Roxadimate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    58882-17-0

    Molecular formula
    C15H23NO4

    SMILES
    CCOC(=O)C1=CC=C(C=C1)N(CC(C)O)CC(C)O

    Safety labels

  • Odor profile

    Fragrance
    Sweet 41.91%
    Odorless 41.23%
    Floral 30.35%
    Grape 29.81%
    Vanilla 24.21%
    Milky 22.8%
    Fruity 21.63%
    Creamy 20.14%
    Powdery 20.04%
    Savory 19.83%

     

    Flavor
    Fruity 63.7%
    Bitter 39.21%
    Odorless 36.75%
    Mild 35.17%
    Grape 26.55%
    Sweet 24.66%
    Floral 22.79%
    Sweet-like 20.68%
    Tropical 20.32%
    Orange flower 20.05%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.56 (neutral)

    Molecular weight
    281.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    471°C

    Flash point

    • 199.85 ˚C est.

  • Synonyms

    • Roxadimate
    • 58882-17-0
    • Ethyl dihydroxypropyl PABA
    • Roxadimato
    • Roxadimatum
    • 4-[Bis(2-hydroxypropyl)amino]benzoic acid, ethyl ester
    • Roxadimate [USAN:INN]
    • Roxadimatum [INN-Latin]
    • Roxadimato [INN-Spanish]
    • Ethyl 4-(bis(hydroxypropyl)) aminobenzoate
    • ROXADIMATE [INN]
    • EINECS 261-482-8
    • ROXADIMATE [USAN]
    • ROXADIMATE [MART.]
    • ROXADIMATE [WHO-DD]
    • Benzoic acid, 4-[bis(2-hydroxypropyl)amino]-, ethyl ester
    • 54M9O25201
    • Ethyl (+-)-p-(bis(2-hydroxypropyl)amino)benzoate
    • Ethyl dihydroxypropyl p-aminobenzoate
    • Benzoic acid, 4-(bis(2-hydroxypropyl)amino)-, ethyl ester
    • ethyl 4-(bis(hydroxypropyl))aminobenzoate
    • ETHYL DIHYDROXYPROPYL PABA [VANDF]
    • Roxadimatum (INN-Latin)
    • Roxadimato (INN-Spanish)
    • ROXADIMATE (MART.)
    • 4-(Bis(2-hydroxypropyl)amino)benzoic acid, ethyl ester
    • RefChem:883870
    • ETHYL DIHYDROXYPROPYL PABA [INCI]
    • ethyl 4-[bis(2-hydroxypropyl)amino]benzoate
    • AMERSCREEN P
    • Ethyl 4-(bis(2-hydroxypropyl)amino)benzoate
    • 4-[BIS(2-HYDROXYPROPYL)AMINO]BENZOIC ACID ETHYL ESTER
    • 4-[Bis(2-hydroxypropyl)amino]benzoic Acid Ethyl Ester, 90%
    • 4-[Bis(2-hydroxypropyl)amino]benzoic Acid Ethyl Ester, 90per cent
    • UNII-54M9O25201
    • Benzoic acid, 4-[bis(2-hydroxypropyl)amino]-, ethyl ester; Amerscreen P; Ethyl 4-[N,N-di(2-hydroxypropyl)amino]benzoate; Ethyl dihydroxypropyl PABA; Roxadimate; 4-[Bis(2-hydroxypropyl)amino]benzoic Acid Ethyl Ester
    • starbld0000295
    • Roxadimate (USAN/INN)
    • SCHEMBL15518
    • CHEMBL2105417
    • DTXSID70866716
    • AKOS027321165
    • FB18673
    • SB82440
    • NS00013659
    • D05770
    • ethyl N,N-bis(2-hydroxypropyl)-p-aminobenzoate
    • SBI-0654117.0001
    • Q27261226
    • ETHYL (+/-)-P-(BIS(2-HYDROXYPROPYL)AMINO)BENZOATE
    • 58882-17-0

  • Applications

    Roxadimate (CAS 58882-17-0) is described as an intermediate in specialty chemical synthesis and may function as a solvent or processing aid in tailored formulations. In industrial materials, it can act as a plasticizer or stabilizer for polymers, and as a processing additive in coatings and inks, and may serve as a solvent or carrier in cleaning formulations. Additionally, it may be evaluated for cosmetic or personal care applications as an additive or fragrance-related fixative, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 108.24
    methanol 291.87
    isopropanol 39.35
    water 2.83
    ethyl acetate 21.96
    n-propanol 62.28
    acetone 53.28
    n-butanol 41.31
    acetonitrile 26.83
    DMF 195.08
    toluene 5.72
    isobutanol 34.58
    1,4-dioxane 41.43
    methyl acetate 22.6
    THF 98.86
    2-butanone 27.15
    n-pentanol 40.96
    sec-butanol 32.62
    n-hexane 0.66
    ethylene glycol 55.85
    NMP 200.75
    cyclohexane 1.01
    DMSO 454.8
    n-butyl acetate 18.66
    n-octanol 14.83
    chloroform 58.38
    n-propyl acetate 22.08
    acetic acid 210.91
    dichloromethane 82.63
    cyclohexanone 77.24
    propylene glycol 84.52
    isopropyl acetate 14.15
    DMAc 235.26
    2-ethoxyethanol 105.49
    isopentanol 29.1
    n-heptane 0.5
    ethyl formate 31.58
    1,2-dichloroethane 43.17
    n-hexanol 22.98
    2-methoxyethanol 162.84
    isobutyl acetate 16.11
    tetrachloromethane 3.95
    n-pentyl acetate 14.35
    transcutol 172.07
    n-heptanol 14.2
    ethylbenzene 5.52
    MIBK 17.15
    2-propoxyethanol 72.21
    tert-butanol 39.1
    MTBE 11.11
    2-butoxyethanol 41.32
    propionic acid 72.94
    o-xylene 7.57
    formic acid 178.25
    diethyl ether 9.69
    m-xylene 7.29
    p-xylene 7.85
    chlorobenzene 14.04
    dimethyl carbonate 18.15
    n-octane 0.45
    formamide 153.96
    cyclopentanone 106.74
    2-pentanone 23.44
    anisole 17.41
    cyclopentyl methyl ether 29.46
    gamma-butyrolactone 134.62
    1-methoxy-2-propanol 84.85
    pyridine 34.66
    3-pentanone 17.35
    furfural 115.0
    n-dodecane 0.46
    diethylene glycol 94.5
    diisopropyl ether 2.97
    tert-amyl alcohol 33.29
    acetylacetone 40.77
    n-hexadecane 0.53
    acetophenone 33.88
    methyl propionate 28.36
    isopentyl acetate 18.86
    trichloroethylene 84.99
    n-nonanol 13.74
    cyclohexanol 33.12
    benzyl alcohol 36.66
    2-ethylhexanol 12.82
    isooctanol 12.23
    dipropyl ether 7.71
    1,2-dichlorobenzene 17.35
    ethyl lactate 33.25
    propylene carbonate 66.24
    n-methylformamide 94.07
    2-pentanol 16.02
    n-pentane 0.48
    1-propoxy-2-propanol 41.33
    1-methoxy-2-propyl acetate 31.99
    2-(2-methoxypropoxy) propanol 50.3
    mesitylene 4.75
    ε-caprolactone 72.27
    p-cymene 5.38
    epichlorohydrin 108.79
    1,1,1-trichloroethane 16.08
    2-aminoethanol 97.98
    morpholine-4-carbaldehyde 135.48
    sulfolane 213.55
    2,2,4-trimethylpentane 0.72
    2-methyltetrahydrofuran 43.54
    n-hexyl acetate 22.56
    isooctane 0.39
    2-(2-butoxyethoxy)ethanol 60.47
    sec-butyl acetate 12.96
    tert-butyl acetate 17.63
    decalin 1.15
    glycerin 127.67
    diglyme 98.06
    acrylic acid 81.56
    isopropyl myristate 8.25
    n-butyric acid 63.27
    acetyl acetate 21.53
    di(2-ethylhexyl) phthalate 18.76
    ethyl propionate 18.98
    nitromethane 164.85
    1,2-diethoxyethane 24.89
    benzonitrile 27.87
    trioctyl phosphate 12.83
    1-bromopropane 13.25
    gamma-valerolactone 135.77
    n-decanol 9.97
    triethyl phosphate 16.16
    4-methyl-2-pentanol 10.52
    propionitrile 20.6
    vinylene carbonate 62.63
    1,1,2-trichlorotrifluoroethane 130.5
    DMS 25.98
    cumene 5.68
    2-octanol 8.83
    2-hexanone 22.82
    octyl acetate 12.76
    limonene 7.27
    1,2-dimethoxyethane 90.5
    ethyl orthosilicate 14.49
    tributyl phosphate 14.66
    diacetone alcohol 41.99
    N,N-dimethylaniline 19.02
    acrylonitrile 34.82
    aniline 20.5
    1,3-propanediol 94.87
    bromobenzene 11.25
    dibromomethane 38.83
    1,1,2,2-tetrachloroethane 64.14
    2-methyl-cyclohexyl acetate 23.36
    tetrabutyl urea 22.4
    diisobutyl methanol 6.63
    2-phenylethanol 28.4
    styrene 5.86
    dioctyl adipate 20.7
    dimethyl sulfate 52.76
    ethyl butyrate 17.06
    methyl lactate 44.57
    butyl lactate 29.54
    diethyl carbonate 14.98
    propanediol butyl ether 55.02
    triethyl orthoformate 16.1
    p-tert-butyltoluene 4.69
    methyl 4-tert-butylbenzoate 34.03
    morpholine 70.53
    tert-butylamine 11.8
    n-dodecanol 7.08
    dimethoxymethane 61.92
    ethylene carbonate 48.5
    cyrene 71.39
    2-ethoxyethyl acetate 26.82
    2-ethylhexyl acetate 14.55
    1,2,4-trichlorobenzene 25.81
    4-methylpyridine 33.21
    dibutyl ether 8.41
    2,6-dimethyl-4-heptanol 6.63
    DEF 49.31
    dimethyl isosorbide 71.76
    tetrachloroethylene 36.63
    eugenol 39.71
    triacetin 39.41
    span 80 42.41
    1,4-butanediol 55.14
    1,1-dichloroethane 20.8
    2-methyl-1-pentanol 32.21
    methyl formate 71.29
    2-methyl-1-butanol 32.97
    n-decane 0.82
    butyronitrile 21.42
    3,7-dimethyl-1-octanol 12.74
    1-chlorooctane 4.76
    1-chlorotetradecane 1.84
    n-nonane 0.72
    undecane 0.6
    tert-butylcyclohexane 1.0
    cyclooctane 0.48
    cyclopentanol 42.16
    tetrahydropyran 26.76
    tert-amyl methyl ether 12.85
    2,5,8-trioxanonane 74.92
    1-hexene 3.59
    2-isopropoxyethanol 57.34
    2,2,2-trifluoroethanol 70.12
    methyl butyrate 29.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction