Salicyloyl phytosphingosine

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  • Identifiers

    CAS number
    212908-67-3

    Molecular formula
    C25H43NO5

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)C1=CC=CC=C1O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 45.48%
    Waxy 28.93%
    Oily 27.86%
    Savory 27.69%
    Cooling 27.43%
    Herbal 25.51%
    Citrus 24.82%
    Sweet 24.56%
    Fresh 24.52%
    Milky 23.31%

     

    Flavor
    Odorless 42.76%
    Bland 39.12%
    Mild 32.94%
    Bitter 29.47%
    Sweet-like 20.99%
    Faint 20.24%
    Slightly waxy 20.01%
    Cedarleaf 19.84%
    Herbal 19.56%
    Delicate 19.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.8

    pKa est.
    8.04 (weak base)

    Molecular weight
    437.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1018°C

    Flash point

    • 250.7 ˚C est.

  • Synonyms

    • Salicyloyl phytosphingosine
    • Phytosphingosine slc
    • 212908-67-3
    • U891J4JCNH
    • UNII-U891J4JCNH
    • Benzamide, N-((1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)-2-hydroxy-
    • PhytoEFA
    • MICELLAROtic Cleanser
    • RefChem:56429
    • phytosphingosine salicyloyl
    • SuffusionPS Hypo-Allergenic
    • DOUXO Calm Micro-emulsion Spray
    • 2-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]benzamide
    • Salicyloyl phytosphingosine [INCI]
    • SCHEMBL8405511
    • SCHEMBL29388707
    • Q27290849
    • 212908-67-3

  • Applications

    Salicyloyl phytosphingosine, CAS 212908-67-3, is used primarily in cosmetics and personal care as a ceramide-like lipid to support the skin barrier, provide moisturization, and improve skin feel. In hair care, it can serve as a conditioning and emollient ingredient to enhance softness and manageability. In pharmaceutical and topical delivery contexts, it may act as a lipid-based carrier or excipient for actives, or be viewed as a precursor for more complex ceramides and sphingolipids. As a synthetic intermediate for ceramide and sphingolipid chemistry, salicyloyl phytosphingosine is evaluated in research and development workflows for lipid formulation and related products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.09
    methanol 49.84
    isopropanol 13.85
    water 1.65
    ethyl acetate 14.97
    n-propanol 22.29
    acetone 55.55
    n-butanol 14.43
    acetonitrile 7.6
    DMF 128.4
    toluene 6.22
    isobutanol 13.4
    1,4-dioxane 38.5
    methyl acetate 20.24
    THF 135.41
    2-butanone 35.5
    n-pentanol 13.4
    sec-butanol 15.4
    n-hexane 0.74
    ethylene glycol 9.01
    NMP 214.53
    cyclohexane 2.33
    DMSO 381.95
    n-butyl acetate 11.61
    n-octanol 10.78
    chloroform 23.17
    n-propyl acetate 15.17
    acetic acid 82.34
    dichloromethane 23.46
    cyclohexanone 84.49
    propylene glycol 19.16
    isopropyl acetate 14.21
    DMAc 243.71
    2-ethoxyethanol 45.23
    isopentanol 12.16
    n-heptane 0.8
    ethyl formate 17.45
    1,2-dichloroethane 22.94
    n-hexanol 9.33
    2-methoxyethanol 69.28
    isobutyl acetate 9.98
    tetrachloromethane 8.46
    n-pentyl acetate 24.38
    transcutol 119.26
    n-heptanol 13.98
    ethylbenzene 4.43
    MIBK 17.25
    2-propoxyethanol 34.25
    tert-butanol 20.32
    MTBE 13.47
    2-butoxyethanol 44.52
    propionic acid 37.78
    o-xylene 7.66
    formic acid 47.93
    diethyl ether 7.46
    m-xylene 5.3
    p-xylene 6.02
    chlorobenzene 8.38
    dimethyl carbonate 20.87
    n-octane 0.69
    formamide 75.06
    cyclopentanone 118.93
    2-pentanone 24.51
    anisole 10.5
    cyclopentyl methyl ether 36.97
    gamma-butyrolactone 121.97
    1-methoxy-2-propanol 47.06
    pyridine 31.35
    3-pentanone 22.64
    furfural 71.9
    n-dodecane 0.48
    diethylene glycol 27.87
    diisopropyl ether 3.14
    tert-amyl alcohol 21.05
    acetylacetone 49.7
    n-hexadecane 0.54
    acetophenone 22.24
    methyl propionate 23.66
    isopentyl acetate 14.07
    trichloroethylene 46.02
    n-nonanol 10.88
    cyclohexanol 24.43
    benzyl alcohol 16.71
    2-ethylhexanol 6.62
    isooctanol 11.67
    dipropyl ether 6.51
    1,2-dichlorobenzene 10.4
    ethyl lactate 19.64
    propylene carbonate 51.32
    n-methylformamide 54.84
    2-pentanol 8.35
    n-pentane 0.65
    1-propoxy-2-propanol 25.79
    1-methoxy-2-propyl acetate 26.36
    2-(2-methoxypropoxy) propanol 32.16
    mesitylene 3.63
    ε-caprolactone 72.15
    p-cymene 3.73
    epichlorohydrin 75.86
    1,1,1-trichloroethane 21.16
    2-aminoethanol 24.39
    morpholine-4-carbaldehyde 111.6
    sulfolane 310.27
    2,2,4-trimethylpentane 0.9
    2-methyltetrahydrofuran 51.84
    n-hexyl acetate 24.53
    isooctane 0.41
    2-(2-butoxyethoxy)ethanol 47.88
    sec-butyl acetate 10.78
    tert-butyl acetate 23.17
    decalin 1.32
    glycerin 37.95
    diglyme 85.31
    acrylic acid 38.07
    isopropyl myristate 7.25
    n-butyric acid 39.77
    acetyl acetate 16.56
    di(2-ethylhexyl) phthalate 12.29
    ethyl propionate 13.66
    nitromethane 92.0
    1,2-diethoxyethane 21.16
    benzonitrile 11.28
    trioctyl phosphate 10.42
    1-bromopropane 7.1
    gamma-valerolactone 151.37
    n-decanol 6.91
    triethyl phosphate 11.76
    4-methyl-2-pentanol 6.2
    propionitrile 7.1
    vinylene carbonate 39.13
    1,1,2-trichlorotrifluoroethane 106.19
    DMS 21.81
    cumene 3.81
    2-octanol 9.27
    2-hexanone 18.47
    octyl acetate 12.02
    limonene 6.13
    1,2-dimethoxyethane 50.61
    ethyl orthosilicate 10.98
    tributyl phosphate 11.24
    diacetone alcohol 46.92
    N,N-dimethylaniline 11.93
    acrylonitrile 11.3
    aniline 14.55
    1,3-propanediol 30.66
    bromobenzene 6.87
    dibromomethane 13.2
    1,1,2,2-tetrachloroethane 51.48
    2-methyl-cyclohexyl acetate 16.0
    tetrabutyl urea 17.0
    diisobutyl methanol 4.63
    2-phenylethanol 14.37
    styrene 4.34
    dioctyl adipate 16.17
    dimethyl sulfate 66.94
    ethyl butyrate 11.7
    methyl lactate 32.98
    butyl lactate 32.75
    diethyl carbonate 8.84
    propanediol butyl ether 40.56
    triethyl orthoformate 13.4
    p-tert-butyltoluene 3.94
    methyl 4-tert-butylbenzoate 34.55
    morpholine 60.64
    tert-butylamine 8.09
    n-dodecanol 4.53
    dimethoxymethane 48.6
    ethylene carbonate 33.13
    cyrene 50.36
    2-ethoxyethyl acetate 36.61
    2-ethylhexyl acetate 10.38
    1,2,4-trichlorobenzene 16.17
    4-methylpyridine 21.12
    dibutyl ether 7.8
    2,6-dimethyl-4-heptanol 4.63
    DEF 43.37
    dimethyl isosorbide 57.94
    tetrachloroethylene 38.86
    eugenol 32.23
    triacetin 38.56
    span 80 31.85
    1,4-butanediol 14.57
    1,1-dichloroethane 14.82
    2-methyl-1-pentanol 12.62
    methyl formate 39.86
    2-methyl-1-butanol 13.84
    n-decane 0.97
    butyronitrile 7.06
    3,7-dimethyl-1-octanol 8.25
    1-chlorooctane 4.74
    1-chlorotetradecane 1.6
    n-nonane 0.82
    undecane 0.65
    tert-butylcyclohexane 0.99
    cyclooctane 0.8
    cyclopentanol 38.35
    tetrahydropyran 37.03
    tert-amyl methyl ether 14.29
    2,5,8-trioxanonane 54.71
    1-hexene 2.53
    2-isopropoxyethanol 28.02
    2,2,2-trifluoroethanol 46.74
    methyl butyrate 21.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction