    n-butyric acid 4.79
    acetyl acetate 1.12
    di(2-ethylhexyl) phthalate 0.32
    ethyl propionate 0.97
    nitromethane 16.82
    1,2-diethoxyethane 1.8
    benzonitrile 0.42
    trioctyl phosphate 0.34
    1-bromopropane 0.5
    gamma-valerolactone 28.71
    n-decanol 0.46
    triethyl phosphate 0.35
    4-methyl-2-pentanol 0.31
    propionitrile 1.18
    vinylene carbonate 2.91
    1,1,2-trichlorotrifluoroethane 14.39
    DMS 1.14
    cumene 0.06
    2-octanol 0.47
    2-hexanone 0.92
    octyl acetate 0.53
    limonene 0.12
    1,2-dimethoxyethane 9.69
    ethyl orthosilicate 0.34
    tributyl phosphate 0.29
    diacetone alcohol 3.24
    N,N-dimethylaniline 0.39
    acrylonitrile 2.26
    aniline 1.46
    1,3-propanediol 12.33
    bromobenzene 0.12
    dibromomethane 0.54
    1,1,2,2-tetrachloroethane 1.56
    2-methyl-cyclohexyl acetate 0.3
    tetrabutyl urea 0.67
    diisobutyl methanol 0.12
    2-phenylethanol 0.66
    styrene 0.15
    dioctyl adipate 0.51
    dimethyl sulfate 6.59
    ethyl butyrate 0.67
    methyl lactate 8.35
    butyl lactate 1.71
    diethyl carbonate 0.39
    propanediol butyl ether 4.6
    triethyl orthoformate 0.7
    p-tert-butyltoluene 0.07
    methyl 4-tert-butylbenzoate 1.04
    morpholine 17.28
    tert-butylamine 0.37
    n-dodecanol 0.27
    dimethoxymethane 15.8
    ethylene carbonate 2.27
    cyrene 3.82
    2-ethoxyethyl acetate 2.32
    2-ethylhexyl acetate 0.26
    1,2,4-trichlorobenzene 0.26
    4-methylpyridine 2.32
    dibutyl ether 0.47
    2,6-dimethyl-4-heptanol 0.12
    DEF 6.16
    dimethyl isosorbide 2.76
    tetrachloroethylene 1.21
    eugenol 1.26
    triacetin 1.41
    span 80 2.68
    1,4-butanediol 3.27
    1,1-dichloroethane 0.54
    2-methyl-1-pentanol 0.49
    methyl formate 11.73
    2-methyl-1-butanol 1.19
    n-decane 0.04
    butyronitrile 0.85
    3,7-dimethyl-1-octanol 0.28
    1-chlorooctane 0.18
    1-chlorotetradecane 0.06
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 3.45
    tetrahydropyran 4.17
    tert-amyl methyl ether 0.76
    2,5,8-trioxanonane 4.47
    1-hexene 0.13
    2-isopropoxyethanol 3.68
    2,2,2-trifluoroethanol 6.36
    methyl butyrate 1.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction