Salicylamide

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  • Identifiers

    CAS number
    65-45-2

    Molecular formula
    C7H7NO2

    SMILES
    C1=CC=C(C(=C1)C(=O)N)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 52.09%
    Phenolic 37.36%
    Bitter 34.48%
    Sweet 33.93%
    Burnt 27.33%
    Balsamic 24.76%
    Savory 24.3%
    Spicy 23.3%
    Musty 20.79%
    Medicinal 20.68%

     

    Flavor
    Phenolic 54.23%
    Mild 43.7%
    Odorless 42.16%
    Nutty 42.11%
    Bitter 32.79%
    Faint 27.19%
    Urine 24.25%
    Cadaverous 22.63%
    Sour 22.6%
    Nitrile 22.49%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    8.45 (weak base)

    Molecular weight
    137.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 284 °F (NTP, 1992)
    • 142 °C
    • 140 °C

    Boiling point

    • 518 °F at 760 mmHg (decomposes) (NTP, 1992)
    • 181.5 °C
    • 181.5 °C @ 14 MM HG
    • 181.50 °C. @ 760.00 mm Hg

    Flash point

    • 140.96 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • 2060 mg/L (at 25 °C)
    • SOLUBILITY IN WATER: 0.2% @ 30 °C; 0.8% @ 47 °C; IN GLYCEROL: 2.0% @ 5 °C; 5.0% @ 39 °C; 10.0% @ 60 °C; IN PROPYLENE GLYCOL: 10.0% @ 5 °C
    • SLIGHTLY SOL IN NAPHTHA, CARBON TETRACHLORIDE
    • FREELY SOL IN SOLN OF ALKALIES
    • SOL IN CHLOROFORM, ALC, ETHER
    • Water solubility = 2.06X10+3 mg/L at 25 °C
    • 2060 mg/L @ 25 °C (exp)

  • Synonyms

    • salicylamide
    • 2-Hydroxybenzamide
    • 65-45-2
    • o-Hydroxybenzamide
    • 2-Carbamoylphenol
    • Salicylic acid amide
    • Benzamide, 2-hydroxy-
    • Urtosal
    • 2-Carboxamidophenol
    • Algiamida
    • Amidosal
    • Dolomide
    • Dropsprin
    • Eggosalil
    • Flarpirina
    • Liquiprin
    • Morsarinas
    • Panithal
    • Raspberin
    • Salamide
    • Saliamid
    • Saliamin
    • Salizell
    • Serramida
    • Algamon
    • Allevin
    • Anamid
    • Andasol
    • Novecyl
    • Oramid
    • Salicim
    • Salipur
    • Salrin
    • Salymid
    • Acket
    • Afko-Sal
    • Amid-Sal
    • Salicilamida
    • Benzamide, o-hydroxy-
    • Salicilamide
    • Salicylamidum
    • Amid kyseliny salicylove
    • MFCD00007978
    • NSC 3115
    • OHB
    • Salicylamid
    • CCRIS 6045
    • HSDB 227
    • Cidal
    • Samid
    • H.P. 34
    • SR 4326
    • Benzoic acid, 2-hydroxy-, amide
    • UNII-EM8BM710ZC
    • NSC-3115
    • EINECS 200-609-3
    • EM8BM710ZC
    • 2-Hydroxy-benzamide
    • BRN 0742439
    • DTXSID3021726
    • CHEBI:32114
    • AI3-03454
    • CHEMBL27577
    • MLS000069486
    • DTXCID501726
    • EC 200-609-3
    • 4-10-00-00169 (Beilstein Handbook Reference)
    • NCGC00091414-02
    • SMR000046394
    • Salicylamide 100 microg/mL in Acetonitrile
    • SALICYLAMIDE (MART.)
    • SALICYLAMIDE [MART.]
    • Salizell (VAN)
    • Benesal (VAN)
    • SALICYLAMIDE (USP-RS)
    • SALICYLAMIDE [USP-RS]
    • Salicilamide [DCIT]
    • Salicilamide [Italian]
    • SALICYLAMIDE (USP MONOGRAPH)
    • SALICYLAMIDE [USP MONOGRAPH]
    • Salicylamidum [INN-Latin]
    • CAS-65-45-2
    • Salicilamida [INN-Spanish]
    • Amid kyseliny salicylove [Czech]
    • hydroxy benzamide
    • dihydroxybenzalamine
    • Salicylamide [USP:INN:BAN:JAN]
    • Salicylamide (TN)
    • Salicylamide, 99%
    • Spectrum_000946
    • Salicylamide (Standard)
    • Opera_ID_1684
    • Spectrum2_001312
    • Spectrum3_000564
    • Spectrum4_000499
    • Spectrum5_001032
    • SALICYLAMIDE [MI]
    • WLN: ZVR BQ
    • SALICYLAMIDE [INN]
    • SALICYLAMIDE [JAN]
    • SALICYLAMIDE [HSDB]
    • NCIOpen2_001127
    • SALICYLAMIDE [VANDF]
    • Oprea1_069894
    • SCHEMBL21646
    • BSPBio_001948
    • KBioGR_001017
    • KBioSS_001426
    • DivK1c_000858
    • SALICYLAMIDE [WHO-DD]
    • SPECTRUM1500532
    • Salicylamide (JAN/USP/INN)
    • SPBio_001403
    • benzenecarboxamide, 2-hydroxy-
    • HMS502K20
    • HY-B0811R
    • KBio1_000858
    • KBio2_001426
    • KBio2_003994
    • KBio2_006562
    • KBio3_001448
    • N02BA05
    • NSC3115
    • NINDS_000858
    • HMS1920P14
    • HMS2092G15
    • HMS2232E07
    • Pharmakon1600-01500532

  • Applications

    Salicylamide (CAS 65-45-2) is primarily used as a chemical intermediate and building block in organic synthesis, especially for salicylamide-related derivatives in pharmaceutical research; it also serves as a precursor for specialty polymers and resin formulations in the plastics and coatings sector; in fragrance and perfumery it may be encountered as an odorant or intermediate for aroma compounds; in analytical chemistry it is used as a reagent and reference material for structure and property determination.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 114.77
    methanol 182.38
    isopropanol 71.69
    water 10.7
    ethyl acetate 108.76
    n-propanol 71.14
    acetone 299.29
    n-butanol 53.18
    acetonitrile 87.55
    DMF 458.07
    toluene 7.65
    isobutanol 40.57
    1,4-dioxane 260.48
    methyl acetate 121.27
    THF 746.82
    2-butanone 141.57
    n-pentanol 47.77
    sec-butanol 44.3
    n-hexane 1.96
    ethylene glycol 96.91
    NMP 283.25
    cyclohexane 0.39
    DMSO 842.33
    n-butyl acetate 30.64
    n-octanol 28.87
    chloroform 11.54
    n-propyl acetate 44.92
    acetic acid 103.63
    dichloromethane 10.81
    cyclohexanone 101.14
    propylene glycol 66.48
    isopropyl acetate 52.71
    DMAc 222.05
    2-ethoxyethanol 117.64
    isopentanol 40.44
    n-heptane 2.21
    ethyl formate 64.99
    1,2-dichloroethane 17.82
    n-hexanol 48.37
    2-methoxyethanol 227.81
    isobutyl acetate 24.38
    tetrachloromethane 5.1
    n-pentyl acetate 25.24
    transcutol 107.47
    n-heptanol 31.43
    ethylbenzene 4.58
    MIBK 66.21
    2-propoxyethanol 122.36
    tert-butanol 77.59
    MTBE 43.87
    2-butoxyethanol 63.72
    propionic acid 79.26
    o-xylene 7.13
    formic acid 120.47
    diethyl ether 54.56
    m-xylene 10.29
    p-xylene 6.18
    chlorobenzene 8.9
    dimethyl carbonate 71.92
    n-octane 1.16
    formamide 170.63
    cyclopentanone 271.33
    2-pentanone 118.0
    anisole 29.03
    cyclopentyl methyl ether 104.42
    gamma-butyrolactone 320.17
    1-methoxy-2-propanol 167.93
    pyridine 43.14
    3-pentanone 63.66
    furfural 135.38
    n-dodecane 1.29
    diethylene glycol 134.9
    diisopropyl ether 14.76
    tert-amyl alcohol 44.88
    acetylacetone 143.87
    n-hexadecane 1.44
    acetophenone 28.79
    methyl propionate 102.2
    isopentyl acetate 24.94
    trichloroethylene 26.98
    n-nonanol 24.6
    cyclohexanol 30.91
    benzyl alcohol 29.35
    2-ethylhexanol 22.27
    isooctanol 23.64
    dipropyl ether 26.83
    1,2-dichlorobenzene 8.32
    ethyl lactate 38.67
    propylene carbonate 89.36
    n-methylformamide 215.07
    2-pentanol 38.93
    n-pentane 1.34
    1-propoxy-2-propanol 69.28
    1-methoxy-2-propyl acetate 55.91
    2-(2-methoxypropoxy) propanol 47.7
    mesitylene 7.43
    ε-caprolactone 74.56
    p-cymene 6.39
    epichlorohydrin 212.8
    1,1,1-trichloroethane 15.69
    2-aminoethanol 106.07
    morpholine-4-carbaldehyde 200.01
    sulfolane 373.72
    2,2,4-trimethylpentane 1.51
    2-methyltetrahydrofuran 176.96
    n-hexyl acetate 33.99
    isooctane 1.83
    2-(2-butoxyethoxy)ethanol 67.66
    sec-butyl acetate 26.3
    tert-butyl acetate 53.14
    decalin 1.25
    glycerin 128.6
    diglyme 105.62
    acrylic acid 75.57
    isopropyl myristate 15.41
    n-butyric acid 73.43
    acetyl acetate 46.4
    di(2-ethylhexyl) phthalate 17.16
    ethyl propionate 47.27
    nitromethane 286.48
    1,2-diethoxyethane 31.81
    benzonitrile 22.35
    trioctyl phosphate 17.15
    1-bromopropane 10.29
    gamma-valerolactone 242.44
    n-decanol 18.5
    triethyl phosphate 17.5
    4-methyl-2-pentanol 26.59
    propionitrile 50.71
    vinylene carbonate 60.42
    1,1,2-trichlorotrifluoroethane 100.35
    DMS 31.7
    cumene 5.16
    2-octanol 20.52
    2-hexanone 61.15
    octyl acetate 21.84
    limonene 9.4
    1,2-dimethoxyethane 164.29
    ethyl orthosilicate 15.63
    tributyl phosphate 16.72
    diacetone alcohol 92.16
    N,N-dimethylaniline 21.13
    acrylonitrile 67.99
    aniline 23.99
    1,3-propanediol 107.91
    bromobenzene 5.45
    dibromomethane 7.1
    1,1,2,2-tetrachloroethane 26.58
    2-methyl-cyclohexyl acetate 20.92
    tetrabutyl urea 24.37
    diisobutyl methanol 15.62
    2-phenylethanol 33.33
    styrene 4.66
    dioctyl adipate 21.12
    dimethyl sulfate 131.37
    ethyl butyrate 27.35
    methyl lactate 84.46
    butyl lactate 27.53
    diethyl carbonate 18.0
    propanediol butyl ether 51.68
    triethyl orthoformate 19.79
    p-tert-butyltoluene 6.92
    methyl 4-tert-butylbenzoate 38.13
    morpholine 225.24
    tert-butylamine 30.11
    n-dodecanol 13.85
    dimethoxymethane 265.77
    ethylene carbonate 51.72
    cyrene 59.23
    2-ethoxyethyl acetate 35.3
    2-ethylhexyl acetate 17.35
    1,2,4-trichlorobenzene 11.88
    4-methylpyridine 43.7
    dibutyl ether 17.03
    2,6-dimethyl-4-heptanol 15.62
    DEF 88.33
    dimethyl isosorbide 71.41
    tetrachloroethylene 16.34
    eugenol 42.08
    triacetin 33.27
    span 80 37.99
    1,4-butanediol 52.77
    1,1-dichloroethane 17.41
    2-methyl-1-pentanol 32.1
    methyl formate 189.97
    2-methyl-1-butanol 33.2
    n-decane 2.01
    butyronitrile 48.71
    3,7-dimethyl-1-octanol 20.42
    1-chlorooctane 10.17
    1-chlorotetradecane 4.03
    n-nonane 1.72
    undecane 1.57
    tert-butylcyclohexane 1.85
    cyclooctane 0.42
    cyclopentanol 73.15
    tetrahydropyran 99.22
    tert-amyl methyl ether 31.95
    2,5,8-trioxanonane 79.51
    1-hexene 8.64
    2-isopropoxyethanol 72.12
    2,2,2-trifluoroethanol 61.72
    methyl butyrate 55.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction