(+)-Schisandrin B

Overview IFRA Request a quote

  • Identifiers

    CAS number
    82467-52-5

    Molecular formula
    C23H28O6

    SMILES
    C[C@H]1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C[C@H]1C)OC)OC)OC)OC)OCO3

    Safety labels

  • Odor profile

    Fragrance
    Spicy 62.97%
    Woody 48.22%
    Phenolic 47.05%
    Smoky 33.27%
    Balsamic 33.26%
    Powdery 29.37%
    Dry 28.05%
    Leathery 27.89%
    Musk 27.22%
    Amber 26.02%

     

    Flavor
    Bitter 72.76%
    Parsley 23.25%
    Bland 22.3%
    Eugenol 21.7%
    Cedarleaf 20.99%
    Carrot 19.97%
    Ripe apricot 19.87%
    Red fruit 19.67%
    Spice 19.57%
    Lovage 19.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.1

    pKa est.
    7.29 (neutral)

    Molecular weight
    400.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    626°C

    Flash point

    • 198.28 ˚C est.

  • Synonyms

    • (+)-Schisandrin B
    • Deoxygomisin A
    • 82467-52-5
    • (+)-gamma-Schizandrin
    • CHEBI:132471
    • DTXSID10231747
    • RefChem:1048996
    • DTXCID40154238
    • gomisin N
    • Isokadsuranin
    • 69176-52-9
    • Wuweizisu B
    • (-)-Gomisin N
    • Gamma-schizandrin
    • ( )-Schisandrin B
    • gamma-Schisandrin
    • UNII-DKO6O75Z5V
    • DKO6O75Z5V
    • 02XA4X3KZW
    • CHEBI:4410
    • (9R,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene
    • Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aS)-
    • (6R,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
    • Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, stereoisomer
    • AC1L4JAK
    • schisanthenol
    • r-schizandrin
    • Gomisin-N
    • (+)-schizandrin B
    • (+)-gamma-schisandrin
    • (+/-)-y-schizandrin
    • (+/-)-gamma-schizandrin
    • UNII-02XA4X3KZW
    • .GAMMA.-SCHISANDRIN
    • .GAMMA.-SCHIZANDRIN
    • SCHEMBL713266
    • CHEMBL402435
    • orb1299057
    • SCHEMBL29485034
    • SCHEMBL30072019
    • GTPL13774
    • SCHISANDRIN B, (+/-)-
    • HY-N2267
    • HY-N6866
    • BDBM50595039
    • MFCD00887634
    • (+/-)-.GAMMA.-SCHISANDRIN
    • (+/-)-.GAMMA.-SCHIZANDRIN
    • AKOS015965220
    • EBC-469152
    • FG65499
    • FI74454
    • AC-20310
    • AC-34238
    • AC-34828
    • MS-26802
    • CS-0019596
    • CS-0027857
    • E80780
    • E87117
    • SCHISANDRIN B (.GAMMA.-SCHISANDRIN) (CONSTITUENT OF NORTHERN SCHISANDRA) [DSC]
    • (6R,7S)-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-11H-benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
    • (6R,7S,13AS)-5,6,7,8-TETRAHYDRO-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO(3,4)CYCLOOCTA(1,2-F)(1,3)BENZODIOXOLE
    • (6R,7S13aR)-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-11H-benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
    • (9R,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.0^{2,7}.0^{14,18}]nonadeca-1(19),2,4,6,12,14(18)-hexaene
    • 1,2,3,12-tetramethoxy-6,7-dimethyl- 10,11-methylenedioxy-5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene
    • BENZO(3,4)CYCLOOCTA(1,2-F)(1,3)BENZODIOXOLE, 5,6,7,8-TETRAHYDRO-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYL-, (6R,7S,13AR)-REL-
    • 69176-52-9

  • Applications

    (+)-Schisandrin B, CAS 82467-52-5, is primarily encountered in research on Schisandra-derived lignans and is often evaluated as a bioactive constituent in cosmetic formulations for antioxidant-related applications; it may be included in nutraceutical or dietary supplement extracts derived from Schisandra chinensis; in pharmaceutical research it is studied for pharmacological activity as a representative lignan; and in analytical chemistry it serves as a reference standard for phytochemical profiling and quality control of Schisandra-containing extracts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.47
    methanol 13.56
    isopropanol 17.65
    water 0.37
    ethyl acetate 139.57
    n-propanol 22.38
    acetone 113.44
    n-butanol 25.29
    acetonitrile 63.72
    DMF 129.2
    toluene 48.22
    isobutanol 22.03
    1,4-dioxane 109.83
    methyl acetate 115.7
    THF 172.21
    2-butanone 97.72
    n-pentanol 25.13
    sec-butanol 21.75
    n-hexane 5.74
    ethylene glycol 12.19
    NMP 234.83
    cyclohexane 13.98
    DMSO 122.16
    n-butyl acetate 96.62
    n-octanol 19.67
    chloroform 443.41
    n-propyl acetate 86.3
    acetic acid 143.67
    dichloromethane 444.12
    cyclohexanone 179.75
    propylene glycol 10.31
    isopropyl acetate 102.6
    DMAc 183.48
    2-ethoxyethanol 59.16
    isopentanol 33.27
    n-heptane 5.71
    ethyl formate 91.77
    1,2-dichloroethane 269.32
    n-hexanol 34.42
    2-methoxyethanol 67.66
    isobutyl acetate 67.79
    tetrachloromethane 108.5
    n-pentyl acetate 84.27
    transcutol 114.13
    n-heptanol 26.4
    ethylbenzene 30.93
    MIBK 73.08
    2-propoxyethanol 85.78
    tert-butanol 28.79
    MTBE 41.87
    2-butoxyethanol 66.97
    propionic acid 74.62
    o-xylene 41.13
    formic acid 46.77
    diethyl ether 56.61
    m-xylene 38.41
    p-xylene 42.74
    chlorobenzene 127.17
    dimethyl carbonate 125.24
    n-octane 3.68
    formamide 69.13
    cyclopentanone 217.77
    2-pentanone 95.53
    anisole 56.25
    cyclopentyl methyl ether 92.85
    gamma-butyrolactone 278.94
    1-methoxy-2-propanol 58.46
    pyridine 137.03
    3-pentanone 95.88
    furfural 261.39
    n-dodecane 3.04
    diethylene glycol 71.74
    diisopropyl ether 27.67
    tert-amyl alcohol 31.38
    acetylacetone 179.78
    n-hexadecane 3.65
    acetophenone 88.9
    methyl propionate 121.3
    isopentyl acetate 97.36
    trichloroethylene 597.99
    n-nonanol 21.67
    cyclohexanol 50.05
    benzyl alcohol 57.22
    2-ethylhexanol 34.47
    isooctanol 26.42
    dipropyl ether 34.8
    1,2-dichlorobenzene 156.81
    ethyl lactate 60.63
    propylene carbonate 209.79
    n-methylformamide 70.08
    2-pentanol 24.17
    n-pentane 6.28
    1-propoxy-2-propanol 59.02
    1-methoxy-2-propyl acetate 116.74
    2-(2-methoxypropoxy) propanol 68.56
    mesitylene 28.27
    ε-caprolactone 193.04
    p-cymene 32.12
    epichlorohydrin 325.14
    1,1,1-trichloroethane 296.4
    2-aminoethanol 15.94
    morpholine-4-carbaldehyde 202.8
    sulfolane 309.78
    2,2,4-trimethylpentane 6.53
    2-methyltetrahydrofuran 117.04
    n-hexyl acetate 76.98
    isooctane 4.43
    2-(2-butoxyethoxy)ethanol 71.28
    sec-butyl acetate 71.02
    tert-butyl acetate 99.55
    decalin 10.52
    glycerin 30.0
    diglyme 140.38
    acrylic acid 100.93
    isopropyl myristate 34.67
    n-butyric acid 108.23
    acetyl acetate 189.33
    di(2-ethylhexyl) phthalate 49.51
    ethyl propionate 88.12
    nitromethane 269.12
    1,2-diethoxyethane 63.19
    benzonitrile 86.59
    trioctyl phosphate 36.18
    1-bromopropane 99.04
    gamma-valerolactone 270.95
    n-decanol 16.67
    triethyl phosphate 68.6
    4-methyl-2-pentanol 23.68
    propionitrile 52.46
    vinylene carbonate 230.48
    1,1,2-trichlorotrifluoroethane 306.17
    DMS 122.46
    cumene 26.15
    2-octanol 19.23
    2-hexanone 67.51
    octyl acetate 45.98
    limonene 40.11
    1,2-dimethoxyethane 95.29
    ethyl orthosilicate 60.52
    tributyl phosphate 44.2
    diacetone alcohol 86.21
    N,N-dimethylaniline 45.65
    acrylonitrile 81.1
    aniline 65.14
    1,3-propanediol 31.16
    bromobenzene 146.53
    dibromomethane 257.07
    1,1,2,2-tetrachloroethane 396.27
    2-methyl-cyclohexyl acetate 86.46
    tetrabutyl urea 51.38
    diisobutyl methanol 22.29
    2-phenylethanol 68.23
    styrene 37.42
    dioctyl adipate 61.11
    dimethyl sulfate 215.06
    ethyl butyrate 80.17
    methyl lactate 80.09
    butyl lactate 64.38
    diethyl carbonate 75.64
    propanediol butyl ether 40.84
    triethyl orthoformate 66.65
    p-tert-butyltoluene 29.25
    methyl 4-tert-butylbenzoate 95.2
    morpholine 108.93
    tert-butylamine 18.4
    n-dodecanol 13.27
    dimethoxymethane 107.76
    ethylene carbonate 185.07
    cyrene 106.87
    2-ethoxyethyl acetate 124.42
    2-ethylhexyl acetate 86.99
    1,2,4-trichlorobenzene 179.83
    4-methylpyridine 116.68
    dibutyl ether 26.7
    2,6-dimethyl-4-heptanol 22.29
    DEF 131.14
    dimethyl isosorbide 135.92
    tetrachloroethylene 295.62
    eugenol 82.49
    triacetin 106.63
    span 80 53.24
    1,4-butanediol 18.04
    1,1-dichloroethane 191.26
    2-methyl-1-pentanol 34.99
    methyl formate 90.16
    2-methyl-1-butanol 30.53
    n-decane 4.82
    butyronitrile 50.71
    3,7-dimethyl-1-octanol 24.94
    1-chlorooctane 21.75
    1-chlorotetradecane 10.74
    n-nonane 4.0
    undecane 3.67
    tert-butylcyclohexane 7.61
    cyclooctane 6.54
    cyclopentanol 50.2
    tetrahydropyran 91.32
    tert-amyl methyl ether 44.78
    2,5,8-trioxanonane 101.3
    1-hexene 17.21
    2-isopropoxyethanol 54.88
    2,2,2-trifluoroethanol 130.59
    methyl butyrate 98.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction