Riboflavin

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  • Identifiers

    CAS number
    83-88-5

    Molecular formula
    C17H20N4O6

    SMILES
    CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 76.96%
    Savory 22.49%
    Bitter 21.54%
    Milky 20.41%
    Cooked 16.75%
    Fatty 15.48%
    Sweet 15.32%
    Burnt 14.11%
    Roasted 13.73%
    Animal 13.72%

     

    Flavor
    Bitter 82.45%
    Odorless 51.78%
    Bland 33.11%
    Sweet-like 24.52%
    Mild 21.39%
    Very mild 20.73%
    Cedarleaf 18.83%
    Nitrile 18.6%
    Parsley 18.1%
    Heather 18.03%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.5

    pKa est.
    6.42 (neutral)

    Molecular weight
    376.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2608°C

    Melting point expt.

    • 280 dec °C
    • 280 °C (decomposes)
    • MP: Decomposes at 278-282 °C (darkens at about 240 °C)
    • 290 °C

    Flash point

    • 364.02 ˚C est.

    Solubility expt.

    • 84.7 mg/L (at 25 °C)
    • Soluble in sodium chloride solutions; 0.0045 g/100 mL of absolute ethanol at 27.5 °C; slightly sol in cyclohexanol, amyl acetate and benzyl alcohol, phenol; insoluble in ether, chloroform, acetone, benzene; very soluble in dilute alkalies (with decomposition)
    • SOLUBILITY IN WATER AT 25 °C: 10-13 MG/100 ML
    • Slightly soluble in alcohols; insoluble in lipid solvents
    • Insoluble in ethyl ether, acetone, chloroform; slightly soluble in ethanol
    • In water, of 0.1 g/L at 20 °C; 0.071 g/L and 0.085 g/L at 25 °C
    • 0.0847 mg/mL
    • Solubility in water, g/100ml at 25 °C: 0.01

  • Synonyms

    • riboflavin
    • vitamin B2
    • Riboflavine
    • Lactoflavin
    • 83-88-5
    • Vitamin G
    • Lactoflavine
    • Flavaxin
    • Beflavine
    • Riboflavinum
    • Beflavin
    • Riboderm
    • Riboflavina
    • Ribipca
    • Lactobene
    • Ribocrisina
    • Ribotone
    • Vitaflavine
    • Flaxain
    • Ribosyn
    • Ribovel
    • Vitamin Bi
    • Flavin BB
    • Russupteridine Yellow III
    • Vitasan B2
    • HYRE
    • Bisulase
    • 6,7-Dimethyl-9-D-ribitylisoalloxazine
    • Riboflavinequinone
    • 7,8-Dimethyl-10-ribitylisoalloxazine
    • Lacto-flavin
    • Fiboflavin
    • Dermadram
    • E101
    • vitamin-b2
    • Aqua-Flave
    • C.I. Food Yellow 15
    • Vitamin B-2
    • Ins no.101(iii)
    • DTXSID8021777
    • Ins-101(iii)
    • 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
    • E-101(iii)
    • TLM2976OFR
    • Vitamin b2 (as riboflavin)
    • 7,8-dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
    • 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
    • CHEBI:17015
    • INS NO. 101(I)
    • Isoalloxazine, 7,8-dimethyl-10-D-ribityl-
    • C.I. 50900
    • NSC-33298
    • NCI-0033298
    • DTXCID401777
    • Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
    • 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
    • Benzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
    • 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
    • Vitamin B 2
    • Freeda
    • vitaminum b2
    • 7,8-dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo(g)pteridine-2,4-dione
    • 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo(g)pteridine-2,4(3H,10H)-dione
    • 7,8-dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)-2H,3H,4H,10H-benzo(g)pteridine-2,4-dione
    • 7,8-dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo(g)pteridine-2,4(3H,10H)-dione
    • PureVita Vitamin B2
    • RefChem:6201
    • A11HA04
    • S01XA26
    • 7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo(g)pteridine-2,4-dione
    • CHEBI:176838
    • 201-507-1
    • NSC33298
    • (-)-riboflavin
    • Riboflavin (Vitamin B2)
    • MFCD00005022
    • 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
    • C17H20N4O6
    • Riboflavin RS
    • 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol
    • D-Ribitol, 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin-10(2H)-yl)-
    • NSC 33298
    • Riboflavine [INN-French]
    • Riboflavinum [INN-Latin]
    • Riboflavina [INN-Spanish]
    • HSDB 817
    • (?)-Riboflavin
    • Riboflavin (B2)
    • 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
    • CCRIS 1904
    • Riboflavin galactoside
    • Riboflavin (Vit B2)
    • EINECS 201-507-1
    • UNII-TLM2976OFR
    • Riboflavin [USP:INN:BAN]
    • AI3-14697
    • Riboflavin CRS
    • 1kyv
    • 2ccb
    • 2vxa
    • ()-Riboflavin
    • San Yellow B
    • CAS-83-88-5
    • NCGC00017291-05
    • Bisulase (TN)
    • Food Yellow 15
    • Prestwick_442
    • Riboflavin (Standard)
    • Vitamin B2-Riboflavin
    • 2fl5
    • 2vx9
    • 4d1y
    • RIBOFLAVIN [II]
    • RIBOFLAVIN [MI]
    • RIBOFLAVIN [FCC]
    • RIBOFLAVIN [INN]
    • RIBOFLAVIN [JAN]
    • Vitamin B2; E101
    • Prestwick3_000634
    • RIBOFLAVIN [HSDB]
    • RIBOFLAVIN [VANDF]
    • Epitope ID:161730
    • RIBOFLAVINUM [HPUS]
    • RIBOFLAVIN [MART.]
    • SCHEMBL7706
    • CHEMBL1534
    • RIBOFLAVIN [USP-RS]
    • 83-88-5

  • Applications

    Riboflavin (CAS 83-88-5) is the vitamin B2 used as a nutritional supplement in foods and beverages, and as a yellow color additive in foods and cosmetics (commonly referenced as E101); it also serves as a feed additive for livestock and companion animals; it is an ingredient in pharmaceuticals and nutraceuticals; it functions as a cosmetic colorant in personal care products; in analytical and research contexts, riboflavin is used as a fluorescent standard and as a reagent in biochemical assays.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.64
    methanol 11.88
    isopropanol 3.65
    water 6.93
    ethyl acetate 0.23
    n-propanol 6.31
    acetone 1.52
    n-butanol 2.58
    acetonitrile 0.91
    DMF 32.54
    toluene 0.09
    isobutanol 2.03
    1,4-dioxane 1.34
    methyl acetate 0.77
    THF 5.35
    2-butanone 2.1
    n-pentanol 1.66
    sec-butanol 2.73
    n-hexane 0.06
    ethylene glycol 35.13
    NMP 64.04
    cyclohexane 0.09
    DMSO 104.5
    n-butyl acetate 0.44
    n-octanol 0.23
    chloroform 0.28
    n-propyl acetate 0.39
    acetic acid 34.8
    dichloromethane 0.36
    cyclohexanone 3.48
    propylene glycol 25.19
    isopropyl acetate 0.15
    DMAc 47.96
    2-ethoxyethanol 14.04
    isopentanol 1.21
    n-heptane 0.08
    ethyl formate 1.31
    1,2-dichloroethane 0.47
    n-hexanol 1.05
    2-methoxyethanol 43.91
    isobutyl acetate 0.14
    tetrachloromethane 0.2
    n-pentyl acetate 0.31
    transcutol 5.62
    n-heptanol 0.64
    ethylbenzene 0.08
    MIBK 0.31
    2-propoxyethanol 7.53
    tert-butanol 1.77
    MTBE 0.18
    2-butoxyethanol 3.79
    propionic acid 7.83
    o-xylene 0.12
    formic acid 133.29
    diethyl ether 0.29
    m-xylene 0.08
    p-xylene 0.12
    chlorobenzene 0.06
    dimethyl carbonate 1.13
    n-octane 0.03
    formamide 126.17
    cyclopentanone 6.31
    2-pentanone 0.68
    anisole 0.17
    cyclopentyl methyl ether 0.84
    gamma-butyrolactone 9.05
    1-methoxy-2-propanol 12.68
    pyridine 1.94
    3-pentanone 0.7
    furfural 8.84
    n-dodecane 0.02
    diethylene glycol 20.35
    diisopropyl ether 0.07
    tert-amyl alcohol 1.52
    acetylacetone 0.69
    n-hexadecane 0.02
    acetophenone 0.55
    methyl propionate 0.86
    isopentyl acetate 0.38
    trichloroethylene 0.65
    n-nonanol 0.27
    cyclohexanol 1.68
    benzyl alcohol 1.03
    2-ethylhexanol 0.41
    isooctanol 0.39
    dipropyl ether 0.42
    1,2-dichlorobenzene 0.09
    ethyl lactate 1.8
    propylene carbonate 2.24
    n-methylformamide 26.62
    2-pentanol 0.85
    n-pentane 0.08
    1-propoxy-2-propanol 3.33
    1-methoxy-2-propyl acetate 0.93
    2-(2-methoxypropoxy) propanol 2.69
    mesitylene 0.06
    ε-caprolactone 3.29
    p-cymene 0.11
    epichlorohydrin 4.09
    1,1,1-trichloroethane 0.15
    2-aminoethanol 33.76
    morpholine-4-carbaldehyde 22.53
    sulfolane 33.29
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.55
    n-hexyl acetate 0.23
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.82
    sec-butyl acetate 0.16
    tert-butyl acetate 0.21
    decalin 0.03
    glycerin 67.32
    diglyme 5.28
    acrylic acid 12.98
    isopropyl myristate 0.12
    n-butyric acid 3.43
    acetyl acetate 0.16
    di(2-ethylhexyl) phthalate 0.41
    ethyl propionate 0.32
    nitromethane 18.22
    1,2-diethoxyethane 0.46
    benzonitrile 0.4
    trioctyl phosphate 0.36
    1-bromopropane 0.25
    gamma-valerolactone 17.08
    n-decanol 0.22
    triethyl phosphate 0.58
    4-methyl-2-pentanol 0.33
    propionitrile 0.93
    vinylene carbonate 1.85
    1,1,2-trichlorotrifluoroethane 18.84
    DMS 0.45
    cumene 0.07
    2-octanol 0.25
    2-hexanone 0.68
    octyl acetate 0.21
    limonene 0.16
    1,2-dimethoxyethane 5.48
    ethyl orthosilicate 0.47
    tributyl phosphate 0.37
    diacetone alcohol 2.23
    N,N-dimethylaniline 0.29
    acrylonitrile 1.89
    aniline 0.66
    1,3-propanediol 24.89
    bromobenzene 0.04
    dibromomethane 0.25
    1,1,2,2-tetrachloroethane 0.79
    2-methyl-cyclohexyl acetate 0.47
    tetrabutyl urea 0.9
    diisobutyl methanol 0.21
    2-phenylethanol 0.81
    styrene 0.07
    dioctyl adipate 0.3
    dimethyl sulfate 4.73
    ethyl butyrate 0.42
    methyl lactate 5.76
    butyl lactate 1.31
    diethyl carbonate 0.36
    propanediol butyl ether 3.6
    triethyl orthoformate 0.55
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 0.89
    morpholine 5.01
    tert-butylamine 0.51
    n-dodecanol 0.16
    dimethoxymethane 4.08
    ethylene carbonate 1.3
    cyrene 7.57
    2-ethoxyethyl acetate 0.57
    2-ethylhexyl acetate 0.28
    1,2,4-trichlorobenzene 0.18
    4-methylpyridine 0.78
    dibutyl ether 0.14
    2,6-dimethyl-4-heptanol 0.21
    DEF 2.54
    dimethyl isosorbide 3.92
    tetrachloroethylene 0.81
    eugenol 1.62
    triacetin 0.63
    span 80 2.17
    1,4-butanediol 8.88
    1,1-dichloroethane 0.16
    2-methyl-1-pentanol 0.85
    methyl formate 9.75
    2-methyl-1-butanol 1.54
    n-decane 0.03
    butyronitrile 0.58
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.06
    1-chlorotetradecane 0.03
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 4.27
    tetrahydropyran 1.03
    tert-amyl methyl ether 0.28
    2,5,8-trioxanonane 4.31
    1-hexene 0.17
    2-isopropoxyethanol 3.31
    2,2,2-trifluoroethanol 18.78
    methyl butyrate 0.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction