Salinomycin

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  • Identifiers

    CAS number
    53003-10-4

    Molecular formula
    C42H70O11

    SMILES
    CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Odorless 42.6%
    Cooling 31.77%
    Mint 31.53%
    Woody 25.88%
    Lactonic 21.21%
    Milky 20.72%
    Spicy 20.4%
    Sweet 19.12%
    Savory 18.61%
    Grapefruit 18.11%

     

    Flavor
    Bitter 49.39%
    Fatty 24.14%
    Sweet-like 22.42%
    Odorless 22.0%
    Cedarleaf 21.84%
    Green tea 20.09%
    Bland 20.03%
    Bouillon 19.97%
    Metallic 19.91%
    Carrot 19.84%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    5.59 (weak acid)

    Molecular weight
    751.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    259°C

    Melting point expt.

    • 112.5-113.5 °C

    Flash point

    • 178.94 ˚C est.

  • Synonyms

    • salinomycin
    • 53003-10-4
    • Procoxacin
    • Coxistac
    • Salinomicina
    • Salinomycine
    • Salinomycinum
    • DTXSID4048486
    • 62UXS86T64
    • (2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
    • Salinomycin Mycelia
    • (2R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((3S,5S,7R,9S,10S,12R,15R)-3-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl)-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro(4.1.57.35)pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyloxan-2-yl)butanoic acid
    • RefChem:57321
    • DTXCID4028460
    • (alphaR,2R,5S,6R)-alpha-ethyl-6-((1S,2S,3S,5R)-5-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxydispiro(4.1.5.3)-pentadec-13-en-9-yl)-2-hydroxy-1,3-dimethyl-4-oxoheptyl)-tetrahydro-5-methyl-2H-pyran-2-acetic acid
    • 258-290-1
    • MFCD25541652
    • Salinomycin (INN)
    • SALINOMYCIN [INN]
    • Bio-cox
    • Salinomycin [INN:BAN]
    • Salinomycine [INN-French]
    • Salinomycinum [INN-Latin]
    • Salinomicina [INN-Spanish]
    • UNII-62UXS86T64
    • K 364
    • HSDB 7032
    • Procoxacin (TN)
    • 1,6,8-Trioxadispiro[4.1.5.3]pentadecane, salinomycin deriv.; Antibiotic 61477; Coxistac; Stereoisomer of a-ethyl-6-[5-[2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-2H-pyran-2-acetic acid; Salinomycin
    • AHR 3096
    • EINECS 258-290-1
    • C42H70O11
    • SALINOMYCIN [MI]
    • Salinomycin Sodium Premix
    • SALINOMYCIN [JAN]
    • SALINOMYCIN [HSDB]
    • SCHEMBL36890
    • orb1710669
    • CHEMBL1208572
    • CHEBI:80025
    • GTPL11088
    • BDBM430647
    • HMS6018M13
    • MSK000595
    • NSC757437
    • s2352
    • AKOS030526154
    • CCG-208535
    • CS-1299
    • DB11544
    • EBC-454735
    • MSK000595-100M
    • NSC-757437
    • MSK000595-1000M
    • BS-17023
    • E716
    • HY-15597
    • SY252444
    • NS00007817
    • Salinomycin Solution in Methanol, 100ug/mL
    • Salinomycin Solution in Methanol, 1000ug/mL
    • D08502
    • Q411909
    • SR-05000002207-3
    • Salinomycin, from Streptomyces albus, >=98% (HPLC)
    • (2R)-2-[(2R,5S,6R)-6-[(1S,2S,3S,5R)-5-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-tetrahydropyran-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxo-heptyl]-5-methyl-tetrahydropyran-2-yl]butanoic acid
    • (2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5?.3?]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
    • (2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
    • (2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5~7~.3~5~]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl}butanoic acid
    • (R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid
    • (R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoicacid
    • 53003-10-4

  • Applications

    Salinomycin (CAS 53003-10-4) is a polyether ionophore antibiotic used primarily in veterinary medicine as a feed additive to prevent coccidiosis in poultry and other livestock, and to improve feed efficiency and growth under farm conditions. It is formulated in veterinary drugs and premixes for animal nutrition and its use is typically limited to approved indications within the feed industry. In research settings, salinomycin serves as an ionophore tool to study cellular ion transport and membrane biology in cell culture. In industrial contexts, it can appear in analytical and regulatory discussions as a reference compound for ionophore antibiotics, with usage governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 142.9
    methanol 206.8
    isopropanol 80.77
    water 0.34
    ethyl acetate 92.98
    n-propanol 166.23
    acetone 117.83
    n-butanol 88.64
    acetonitrile 31.14
    DMF 390.07
    toluene 38.85
    isobutanol 73.26
    1,4-dioxane 194.82
    methyl acetate 87.8
    THF 501.33
    2-butanone 129.78
    n-pentanol 61.69
    sec-butanol 71.23
    n-hexane 1.3
    ethylene glycol 39.46
    NMP 654.96
    cyclohexane 1.95
    DMSO 340.85
    n-butyl acetate 34.5
    n-octanol 19.27
    chloroform 157.7
    n-propyl acetate 39.16
    acetic acid 428.48
    dichloromethane 140.06
    cyclohexanone 214.88
    propylene glycol 90.16
    isopropyl acetate 52.7
    DMAc 467.13
    2-ethoxyethanol 196.37
    isopentanol 40.95
    n-heptane 0.94
    ethyl formate 69.05
    1,2-dichloroethane 78.42
    n-hexanol 34.55
    2-methoxyethanol 338.03
    isobutyl acetate 22.8
    tetrachloromethane 21.21
    n-pentyl acetate 46.42
    transcutol 201.55
    n-heptanol 26.42
    ethylbenzene 12.97
    MIBK 41.63
    2-propoxyethanol 175.82
    tert-butanol 41.0
    MTBE 31.49
    2-butoxyethanol 106.21
    propionic acid 160.03
    o-xylene 20.27
    formic acid 183.13
    diethyl ether 49.77
    m-xylene 18.68
    p-xylene 13.41
    chlorobenzene 46.56
    dimethyl carbonate 96.56
    n-octane 0.48
    formamide 168.78
    cyclopentanone 340.59
    2-pentanone 96.88
    anisole 37.22
    cyclopentyl methyl ether 115.11
    gamma-butyrolactone 404.57
    1-methoxy-2-propanol 250.2
    pyridine 172.04
    3-pentanone 77.12
    furfural 230.8
    n-dodecane 0.35
    diethylene glycol 122.82
    diisopropyl ether 8.11
    tert-amyl alcohol 44.17
    acetylacetone 115.44
    n-hexadecane 0.41
    acetophenone 57.02
    methyl propionate 124.92
    isopentyl acetate 30.06
    trichloroethylene 192.59
    n-nonanol 19.67
    cyclohexanol 60.01
    benzyl alcohol 66.57
    2-ethylhexanol 13.08
    isooctanol 17.04
    dipropyl ether 17.39
    1,2-dichlorobenzene 38.53
    ethyl lactate 44.36
    propylene carbonate 149.99
    n-methylformamide 238.43
    2-pentanol 36.73
    n-pentane 1.65
    1-propoxy-2-propanol 85.65
    1-methoxy-2-propyl acetate 71.85
    2-(2-methoxypropoxy) propanol 63.36
    mesitylene 7.64
    ε-caprolactone 232.93
    p-cymene 6.22
    epichlorohydrin 338.35
    1,1,1-trichloroethane 55.1
    2-aminoethanol 126.0
    morpholine-4-carbaldehyde 455.85
    sulfolane 510.21
    2,2,4-trimethylpentane 1.07
    2-methyltetrahydrofuran 178.61
    n-hexyl acetate 51.41
    isooctane 0.55
    2-(2-butoxyethoxy)ethanol 90.78
    sec-butyl acetate 25.51
    tert-butyl acetate 43.51
    decalin 1.36
    glycerin 133.86
    diglyme 150.91
    acrylic acid 187.93
    isopropyl myristate 11.44
    n-butyric acid 176.21
    acetyl acetate 70.56
    di(2-ethylhexyl) phthalate 25.18
    ethyl propionate 38.94
    nitromethane 328.33
    1,2-diethoxyethane 41.93
    benzonitrile 35.62
    trioctyl phosphate 16.66
    1-bromopropane 37.56
    gamma-valerolactone 581.9
    n-decanol 10.76
    triethyl phosphate 18.11
    4-methyl-2-pentanol 15.39
    propionitrile 36.66
    vinylene carbonate 151.93
    1,1,2-trichlorotrifluoroethane 282.78
    DMS 47.55
    cumene 7.1
    2-octanol 12.22
    2-hexanone 46.7
    octyl acetate 23.11
    limonene 9.96
    1,2-dimethoxyethane 134.86
    ethyl orthosilicate 16.67
    tributyl phosphate 15.67
    diacetone alcohol 81.96
    N,N-dimethylaniline 27.73
    acrylonitrile 61.48
    aniline 73.96
    1,3-propanediol 160.77
    bromobenzene 40.08
    dibromomethane 80.0
    1,1,2,2-tetrachloroethane 142.0
    2-methyl-cyclohexyl acetate 29.23
    tetrabutyl urea 24.68
    diisobutyl methanol 5.64
    2-phenylethanol 49.29
    styrene 15.58
    dioctyl adipate 26.99
    dimethyl sulfate 169.96
    ethyl butyrate 26.93
    methyl lactate 130.08
    butyl lactate 51.11
    diethyl carbonate 16.73
    propanediol butyl ether 93.83
    triethyl orthoformate 23.61
    p-tert-butyltoluene 6.25
    methyl 4-tert-butylbenzoate 62.44
    morpholine 318.11
    tert-butylamine 12.86
    n-dodecanol 5.92
    dimethoxymethane 255.59
    ethylene carbonate 122.18
    cyrene 124.63
    2-ethoxyethyl acetate 86.23
    2-ethylhexyl acetate 23.56
    1,2,4-trichlorobenzene 61.17
    4-methylpyridine 124.97
    dibutyl ether 10.77
    2,6-dimethyl-4-heptanol 5.64
    DEF 144.16
    dimethyl isosorbide 99.69
    tetrachloroethylene 99.93
    eugenol 57.48
    triacetin 75.96
    span 80 70.46
    1,4-butanediol 64.73
    1,1-dichloroethane 65.36
    2-methyl-1-pentanol 35.94
    methyl formate 152.95
    2-methyl-1-butanol 55.32
    n-decane 0.82
    butyronitrile 30.87
    3,7-dimethyl-1-octanol 12.62
    1-chlorooctane 6.22
    1-chlorotetradecane 1.69
    n-nonane 0.67
    undecane 0.5
    tert-butylcyclohexane 0.98
    cyclooctane 0.82
    cyclopentanol 116.75
    tetrahydropyran 132.51
    tert-amyl methyl ether 30.41
    2,5,8-trioxanonane 88.53
    1-hexene 6.48
    2-isopropoxyethanol 95.91
    2,2,2-trifluoroethanol 140.97
    methyl butyrate 52.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction