Schisandrin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    7432-28-2

    Molecular formula
    C24H32O7

    SMILES
    C[C@H]1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C[C@]1(C)O)OC)OC)OC)OC)OC)OC

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Spicy 53.13%
    Phenolic 46.56%
    Woody 46.31%
    Vanilla 39.54%
    Balsamic 38.08%
    Floral 35.2%
    Powdery 35.02%
    Smoky 33.5%
    Sweet 31.41%
    Musk 26.97%

     

    Flavor
    Bitter 64.7%
    Parsley 24.1%
    Bland 23.04%
    Eugenol 22.87%
    Spice 22.53%
    Earth 21.72%
    Cedarleaf 21.58%
    Camphor 21.23%
    Carrot 21.05%
    Sweet-like 20.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    7.42 (neutral)

    Molecular weight
    432.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    868°C

    Flash point

    • 201.43 ˚C est.

  • Synonyms

    • Schisandrin
    • Schizandrin
    • 7432-28-2
    • Wuweizichun A
    • Schizandrol A
    • Wuweizi alcohol A
    • G01BQC0879
    • Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer
    • (9S,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo(10.4.0.02,7)hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
    • (9S,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
    • RefChem:47480
    • 694-563-5
    • 3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo(10.4.0.02,7)hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
    • wuweizisu A
    • Schizandrol
    • (+)-Schizandrin
    • MFCD00905761
    • (6S,7S,12aR)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol
    • (6S,7S)-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol
    • Schisandrine
    • hexamethoxy(dimethyl)[?]ol
    • Gomisins
    • Wuweizins
    • Omija
    • C24H32O7
    • Magnolia Vine
    • Schisandrin CRS
    • (+)-schisandrin
    • Wu-wei-zi
    • Gomisins (Japanese)
    • Wuweizins (Chinese)
    • SCHIZANDRINE
    • Schisandrin (Standard)
    • Schisandrins (Russian)
    • (9S,10S)-Schizandrin
    • SCHISANDRIN [USP-RS]
    • MLS000728484
    • SCHEMBL568558
    • UNII-G01BQC0879
    • CHEMBL253688
    • SCHEMBL29389398
    • SCHEMBL29725105
    • HY-N0691R
    • Schizandrin, >=98% (HPLC)
    • 7ALPHA-HYDROXYSCHIZANDRONOL
    • HMS2227F11
    • HMS3885M06
    • HY-N0691
    • BDBM50485610
    • s3823
    • AKOS032962032
    • CCG-269043
    • CS-3663
    • EBC-459147
    • NCGC00247516-01
    • SMR000445691
    • NS00097345
    • Q27151398
    • Schizandrin, EuropePharmacopoeia (EP) Reference Standard
    • Schisandrin, United States Pharmacopeia (USP) Reference Standard
    • SCHISANDRIN (SCHISANDROL A) (CONSTITUENT OF NORTHERN SCHISANDRA) [DSC]
    • (9S,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyl-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
    • (9S,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.0,2,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
    • DIBENZO(A,C)CYCLOOCTEN-6-OL, 5,6,7,8-TETRAHYDRO-1,2,3,10,11,12-HEXAMETHOXY-6,7-DIMETHYL-, (6S,7S,12AR)-
    • Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxy-, stereoisomer
    • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S)-
    • 7432-28-2

  • Applications

    Schisandrin, a lignan isolated from Schisandra chinensis, is primarily employed in pharmaceutical and natural-product research as a bioactive compound and lead scaffold for lignan derivatives, with investigations of antioxidant activity in vitro to support drug-discovery workflows. It is also used in nutraceuticals and herbal products as an active constituent of Schisandra extracts, with evaluation for inclusion in standardized botanical formulations within regulatory frameworks. In cosmetics and personal care, schisandrin may be used as an antioxidant ingredient to help stabilize formulations and protect materials from oxidative degradation. In analytical laboratories, it serves as a reference compound for chromatographic methods used to characterize Schisandra extracts and related lignans, aiding quality control and method development. Overall, these applications are research-driven and formulation-oriented, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.95
    methanol 17.89
    isopropanol 21.02
    water 0.44
    ethyl acetate 110.4
    n-propanol 24.31
    acetone 90.91
    n-butanol 23.77
    acetonitrile 49.42
    DMF 131.06
    toluene 22.5
    isobutanol 21.31
    1,4-dioxane 82.18
    methyl acetate 94.26
    THF 112.51
    2-butanone 73.14
    n-pentanol 24.62
    sec-butanol 23.64
    n-hexane 4.7
    ethylene glycol 15.11
    NMP 205.28
    cyclohexane 8.01
    DMSO 132.86
    n-butyl acetate 69.24
    n-octanol 17.77
    chloroform 248.67
    n-propyl acetate 64.05
    acetic acid 150.81
    dichloromethane 226.01
    cyclohexanone 116.15
    propylene glycol 14.79
    isopropyl acetate 75.52
    DMAc 184.87
    2-ethoxyethanol 57.3
    isopentanol 26.02
    n-heptane 5.01
    ethyl formate 70.02
    1,2-dichloroethane 145.98
    n-hexanol 29.91
    2-methoxyethanol 65.99
    isobutyl acetate 44.06
    tetrachloromethane 68.42
    n-pentyl acetate 62.08
    transcutol 91.79
    n-heptanol 23.61
    ethylbenzene 17.34
    MIBK 50.1
    2-propoxyethanol 74.63
    tert-butanol 30.39
    MTBE 36.28
    2-butoxyethanol 56.48
    propionic acid 72.08
    o-xylene 23.67
    formic acid 51.49
    diethyl ether 46.37
    m-xylene 18.8
    p-xylene 23.32
    chlorobenzene 59.47
    dimethyl carbonate 103.78
    n-octane 2.98
    formamide 70.43
    cyclopentanone 141.9
    2-pentanone 71.23
    anisole 36.68
    cyclopentyl methyl ether 62.12
    gamma-butyrolactone 198.12
    1-methoxy-2-propanol 63.33
    pyridine 75.02
    3-pentanone 69.19
    furfural 161.09
    n-dodecane 2.28
    diethylene glycol 65.97
    diisopropyl ether 19.93
    tert-amyl alcohol 33.25
    acetylacetone 126.8
    n-hexadecane 2.6
    acetophenone 62.3
    methyl propionate 99.35
    isopentyl acetate 63.7
    trichloroethylene 288.87
    n-nonanol 19.17
    cyclohexanol 38.33
    benzyl alcohol 39.64
    2-ethylhexanol 26.49
    isooctanol 21.25
    dipropyl ether 29.72
    1,2-dichlorobenzene 81.37
    ethyl lactate 55.07
    propylene carbonate 146.76
    n-methylformamide 70.49
    2-pentanol 23.28
    n-pentane 5.14
    1-propoxy-2-propanol 54.72
    1-methoxy-2-propyl acetate 91.67
    2-(2-methoxypropoxy) propanol 55.91
    mesitylene 13.94
    ε-caprolactone 131.62
    p-cymene 20.58
    epichlorohydrin 185.13
    1,1,1-trichloroethane 159.27
    2-aminoethanol 19.6
    morpholine-4-carbaldehyde 170.58
    sulfolane 256.38
    2,2,4-trimethylpentane 5.13
    2-methyltetrahydrofuran 74.72
    n-hexyl acetate 56.03
    isooctane 2.78
    2-(2-butoxyethoxy)ethanol 55.18
    sec-butyl acetate 49.17
    tert-butyl acetate 70.93
    decalin 6.57
    glycerin 35.76
    diglyme 106.24
    acrylic acid 89.61
    isopropyl myristate 24.05
    n-butyric acid 89.53
    acetyl acetate 145.45
    di(2-ethylhexyl) phthalate 35.59
    ethyl propionate 66.77
    nitromethane 237.76
    1,2-diethoxyethane 46.31
    benzonitrile 50.48
    trioctyl phosphate 27.75
    1-bromopropane 58.88
    gamma-valerolactone 183.65
    n-decanol 14.42
    triethyl phosphate 53.12
    4-methyl-2-pentanol 18.53
    propionitrile 40.36
    vinylene carbonate 155.7
    1,1,2-trichlorotrifluoroethane 215.24
    DMS 95.52
    cumene 15.73
    2-octanol 16.31
    2-hexanone 49.67
    octyl acetate 33.91
    limonene 28.22
    1,2-dimethoxyethane 77.82
    ethyl orthosilicate 45.87
    tributyl phosphate 32.76
    diacetone alcohol 74.32
    N,N-dimethylaniline 33.93
    acrylonitrile 60.25
    aniline 38.46
    1,3-propanediol 31.26
    bromobenzene 62.27
    dibromomethane 140.13
    1,1,2,2-tetrachloroethane 222.82
    2-methyl-cyclohexyl acetate 58.95
    tetrabutyl urea 40.07
    diisobutyl methanol 17.19
    2-phenylethanol 46.25
    styrene 20.38
    dioctyl adipate 43.64
    dimethyl sulfate 180.17
    ethyl butyrate 58.72
    methyl lactate 81.55
    butyl lactate 51.72
    diethyl carbonate 55.98
    propanediol butyl ether 39.51
    triethyl orthoformate 50.79
    p-tert-butyltoluene 18.76
    methyl 4-tert-butylbenzoate 72.77
    morpholine 86.13
    tert-butylamine 17.88
    n-dodecanol 10.92
    dimethoxymethane 91.52
    ethylene carbonate 129.07
    cyrene 85.36
    2-ethoxyethyl acetate 92.2
    2-ethylhexyl acetate 57.93
    1,2,4-trichlorobenzene 95.37
    4-methylpyridine 66.4
    dibutyl ether 19.53
    2,6-dimethyl-4-heptanol 17.19
    DEF 106.46
    dimethyl isosorbide 101.08
    tetrachloroethylene 170.28
    eugenol 58.34
    triacetin 89.11
    span 80 46.65
    1,4-butanediol 19.05
    1,1-dichloroethane 108.38
    2-methyl-1-pentanol 28.15
    methyl formate 78.4
    2-methyl-1-butanol 26.13
    n-decane 3.75
    butyronitrile 37.27
    3,7-dimethyl-1-octanol 18.81
    1-chlorooctane 15.69
    1-chlorotetradecane 7.48
    n-nonane 3.22
    undecane 2.8
    tert-butylcyclohexane 4.88
    cyclooctane 3.69
    cyclopentanol 41.42
    tetrahydropyran 62.83
    tert-amyl methyl ether 40.76
    2,5,8-trioxanonane 77.9
    1-hexene 14.03
    2-isopropoxyethanol 49.12
    2,2,2-trifluoroethanol 127.37
    methyl butyrate 73.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction